Synthetic Oligosaccharides for Staphylococcus Vaccine

ABSTRACT

The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)-glucosamine species having a definite number of monosaccharide units, including a set pattern of acetylated and non-acetylated residues. The invention further provides antibodies to these synthetic oligo-β-(1→6)-glucosamines as well as compositions thereof and methods for treating and preventing infections caused by bacteria expressing poly-β-(1→6)-glucosamines, such as  Staphylococcus aureus.

FIELD OF THE INVENTION

The present invention relates to synthetic oligo-β-(1→6)-glucosaminestructures exhibiting a defined substitution pattern.

BACKGROUND

Staphylococcal infection can lead to a wide range of severe clinicaldisease manifestations and represents a major public healthcare concern.The cell walls of Staphylococci contain a diverse array of glycopeptidesand glycolipids that serve both structural and virulence functions. Thecell wall is comprised primarily of peptidoglycan, a peptide crosslinkedpolymer of poly-N-acetylglucosamine (PNAG), N-acetylmuramic acid, andglycolipids, including wall teichoic acids (WTA) and lipoteichoic acid(LTA).

Cell wall related factors possess many unique features making themparticularly attractive therapeutic targets. Importantly, cell wallcomponents are expressed in the initial colonization, local infectionand systemic stages of disease. Unfortunately, a lack of consistentaccess to material, along with toxicity issues hinder cell-wall targetedvaccine development. For example, LTA is toxic and could not be used asthe basis of a vaccine candidate without modification.

Recently, the properties of a cell wall associated polysaccharide,poly-1,6-N-acetylglucosamine (PNAG), also known as polysaccharideintercellular adhesion molecule (PIA), have been described. PNAG servesseveral key biological functions at various stages of the bacterialinfection cycle including adhesion to bacterial and host surfaces,promotion of biofilm formation and protection againstantibody-independent opsonic killing. The PNAG molecule and itsderivatives are able to mediate all these functions due to a diversedistribution pattern of amine and acetylation modifications to the corestructure (FIG. 1). The core structure is comprised of a glucosaminebackbone which is only generated by bacterial pathogens. The backbonestructure is modified with acetyl or amine groups with variable spacing.

The PNAG molecule has been used in vaccine studies (See Pier et al.,U.S. Publication 2005/0118198). Data generated using purified PNAG-basedmaterial demonstrates the viability of this carbohydrate-based vaccineapproach (Maira-Litran et al., Infect. Immun., 73:6752, 2005). However,in spite of the aforementioned PNAG-focused studies revealing thatfunctional protection and opsonization activity is dependent on thepresence of an amine-rich modified PNAG structure (<50% acetylatedpositions), the major component of biofilms is secreted PNAG thatcontains mostly (>95%) N-acetylated positions. Accordingly,carbohydrate-based vaccine development is in need of a betterunderstanding of the requirements for maintaining an appropriateacetylation-amine balance in lead PNAG-based vaccine target selection.

A methodology for preparing synthetic PNAGs was described (Gening etal., Infect. Immun., 78:764, 2010, epub Nov. 30, 2009; WO 2010/011284A2). The described synthetic PNAGs were limited to homogenous PNAGcompositions that are fully acetylated or fully non-acetylated; neitherof these references, nor those cited therein, described a methodologyfor synthesizing homogenous mixed PNAGs having a predetermined numberand predetermined arrangement of acetylated and deacetylated residues.Moreover, although the previous purification-chemical process utilizingpurified PNAG material that was subsequently chemically treated to yieldan appropriate range of N-acetylated versus free amine positions on thePNAG molecule (Maira-Litran et al., supra), the purification-chemicalprocess is only able to provide a range of heterogeneous material andtherefore only average numbers on the degree of acetylation areavailable. Moreover, there is no information on the position of theacetylated residues. Accordingly, the prior art processes failed toprovide oligosaccharides with spatially defined acetyl-amine positions,such as an amine every third position on the glucosamine polymer, forexample. As such, the identification of a precise acetyl-amine sequencerequired to generate a desired immune response can neither be achievedby this method nor predicted a priori.

In view of the above, the present invention provides several benefitsfor vaccine development, especially against S. aureus, includingproduction of homogenous antigen compositions with mixed acetyl/aminepositions at high purity and at robust levels without contaminatingcarbohydrate structures that are an almost inevitable consequence ofisolation from biological mixtures.

SUMMARY

The present invention provides oligosaccharides(oligo-β-(1→6)-glucosamine structures) 1a

where R¹ and R² are each independently selected from H or C(O)CH₃, whereat least one R¹ or R² in the oligosaccharide is H and at least anotheris C(O)CH₃; n is an integer of at least 3, X is a linker, and Y is H ora carrier; and wherein each occurrence R¹ can be the same or different.

The present invention provides compositions and methods for synthesizingoligo-β-(1→6)-glucosamine structures and conjugates that have a specificnumber of monosaccharide units and a fixed, defined pattern ofacetylated and non-acetylated residues.

The present invention further provides immunogenic and immunoprotectivecompositions containing synthetic oligo-β-(1→6)-glucosamines 1a andantibodies derived therefrom for diagnosing, treating, and preventinginfections caused by bacteria such as Staphylococcus aureus and others.

The present invention further provides a method for chemoselectivelydeprotecting one of at least two different nitrogen protecting groups inan aminosugar, in particular in an oligo-β-(1→6)-glucosamine.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 depicts an exemplary core structure of anoligo-β-(1→6)-glucosamine comprised of a glucosamine backbone unique tobacterial pathogens. The backbone structure can be modified withN-acetyl groups with variable spacing.

FIG. 2A depicts naturally-derived PNAG polysaccharides and FIG. 2Bdepicts a synthetic PNAG oligosaccharide, including potentialconjugation sites in FIGS. 2A and 2B.

FIG. 3 depicts a reaction scheme for synthesizing four monosaccharidebuilding blocks which can be used to synthesize any dPNAG/PNAGoligosaccharide.

FIGS. 4A-4D depict a series of reaction schemes for assemblingdisaccharide building blocks from the four monosaccharide buildingblocks depicted in FIG. 3.

FIGS. 5A and 5B depict a reaction scheme for synthesizing a 6-mer thiololigosaccharide 37.

FIGS. 6A and 6B depict a reaction scheme for synthesizing a 12-mer thiololigosaccharide 40.

FIG. 7 depicts a reaction scheme for synthesizing an 18-mer thiololigosaccharide 34.

FIGS. 8A and 8B depict a reaction scheme for conjugating the 6-mer thiololigosaccharide 37 to BSA (A) or KLH (B) to form a 6-Mix-BSA conjugate41 or a 6-Mix-KLH conjugate 42, respectively. In the nomenclature usedherein, e.g. “6-Mix,” “12-NH₂” and “18-NHAc,” the number refers to thenumber of monosaccharide units, “Mix” refers to an oligosaccharide witha fixed pattern of both acetyl and amine groups at R¹ and R², “NH₂”refers to an oligosaccharide with amine groups at R¹ and R², and “NHAc”refers to an oligosaccharide with acetyl groups at R¹ and R².

FIGS. 9A and 9B depict a reaction scheme for conjugating the 12-merthiol oligosaccharide 40 to BSA (A) or KLH (B) to form a 12-Mix-BSAconjugate 43 or 12-Mix-KLH conjugate 44, respectively.

FIGS. 10A and 10B depict a reaction scheme for conjugating the 18-merthiol oligosaccharide 34 to BSA (A) or KLH (B) to form an 18-Mix-BSAconjugate 45 or 18-Mix-KLH conjugate 46, respectively.

FIGS. 11A-11C depict IgG antibody titers as a function ofantibody-antigen complex absorption (OD₄₅₀) at the indicated serumdilutions obtained from 3 successive bleeds (pre-immune, ^(1st) bleed,and final bleed) in rabbits immunized with KLH conjugates correspondingto: (A) 6-Mix-KLH 42; (B) 12-Mix-KLH 44; and (C) 18-Mix-KLH 46. In eachcase, the antisera were incubated on ELISA plates adsorbed with theircorresponding BSA conjugate, specifically, (A) 6-Mix-BSA 41; (B)12-Mix-BSA 43; and (C) 18-Mix-BSA 45.

FIGS. 11D-11F depict IgG antibody titers from antigen-specificantigen-KLH conjugate-derived antibodies recovered at three successivestages of affinity purification, including pre-affinity purification(3^(rd) bleed), the flow-through fraction and the antibody-enriched(purified) fraction from rabbits immunized with KLH conjugates. Resultsare shown as a function of antibody-antigen complex absorption (OD₄₅₀)at the indicated serum dilutions obtained from the above-describedantibody-enriched fractions generated against antigen-KLH conjugatescorresponding to: (A) 6-Mix-KLH 42; (B) 12-Mix-KLH 44; and (C)18-Mix-KLH 46. In each case, the antisera were incubated on ELISA platesadsorbed with their corresponding BSA conjugate, specifically, (A)6-Mix-BSA 41; (B) 12-Mix-BSA 43; and (C) 18-Mix-BSA 45.

FIGS. 12A-12G depict the results of a cross-ELISA assay examining thespecificity and cross-reactivity between fully non-acetylated (6-NH₂,12-NH₂, 18-NH₂); mixed (6-Mix, 12-Mix, 18-Mix) and fully acetylated(6-NHAc, 12-NHAc, 18-NHAc) oligosaccharides 1a and antibodies derivedtherefrom. In FIGS. 12A-12G, antisera from rabbits immunized with theindicated antigen-KLH conjugates corresponding to (left to right) 6-NH₂,6-Mix, 6-NHAc, 12-NH₂, 12-Mix, 12-NHAc, 18-NH₂, 18-Mix, and 18-NHAc wereincubated in each case with an ELISA plate adsorbed with a differentantigen-BSA conjugate, specifically: (A) 6-NH₂-BSA; (B) 6-Mix-BSA; (C)6-NHAc-BSA; (D) 12-NH₂-BSA; (E) 12-Mix-BSA; (F) 12-NHAc-BSA; (G)18-Mix-BSA. Results are shown as a function of antibody-antigen complexabsorption (OD₄₅₀) representing the averages from two rabbit antiserasin each case at the indicated serum dilutions, whereby total OD₄₅₀ ismeasured by subtracting away the background OD₄₅₀ from KLH antibodiesalone.

FIGS. 13A-13D depict the results of a whole-cell ELISA assay examiningthe binding of pre-immune sera (A, C) or immune sera (B, D) generatedfrom rabbits immunized against (left to right) KLH control,non-acetylated (12-NH₂); mixed (12-Mix) and non-acetylated (12-NHAc)oligo-β-(1→6)-glucosamines and S. epidermidis coated onto ELISA fixedwith methanol (A, B) or formalin (C, D). Results are shown as a functionof antibody-antigen complex absorption (OD₄₅₀) at the indicated serumdilutions.

DETAILED DESCRIPTION Definitions

In order to provide a clear and consistent understanding of thespecification and claims, the following definitions are provided.

Units, prefixes, and symbols may be denoted in their SI accepted form.Numeric ranges recited herein are inclusive of the numbers defining therange and include and are supportive of each integer within the definedrange. Unless otherwise noted, the terms “a” or “an” are to be construedas meaning “at least one of.” The section headings used herein are fororganizational purposes only and are not to be construed as limiting thesubject matter described. All documents, or portions of documents, citedin this application, including but not limited to patents, patentapplications, articles, books, and treatises, are hereby expresslyincorporated by reference in their entirety for any purpose.

As used herein, “oligosaccharide” refers to a compound containing two ormore monosaccharide units. Oligosaccharides are considered to have areducing end and a non-reducing end, whether or not the monosaccharideunit at the reducing end is in fact a reducing sugar. In accordance withaccepted nomenclature, oligosaccharides are depicted herein with thenon-reducing end on the left and the reducing end on the right. Alloligosaccharides described herein are described with the name orabbreviation for the non-reducing monosaccharide (e.g., Gal), precededby the configuration of the glycosidic bond (α or β) the ring bond, thering position of the reducing monosaccharide involved in the bond, andthen the name or abbreviation of the reducing monosaccharide (e.g.,GlcNAc). The linkage between two sugars may be expressed, for example,as 2,3, 2→0.3, or 2-3. Each monosaccharide is a pyranose or furanose.

As used herein, “monosaccharide” or “monosaccharide unit” refers to asingle sugar residue in an oligosaccharide, including derivativestherefrom. Within the context of an oligosaccharide, an individualmonomer unit is a monosaccharide which is (or can be) bound through ahydroxyl group to another monosaccharide.

As used herein, “endotoxin-free” refers to an oligosaccharide that doesnot contain endotoxins or endotoxin components normally present inisolated bacterial carbohydrates and polysaccharides.

As used herein, “synthetic” refers to material which is substantially oressentially free from components, such as endotoxins, glycolipids,unrelated oligosaccharides, etc., which normally accompany a compoundwhen it is isolated. Typically, synthetic compounds are at least about90% pure, usually at least about 95%, and preferably at least about 99%pure. Purity can be indicated by a number of means well known in theart. Preferably, purity is measured by HPLC. The identity of thesynthetic material can be determined by mass spectroscopy and/or NMRspectroscopy.

As used herein the term “linker” refers to either a bond or a moietywhich at one end exhibits a grouping able to enter into a covalentbonding with a reactive functional group of the carrier, e.g. an amino,thiol, or carboxyl group, and at the other end a grouping likewise ableto enter into a covalent bonding with a hydroxyl group or an amino groupof an oligosaccharide according to the present invention. Between thetwo functional groups of the linker molecule there is a biocompatiblebridging molecule of suitable length, e.g. substituted or unsubstitutedheteroalkylene, arylalkylene, alkylene, alkenylene, or (oligo)alkyleneglycol groups. Linkers preferably include a substituted or unsubstituted(C₁-C₁₀) alkylene group or an substituted or unsubstituted (C₂-C₁₀)alkenylene group.

As used herein, the term “percentage of N-acetylated monosaccharideunits in the oligomer” refers to the number of N-acetylatedmonosaccharide units in the oligosaccharide z, the percentage ofN-acetylated monosaccharide units is y, where y is z/(n+1)*100.

As used herein, the term “carrier” refers to a protein, peptide, lipid,polymer, dendrimer, virosome, virus-like particle (VLP), or combinationthereof, which is coupled to the oligosaccharide to enhance theimmunogenicity of the resulting oligosaccharide-carrier conjugate to agreater degree than the oligosaccharide alone.

As used herein, “protein carrier” refers to a protein, peptide orfragment thereof, which is coupled or conjugated to an oligosaccharideto enhance the immunogenicity of the resulting oligosaccharide-proteincarrier conjugate to a greater degree than the oligosaccharide alone.For example, when used as a carrier, the protein carrier may serve as aT-dependent antigen which can activate and recruit T-cells and therebyaugment T-cell dependent antibody production.

As used herein, “conjugated” refers to a chemical linkage, eithercovalent or non-covalent, that proximally associates an oligosaccharidewith a carrier so that the oligosaccharide conjugate has increasedimmunogenicity relative to an unconjugated oligosaccharide.

As used herein, “conjugate” refers to an oligosaccharide chemicallycoupled to a carrier through a linker and/or a cross-linking agent.

As used herein, “passive immunity” refers to the administration ofantibodies to a subject, whereby the antibodies are produced in adifferent subject (including subjects of the same and different species)such that the antibodies attach to the surface of the bacteria and causethe bacteria to be phagocytosed or killed.

As used herein, “protective immunity” means that a vaccine orimmunization schedule that is administered to a animal induces an immuneresponse that prevents, retards the development of, or reduces theseverity of a disease that is caused by a pathogen or diminishes oraltogether eliminates the symptoms of the disease. Protective immunitymay be predicted based on the ability of serum antibody to activatecomplement-mediated bactericidal activity or confer passive protectionagainst a bacterial infection in a suitable animal challenge model.

As used herein, “immunoprotective composition” refers to a compositionformulated to provide protective immunity in a host.

As used herein, “in a sufficient amount to elicit an immune response” or“in an effective amount to stimulate an immune response” (e.g., toepitopes present in a preparation) means that there is a detectabledifference between an immune response indicator measured before andafter administration of a particular antigen preparation. Immuneresponse indicators include but are not limited to: antibody titer orspecificity, as detected by an assay such as enzyme-linked immunoassay(ELISA), bactericidal assay (e.g., to detect serum bactericidalantibodies), flow cytometry, immunoprecipitation, Ouchter-Lowryimmunodiffusion; binding detection assays of, for example, spot, Westernblot or antigen arrays; cytotoxicity assays, and the like.

As used herein, “antibody” encompasses polyclonal and monoclonalantibody preparations, as well as preparations including hybridantibodies, altered antibodies, F(ab′)² fragments, F(ab) molecules, Fvfragments, single chain fragment variable displayed on phage (scFv),single domain antibodies, chimeric antibodies, humanized antibodies, andfunctional fragments thereof which exhibit immunological bindingproperties of the parent antibody molecule.

As used herein, “monoclonal antibody” refers to an antibody compositionhaving a homogeneous antibody population. The term is not limited by themanner in which it is made. The term encompasses whole immunoglobulinmolecules, as well as Fab molecules, F(ab′)₂ fragments, Fv fragments,single chain fragment variable displayed on phage (scFv), and othermolecules that exhibit immunological binding properties of the parentmonoclonal antibody molecule.

As used herein, “specifically binds to an antibody” or “specificallyimmunoreactive with”, when referring to an oligosaccharide, protein orpeptide, refers to a binding reaction which is based on and/or isprobative of the presence of the antigen in a sample which may alsoinclude a heterogeneous population of other molecules. Thus, underdesignated immunoassay conditions, the specified antibody or antibodiesbind(s) to a particular antigen or antigens in a sample and does notbind in a significant amount to other molecules present in the sample.Specific binding to an antibody under such conditions may require anantibody or antiserum that is selected for its specificity for aparticular antigen or antigens.

As used herein, “antigen” refers to any substance that may bespecifically bound by an antibody molecule.

As used herein, “immunogen” and “immunogenic composition” refer to anantigenic composition capable of initiating lymphocyte activationresulting in an antigen-specific immune response.

As used herein the term “poly-N-acetyl glucosamine” or “PNAG” refers toan oligoglucosamine having 100% acetyl substitution.

As used herein the term “deacetylated poly-N-acetyl glucosamine” or“dPNAG” refers to an oligoglucosamine having less than 100% acetylsubstitution. The dPNAG may comprise a mixture of dPNAGs with varyingdegree of acetylation.

As used herein, “epitope” refers to a site on an antigen to whichspecific B cells and/or T cells respond. The term is also usedinterchangeably with “antigenic determinant” or “antigenic determinantsite.” B cell epitope sites on proteins, oligosaccharides, or otherbiopolymers may be composed of moieties from different parts of themacromolecule that have been brought together by folding. Epitopes ofthis kind are referred to as conformational or discontinuous epitopes,since the site is composed of segments the polymer that arediscontinuous in the linear sequence but are continuous in the foldedconformation(s). Epitopes that are composed of single segments ofbiopolymers or other molecules are termed continuous or linear epitopes.T cell epitopes are generally restricted to linear peptides. Antibodiesthat recognize the same epitope can be identified in a simpleimmunoassay showing the ability of one antibody to block the binding ofanother antibody to a target antigen.

As used herein, the term “in a first monosaccharide unit R¹ is H, and ina second monosaccharide unit R¹ or R² is C(O)CH₃, said secondmonosaccharide unit is located three monosaccharide units from the firstmonosaccharide unit” refers to a substitution pattern as illustrated inthe following scheme:

As used herein the term “# sequential C(O)CH₃ groups are located insubsequent monosaccharide units” or “# sequential H groups are locatedin subsequent monosaccharide units” refers to structure, wherein therespective C(O)CH₃ and H groups are located in adjacent monosaccharideunits. The following example illustrates the structural motif for 3sequential C(O)CH₃ groups:

As used herein the term “selective conversion” means that theselectivity of the specific reaction over another reaction is at least10 fold, at least 100 fold or at least 1000 fold.

The term Ac means acetyl (—C(O)CH₃).

The term TBS means tert-butyldimethylsilyl.

The term Troc means 2,2,2-trichloroethoxycarbonyl.

The term TCl means trichloroacetimidate.

The term Phth means phthaloyl.

The term TFA means trifluoroacetate.

The term TCA means trichloroacetate.

The term Cbz means benzyloxycarbonyl.

The term Bz means benzoyl.

The term Bn means benzyl.

The term TES means triethylsilyl.

The term TBDPS means tert-butyldiphenylsilyl.

The term MCA means monochloracetate.

The term Lev means levulinoyl.

The term ADMB means 4-O-acetyl 12,2 dimethylbutanoate.

The term Tr means triphenylmethyl.

The term DMT means dimethoxytrityl.

The term FMOC means 9-fluorenylmethyl carbonate.

The term Alloc means Allyloxycarbonyl.

The term Nap means napthyl.

The term SEt means thioethyl.

The term SPh means thiophenyl.

The term SToI means thiotolyl.

The term SAdm means thioadamantyl.

Synthetic Oligosaccharides

The present invention provides oligosaccharides 1a:

where R¹ and R² are each independently H or COCH₃, where at least one R¹or R² in the oligosaccharide is H and at least another is COCH₃; n is aninteger of at least 3, X is a bond or a linker, and Y is H or a carrier;and where each occurrence of R¹ can be the same or different.

In the oligosaccharide 1a, the number of acetylated monosaccharide unitsin the oligosaccharide is z and the percentage of acetylatedmonosaccharide units is y, where y is z/(n+1)*100.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is 75% or less.

In another embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is 70% or less.

In another embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is 60% or less.

In another embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is 50% or less.

In another embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is 40% or less.

In another embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is 30% or less.

In another embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is 20% or less.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is at least 15%.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is at least 20%.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is at least 30%.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is at least 40%.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is at least 45%.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is at least 50%.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is at least 55%.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is at least 60%.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is at least 65%.

In one embodiment the percentage of the N-acetylated monosaccharideunits in the oligomer is between 10% and 70%, 20% to 70%, 30% to 70%,30% to 60%, or 30% to 50%.

In one embodiment at least 3 of the R¹ and R² groups are C(O)CH₃.

In one embodiment at least 3 of the R¹ and R² groups are H.

In one embodiment n is 5 and 3 of the R¹ or R² groups are C(O)CH₃.

In one embodiment n is 6 or 7 and at least 4 of the R¹ or R² groups areC(O)CH₃.

In one embodiment n is 8 or 9 and at least 5 of the R¹ or R² groups areC(O)CH₃.

In one embodiment n is 10 or 11 and at least 6 of the R¹ or R² groupsare C(O)CH₃.

In one embodiment n is 5 and 3 of the R¹ or R² groups are H.

In one embodiment n is 6 or 7 and at least 4 of the R¹ or R² groups areH.

In one embodiment n is 8 or 9 and at least 5 of the R¹ or R² groups areH.

In one embodiment n is 10 or 11 and at least 6 of the R¹ or R² groupsare H. In one embodiment the group X is a bond.

In another embodiment the group X is a linker.

In one embodiment the carrier group Y is H.

In another embodiment the carrier group Y is a carrier.

In one embodiment, the X is a bond and Y is —H.

Specific embodiments of the present invention are shown below:

Exemplary embodiments of the present invention are shown in thefollowing Tables 1 to 9. tetrasaccharides (n=3, Table 1),pentasaccharides (n=4, Table 2), hexasaccharides (n=5, Table 3),heptasaccharides (n=6, Table 4), octasaccharides (n=7, Table 5),nonasaccharides (n=8, Table 6), decasaccharides (n=9, Table 7),undecasaccharides (n=10, Table 8), and dodecasaccharides (n=11, Table9).

In the following tables, the nomenclature “n#, R1” (i.e., n1′R1)”identifies the monomeric unit in an oligosaccharide of (n+1) units. Thefirst unit is attached to the monosaccharide bearing R² and the second,third, etc. units follow.

For example, when n is 3, the oligosaccharide (a tetrasaccharide) isshown below:

TABLE 1 Tetrasaccharides (Y is either H or a carrier) Compound R2 n1, R1n2, R1 n3, R1 1001 H H H acetyl 1002 H H Acetyl H 1003 H H Acetyl acetyl1004 H acetyl H H 1005 H acetyl H acetyl 1006 H acetyl Acetyl H 1007 Hacetyl acetyl acetyl 1008 acetyl H H H 1009 acetyl H H acetyl 1010acetyl H acetyl H 1011 acetyl H acetyl acetyl 1012 acetyl acetyl H H1013 acetyl acetyl H acetyl 1014 acetyl acetyl acetyl H

TABLE 2 (pentasaccharides) (Y is either H or a carrier) Compound R2 n1,R1 n2, R1 n3, R1 n4, R1 1015 H H H H acetyl 1016 H H H acetyl H 1017 H HH acetyl acetyl 1018 H H acetyl H H 1019 H H acetyl H acetyl 1020 H Hacetyl acetyl H 1021 H H acetyl acetyl acetyl 1022 H acetyl H H H 1023 Hacetyl H H acetyl 1024 H acetyl H acetyl H 1025 H acetyl H acetyl acetyl1026 H acetyl acetyl H H 1027 H acetyl acetyl H acetyl 1028 H acetylacetyl acetyl H 1029 H acetyl acetyl acetyl acetyl 1030 acetyl H H H H1031 acetyl H H H acetyl 1032 acetyl H H acetyl H 1033 acetyl H H acetylacetyl 1034 acetyl H acetyl H H 1035 acetyl H acetyl H acetyl 1036acetyl H acetyl acetyl H 1037 acetyl H acetyl acetyl acetyl 1038 acetylacetyl H H H 1039 acetyl acetyl H H acetyl 1040 acetyl acetyl H acetyl H1041 acetyl acetyl H acetyl acetyl 1042 acetyl acetyl acetyl H H 1043acetyl acetyl acetyl H acetyl 1044 acetyl acetyl acetyl acetyl H

TABLE 3 (hexasaccharides) (Y is either H or a carrier) Compound R2 n1,R1 n2, R1 n3, R1 n4, R1 n5, R1 1045 H H H H H acetyl 1046 H H H H acetylH 1047 H H H H acetyl acetyl 1048 H H H acetyl H H 1049 H H H acetyl Hacetyl 1050 H H H acetyl acetyl H 1051 H H H acetyl acetyl acetyl 1052 HH Acetyl H H H 1053 H H Acetyl H H acetyl 1054 H H Acetyl H acetyl H1055 H H Acetyl H acetyl acetyl 1056 H H Acetyl acetyl H H 1057 H HAcetyl acetyl H acetyl 1058 H H Acetyl acetyl acetyl H 1059 H H Acetylacetyl acetyl acetyl 1060 H acetyl H H H H 1061 H acetyl H H H acetyl1062 H acetyl H H acetyl H 1063 H acetyl H H acetyl acetyl 1064 H acetylH acetyl H H 1065 H acetyl H acetyl H acetyl 1066 H acetyl H acetylacetyl H 1067 H acetyl H acetyl acetyl acetyl 1068 H acetyl Acetyl H H H1069 H acetyl Acetyl H H acetyl 1070 H acetyl Acetyl H acetyl H 1071 Hacetyl Acetyl H acetyl acetyl 1072 H acetyl Acetyl acetyl H H 1073 Hacetyl Acetyl acetyl H acetyl 1074 H acetyl Acetyl acetyl acetyl H 1075H acetyl Acetyl acetyl acetyl acetyl 1076 acetyl H H H H H 1077 acetyl HH H H acetyl 1078 acetyl H H H acetyl H 1079 acetyl H H H acetyl acetyl1080 acetyl H H acetyl H H 1081 acetyl H H acetyl H acetyl 1082 acetyl HH acetyl acetyl H 1083 acetyl H H acetyl acetyl acetyl 1084 acetyl HAcetyl H H H 1085 acetyl H Acetyl H H acetyl 1086 acetyl H Acetyl Hacetyl H 1087 acetyl H Acetyl H acetyl acetyl 1088 acetyl H Acetylacetyl H H 1089 acetyl H Acetyl acetyl H acetyl 1090 acetyl H Acetylacetyl acetyl H 1091 acetyl H Acetyl acetyl acetyl acetyl 1092 acetylacetyl H H H H 1093 acetyl acetyl H H H acetyl 1094 acetyl acetyl H Hacetyl H 1095 acetyl acetyl H H acetyl acetyl 1096 acetyl acetyl Hacetyl H H 1097 acetyl acetyl H acetyl H acetyl 1098 acetyl acetyl Hacetyl acetyl H 1099 acetyl acetyl H acetyl acetyl acetyl 1100 acetylacetyl Acetyl H H H 1101 acetyl acetyl Acetyl H H acetyl 1102 acetylacetyl Acetyl H acetyl H 1103 acetyl acetyl Acetyl H acetyl acetyl 1104acetyl acetyl Acetyl acetyl H H 1105 acetyl acetyl Acetyl acetyl Hacetyl 1106 acetyl acetyl Acetyl acetyl acetyl H

TABLE 4 (heptasaccharides) (Y is either H or a carrier) n1, n2, CompoundR2 R1 R1 n3, R1 n4, R1 n5, R1 n6, R1 1107 H H H H H H acetyl 1108 H H HH H acetyl H 1109 H H H H H acetyl acetyl 1110 H H H H acetyl H H 1111 HH H H acetyl H acetyl 1112 H H H H acetyl acetyl H 1113 H H H H acetylacetyl acetyl 1114 H H H acetyl H H H 1115 H H H acetyl H H acetyl 1116H H H acetyl H acetyl H 1117 H H H acetyl H acetyl acetyl 1118 H H Hacetyl acetyl H H 1119 H H H acetyl acetyl H acetyl 1120 H H H acetylacetyl acetyl H 1121 H H H acetyl acetyl acetyl acetyl 1122 H H acetyl HH H H 1123 H H acetyl H H H acetyl 1124 H H acetyl H H acetyl H 1125 H Hacetyl H H acetyl acetyl 1126 H H acetyl H acetyl H H 1127 H H acetyl Hacetyl H acetyl 1128 H H acetyl H acetyl acetyl H 1129 H H acetyl Hacetyl acetyl acetyl 1130 H H acetyl acetyl H H H 1131 H H acetyl acetylH H acetyl 1132 H H acetyl acetyl H acetyl H 1133 H H acetyl acetyl Hacetyl acetyl 1134 H H acetyl acetyl acetyl H H 1135 H H acetyl acetylacetyl H acetyl 1136 H H acetyl acetyl acetyl acetyl H 1137 H H acetylacetyl acetyl acetyl acetyl 1138 H acetyl H H H H H 1139 H acetyl H H HH acetyl 1140 H acetyl H H H acetyl H 1141 H acetyl H H H acetyl acetyl1142 H acetyl H H acetyl H H 1143 H acetyl H H acetyl H acetyl 1144 Hacetyl H H acetyl acetyl H 1145 H acetyl H H acetyl acetyl acetyl 1146 Hacetyl H acetyl H H H 1147 H acetyl H acetyl H H acetyl 1148 H acetyl Hacetyl H acetyl H 1149 H acetyl H acetyl H acetyl acetyl 1150 H acetyl Hacetyl acetyl H H 1151 H acetyl H acetyl acetyl H acetyl 1152 H acetyl Hacetyl acetyl acetyl H 1153 H acetyl H acetyl acetyl acetyl acetyl 1154H acetyl acetyl H H H H 1155 H acetyl acetyl H H H acetyl 1156 H acetylacetyl H H acetyl H 1157 H acetyl acetyl H H acetyl acetyl 1158 H acetylacetyl H acetyl H H 1159 H acetyl acetyl H acetyl H acetyl 1160 H acetylacetyl H acetyl acetyl H 1161 H acetyl acetyl H acetyl acetyl acetyl1162 H acetyl acetyl acetyl H H H 1163 H acetyl acetyl acetyl H H acetyl1164 H acetyl acetyl acetyl H acetyl H 1165 H acetyl acetyl acetyl Hacetyl acetyl 1166 H acetyl acetyl acetyl acetyl H H 1167 H acetylacetyl acetyl acetyl H acetyl 1168 H acetyl acetyl acetyl acetyl acetylH 1169 H acetyl acetyl acetyl acetyl acetyl acetyl 1170 acetyl H H H H HH 1171 acetyl H H H H H acetyl 1172 acetyl H H H H acetyl H 1173 acetylH H H H acetyl acetyl 1174 acetyl H H H acetyl H H 1175 acetyl H H Hacetyl H acetyl 1176 acetyl H H H acetyl acetyl H 1177 acetyl H H Hacetyl acetyl acetyl 1178 acetyl H H acetyl H H H 1179 acetyl H H acetylH H acetyl 1180 acetyl H H acetyl H acetyl H 1181 acetyl H H acetyl Hacetyl acetyl 1182 acetyl H H acetyl acetyl H H 1183 acetyl H H acetylacetyl H acetyl 1184 acetyl H H acetyl acetyl acetyl H 1185 acetyl H Hacetyl acetyl acetyl acetyl 1186 acetyl H acetyl H H H H 1187 acetyl Hacetyl H H H acetyl 1188 acetyl H acetyl H H acetyl H 1189 acetyl Hacetyl H H acetyl acetyl 1190 acetyl H acetyl H acetyl H H 1191 acetyl Hacetyl H acetyl H acetyl 1192 acetyl H acetyl H acetyl acetyl H 1193acetyl H acetyl H acetyl acetyl acetyl 1194 acetyl H acetyl acetyl H H H1195 acetyl H acetyl acetyl H H acetyl 1196 acetyl H acetyl acetyl Hacetyl H 1197 acetyl H acetyl acetyl H acetyl acetyl 1198 acetyl Hacetyl acetyl acetyl H H 1199 acetyl H acetyl acetyl acetyl H acetyl1200 acetyl H acetyl acetyl acetyl acetyl H 1201 acetyl H acetyl acetylacetyl acetyl acetyl 1202 acetyl acetyl H H H H H 1203 acetyl acetyl H HH H acetyl 1204 acetyl acetyl H H H acetyl H 1205 acetyl acetyl H H Hacetyl acetyl 1206 acetyl acetyl H H acetyl H H 1207 acetyl acetyl H Hacetyl H acetyl 1208 acetyl acetyl H H acetyl acetyl H 1209 acetylacetyl H H acetyl acetyl acetyl 1210 acetyl acetyl H acetyl H H H 1211acetyl acetyl H acetyl H H acetyl 1212 acetyl acetyl H acetyl H acetyl H1213 acetyl acetyl H acetyl H acetyl acetyl 1214 acetyl acetyl H acetylacetyl H H 1215 acetyl acetyl H acetyl acetyl H acetyl 1216 acetylacetyl H acetyl acetyl acetyl H 1217 acetyl acetyl H acetyl acetylacetyl acetyl 1218 acetyl acetyl acetyl H H H H 1219 acetyl acetylacetyl H H H acetyl 1220 acetyl acetyl acetyl H H acetyl H 1221 acetylacetyl acetyl H H acetyl acetyl 1222 acetyl acetyl acetyl H acetyl H H1223 acetyl acetyl acetyl H acetyl H acetyl 1224 acetyl acetyl acetyl Hacetyl acetyl H 1225 acetyl acetyl acetyl H acetyl acetyl acetyl 1226acetyl acetyl acetyl acetyl H H H 1227 acetyl acetyl acetyl acetyl H Hacetyl 1228 acetyl acetyl acetyl acetyl H acetyl H 1229 acetyl acetylacetyl acetyl H acetyl acetyl 1230 acetyl acetyl acetyl acetyl acetyl HH 1231 acetyl acetyl acetyl acetyl acetyl H acetyl 1232 acetyl acetylacetyl acetyl acetyl acetyl H

TABLE 5 (octasaccharides) (Y is either H or a carrier) n2, n3, n4, n5,n6, n7, Compound R2 n1, R1 R1 R1 R1 R1 R1 R1 1233 H H H H H H H acetyl1234 H H H H H H acetyl H 1235 H H H H H H acetyl acetyl 1236 H H H H Hacetyl H H 1237 H H H H H acetyl H acetyl 1238 H H H H H acetyl acetyl H1239 H H H H H acetyl acetyl acetyl 1240 H H H H acetyl H H H 1241 H H HH acetyl H H acetyl 1242 H H H H acetyl H acetyl H 1243 H H H H acetyl Hacetyl acetyl 1244 H H H H acetyl acetyl H H 1245 H H H H acetyl acetylH acetyl 1246 H H H H acetyl acetyl acetyl H 1247 H H H H acetyl acetylacetyl acetyl 1248 H H H acetyl H H H H 1249 H H H acetyl H H H acetyl1250 H H H acetyl H H acetyl H 1251 H H H acetyl H H acetyl acetyl 1252H H H acetyl H acetyl H H 1253 H H H acetyl H acetyl H acetyl 1254 H H Hacetyl H acetyl acetyl H 1255 H H H acetyl H acetyl acetyl acetyl 1256 HH H acetyl acetyl H H H 1257 H H H acetyl acetyl H H acetyl 1258 H H Hacetyl acetyl H acetyl H 1259 H H H acetyl acetyl H acetyl acetyl 1260 HH H acetyl acetyl acetyl H H 1261 H H H acetyl acetyl acetyl H acetyl1262 H H H acetyl acetyl acetyl acetyl H 1263 H H H acetyl acetyl acetylacetyl acetyl 1264 H H acetyl H H H H H 1265 H H acetyl H H H H acetyl1266 H H acetyl H H H acetyl H 1267 H H acetyl H H H acetyl acetyl 1268H H acetyl H H acetyl H H 1269 H H acetyl H H acetyl H acetyl 1270 H Hacetyl H H acetyl acetyl H 1271 H H acetyl H H acetyl acetyl acetyl 1272H H acetyl H acetyl H H H 1273 H H acetyl H acetyl H H acetyl 1274 H Hacetyl H acetyl H acetyl H 1275 H H acetyl H acetyl H acetyl acetyl 1276H H acetyl H acetyl acetyl H H 1277 H H acetyl H acetyl acetyl H acetyl1278 H H acetyl H acetyl acetyl acetyl H 1279 H H acetyl H acetyl acetylacetyl acetyl 1280 H H acetyl acetyl H H H H 1281 H H acetyl acetyl H HH acetyl 1282 H H acetyl acetyl H H acetyl H 1283 H H acetyl acetyl H Hacetyl acetyl 1284 H H acetyl acetyl H acetyl H H 1285 H H acetyl acetylH acetyl H acetyl 1286 H H acetyl acetyl H acetyl acetyl H 1287 H Hacetyl acetyl H acetyl acetyl acetyl 1288 H H acetyl acetyl acetyl H H H1289 H H acetyl acetyl acetyl H H acetyl 1290 H H acetyl acetyl acetyl Hacetyl H 1291 H H acetyl acetyl acetyl H acetyl acetyl 1292 H H acetylacetyl acetyl acetyl H H 1293 H H acetyl acetyl acetyl acetyl H acetyl1294 H H acetyl acetyl acetyl acetyl acetyl H 1295 H H acetyl acetylacetyl acetyl acetyl acetyl 1296 H acetyl H H H H H H 1297 H acetyl H HH H H acetyl 1298 H acetyl H H H H acetyl H 1299 H acetyl H H H H acetylacetyl 1300 H acetyl H H H acetyl H H 1301 H acetyl H H H acetyl Hacetyl 1302 H acetyl H H H acetyl acetyl H 1303 H acetyl H H H acetylacetyl acetyl 1304 H acetyl H H acetyl H H H 1305 H acetyl H H acetyl HH acetyl 1306 H acetyl H H acetyl H acetyl H 1307 H acetyl H H acetyl Hacetyl acetyl 1308 H acetyl H H acetyl acetyl H H 1309 H acetyl H Hacetyl acetyl H acetyl 1310 H acetyl H H acetyl acetyl acetyl H 1311 Hacetyl H H acetyl acetyl acetyl acetyl 1312 H acetyl H acetyl H H H H1313 H acetyl H acetyl H H H acetyl 1314 H acetyl H acetyl H H acetyl H1315 H acetyl H acetyl H H acetyl acetyl 1316 H acetyl H acetyl H acetylH H 1317 H acetyl H acetyl H acetyl H acetyl 1318 H acetyl H acetyl Hacetyl acetyl H 1319 H acetyl H acetyl H acetyl acetyl acetyl 1320 Hacetyl H acetyl acetyl H H H 1321 H acetyl H acetyl acetyl H H acetyl1322 H acetyl H acetyl acetyl H acetyl H 1323 H acetyl H acetyl acetyl Hacetyl acetyl 1324 H acetyl H acetyl acetyl acetyl H H 1325 H acetyl Hacetyl acetyl acetyl H acetyl 1326 H acetyl H acetyl acetyl acetylacetyl H 1327 H acetyl H acetyl acetyl acetyl acetyl acetyl 1328 Hacetyl acetyl H H H H H 1329 H acetyl acetyl H H H H acetyl 1330 Hacetyl acetyl H H H acetyl H 1331 H acetyl acetyl H H H acetyl acetyl1332 H acetyl acetyl H H acetyl H H 1333 H acetyl acetyl H H acetyl Hacetyl 1334 H acetyl acetyl H H acetyl acetyl H 1335 H acetyl acetyl H Hacetyl acetyl acetyl 1336 H acetyl acetyl H acetyl H H H 1337 H acetylacetyl H acetyl H H acetyl 1338 H acetyl acetyl H acetyl H acetyl H 1339H acetyl acetyl H acetyl H acetyl acetyl 1340 H acetyl acetyl H acetylacetyl H H 1341 H acetyl acetyl H acetyl acetyl H acetyl 1342 H acetylacetyl H acetyl acetyl acetyl H 1343 H acetyl acetyl H acetyl acetylacetyl acetyl 1344 H acetyl acetyl acetyl H H H H 1345 H acetyl acetylacetyl H H H acetyl 1346 H acetyl acetyl acetyl H H acetyl H 1347 Hacetyl acetyl acetyl H H acetyl acetyl 1348 H acetyl acetyl acetyl Hacetyl H H 1349 H acetyl acetyl acetyl H acetyl H acetyl 1350 H acetylacetyl acetyl H acetyl acetyl H 1351 H acetyl acetyl acetyl H acetylacetyl acetyl 1352 H acetyl acetyl acetyl acetyl H H H 1353 H acetylacetyl acetyl acetyl H H acetyl 1354 H acetyl acetyl acetyl acetyl Hacetyl H 1355 H acetyl acetyl acetyl acetyl H acetyl acetyl 1356 Hacetyl acetyl acetyl acetyl acetyl H H 1357 H acetyl acetyl acetylacetyl acetyl H acetyl 1358 H acetyl acetyl acetyl acetyl acetyl acetylH 1359 H acetyl acetyl acetyl acetyl acetyl acetyl acetyl 1360 acetyl HH H H H H H 1361 acetyl H H H H H H acetyl 1362 acetyl H H H H H acetylH 1363 acetyl H H H H H acetyl acetyl 1364 acetyl H H H H acetyl H H1365 acetyl H H H H acetyl H acetyl 1366 acetyl H H H H acetyl acetyl H1367 acetyl H H H H acetyl acetyl acetyl 1368 acetyl H H H acetyl H H H1369 acetyl H H H acetyl H H acetyl 1370 acetyl H H H acetyl H acetyl H1371 acetyl H H H acetyl H acetyl acetyl 1372 acetyl H H H acetyl acetylH H 1373 acetyl H H H acetyl acetyl H acetyl 1374 acetyl H H H acetylacetyl acetyl H 1375 acetyl H H H acetyl acetyl acetyl acetyl 1376acetyl H H acetyl H H H H 1377 acetyl H H acetyl H H H acetyl 1378acetyl H H acetyl H H acetyl H 1379 acetyl H H acetyl H H acetyl acetyl1380 acetyl H H acetyl H acetyl H H 1381 acetyl H H acetyl H acetyl Hacetyl 1382 acetyl H H acetyl H acetyl acetyl H 1383 acetyl H H acetyl Hacetyl acetyl acetyl 1384 acetyl H H acetyl acetyl H H H 1385 acetyl H Hacetyl acetyl H H acetyl 1386 acetyl H H acetyl acetyl H acetyl H 1387acetyl H H acetyl acetyl H acetyl acetyl 1388 acetyl H H acetyl acetylacetyl H H 1389 acetyl H H acetyl acetyl acetyl H acetyl 1390 acetyl H Hacetyl acetyl acetyl acetyl H 1391 acetyl H H acetyl acetyl acetylacetyl acetyl 1392 acetyl H acetyl H H H H H 1393 acetyl H acetyl H H HH acetyl 1394 acetyl H acetyl H H H acetyl H 1395 acetyl H acetyl H H Hacetyl acetyl 1396 acetyl H acetyl H H acetyl H H 1397 acetyl H acetyl HH acetyl H acetyl 1398 acetyl H acetyl H H acetyl acetyl H 1399 acetyl Hacetyl H H acetyl acetyl acetyl 1400 acetyl H acetyl H acetyl H H H 1401acetyl H acetyl H acetyl H H acetyl 1402 acetyl H acetyl H acetyl Hacetyl H 1403 acetyl H acetyl H acetyl H acetyl acetyl 1404 acetyl Hacetyl H acetyl acetyl H H 1405 acetyl H acetyl H acetyl acetyl H acetyl1406 acetyl H acetyl H acetyl acetyl acetyl H 1407 acetyl H acetyl Hacetyl acetyl acetyl acetyl 1408 acetyl H acetyl acetyl H H H H 1409acetyl H acetyl acetyl H H H acetyl 1410 acetyl H acetyl acetyl H Hacetyl H 1411 acetyl H acetyl acetyl H H acetyl acetyl 1412 acetyl Hacetyl acetyl H acetyl H H 1413 acetyl H acetyl acetyl H acetyl H acetyl1414 acetyl H acetyl acetyl H acetyl acetyl H 1415 acetyl H acetylacetyl H acetyl acetyl acetyl 1416 acetyl H acetyl acetyl acetyl H H H1417 acetyl H acetyl acetyl acetyl H H acetyl 1418 acetyl H acetylacetyl acetyl H acetyl H 1419 acetyl H acetyl acetyl acetyl H acetylacetyl 1420 acetyl H acetyl acetyl acetyl acetyl H H 1421 acetyl Hacetyl acetyl acetyl acetyl H acetyl 1422 acetyl H acetyl acetyl acetylacetyl acetyl H 1423 acetyl H acetyl acetyl acetyl acetyl acetyl acetyl1424 acetyl acetyl H H H H H H 1425 acetyl acetyl H H H H H acetyl 1426acetyl acetyl H H H H acetyl H 1427 acetyl acetyl H H H H acetyl acetyl1428 acetyl acetyl H H H acetyl H H 1429 acetyl acetyl H H H acetyl Hacetyl 1430 acetyl acetyl H H H acetyl acetyl H 1431 acetyl acetyl H H Hacetyl acetyl acetyl 1432 acetyl acetyl H H acetyl H H H 1433 acetylacetyl H H acetyl H H acetyl 1434 acetyl acetyl H H acetyl H acetyl H1435 acetyl acetyl H H acetyl H acetyl acetyl 1436 acetyl acetyl H Hacetyl acetyl H H 1437 acetyl acetyl H H acetyl acetyl H acetyl 1438acetyl acetyl H H acetyl acetyl acetyl H 1439 acetyl acetyl H H acetylacetyl acetyl acetyl 1440 acetyl acetyl H acetyl H H H H 1441 acetylacetyl H acetyl H H H acetyl 1442 acetyl acetyl H acetyl H H acetyl H1443 acetyl acetyl H acetyl H H acetyl acetyl 1444 acetyl acetyl Hacetyl H acetyl H H 1445 acetyl acetyl H acetyl H acetyl H acetyl 1446acetyl acetyl H acetyl H acetyl acetyl H 1447 acetyl acetyl H acetyl Hacetyl acetyl acetyl 1448 acetyl acetyl H acetyl acetyl H H H 1449acetyl acetyl H acetyl acetyl H H acetyl 1450 acetyl acetyl H acetylacetyl H acetyl H 1451 acetyl acetyl H acetyl acetyl H acetyl acetyl1452 acetyl acetyl H acetyl acetyl acetyl H H 1453 acetyl acetyl Hacetyl acetyl acetyl H acetyl 1454 acetyl acetyl H acetyl acetyl acetylacetyl H 1455 acetyl acetyl H acetyl acetyl acetyl acetyl acetyl 1456acetyl acetyl acetyl H H H H H 1457 acetyl acetyl acetyl H H H H acetyl1458 acetyl acetyl acetyl H H H acetyl H 1459 acetyl acetyl acetyl H H Hacetyl acetyl 1460 acetyl acetyl acetyl H H acetyl H H 1461 acetylacetyl acetyl H H acetyl H acetyl 1462 acetyl acetyl acetyl H H acetylacetyl H 1463 acetyl acetyl acetyl H H acetyl acetyl acetyl 1464 acetylacetyl acetyl H acetyl H H H 1465 acetyl acetyl acetyl H acetyl H Hacetyl 1466 acetyl acetyl acetyl H acetyl H acetyl H 1467 acetyl acetylacetyl H acetyl H acetyl acetyl 1468 acetyl acetyl acetyl H acetylacetyl H H 1469 acetyl acetyl acetyl H acetyl acetyl H acetyl 1470acetyl acetyl acetyl H acetyl acetyl acetyl H 1471 acetyl acetyl acetylH acetyl acetyl acetyl acetyl 1472 acetyl acetyl acetyl acetyl H H H H1473 acetyl acetyl acetyl acetyl H H H acetyl 1474 acetyl acetyl acetylacetyl H H acetyl H 1475 acetyl acetyl acetyl acetyl H H acetyl acetyl1476 acetyl acetyl acetyl acetyl H acetyl H H 1477 acetyl acetyl acetylacetyl H acetyl H acetyl 1478 acetyl acetyl acetyl acetyl H acetylacetyl H 1479 acetyl acetyl acetyl acetyl H acetyl acetyl acetyl 1480acetyl acetyl acetyl acetyl acetyl H H H 1481 acetyl acetyl acetylacetyl acetyl H H acetyl 1482 acetyl acetyl acetyl acetyl acetyl Hacetyl H 1483 acetyl acetyl acetyl acetyl acetyl H acetyl acetyl 1484acetyl acetyl acetyl acetyl acetyl acetyl H H 1485 acetyl acetyl acetylacetyl acetyl acetyl H acetyl 1486 acetyl acetyl acetyl acetyl acetylacetyl acetyl H

TABLE 6 (nonasaccharides) (Y is either H or a carrier) n5, n6 CompoundR2 n1, R1 n2, R1 n3, R1 n4, R1 R1 R1 1107 H H H H H H acetyl 1108 H H HH H acetyl H 1109 H H H H H acetyl acetyl 1110 H H H H acetyl H H 1111 HH H H acetyl H acetyl 1112 H H H H acetyl acetyl H 1113 H H H H acetylacetyl acetyl 1114 H H H acetyl H H H 1115 H H H acetyl H H acetyl 1116H H H acetyl H acetyl H 1117 H H H acetyl H acetyl acetyl 1118 H H Hacetyl acetyl H H 1119 H H H acetyl acetyl H acetyl 1120 H H H acetylacetyl acetyl H 1121 H H H acetyl acetyl acetyl acetyl 1122 H H acetyl HH H H 1123 H H acetyl H H H acetyl 1124 H H acetyl H H acetyl H 1125 H Hacetyl H H acetyl acetyl 1126 H H acetyl H acetyl H H 1127 H H acetyl Hacetyl H acetyl 1128 H H acetyl H acetyl acetyl H 1129 H H acetyl Hacetyl acetyl acetyl 1130 H H acetyl acetyl H H H 1131 H H acetyl acetylH H acetyl 1132 H H acetyl acetyl H acetyl H 1133 H H acetyl acetyl Hacetyl acetyl 1134 H H acetyl acetyl acetyl H H 1135 H H acetyl acetylacetyl H acetyl 1136 H H acetyl acetyl acetyl acetyl H 1137 H H acetylacetyl acetyl acetyl acetyl 1138 H acetyl H H H H H 1139 H acetyl H H HH acetyl 1140 H acetyl H H H acetyl H 1141 H acetyl H H H acetyl acetyl1142 H acetyl H H acetyl H H 1143 H acetyl H H acetyl H acetyl 1144 Hacetyl H H acetyl acetyl H 1145 H acetyl H H acetyl acetyl acetyl 1146 Hacetyl H acetyl H H H 1147 H acetyl H acetyl H H acetyl 1148 H acetyl Hacetyl H acetyl H 1149 H acetyl H acetyl H acetyl acetyl 1150 H acetyl Hacetyl acetyl H H 1151 H acetyl H acetyl acetyl H acetyl 1152 H acetyl Hacetyl acetyl acetyl H 1153 H acetyl H acetyl acetyl acetyl acetyl 1154H acetyl acetyl H H H H 1155 H acetyl acetyl H H H acetyl 1156 H acetylacetyl H H acetyl H 1157 H acetyl acetyl H H acetyl acetyl 1158 H acetylacetyl H acetyl H H 1159 H acetyl acetyl H acetyl H acetyl 1160 H acetylacetyl H acetyl acetyl H 1161 H acetyl acetyl H acetyl acetyl acetyl1162 H acetyl acetyl acetyl H H H 1163 H acetyl acetyl acetyl H H acetyl1164 H acetyl acetyl acetyl H acetyl H 1165 H acetyl acetyl acetyl Hacetyl acetyl 1166 H acetyl acetyl acetyl acetyl H H 1167 H acetylacetyl acetyl acetyl H acetyl 1168 H acetyl acetyl acetyl acetyl acetylH 1169 H acetyl acetyl acetyl acetyl acetyl acetyl 1170 acetyl H H H H HH 1171 acetyl H H H H H acetyl 1172 acetyl H H H H acetyl H 1173 acetylH H H H acetyl acetyl 1174 acetyl H H H acetyl H H 1175 acetyl H H Hacetyl H acetyl 1176 acetyl H H H acetyl acetyl H 1177 acetyl H H Hacetyl acetyl acetyl 1178 acetyl H H acetyl H H H 1179 acetyl H H acetylH H acetyl 1180 acetyl H H acetyl H acetyl H 1181 acetyl H H acetyl Hacetyl acetyl 1182 acetyl H H acetyl acetyl H H 1183 acetyl H H acetylacetyl H acetyl 1184 acetyl H H acetyl acetyl acetyl H 1185 acetyl H Hacetyl acetyl acetyl acetyl 1186 acetyl H acetyl H H H H 1187 acetyl Hacetyl H H H acetyl 1188 acetyl H acetyl H H acetyl H 1189 acetyl Hacetyl H H acetyl acetyl 1190 acetyl H acetyl H acetyl H H 1191 acetyl Hacetyl H acetyl H acetyl 1192 acetyl H acetyl H acetyl acetyl H 1193acetyl H acetyl H acetyl acetyl acetyl 1194 acetyl H acetyl acetyl H H H1195 acetyl H acetyl acetyl H H acetyl 1196 acetyl H acetyl acetyl Hacetyl H 1197 acetyl H acetyl acetyl H acetyl acetyl 1198 acetyl Hacetyl acetyl acetyl H H 1199 acetyl H acetyl acetyl acetyl H acetyl1200 acetyl H acetyl acetyl acetyl acetyl H 1201 acetyl H acetyl acetylacetyl acetyl acetyl 1202 acetyl acetyl H H H H H 1203 acetyl acetyl H HH H acetyl 1204 acetyl acetyl H H H acetyl H 1205 acetyl acetyl H H Hacetyl acetyl 1206 acetyl acetyl H H acetyl H H 1207 acetyl acetyl H Hacetyl H acetyl 1208 acetyl acetyl H H acetyl acetyl H 1209 acetylacetyl H H acetyl acetyl acetyl 1210 acetyl acetyl H acetyl H H H 1211acetyl acetyl H acetyl H H acetyl 1212 acetyl acetyl H acetyl H acetyl H1213 acetyl acetyl H acetyl H acetyl acetyl 1214 acetyl acetyl H acetylacetyl H H 1215 acetyl acetyl H acetyl acetyl H acetyl 1216 acetylacetyl H acetyl acetyl acetyl H 1217 acetyl acetyl H acetyl acetylacetyl acetyl 1218 acetyl acetyl acetyl H H H H 1219 acetyl acetylacetyl H H H acetyl 1220 acetyl acetyl acetyl H H acetyl H 1221 acetylacetyl acetyl H H acetyl acetyl 1222 acetyl acetyl acetyl H acetyl H H1223 acetyl acetyl acetyl H acetyl H acetyl 1224 acetyl acetyl acetyl Hacetyl acetyl H 1225 acetyl acetyl acetyl H acetyl acetyl acetyl 1226acetyl acetyl acetyl acetyl H H H 1227 acetyl acetyl acetyl acetyl H Hacetyl 1228 acetyl acetyl acetyl acetyl H acetyl H 1229 acetyl acetylacetyl acetyl H acetyl acetyl 1230 acetyl acetyl acetyl acetyl acetyl HH 1231 acetyl acetyl acetyl acetyl acetyl H acetyl 1232 acetyl acetylacetyl acetyl acetyl acetyl H

TABLE 7 (Decasaccharides) (Y is either H or a carrier) Compound R2 n1,R1 n2, R1 n3, R1 n4, R1 n5, R1 n6, R1 n7, R1 n8, R1 n9, R1 1997 H H H HH H H H H acetyl 1998 H H H H H H H H acetyl H 1999 H H H H H H H Hacetyl acetyl 2000 H H H H H H H acetyl H H 2001 H H H H H H H acetyl Hacetyl 2002 H H H H H H H acetyl acetyl H 2003 H H H H H H H acetylacetyl acetyl 2004 H H H H H H acetyl H H H 2005 H H H H H H acetyl H Hacetyl 2006 H H H H H H acetyl H acetyl H 2007 H H H H H H acetyl Hacetyl acetyl 2008 H H H H H H acetyl acetyl H H 2009 H H H H H H acetylacetyl H acetyl 2010 H H H H H H acetyl acetyl acetyl H 2011 H H H H H Hacetyl acetyl acetyl acetyl 2012 H H H H H acetyl H H H H 2013 H H H H Hacetyl H H H acetyl 2014 H H H H H acetyl H H acetyl H 2015 H H H H Hacetyl H H acetyl acetyl 2016 H H H H H acetyl H acetyl H H 2017 H H H HH acetyl H acetyl H acetyl 2018 H H H H H acetyl H acetyl acetyl H 2019H H H H H acetyl H acetyl acetyl acetyl 2020 H H H H H acetyl acetyl H HH 2021 H H H H H acetyl acetyl H H acetyl 2022 H H H H H acetyl acetyl Hacetyl H 2023 H H H H H acetyl acetyl H acetyl acetyl 2024 H H H H Hacetyl acetyl acetyl H H 2025 H H H H H acetyl acetyl acetyl H acetyl2026 H H H H H acetyl acetyl acetyl acetyl H 2027 H H H H H acetylacetyl acetyl acetyl acetyl 2028 H H H H acetyl H H H H H 2029 H H H Hacetyl H H H H acetyl 2030 H H H H acetyl H H H acetyl H 2031 H H H Hacetyl H H H acetyl acetyl 2032 H H H H acetyl H H acetyl H H 2033 H H HH acetyl H H acetyl H acetyl 2034 H H H H acetyl H H acetyl acetyl H2035 H H H H acetyl H H acetyl acetyl acetyl 2036 H H H H acetyl Hacetyl H H H 2037 H H H H acetyl H acetyl H H acetyl 2038 H H H H acetylH acetyl H acetyl H 2039 H H H H acetyl H acetyl H acetyl acetyl 2040 HH H H acetyl H acetyl acetyl H H 2041 H H H H acetyl H acetyl acetyl Hacetyl 2042 H H H H acetyl H acetyl acetyl acetyl H 2043 H H H H acetylH acetyl acetyl acetyl acetyl 2044 H H H H acetyl acetyl H H H H 2045 HH H H acetyl acetyl H H H acetyl 2046 H H H H acetyl acetyl H H acetyl H2047 H H H H acetyl acetyl H H acetyl acetyl 2048 H H H H acetyl acetylH acetyl H H 2049 H H H H acetyl acetyl H acetyl H acetyl 2050 H H H Hacetyl acetyl H acetyl acetyl H 2051 H H H H acetyl acetyl H acetylacetyl acetyl 2052 H H H H acetyl acetyl acetyl H H H 2053 H H H Hacetyl acetyl acetyl H H acetyl 2054 H H H H acetyl acetyl acetyl Hacetyl H 2055 H H H H acetyl acetyl acetyl H acetyl acetyl 2056 H H H Hacetyl acetyl acetyl acetyl H H 2057 H H H H acetyl acetyl acetyl acetylH acetyl 2058 H H H H acetyl acetyl acetyl acetyl acetyl H 2059 H H H Hacetyl acetyl acetyl acetyl acetyl acetyl 2060 H H H acetyl H H H H H H2061 H H H acetyl H H H H H acetyl 2062 H H H acetyl H H H H acetyl H2063 H H H acetyl H H H H acetyl acetyl 2064 H H H acetyl H H H acetyl HH 2065 H H H acetyl H H H acetyl H acetyl 2066 H H H acetyl H H H acetylacetyl H 2067 H H H acetyl H H H acetyl acetyl acetyl 2068 H H H acetylH H acetyl H H H 2069 H H H acetyl H H acetyl H H acetyl 2070 H H Hacetyl H H acetyl H acetyl H 2071 H H H acetyl H H acetyl H acetylacetyl 2072 H H H acetyl H H acetyl acetyl H H 2073 H H H acetyl H Hacetyl acetyl H acetyl 2074 H H H acetyl H H acetyl acetyl acetyl H 2075H H H acetyl H H acetyl acetyl acetyl acetyl 2076 H H H acetyl H acetylH H H H 2077 H H H acetyl H acetyl H H H acetyl 2078 H H H acetyl Hacetyl H H acetyl H 2079 H H H acetyl H acetyl H H acetyl acetyl 2080 HH H acetyl H acetyl H acetyl H H 2081 H H H acetyl H acetyl H acetyl Hacetyl 2082 H H H acetyl H acetyl H acetyl acetyl H 2083 H H H acetyl Hacetyl H acetyl acetyl acetyl 2084 H H H acetyl H acetyl acetyl H H H2085 H H H acetyl H acetyl acetyl H H acetyl 2086 H H H acetyl H acetylacetyl H acetyl H 2087 H H H acetyl H acetyl acetyl H acetyl acetyl 2088H H H acetyl H acetyl acetyl acetyl H H 2089 H H H acetyl H acetylacetyl acetyl H acetyl 2090 H H H acetyl H acetyl acetyl acetyl acetyl H2091 H H H acetyl H acetyl acetyl acetyl acetyl acetyl 2092 H H H acetylacetyl H H H H H 2093 H H H acetyl acetyl H H H H acetyl 2094 H H Hacetyl acetyl H H H acetyl H 2095 H H H acetyl acetyl H H H acetylacetyl 2096 H H H acetyl acetyl H H acetyl H H 2097 H H H acetyl acetylH H acetyl H acetyl 2098 H H H acetyl acetyl H H acetyl acetyl H 2099 HH H acetyl acetyl H H acetyl acetyl acetyl 2100 H H H acetyl acetyl Hacetyl H H H 2101 H H H acetyl acetyl H acetyl H H acetyl 2102 H H Hacetyl acetyl H acetyl H acetyl H 2103 H H H acetyl acetyl H acetyl Hacetyl acetyl 2104 H H H acetyl acetyl H acetyl acetyl H H 2105 H H Hacetyl acetyl H acetyl acetyl H acetyl 2106 H H H acetyl acetyl H acetylacetyl acetyl H 2107 H H H acetyl acetyl H acetyl acetyl acetyl acetyl2108 H H H acetyl acetyl acetyl H H H H 2109 H H H acetyl acetyl acetylH H H acetyl 2110 H H H acetyl acetyl acetyl H H acetyl H 2111 H H Hacetyl acetyl acetyl H H acetyl acetyl 2112 H H H acetyl acetyl acetyl Hacetyl H H 2113 H H H acetyl acetyl acetyl H acetyl H acetyl 2114 H H Hacetyl acetyl acetyl H acetyl acetyl H 2115 H H H acetyl acetyl acetyl Hacetyl acetyl acetyl 2116 H H H acetyl acetyl acetyl acetyl H H H 2117 HH H acetyl acetyl acetyl acetyl H H acetyl 2118 H H H acetyl acetylacetyl acetyl H acetyl H 2119 H H H acetyl acetyl acetyl acetyl H acetylacetyl 2120 H H H acetyl acetyl acetyl acetyl acetyl H H 2121 H H Hacetyl acetyl acetyl acetyl acetyl H acetyl 2122 H H H acetyl acetylacetyl acetyl acetyl acetyl H 2123 H H H acetyl acetyl acetyl acetylacetyl acetyl acetyl 2124 H H acetyl H H H H H H H 2125 H H acetyl H H HH H H acetyl 2126 H H acetyl H H H H H acetyl H 2127 H H acetyl H H H HH acetyl acetyl 2128 H H acetyl H H H H acetyl H H 2129 H H acetyl H H HH acetyl H acetyl 2130 H H acetyl H H H H acetyl acetyl H 2131 H Hacetyl H H H H acetyl acetyl acetyl 2132 H H acetyl H H H acetyl H H H2133 H H acetyl H H H acetyl H H acetyl 2134 H H acetyl H H H acetyl Hacetyl H 2135 H H acetyl H H H acetyl H acetyl acetyl 2136 H H acetyl HH H acetyl acetyl H H 2137 H H acetyl H H H acetyl acetyl H acetyl 2138H H acetyl H H H acetyl acetyl acetyl H 2139 H H acetyl H H H acetylacetyl acetyl acetyl 2140 H H acetyl H H acetyl H H H H 2141 H H acetylH H acetyl H H H acetyl 2142 H H acetyl H H acetyl H H acetyl H 2143 H Hacetyl H H acetyl H H acetyl acetyl 2144 H H acetyl H H acetyl H acetylH H 2145 H H acetyl H H acetyl H acetyl H acetyl 2146 H H acetyl H Hacetyl H acetyl acetyl H 2147 H H acetyl H H acetyl H acetyl acetylacetyl 2148 H H acetyl H H acetyl acetyl H H H 2149 H H acetyl H Hacetyl acetyl H H acetyl 2150 H H acetyl H H acetyl acetyl H acetyl H2151 H H acetyl H H acetyl acetyl H acetyl acetyl 2152 H H acetyl H Hacetyl acetyl acetyl H H 2153 H H acetyl H H acetyl acetyl acetyl Hacetyl 2154 H H acetyl H H acetyl acetyl acetyl acetyl H 2155 H H acetylH H acetyl acetyl acetyl acetyl acetyl 2156 H H acetyl H acetyl H H H HH 2157 H H acetyl H acetyl H H H H acetyl 2158 H H acetyl H acetyl H H Hacetyl H 2159 H H acetyl H acetyl H H H acetyl acetyl 2160 H H acetyl Hacetyl H H acetyl H H 2161 H H acetyl H acetyl H H acetyl H acetyl 2162H H acetyl H acetyl H H acetyl acetyl H 2163 H H acetyl H acetyl H Hacetyl acetyl acetyl 2164 H H acetyl H acetyl H acetyl H H H 2165 H Hacetyl H acetyl H acetyl H H acetyl 2166 H H acetyl H acetyl H acetyl Hacetyl H 2167 H H acetyl H acetyl H acetyl H acetyl acetyl 2168 H Hacetyl H acetyl H acetyl acetyl H H 2169 H H acetyl H acetyl H acetylacetyl H acetyl 2170 H H acetyl H acetyl H acetyl acetyl acetyl H 2171 HH acetyl H acetyl H acetyl acetyl acetyl acetyl 2172 H H acetyl H acetylacetyl H H H H 2173 H H acetyl H acetyl acetyl H H H acetyl 2174 H Hacetyl H acetyl acetyl H H acetyl H 2175 H H acetyl H acetyl acetyl H Hacetyl acetyl 2176 H H acetyl H acetyl acetyl H acetyl H H 2177 H Hacetyl H acetyl acetyl H acetyl H acetyl 2178 H H acetyl H acetyl acetylH acetyl acetyl H 2179 H H acetyl H acetyl acetyl H acetyl acetyl acetyl2180 H H acetyl H acetyl acetyl acetyl H H H 2181 H H acetyl H acetylacetyl acetyl H H acetyl 2182 H H acetyl H acetyl acetyl acetyl H acetylH 2183 H H acetyl H acetyl acetyl acetyl H acetyl acetyl 2184 H H acetylH acetyl acetyl acetyl acetyl H H 2185 H H acetyl H acetyl acetyl acetylacetyl H acetyl 2186 H H acetyl H acetyl acetyl acetyl acetyl acetyl H2187 H H acetyl H acetyl acetyl acetyl acetyl acetyl acetyl 2188 H Hacetyl acetyl H H H H H H 2189 H H acetyl acetyl H H H H H acetyl 2190 HH acetyl acetyl H H H H acetyl H 2191 H H acetyl acetyl H H H H acetylacetyl 2192 H H acetyl acetyl H H H acetyl H H 2193 H H acetyl acetyl HH H acetyl H acetyl 2194 H H acetyl acetyl H H H acetyl acetyl H 2195 HH acetyl acetyl H H H acetyl acetyl acetyl 2196 H H acetyl acetyl H Hacetyl H H H 2197 H H acetyl acetyl H H acetyl H H acetyl 2198 H Hacetyl acetyl H H acetyl H acetyl H 2199 H H acetyl acetyl H H acetyl Hacetyl acetyl 2200 H H acetyl acetyl H H acetyl acetyl H H 2201 H Hacetyl acetyl H H acetyl acetyl H acetyl 2202 H H acetyl acetyl H Hacetyl acetyl acetyl H 2203 H H acetyl acetyl H H acetyl acetyl acetylacetyl 2204 H H acetyl acetyl H acetyl H H H H 2205 H H acetyl acetyl Hacetyl H H H acetyl 2206 H H acetyl acetyl H acetyl H H acetyl H 2207 HH acetyl acetyl H acetyl H H acetyl acetyl 2208 H H acetyl acetyl Hacetyl H acetyl H H 2209 H H acetyl acetyl H acetyl H acetyl H acetyl2210 H H acetyl acetyl H acetyl H acetyl acetyl H 2211 H H acetyl acetylH acetyl H acetyl acetyl acetyl 2212 H H acetyl acetyl H acetyl acetyl HH H 2213 H H acetyl acetyl H acetyl acetyl H H acetyl 2214 H H acetylacetyl H acetyl acetyl H acetyl H 2215 H H acetyl acetyl H acetyl acetylH acetyl acetyl 2216 H H acetyl acetyl H acetyl acetyl acetyl H H 2217 HH acetyl acetyl H acetyl acetyl acetyl H acetyl 2218 H H acetyl acetyl Hacetyl acetyl acetyl acetyl H 2219 H H acetyl acetyl H acetyl acetylacetyl acetyl acetyl 2220 H H acetyl acetyl acetyl H H H H H 2221 H Hacetyl acetyl acetyl H H H H acetyl 2222 H H acetyl acetyl acetyl H H Hacetyl H 2223 H H acetyl acetyl acetyl H H H acetyl acetyl 2224 H Hacetyl acetyl acetyl H H acetyl H H 2225 H H acetyl acetyl acetyl H Hacetyl H acetyl 2226 H H acetyl acetyl acetyl H H acetyl acetyl H 2227 HH acetyl acetyl acetyl H H acetyl acetyl acetyl 2228 H H acetyl acetylacetyl H acetyl H H H 2229 H H acetyl acetyl acetyl H acetyl H H acetyl2230 H H acetyl acetyl acetyl H acetyl H acetyl H 2231 H H acetyl acetylacetyl H acetyl H acetyl acetyl 2232 H H acetyl acetyl acetyl H acetylacetyl H H 2233 H H acetyl acetyl acetyl H acetyl acetyl H acetyl 2234 HH acetyl acetyl acetyl H acetyl acetyl acetyl H 2235 H H acetyl acetylacetyl H acetyl acetyl acetyl acetyl 2236 H H acetyl acetyl acetylacetyl H H H H 2237 H H acetyl acetyl acetyl acetyl H H H acetyl 2238 HH acetyl acetyl acetyl acetyl H H acetyl H 2239 H H acetyl acetyl acetylacetyl H H acetyl acetyl 2240 H H acetyl acetyl acetyl acetyl H acetyl HH 2241 H H acetyl acetyl acetyl acetyl H acetyl H acetyl 2242 H H acetylacetyl acetyl acetyl H acetyl acetyl H 2243 H H acetyl acetyl acetylacetyl H acetyl acetyl acetyl 2244 H H acetyl acetyl acetyl acetylacetyl H H H 2245 H H acetyl acetyl acetyl acetyl acetyl H H acetyl 2246H H acetyl acetyl acetyl acetyl acetyl H acetyl H 2247 H H acetyl acetylacetyl acetyl acetyl H acetyl acetyl 2248 H H acetyl acetyl acetylacetyl acetyl acetyl H H 2249 H H acetyl acetyl acetyl acetyl acetylacetyl H acetyl 2250 H H acetyl acetyl acetyl acetyl acetyl acetylacetyl H 2251 H H acetyl acetyl acetyl acetyl acetyl acetyl acetylacetyl 2252 H acetyl H H H H H H H H 2253 H acetyl H H H H H H H acetyl2254 H acetyl H H H H H H acetyl H 2255 H acetyl H H H H H H acetylacetyl 2256 H acetyl H H H H H acetyl H H 2257 H acetyl H H H H H acetylH acetyl 2258 H acetyl H H H H H acetyl acetyl H 2259 H acetyl H H H H Hacetyl acetyl acetyl 2260 H acetyl H H H H acetyl H H H 2261 H acetyl HH H H acetyl H H acetyl 2262 H acetyl H H H H acetyl H acetyl H 2263 Hacetyl H H H H acetyl H acetyl acetyl 2264 H acetyl H H H H acetylacetyl H H 2265 H acetyl H H H H acetyl acetyl H acetyl 2266 H acetyl HH H H acetyl acetyl acetyl H 2267 H acetyl H H H H acetyl acetyl acetylacetyl 2268 H acetyl H H H acetyl H H H H 2269 H acetyl H H H acetyl H HH acetyl 2270 H acetyl H H H acetyl H H acetyl H 2271 H acetyl H H Hacetyl H H acetyl acetyl 2272 H acetyl H H H acetyl H acetyl H H 2273 Hacetyl H H H acetyl H acetyl H acetyl 2274 H acetyl H H H acetyl Hacetyl acetyl H 2275 H acetyl H H H acetyl H acetyl acetyl acetyl 2276 Hacetyl H H H acetyl acetyl H H H 2277 H acetyl H H H acetyl acetyl H Hacetyl 2278 H acetyl H H H acetyl acetyl H acetyl H 2279 H acetyl H H Hacetyl acetyl H acetyl acetyl 2280 H acetyl H H H acetyl acetyl acetyl HH 2281 H acetyl H H H acetyl acetyl acetyl H acetyl 2282 H acetyl H H Hacetyl acetyl acetyl acetyl H 2283 H acetyl H H H acetyl acetyl acetylacetyl acetyl 2284 H acetyl H H acetyl H H H H H 2285 H acetyl H Hacetyl H H H H acetyl 2286 H acetyl H H acetyl H H H acetyl H 2287 Hacetyl H H acetyl H H H acetyl acetyl 2288 H acetyl H H acetyl H Hacetyl H H 2289 H acetyl H H acetyl H H acetyl H acetyl 2290 H acetyl HH acetyl H H acetyl acetyl H 2291 H acetyl H H acetyl H H acetyl acetylacetyl 2292 H acetyl H H acetyl H acetyl H H H 2293 H acetyl H H acetylH acetyl H H acetyl 2294 H acetyl H H acetyl H acetyl H acetyl H 2295 Hacetyl H H acetyl H acetyl H acetyl acetyl 2296 H acetyl H H acetyl Hacetyl acetyl H H 2297 H acetyl H H acetyl H acetyl acetyl H acetyl 2298H acetyl H H acetyl H acetyl acetyl acetyl H 2299 H acetyl H H acetyl Hacetyl acetyl acetyl acetyl 2300 H acetyl H H acetyl acetyl H H H H 2301H acetyl H H acetyl acetyl H H H acetyl 2302 H acetyl H H acetyl acetylH H acetyl H 2303 H acetyl H H acetyl acetyl H H acetyl acetyl 2304 Hacetyl H H acetyl acetyl H acetyl H H 2305 H acetyl H H acetyl acetyl Hacetyl H acetyl 2306 H acetyl H H acetyl acetyl H acetyl acetyl H 2307 Hacetyl H H acetyl acetyl H acetyl acetyl acetyl 2308 H acetyl H H acetylacetyl acetyl H H H 2309 H acetyl H H acetyl acetyl acetyl H H acetyl2310 H acetyl H H acetyl acetyl acetyl H acetyl H 2311 H acetyl H Hacetyl acetyl acetyl H acetyl acetyl 2312 H acetyl H H acetyl acetylacetyl acetyl H H 2313 H acetyl H H acetyl acetyl acetyl acetyl H acetyl2314 H acetyl H H acetyl acetyl acetyl acetyl acetyl H 2315 H acetyl H Hacetyl acetyl acetyl acetyl acetyl acetyl 2316 H acetyl H acetyl H H H HH H 2317 H acetyl H acetyl H H H H H acetyl 2318 H acetyl H acetyl H H HH acetyl H 2319 H acetyl H acetyl H H H H acetyl acetyl 2320 H acetyl Hacetyl H H H acetyl H H 2321 H acetyl H acetyl H H H acetyl H acetyl2322 H acetyl H acetyl H H H acetyl acetyl H 2323 H acetyl H acetyl H HH acetyl acetyl acetyl 2324 H acetyl H acetyl H H acetyl H H H 2325 Hacetyl H acetyl H H acetyl H H acetyl 2326 H acetyl H acetyl H H acetylH acetyl H 2327 H acetyl H acetyl H H acetyl H acetyl acetyl 2328 Hacetyl H acetyl H H acetyl acetyl H H 2329 H acetyl H acetyl H H acetylacetyl H acetyl 2330 H acetyl H acetyl H H acetyl acetyl acetyl H 2331 Hacetyl H acetyl H H acetyl acetyl acetyl acetyl 2332 H acetyl H acetyl Hacetyl H H H H 2333 H acetyl H acetyl H acetyl H H H acetyl 2334 Hacetyl H acetyl H acetyl H H acetyl H 2335 H acetyl H acetyl H acetyl HH acetyl acetyl 2336 H acetyl H acetyl H acetyl H acetyl H H 2337 Hacetyl H acetyl H acetyl H acetyl H acetyl 2338 H acetyl H acetyl Hacetyl H acetyl acetyl H 2339 H acetyl H acetyl H acetyl H acetyl acetylacetyl 2340 H acetyl H acetyl H acetyl acetyl H H H 2341 H acetyl Hacetyl H acetyl acetyl H H acetyl 2342 H acetyl H acetyl H acetyl acetylH acetyl H 2343 H acetyl H acetyl H acetyl acetyl H acetyl acetyl 2344 Hacetyl H acetyl H acetyl acetyl acetyl H H 2345 H acetyl H acetyl Hacetyl acetyl acetyl H acetyl 2346 H acetyl H acetyl H acetyl acetylacetyl acetyl H 2347 H acetyl H acetyl H acetyl acetyl acetyl acetylacetyl 2348 H acetyl H acetyl acetyl H H H H H 2349 H acetyl H acetylacetyl H H H H acetyl 2350 H acetyl H acetyl acetyl H H H acetyl H 2351H acetyl H acetyl acetyl H H H acetyl acetyl 2352 H acetyl H acetylacetyl H H acetyl H H 2353 H acetyl H acetyl acetyl H H acetyl H acetyl2354 H acetyl H acetyl acetyl H H acetyl acetyl H 2355 H acetyl H acetylacetyl H H acetyl acetyl acetyl 2356 H acetyl H acetyl acetyl H acetyl HH H 2357 H acetyl H acetyl acetyl H acetyl H H acetyl 2358 H acetyl Hacetyl acetyl H acetyl H acetyl H 2359 H acetyl H acetyl acetyl H acetylH acetyl acetyl 2360 H acetyl H acetyl acetyl H acetyl acetyl H H 2361 Hacetyl H acetyl acetyl H acetyl acetyl H acetyl 2362 H acetyl H acetylacetyl H acetyl acetyl acetyl H 2363 H acetyl H acetyl acetyl H acetylacetyl acetyl acetyl 2364 H acetyl H acetyl acetyl acetyl H H H H 2365 Hacetyl H acetyl acetyl acetyl H H H acetyl 2366 H acetyl H acetyl acetylacetyl H H acetyl H 2367 H acetyl H acetyl acetyl acetyl H H acetylacetyl 2368 H acetyl H acetyl acetyl acetyl H acetyl H H 2369 H acetyl Hacetyl acetyl acetyl H acetyl H acetyl 2370 H acetyl H acetyl acetylacetyl H acetyl acetyl H 2371 H acetyl H acetyl acetyl acetyl H acetylacetyl acetyl 2372 H acetyl H acetyl acetyl acetyl acetyl H H H 2373 Hacetyl H acetyl acetyl acetyl acetyl H H acetyl 2374 H acetyl H acetylacetyl acetyl acetyl H acetyl H 2375 H acetyl H acetyl acetyl acetylacetyl H acetyl acetyl 2376 H acetyl H acetyl acetyl acetyl acetylacetyl H H 2377 H acetyl H acetyl acetyl acetyl acetyl acetyl H acetyl2378 H acetyl H acetyl acetyl acetyl acetyl acetyl acetyl H 2379 Hacetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl 2380 H acetylacetyl H H H H H H H 2381 H acetyl acetyl H H H H H H acetyl 2382 Hacetyl acetyl H H H H H acetyl H 2383 H acetyl acetyl H H H H H acetylacetyl 2384 H acetyl acetyl H H H H acetyl H H 2385 H acetyl acetyl H HH H acetyl H acetyl 2386 H acetyl acetyl H H H H acetyl acetyl H 2387 Hacetyl acetyl H H H H acetyl acetyl acetyl 2388 H acetyl acetyl H H Hacetyl H H H 2389 H acetyl acetyl H H H acetyl H H acetyl 2390 H acetylacetyl H H H acetyl H acetyl H 2391 H acetyl acetyl H H H acetyl Hacetyl acetyl 2392 H acetyl acetyl H H H acetyl acetyl H H 2393 H acetylacetyl H H H acetyl acetyl H acetyl 2394 H acetyl acetyl H H H acetylacetyl acetyl H 2395 H acetyl acetyl H H H acetyl acetyl acetyl acetyl2396 H acetyl acetyl H H acetyl H H H H 2397 H acetyl acetyl H H acetylH H H acetyl 2398 H acetyl acetyl H H acetyl H H acetyl H 2399 H acetylacetyl H H acetyl H H acetyl acetyl 2400 H acetyl acetyl H H acetyl Hacetyl H H 2401 H acetyl acetyl H H acetyl H acetyl H acetyl 2402 Hacetyl acetyl H H acetyl H acetyl acetyl H 2403 H acetyl acetyl H Hacetyl H acetyl acetyl acetyl 2404 H acetyl acetyl H H acetyl acetyl H HH 2405 H acetyl acetyl H H acetyl acetyl H H acetyl 2406 H acetyl acetylH H acetyl acetyl H acetyl H 2407 H acetyl acetyl H H acetyl acetyl Hacetyl acetyl 2408 H acetyl acetyl H H acetyl acetyl acetyl H H 2409 Hacetyl acetyl H H acetyl acetyl acetyl H acetyl 2410 H acetyl acetyl H Hacetyl acetyl acetyl acetyl H 2411 H acetyl acetyl H H acetyl acetylacetyl acetyl acetyl 2412 H acetyl acetyl H acetyl H H H H H 2413 Hacetyl acetyl H acetyl H H H H acetyl 2414 H acetyl acetyl H acetyl H HH acetyl H 2415 H acetyl acetyl H acetyl H H H acetyl acetyl 2416 Hacetyl acetyl H acetyl H H acetyl H H 2417 H acetyl acetyl H acetyl H Hacetyl H acetyl 2418 H acetyl acetyl H acetyl H H acetyl acetyl H 2419 Hacetyl acetyl H acetyl H H acetyl acetyl acetyl 2420 H acetyl acetyl Hacetyl H acetyl H H H 2421 H acetyl acetyl H acetyl H acetyl H H acetyl2422 H acetyl acetyl H acetyl H acetyl H acetyl H 2423 H acetyl acetyl Hacetyl H acetyl H acetyl acetyl 2424 H acetyl acetyl H acetyl H acetylacetyl H H 2425 H acetyl acetyl H acetyl H acetyl acetyl H acetyl 2426 Hacetyl acetyl H acetyl H acetyl acetyl acetyl H 2427 H acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl 2428 H acetyl acetyl H acetylacetyl H H H H 2429 H acetyl acetyl H acetyl acetyl H H H acetyl 2430 Hacetyl acetyl H acetyl acetyl H H acetyl H 2431 H acetyl acetyl H acetylacetyl H H acetyl acetyl 2432 H acetyl acetyl H acetyl acetyl H acetyl HH 2433 H acetyl acetyl H acetyl acetyl H acetyl H acetyl 2434 H acetylacetyl H acetyl acetyl H acetyl acetyl H 2435 H acetyl acetyl H acetylacetyl H acetyl acetyl acetyl 2436 H acetyl acetyl H acetyl acetylacetyl H H H 2437 H acetyl acetyl H acetyl acetyl acetyl H H acetyl 2438H acetyl acetyl H acetyl acetyl acetyl H acetyl H 2439 H acetyl acetyl Hacetyl acetyl acetyl H acetyl acetyl 2440 H acetyl acetyl H acetylacetyl acetyl acetyl H H 2441 H acetyl acetyl H acetyl acetyl acetylacetyl H acetyl 2442 H acetyl acetyl H acetyl acetyl acetyl acetylacetyl H 2443 H acetyl acetyl H acetyl acetyl acetyl acetyl acetylacetyl 2444 H acetyl acetyl acetyl H H H H H H 2445 H acetyl acetylacetyl H H H H H acetyl 2446 H acetyl acetyl acetyl H H H H acetyl H2447 H acetyl acetyl acetyl H H H H acetyl acetyl 2448 H acetyl acetylacetyl H H H acetyl H H 2449 H acetyl acetyl acetyl H H H acetyl Hacetyl 2450 H acetyl acetyl acetyl H H H acetyl acetyl H 2451 H acetylacetyl acetyl H H H acetyl acetyl acetyl 2452 H acetyl acetyl acetyl H Hacetyl H H H 2453 H acetyl acetyl acetyl H H acetyl H H acetyl 2454 Hacetyl acetyl acetyl H H acetyl H acetyl H 2455 H acetyl acetyl acetyl HH acetyl H acetyl acetyl 2456 H acetyl acetyl acetyl H H acetyl acetyl HH 2457 H acetyl acetyl acetyl H H acetyl acetyl H acetyl 2458 H acetylacetyl acetyl H H acetyl acetyl acetyl H 2459 H acetyl acetyl acetyl H Hacetyl acetyl acetyl acetyl 2460 H acetyl acetyl acetyl H acetyl H H H H2461 H acetyl acetyl acetyl H acetyl H H H acetyl 2462 H acetyl acetylacetyl H acetyl H H acetyl H 2463 H acetyl acetyl acetyl H acetyl H Hacetyl acetyl 2464 H acetyl acetyl acetyl H acetyl H acetyl H H 2465 Hacetyl acetyl acetyl H acetyl H acetyl H acetyl 2466 H acetyl acetylacetyl H acetyl H acetyl acetyl H 2467 H acetyl acetyl acetyl H acetyl Hacetyl acetyl acetyl 2468 H acetyl acetyl acetyl H acetyl acetyl H H H2469 H acetyl acetyl acetyl H acetyl acetyl H H acetyl 2470 H acetylacetyl acetyl H acetyl acetyl H acetyl H 2471 H acetyl acetyl acetyl Hacetyl acetyl H acetyl acetyl 2472 H acetyl acetyl acetyl H acetylacetyl acetyl H H 2473 H acetyl acetyl acetyl H acetyl acetyl acetyl Hacetyl 2474 H acetyl acetyl acetyl H acetyl acetyl acetyl acetyl H 2475H acetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl 2476 Hacetyl acetyl acetyl acetyl H H H H H 2477 H acetyl acetyl acetyl acetylH H H H acetyl 2478 H acetyl acetyl acetyl acetyl H H H acetyl H 2479 Hacetyl acetyl acetyl acetyl H H H acetyl acetyl 2480 H acetyl acetylacetyl acetyl H H acetyl H H 2481 H acetyl acetyl acetyl acetyl H Hacetyl H acetyl 2482 H acetyl acetyl acetyl acetyl H H acetyl acetyl H2483 H acetyl acetyl acetyl acetyl H H acetyl acetyl acetyl 2484 Hacetyl acetyl acetyl acetyl H acetyl H H H 2485 H acetyl acetyl acetylacetyl H acetyl H H acetyl 2486 H acetyl acetyl acetyl acetyl H acetyl Hacetyl H 2487 H acetyl acetyl acetyl acetyl H acetyl H acetyl acetyl2488 H acetyl acetyl acetyl acetyl H acetyl acetyl H H 2489 H acetylacetyl acetyl acetyl H acetyl acetyl H acetyl 2490 H acetyl acetylacetyl acetyl H acetyl acetyl acetyl H 2491 H acetyl acetyl acetylacetyl H acetyl acetyl acetyl acetyl 2492 H acetyl acetyl acetyl acetylacetyl H H H H 2493 H acetyl acetyl acetyl acetyl acetyl H H H acetyl2494 H acetyl acetyl acetyl acetyl acetyl H H acetyl H 2495 H acetylacetyl acetyl acetyl acetyl H H acetyl acetyl 2496 H acetyl acetylacetyl acetyl acetyl H acetyl H H 2497 H acetyl acetyl acetyl acetylacetyl H acetyl H acetyl 2498 H acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl H 2499 H acetyl acetyl acetyl acetyl acetyl H acetylacetyl acetyl 2500 H acetyl acetyl acetyl acetyl acetyl acetyl H H H2501 H acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl 2502 Hacetyl acetyl acetyl acetyl acetyl acetyl H acetyl H 2503 H acetylacetyl acetyl acetyl acetyl acetyl H acetyl acetyl 2504 H acetyl acetylacetyl acetyl acetyl acetyl acetyl H H 2505 H acetyl acetyl acetylacetyl acetyl acetyl acetyl H acetyl 2506 H acetyl acetyl acetyl acetylacetyl acetyl acetyl acetyl H 2507 H acetyl acetyl acetyl acetyl acetylacetyl acetyl acetyl acetyl 2508 acetyl H H H H H H H H H 2509 acetyl HH H H H H H H acetyl 2510 acetyl H H H H H H H acetyl H 2511 acetyl H HH H H H H acetyl acetyl 2512 acetyl H H H H H H acetyl H H 2513 acetyl HH H H H H acetyl H acetyl 2514 acetyl H H H H H H acetyl acetyl H 2515acetyl H H H H H H acetyl acetyl acetyl 2516 acetyl H H H H H acetyl H HH 2517 acetyl H H H H H acetyl H H acetyl 2518 acetyl H H H H H acetyl Hacetyl H 2519 acetyl H H H H H acetyl H acetyl acetyl 2520 acetyl H H HH H acetyl acetyl H H 2521 acetyl H H H H H acetyl acetyl H acetyl 2522acetyl H H H H H acetyl acetyl acetyl H 2523 acetyl H H H H H acetylacetyl acetyl acetyl 2524 acetyl H H H H acetyl H H H H 2525 acetyl H HH H acetyl H H H acetyl 2526 acetyl H H H H acetyl H H acetyl H 2527acetyl H H H H acetyl H H acetyl acetyl 2528 acetyl H H H H acetyl Hacetyl H H 2529 acetyl H H H H acetyl H acetyl H acetyl 2530 acetyl H HH H acetyl H acetyl acetyl H 2531 acetyl H H H H acetyl H acetyl acetylacetyl 2532 acetyl H H H H acetyl acetyl H H H 2533 acetyl H H H Hacetyl acetyl H H acetyl 2534 acetyl H H H H acetyl acetyl H acetyl H2535 acetyl H H H H acetyl acetyl H acetyl acetyl 2536 acetyl H H H Hacetyl acetyl acetyl H H 2537 acetyl H H H H acetyl acetyl acetyl Hacetyl 2538 acetyl H H H H acetyl acetyl acetyl acetyl H 2539 acetyl H HH H acetyl acetyl acetyl acetyl acetyl 2540 acetyl H H H acetyl H H H HH 2541 acetyl H H H acetyl H H H H acetyl 2542 acetyl H H H acetyl H H Hacetyl H 2543 acetyl H H H acetyl H H H acetyl acetyl 2544 acetyl H H Hacetyl H H acetyl H H 2545 acetyl H H H acetyl H H acetyl H acetyl 2546acetyl H H H acetyl H H acetyl acetyl H 2547 acetyl H H H acetyl H Hacetyl acetyl acetyl 2548 acetyl H H H acetyl H acetyl H H H 2549 acetylH H H acetyl H acetyl H H acetyl 2550 acetyl H H H acetyl H acetyl Hacetyl H 2551 acetyl H H H acetyl H acetyl H acetyl acetyl 2552 acetyl HH H acetyl H acetyl acetyl H H 2553 acetyl H H H acetyl H acetyl acetylH acetyl 2554 acetyl H H H acetyl H acetyl acetyl acetyl H 2555 acetyl HH H acetyl H acetyl acetyl acetyl acetyl 2556 acetyl H H H acetyl acetylH H H H 2557 acetyl H H H acetyl acetyl H H H acetyl 2558 acetyl H H Hacetyl acetyl H H acetyl H 2559 acetyl H H H acetyl acetyl H H acetylacetyl 2560 acetyl H H H acetyl acetyl H acetyl H H 2561 acetyl H H Hacetyl acetyl H acetyl H acetyl 2562 acetyl H H H acetyl acetyl H acetylacetyl H 2563 acetyl H H H acetyl acetyl H acetyl acetyl acetyl 2564acetyl H H H acetyl acetyl acetyl H H H 2565 acetyl H H H acetyl acetylacetyl H H acetyl 2566 acetyl H H H acetyl acetyl acetyl H acetyl H 2567acetyl H H H acetyl acetyl acetyl H acetyl acetyl 2568 acetyl H H Hacetyl acetyl acetyl acetyl H H 2569 acetyl H H H acetyl acetyl acetylacetyl H acetyl 2570 acetyl H H H acetyl acetyl acetyl acetyl acetyl H2571 acetyl H H H acetyl acetyl acetyl acetyl acetyl acetyl 2572 acetylH H acetyl H H H H H H 2573 acetyl H H acetyl H H H H H acetyl 2574acetyl H H acetyl H H H H acetyl H 2575 acetyl H H acetyl H H H H acetylacetyl 2576 acetyl H H acetyl H H H acetyl H H 2577 acetyl H H acetyl HH H acetyl H acetyl 2578 acetyl H H acetyl H H H acetyl acetyl H 2579acetyl H H acetyl H H H acetyl acetyl acetyl 2580 acetyl H H acetyl H Hacetyl H H H 2581 acetyl H H acetyl H H acetyl H H acetyl 2582 acetyl HH acetyl H H acetyl H acetyl H 2583 acetyl H H acetyl H H acetyl Hacetyl acetyl 2584 acetyl H H acetyl H H acetyl acetyl H H 2585 acetyl HH acetyl H H acetyl acetyl H acetyl 2586 acetyl H H acetyl H H acetylacetyl acetyl H 2587 acetyl H H acetyl H H acetyl acetyl acetyl acetyl2588 acetyl H H acetyl H acetyl H H H H 2589 acetyl H H acetyl H acetylH H H acetyl 2590 acetyl H H acetyl H acetyl H H acetyl H 2591 acetyl HH acetyl H acetyl H H acetyl acetyl 2592 acetyl H H acetyl H acetyl Hacetyl H H 2593 acetyl H H acetyl H acetyl H acetyl H acetyl 2594 acetylH H acetyl H acetyl H acetyl acetyl H 2595 acetyl H H acetyl H acetyl Hacetyl acetyl acetyl 2596 acetyl H H acetyl H acetyl acetyl H H H 2597acetyl H H acetyl H acetyl acetyl H H acetyl 2598 acetyl H H acetyl Hacetyl acetyl H acetyl H 2599 acetyl H H acetyl H acetyl acetyl H acetylacetyl 2600 acetyl H H acetyl H acetyl acetyl acetyl H H 2601 acetyl H Hacetyl H acetyl acetyl acetyl H acetyl 2602 acetyl H H acetyl H acetylacetyl acetyl acetyl H 2603 acetyl H H acetyl H acetyl acetyl acetylacetyl acetyl 2604 acetyl H H acetyl acetyl H H H H H 2605 acetyl H Hacetyl acetyl H H H H acetyl 2606 acetyl H H acetyl acetyl H H H acetylH 2607 acetyl H H acetyl acetyl H H H acetyl acetyl 2608 acetyl H Hacetyl acetyl H H acetyl H H 2609 acetyl H H acetyl acetyl H H acetyl Hacetyl 2610 acetyl H H acetyl acetyl H H acetyl acetyl H 2611 acetyl H Hacetyl acetyl H H acetyl acetyl acetyl 2612 acetyl H H acetyl acetyl Hacetyl H H H 2613 acetyl H H acetyl acetyl H acetyl H H acetyl 2614acetyl H H acetyl acetyl H acetyl H acetyl H 2615 acetyl H H acetylacetyl H acetyl H acetyl acetyl 2616 acetyl H H acetyl acetyl H acetylacetyl H H 2617 acetyl H H acetyl acetyl H acetyl acetyl H acetyl 2618acetyl H H acetyl acetyl H acetyl acetyl acetyl H 2619 acetyl H H acetylacetyl H acetyl acetyl acetyl acetyl 2620 acetyl H H acetyl acetylacetyl H H H H 2621 acetyl H H acetyl acetyl acetyl H H H acetyl 2622acetyl H H acetyl acetyl acetyl H H acetyl H 2623 acetyl H H acetylacetyl acetyl H H acetyl acetyl 2624 acetyl H H acetyl acetyl acetyl Hacetyl H H 2625 acetyl H H acetyl acetyl acetyl H acetyl H acetyl 2626acetyl H H acetyl acetyl acetyl H acetyl acetyl H 2627 acetyl H H acetylacetyl acetyl H acetyl acetyl acetyl 2628 acetyl H H acetyl acetylacetyl acetyl H H H 2629 acetyl H H acetyl acetyl acetyl acetyl H Hacetyl 2630 acetyl H H acetyl acetyl acetyl acetyl H acetyl H 2631acetyl H H acetyl acetyl acetyl acetyl H acetyl acetyl 2632 acetyl H Hacetyl acetyl acetyl acetyl acetyl H H 2633 acetyl H H acetyl acetylacetyl acetyl acetyl H acetyl 2634 acetyl H H acetyl acetyl acetylacetyl acetyl acetyl H 2635 acetyl H H acetyl acetyl acetyl acetylacetyl acetyl acetyl 2636 acetyl H acetyl H H H H H H H 2637 acetyl Hacetyl H H H H H H acetyl 2638 acetyl H acetyl H H H H H acetyl H 2639acetyl H acetyl H H H H H acetyl acetyl 2640 acetyl H acetyl H H H Hacetyl H H 2641 acetyl H acetyl H H H H acetyl H acetyl 2642 acetyl Hacetyl H H H H acetyl acetyl H 2643 acetyl H acetyl H H H H acetylacetyl acetyl 2644 acetyl H acetyl H H H acetyl H H H 2645 acetyl Hacetyl H H H acetyl H H acetyl 2646 acetyl H acetyl H H H acetyl Hacetyl H 2647 acetyl H acetyl H H H acetyl H acetyl acetyl 2648 acetyl Hacetyl H H H acetyl acetyl H H 2649 acetyl H acetyl H H H acetyl acetylH acetyl 2650 acetyl H acetyl H H H acetyl acetyl acetyl H 2651 acetyl Hacetyl H H H acetyl acetyl acetyl acetyl 2652 acetyl H acetyl H H acetylH H H H 2653 acetyl H acetyl H H acetyl H H H acetyl 2654 acetyl Hacetyl H H acetyl H H acetyl H 2655 acetyl H acetyl H H acetyl H Hacetyl acetyl 2656 acetyl H acetyl H H acetyl H acetyl H H 2657 acetyl Hacetyl H H acetyl H acetyl H acetyl 2658 acetyl H acetyl H H acetyl Hacetyl acetyl H 2659 acetyl H acetyl H H acetyl H acetyl acetyl acetyl2660 acetyl H acetyl H H acetyl acetyl H H H 2661 acetyl H acetyl H Hacetyl acetyl H H acetyl 2662 acetyl H acetyl H H acetyl acetyl H acetylH 2663 acetyl H acetyl H H acetyl acetyl H acetyl acetyl 2664 acetyl Hacetyl H H acetyl acetyl acetyl H H 2665 acetyl H acetyl H H acetylacetyl acetyl H acetyl 2666 acetyl H acetyl H H acetyl acetyl acetylacetyl H 2667 acetyl H acetyl H H acetyl acetyl acetyl acetyl acetyl2668 acetyl H acetyl H acetyl H H H H H 2669 acetyl H acetyl H acetyl HH H H acetyl 2670 acetyl H acetyl H acetyl H H H acetyl H 2671 acetyl Hacetyl H acetyl H H H acetyl acetyl 2672 acetyl H acetyl H acetyl H Hacetyl H H 2673 acetyl H acetyl H acetyl H H acetyl H acetyl 2674 acetylH acetyl H acetyl H H acetyl acetyl H 2675 acetyl H acetyl H acetyl H Hacetyl acetyl acetyl 2676 acetyl H acetyl H acetyl H acetyl H H H 2677acetyl H acetyl H acetyl H acetyl H H acetyl 2678 acetyl H acetyl Hacetyl H acetyl H acetyl H 2679 acetyl H acetyl H acetyl H acetyl Hacetyl acetyl 2680 acetyl H acetyl H acetyl H acetyl acetyl H H 2681acetyl H acetyl H acetyl H acetyl acetyl H acetyl 2682 acetyl H acetyl Hacetyl H acetyl acetyl acetyl H 2683 acetyl H acetyl H acetyl H acetylacetyl acetyl acetyl 2684 acetyl H acetyl H acetyl acetyl H H H H 2685acetyl H acetyl H acetyl acetyl H H H acetyl 2686 acetyl H acetyl Hacetyl acetyl H H acetyl H 2687 acetyl H acetyl H acetyl acetyl H Hacetyl acetyl 2688 acetyl H acetyl H acetyl acetyl H acetyl H H 2689acetyl H acetyl H acetyl acetyl H acetyl H acetyl 2690 acetyl H acetyl Hacetyl acetyl H acetyl acetyl H 2691 acetyl H acetyl H acetyl acetyl Hacetyl acetyl acetyl 2692 acetyl H acetyl H acetyl acetyl acetyl H H H2693 acetyl H acetyl H acetyl acetyl acetyl H H acetyl 2694 acetyl Hacetyl H acetyl acetyl acetyl H acetyl H 2695 acetyl H acetyl H acetylacetyl acetyl H acetyl acetyl 2696 acetyl H acetyl H acetyl acetylacetyl acetyl H H 2697 acetyl H acetyl H acetyl acetyl acetyl acetyl Hacetyl 2698 acetyl H acetyl H acetyl acetyl acetyl acetyl acetyl H 2699acetyl H acetyl H acetyl acetyl acetyl acetyl acetyl acetyl 2700 acetylH acetyl acetyl H H H H H H 2701 acetyl H acetyl acetyl H H H H H acetyl2702 acetyl H acetyl acetyl H H H H acetyl H 2703 acetyl H acetyl acetylH H H H acetyl acetyl 2704 acetyl H acetyl acetyl H H H acetyl H H 2705acetyl H acetyl acetyl H H H acetyl H acetyl 2706 acetyl H acetyl acetylH H H acetyl acetyl H 2707 acetyl H acetyl acetyl H H H acetyl acetylacetyl 2708 acetyl H acetyl acetyl H H acetyl H H H 2709 acetyl H acetylacetyl H H acetyl H H acetyl 2710 acetyl H acetyl acetyl H H acetyl Hacetyl H 2711 acetyl H acetyl acetyl H H acetyl H acetyl acetyl 2712acetyl H acetyl acetyl H H acetyl acetyl H H 2713 acetyl H acetyl acetylH H acetyl acetyl H acetyl 2714 acetyl H acetyl acetyl H H acetyl acetylacetyl H 2715 acetyl H acetyl acetyl H H acetyl acetyl acetyl acetyl2716 acetyl H acetyl acetyl H acetyl H H H H 2717 acetyl H acetyl acetylH acetyl H H H acetyl 2718 acetyl H acetyl acetyl H acetyl H H acetyl H2719 acetyl H acetyl acetyl H acetyl H H acetyl acetyl 2720 acetyl Hacetyl acetyl H acetyl H acetyl H H 2721 acetyl H acetyl acetyl H acetylH acetyl H acetyl 2722 acetyl H acetyl acetyl H acetyl H acetyl acetyl H2723 acetyl H acetyl acetyl H acetyl H acetyl acetyl acetyl 2724 acetylH acetyl acetyl H acetyl acetyl H H H 2725 acetyl H acetyl acetyl Hacetyl acetyl H H acetyl 2726 acetyl H acetyl acetyl H acetyl acetyl Hacetyl H 2727 acetyl H acetyl acetyl H acetyl acetyl H acetyl acetyl2728 acetyl H acetyl acetyl H acetyl acetyl acetyl H H 2729 acetyl Hacetyl acetyl H acetyl acetyl acetyl H acetyl 2730 acetyl H acetylacetyl H acetyl acetyl acetyl acetyl H 2731 acetyl H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl 2732 acetyl H acetyl acetyl acetyl HH H H H 2733 acetyl H acetyl acetyl acetyl H H H H acetyl 2734 acetyl Hacetyl acetyl acetyl H H H acetyl H 2735 acetyl H acetyl acetyl acetyl HH H acetyl acetyl 2736 acetyl H acetyl acetyl acetyl H H acetyl H H 2737acetyl H acetyl acetyl acetyl H H acetyl H acetyl 2738 acetyl H acetylacetyl acetyl H H acetyl acetyl H 2739 acetyl H acetyl acetyl acetyl H Hacetyl acetyl acetyl 2740 acetyl H acetyl acetyl acetyl H acetyl H H H2741 acetyl H acetyl acetyl acetyl H acetyl H H acetyl 2742 acetyl Hacetyl acetyl acetyl H acetyl H acetyl H 2743 acetyl H acetyl acetylacetyl H acetyl H acetyl acetyl 2744 acetyl H acetyl acetyl acetyl Hacetyl acetyl H H 2745 acetyl H acetyl acetyl acetyl H acetyl acetyl Hacetyl 2746 acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl H 2747acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl acetyl 2748 acetylH acetyl acetyl acetyl acetyl H H H H 2749 acetyl H acetyl acetyl acetylacetyl H H H acetyl 2750 acetyl H acetyl acetyl acetyl acetyl H H acetylH 2751 acetyl H acetyl acetyl acetyl acetyl H H acetyl acetyl 2752acetyl H acetyl acetyl acetyl acetyl H acetyl H H 2753 acetyl H acetylacetyl acetyl acetyl H acetyl H acetyl 2754 acetyl H acetyl acetylacetyl acetyl H acetyl acetyl H 2755 acetyl H acetyl acetyl acetylacetyl H acetyl acetyl acetyl 2756 acetyl H acetyl acetyl acetyl acetylacetyl H H H 2757 acetyl H acetyl acetyl acetyl acetyl acetyl H H acetyl2758 acetyl H acetyl acetyl acetyl acetyl acetyl H acetyl H 2759 acetylH acetyl acetyl acetyl acetyl acetyl H acetyl acetyl 2760 acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H H 2761 acetyl H acetylacetyl acetyl acetyl acetyl acetyl H acetyl 2762 acetyl H acetyl acetylacetyl acetyl acetyl acetyl acetyl H 2763 acetyl H acetyl acetyl acetylacetyl acetyl acetyl acetyl acetyl 2764 acetyl acetyl H H H H H H H H2765 acetyl acetyl H H H H H H H acetyl 2766 acetyl acetyl H H H H H Hacetyl H 2767 acetyl acetyl H H H H H H acetyl acetyl 2768 acetyl acetylH H H H H acetyl H H 2769 acetyl acetyl H H H H H acetyl H acetyl 2770acetyl acetyl H H H H H acetyl acetyl H 2771 acetyl acetyl H H H H Hacetyl acetyl acetyl 2772 acetyl acetyl H H H H acetyl H H H 2773 acetylacetyl H H H H acetyl H H acetyl 2774 acetyl acetyl H H H H acetyl Hacetyl H 2775 acetyl acetyl H H H H acetyl H acetyl acetyl 2776 acetylacetyl H H H H acetyl acetyl H H 2777 acetyl acetyl H H H H acetylacetyl H acetyl 2778 acetyl acetyl H H H H acetyl acetyl acetyl H 2779acetyl acetyl H H H H acetyl acetyl acetyl acetyl 2780 acetyl acetyl H HH acetyl H H H H 2781 acetyl acetyl H H H acetyl H H H acetyl 2782acetyl acetyl H H H acetyl H H acetyl H 2783 acetyl acetyl H H H acetylH H acetyl acetyl 2784 acetyl acetyl H H H acetyl H acetyl H H 2785acetyl acetyl H H H acetyl H acetyl H acetyl 2786 acetyl acetyl H H Hacetyl H acetyl acetyl H 2787 acetyl acetyl H H H acetyl H acetyl acetylacetyl 2788 acetyl acetyl H H H acetyl acetyl H H H 2789 acetyl acetyl HH H acetyl acetyl H H acetyl 2790 acetyl acetyl H H H acetyl acetyl Hacetyl H 2791 acetyl acetyl H H H acetyl acetyl H acetyl acetyl 2792acetyl acetyl H H H acetyl acetyl acetyl H H 2793 acetyl acetyl H H Hacetyl acetyl acetyl H acetyl 2794 acetyl acetyl H H H acetyl acetylacetyl acetyl H 2795 acetyl acetyl H H H acetyl acetyl acetyl acetylacetyl 2796 acetyl acetyl H H acetyl H H H H H 2797 acetyl acetyl H Hacetyl H H H H acetyl 2798 acetyl acetyl H H acetyl H H H acetyl H 2799acetyl acetyl H H acetyl H H H acetyl acetyl 2800 acetyl acetyl H Hacetyl H H acetyl H H 2801 acetyl acetyl H H acetyl H H acetyl H acetyl2802 acetyl acetyl H H acetyl H H acetyl acetyl H 2803 acetyl acetyl H Hacetyl H H acetyl acetyl acetyl 2804 acetyl acetyl H H acetyl H acetyl HH H 2805 acetyl acetyl H H acetyl H acetyl H H acetyl 2806 acetyl acetylH H acetyl H acetyl H acetyl H 2807 acetyl acetyl H H acetyl H acetyl Hacetyl acetyl 2808 acetyl acetyl H H acetyl H acetyl acetyl H H 2809acetyl acetyl H H acetyl H acetyl acetyl H acetyl 2810 acetyl acetyl H Hacetyl H acetyl acetyl acetyl H 2811 acetyl acetyl H H acetyl H acetylacetyl acetyl acetyl 2812 acetyl acetyl H H acetyl acetyl H H H H 2813acetyl acetyl H H acetyl acetyl H H H acetyl 2814 acetyl acetyl H Hacetyl acetyl H H acetyl H 2815 acetyl acetyl H H acetyl acetyl H Hacetyl acetyl 2816 acetyl acetyl H H acetyl acetyl H acetyl H H 2817acetyl acetyl H H acetyl acetyl H acetyl H acetyl 2818 acetyl acetyl H Hacetyl acetyl H acetyl acetyl H 2819 acetyl acetyl H H acetyl acetyl Hacetyl acetyl acetyl 2820 acetyl acetyl H H acetyl acetyl acetyl H H H2821 acetyl acetyl H H acetyl acetyl acetyl H H acetyl 2822 acetylacetyl H H acetyl acetyl acetyl H acetyl H 2823 acetyl acetyl H H acetylacetyl acetyl H acetyl acetyl 2824 acetyl acetyl H H acetyl acetylacetyl acetyl H H 2825 acetyl acetyl H H acetyl acetyl acetyl acetyl Hacetyl 2826 acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl H 2827acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl 2828 acetylacetyl H acetyl H H H H H H 2829 acetyl acetyl H acetyl H H H H H acetyl2830 acetyl acetyl H acetyl H H H H acetyl H 2831 acetyl acetyl H acetylH H H H acetyl acetyl 2832 acetyl acetyl H acetyl H H H acetyl H H 2833acetyl acetyl H acetyl H H H acetyl H acetyl 2834 acetyl acetyl H acetylH H H acetyl acetyl H 2835 acetyl acetyl H acetyl H H H acetyl acetylacetyl 2836 acetyl acetyl H acetyl H H acetyl H H H 2837 acetyl acetyl Hacetyl H H acetyl H H acetyl 2838 acetyl acetyl H acetyl H H acetyl Hacetyl H 2839 acetyl acetyl H acetyl H H acetyl H acetyl acetyl 2840acetyl acetyl H acetyl H H acetyl acetyl H H 2841 acetyl acetyl H acetylH H acetyl acetyl H acetyl 2842 acetyl acetyl H acetyl H H acetyl acetylacetyl H 2843 acetyl acetyl H acetyl H H acetyl acetyl acetyl acetyl2844 acetyl acetyl H acetyl H acetyl H H H H 2845 acetyl acetyl H acetylH acetyl H H H acetyl 2846 acetyl acetyl H acetyl H acetyl H H acetyl H2847 acetyl acetyl H acetyl H acetyl H H acetyl acetyl 2848 acetylacetyl H acetyl H acetyl H acetyl H H 2849 acetyl acetyl H acetyl Hacetyl H acetyl H acetyl 2850 acetyl acetyl H acetyl H acetyl H acetylacetyl H 2851 acetyl acetyl H acetyl H acetyl H acetyl acetyl acetyl2852 acetyl acetyl H acetyl H acetyl acetyl H H H 2853 acetyl acetyl Hacetyl H acetyl acetyl H H acetyl 2854 acetyl acetyl H acetyl H acetylacetyl H acetyl H 2855 acetyl acetyl H acetyl H acetyl acetyl H acetylacetyl 2856 acetyl acetyl H acetyl H acetyl acetyl acetyl H H 2857acetyl acetyl H acetyl H acetyl acetyl acetyl H acetyl 2858 acetylacetyl H acetyl H acetyl acetyl acetyl acetyl H 2859 acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl 2860 acetyl acetyl H acetylacetyl H H H H H 2861 acetyl acetyl H acetyl acetyl H H H H acetyl 2862acetyl acetyl H acetyl acetyl H H H acetyl H 2863 acetyl acetyl H acetylacetyl H H H acetyl acetyl 2864 acetyl acetyl H acetyl acetyl H H acetylH H 2865 acetyl acetyl H acetyl acetyl H H acetyl H acetyl 2866 acetylacetyl H acetyl acetyl H H acetyl acetyl H 2867 acetyl acetyl H acetylacetyl H H acetyl acetyl acetyl 2868 acetyl acetyl H acetyl acetyl Hacetyl H H H 2869 acetyl acetyl H acetyl acetyl H acetyl H H acetyl 2870acetyl acetyl H acetyl acetyl H acetyl H acetyl H 2871 acetyl acetyl Hacetyl acetyl H acetyl H acetyl acetyl 2872 acetyl acetyl H acetylacetyl H acetyl acetyl H H 2873 acetyl acetyl H acetyl acetyl H acetylacetyl H acetyl 2874 acetyl acetyl H acetyl acetyl H acetyl acetylacetyl H 2875 acetyl acetyl H acetyl acetyl H acetyl acetyl acetylacetyl 2876 acetyl acetyl H acetyl acetyl acetyl H H H H 2877 acetylacetyl H acetyl acetyl acetyl H H H acetyl 2878 acetyl acetyl H acetylacetyl acetyl H H acetyl H 2879 acetyl acetyl H acetyl acetyl acetyl H Hacetyl acetyl 2880 acetyl acetyl H acetyl acetyl acetyl H acetyl H H2881 acetyl acetyl H acetyl acetyl acetyl H acetyl H acetyl 2882 acetylacetyl H acetyl acetyl acetyl H acetyl acetyl H 2883 acetyl acetyl Hacetyl acetyl acetyl H acetyl acetyl acetyl 2884 acetyl acetyl H acetylacetyl acetyl acetyl H H H 2885 acetyl acetyl H acetyl acetyl acetylacetyl H H acetyl 2886 acetyl acetyl H acetyl acetyl acetyl acetyl Hacetyl H 2887 acetyl acetyl H acetyl acetyl acetyl acetyl H acetylacetyl 2888 acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H H 2889acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H acetyl 2890 acetylacetyl H acetyl acetyl acetyl acetyl acetyl acetyl H 2891 acetyl acetylH acetyl acetyl acetyl acetyl acetyl acetyl acetyl 2892 acetyl acetylacetyl H H H H H H H 2893 acetyl acetyl acetyl H H H H H H acetyl 2894acetyl acetyl acetyl H H H H H acetyl H 2895 acetyl acetyl acetyl H H HH H acetyl acetyl 2896 acetyl acetyl acetyl H H H H acetyl H H 2897acetyl acetyl acetyl H H H H acetyl H acetyl 2898 acetyl acetyl acetyl HH H H acetyl acetyl H 2899 acetyl acetyl acetyl H H H H acetyl acetylacetyl 2900 acetyl acetyl acetyl H H H acetyl H H H 2901 acetyl acetylacetyl H H H acetyl H H acetyl 2902 acetyl acetyl acetyl H H H acetyl Hacetyl H 2903 acetyl acetyl acetyl H H H acetyl H acetyl acetyl 2904acetyl acetyl acetyl H H H acetyl acetyl H H 2905 acetyl acetyl acetyl HH H acetyl acetyl H acetyl 2906 acetyl acetyl acetyl H H H acetyl acetylacetyl H 2907 acetyl acetyl acetyl H H H acetyl acetyl acetyl acetyl2908 acetyl acetyl acetyl H H acetyl H H H H 2909 acetyl acetyl acetyl HH acetyl H H H acetyl 2910 acetyl acetyl acetyl H H acetyl H H acetyl H2911 acetyl acetyl acetyl H H acetyl H H acetyl acetyl 2912 acetylacetyl acetyl H H acetyl H acetyl H H 2913 acetyl acetyl acetyl H Hacetyl H acetyl H acetyl 2914 acetyl acetyl acetyl H H acetyl H acetylacetyl H 2915 acetyl acetyl acetyl H H acetyl H acetyl acetyl acetyl2916 acetyl acetyl acetyl H H acetyl acetyl H H H 2917 acetyl acetylacetyl H H acetyl acetyl H H acetyl 2918 acetyl acetyl acetyl H H acetylacetyl H acetyl H 2919 acetyl acetyl acetyl H H acetyl acetyl H acetylacetyl 2920 acetyl acetyl acetyl H H acetyl acetyl acetyl H H 2921acetyl acetyl acetyl H H acetyl acetyl acetyl H acetyl 2922 acetylacetyl acetyl H H acetyl acetyl acetyl acetyl H 2923 acetyl acetylacetyl H H acetyl acetyl acetyl acetyl acetyl 2924 acetyl acetyl acetylH acetyl H H H H H 2925 acetyl acetyl acetyl H acetyl H H H H acetyl2926 acetyl acetyl acetyl H acetyl H H H acetyl H 2927 acetyl acetylacetyl H acetyl H H H acetyl acetyl 2928 acetyl acetyl acetyl H acetyl HH acetyl H H 2929 acetyl acetyl acetyl H acetyl H H acetyl H acetyl 2930acetyl acetyl acetyl H acetyl H H acetyl acetyl H 2931 acetyl acetylacetyl H acetyl H H acetyl acetyl acetyl 2932 acetyl acetyl acetyl Hacetyl H acetyl H H H 2933 acetyl acetyl acetyl H acetyl H acetyl H Hacetyl 2934 acetyl acetyl acetyl H acetyl H acetyl H acetyl H 2935acetyl acetyl acetyl H acetyl H acetyl H acetyl acetyl 2936 acetylacetyl acetyl H acetyl H acetyl acetyl H H 2937 acetyl acetyl acetyl Hacetyl H acetyl acetyl H acetyl 2938 acetyl acetyl acetyl H acetyl Hacetyl acetyl acetyl H 2939 acetyl acetyl acetyl H acetyl H acetylacetyl acetyl acetyl 2940 acetyl acetyl acetyl H acetyl acetyl H H H H2941 acetyl acetyl acetyl H acetyl acetyl H H H acetyl 2942 acetylacetyl acetyl H acetyl acetyl H H acetyl H 2943 acetyl acetyl acetyl Hacetyl acetyl H H acetyl acetyl 2944 acetyl acetyl acetyl H acetylacetyl H acetyl H H 2945 acetyl acetyl acetyl H acetyl acetyl H acetyl Hacetyl 2946 acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl H 2947acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl acetyl 2948 acetylacetyl acetyl H acetyl acetyl acetyl H H H 2949 acetyl acetyl acetyl Hacetyl acetyl acetyl H H acetyl 2950 acetyl acetyl acetyl H acetylacetyl acetyl H acetyl H 2951 acetyl acetyl acetyl H acetyl acetylacetyl H acetyl acetyl 2952 acetyl acetyl acetyl H acetyl acetyl acetylacetyl H H 2953 acetyl acetyl acetyl H acetyl acetyl acetyl acetyl Hacetyl 2954 acetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H2955 acetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl acetyl2956 acetyl acetyl acetyl acetyl H H H H H H 2957 acetyl acetyl acetylacetyl H H H H H acetyl 2958 acetyl acetyl acetyl acetyl H H H H acetylH 2959 acetyl acetyl acetyl acetyl H H H H acetyl acetyl 2960 acetylacetyl acetyl acetyl H H H acetyl H H 2961 acetyl acetyl acetyl acetyl HH H acetyl H acetyl 2962 acetyl acetyl acetyl acetyl H H H acetyl acetylH 2963 acetyl acetyl acetyl acetyl H H H acetyl acetyl acetyl 2964acetyl acetyl acetyl acetyl H H acetyl H H H 2965 acetyl acetyl acetylacetyl H H acetyl H H acetyl 2966 acetyl acetyl acetyl acetyl H H acetylH acetyl H 2967 acetyl acetyl acetyl acetyl H H acetyl H acetyl acetyl2968 acetyl acetyl acetyl acetyl H H acetyl acetyl H H 2969 acetylacetyl acetyl acetyl H H acetyl acetyl H acetyl 2970 acetyl acetylacetyl acetyl H H acetyl acetyl acetyl H 2971 acetyl acetyl acetylacetyl H H acetyl acetyl acetyl acetyl 2972 acetyl acetyl acetyl acetylH acetyl H H H H 2973 acetyl acetyl acetyl acetyl H acetyl H H H acetyl2974 acetyl acetyl acetyl acetyl H acetyl H H acetyl H 2975 acetylacetyl acetyl acetyl H acetyl H H acetyl acetyl 2976 acetyl acetylacetyl acetyl H acetyl H acetyl H H 2977 acetyl acetyl acetyl acetyl Hacetyl H acetyl H acetyl 2978 acetyl acetyl acetyl acetyl H acetyl Hacetyl acetyl H 2979 acetyl acetyl acetyl acetyl H acetyl H acetylacetyl acetyl 2980 acetyl acetyl acetyl acetyl H acetyl acetyl H H H2981 acetyl acetyl acetyl acetyl H acetyl acetyl H H acetyl 2982 acetylacetyl acetyl acetyl H acetyl acetyl H acetyl H 2983 acetyl acetylacetyl acetyl H acetyl acetyl H acetyl acetyl 2984 acetyl acetyl acetylacetyl H acetyl acetyl acetyl H H 2985 acetyl acetyl acetyl acetyl Hacetyl acetyl acetyl H acetyl 2986 acetyl acetyl acetyl acetyl H acetylacetyl acetyl acetyl H 2987 acetyl acetyl acetyl acetyl H acetyl acetylacetyl acetyl acetyl 2988 acetyl acetyl acetyl acetyl acetyl H H H H H2989 acetyl acetyl acetyl acetyl acetyl H H H H acetyl 2990 acetylacetyl acetyl acetyl acetyl H H H acetyl H 2991 acetyl acetyl acetylacetyl acetyl H H H acetyl acetyl 2992 acetyl acetyl acetyl acetylacetyl H H acetyl H H 2993 acetyl acetyl acetyl acetyl acetyl H H acetylH acetyl 2994 acetyl acetyl acetyl acetyl acetyl H H acetyl acetyl H2995 acetyl acetyl acetyl acetyl acetyl H H acetyl acetyl acetyl 2996acetyl acetyl acetyl acetyl acetyl H acetyl H H H 2997 acetyl acetylacetyl acetyl acetyl H acetyl H H acetyl 2998 acetyl acetyl acetylacetyl acetyl H acetyl H acetyl H 2999 acetyl acetyl acetyl acetylacetyl H acetyl H acetyl acetyl 3000 acetyl acetyl acetyl acetyl acetylH acetyl acetyl H H 3001 acetyl acetyl acetyl acetyl acetyl H acetylacetyl H acetyl 3002 acetyl acetyl acetyl acetyl acetyl H acetyl acetylacetyl H 3003 acetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetylacetyl 3004 acetyl acetyl acetyl acetyl acetyl acetyl H H H H 3005acetyl acetyl acetyl acetyl acetyl acetyl H H H acetyl 3006 acetylacetyl acetyl acetyl acetyl acetyl H H acetyl H 3007 acetyl acetylacetyl acetyl acetyl acetyl H H acetyl acetyl 3008 acetyl acetyl acetylacetyl acetyl acetyl H acetyl H H 3009 acetyl acetyl acetyl acetylacetyl acetyl H acetyl H acetyl 3010 acetyl acetyl acetyl acetyl acetylacetyl H acetyl acetyl H 3011 acetyl acetyl acetyl acetyl acetyl acetylH acetyl acetyl acetyl 3012 acetyl acetyl acetyl acetyl acetyl acetylacetyl H H H 3013 acetyl acetyl acetyl acetyl acetyl acetyl acetyl H Hacetyl 3014 acetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl H3015 acetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl3016 acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H H 3017acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl 3018acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H

TABLE 8 (undecasaccharides) (Y is either H or a carrier) n10; CompoundR2 n1, R1 n2, R1 n3, R1 n4, R1 n5, R1 n6, R1 n7, R1 n8, R1 n9, R1 R13019 H H H H H H H H H H acetyl 3020 H H H H H H H H H acetyl H 3021 H HH H H H H H H acetyl acetyl 3022 H H H H H H H H acetyl H H 3023 H H H HH H H H acetyl H acetyl 3024 H H H H H H H H acetyl acetyl H 3025 H H HH H H H H acetyl acetyl acetyl 3026 H H H H H H H acetyl H H H 3027 H HH H H H H acetyl H H acetyl 3028 H H H H H H H acetyl H acetyl H 3029 HH H H H H H acetyl H acetyl acetyl 3030 H H H H H H H acetyl acetyl H H3031 H H H H H H H acetyl acetyl H acetyl 3032 H H H H H H H acetylacetyl acetyl H 3033 H H H H H H H acetyl acetyl acetyl acetyl 3034 H HH H H H acetyl H H H H 3035 H H H H H H acetyl H H H acetyl 3036 H H H HH H acetyl H H acetyl H 3037 H H H H H H acetyl H H acetyl acetyl 3038 HH H H H H acetyl H acetyl H H 3039 H H H H H H acetyl H acetyl H acetyl3040 H H H H H H acetyl H acetyl acetyl H 3041 H H H H H H acetyl Hacetyl acetyl acetyl 3042 H H H H H H acetyl acetyl H H H 3043 H H H H HH acetyl acetyl H H acetyl 3044 H H H H H H acetyl acetyl H acetyl H3045 H H H H H H acetyl acetyl H acetyl acetyl 3046 H H H H H H acetylacetyl acetyl H H 3047 H H H H H H acetyl acetyl acetyl H acetyl 3048 HH H H H H acetyl acetyl acetyl acetyl H 3049 H H H H H H acetyl acetylacetyl acetyl acetyl 3050 H H H H H acetyl H H H H H 3051 H H H H Hacetyl H H H H acetyl 3052 H H H H H acetyl H H H acetyl H 3053 H H H HH acetyl H H H acetyl acetyl 3054 H H H H H acetyl H H acetyl H H 3055 HH H H H acetyl H H acetyl H acetyl 3056 H H H H H acetyl H H acetylacetyl H 3057 H H H H H acetyl H H acetyl acetyl acetyl 3058 H H H H Hacetyl H acetyl H H H 3059 H H H H H acetyl H acetyl H H acetyl 3060 H HH H H acetyl H acetyl H acetyl H 3061 H H H H H acetyl H acetyl H acetylacetyl 3062 H H H H H acetyl H acetyl acetyl H H 3063 H H H H H acetyl Hacetyl acetyl H acetyl 3064 H H H H H acetyl H acetyl acetyl acetyl H3065 H H H H H acetyl H acetyl acetyl acetyl acetyl 3066 H H H H Hacetyl acetyl H H H H 3067 H H H H H acetyl acetyl H H H acetyl 3068 H HH H H acetyl acetyl H H acetyl H 3069 H H H H H acetyl acetyl H H acetylacetyl 3070 H H H H H acetyl acetyl H acetyl H H 3071 H H H H H acetylacetyl H acetyl H acetyl 3072 H H H H H acetyl acetyl H acetyl acetyl H3073 H H H H H acetyl acetyl H acetyl acetyl acetyl 3074 H H H H Hacetyl acetyl acetyl H H H 3075 H H H H H acetyl acetyl acetyl H Hacetyl 3076 H H H H H acetyl acetyl acetyl H acetyl H 3077 H H H H Hacetyl acetyl acetyl H acetyl acetyl 3078 H H H H H acetyl acetyl acetylacetyl H H 3079 H H H H H acetyl acetyl acetyl acetyl H acetyl 3080 H HH H H acetyl acetyl acetyl acetyl acetyl H 3081 H H H H H acetyl acetylacetyl acetyl acetyl acetyl 3082 H H H H acetyl H H H H H H 3083 H H H Hacetyl H H H H H acetyl 3084 H H H H acetyl H H H H acetyl H 3085 H H HH acetyl H H H H acetyl acetyl 3086 H H H H acetyl H H H acetyl H H 3087H H H H acetyl H H H acetyl H acetyl 3088 H H H H acetyl H H H acetylacetyl H 3089 H H H H acetyl H H H acetyl acetyl acetyl 3090 H H H Hacetyl H H acetyl H H H 3091 H H H H acetyl H H acetyl H H acetyl 3092 HH H H acetyl H H acetyl H acetyl H 3093 H H H H acetyl H H acetyl Hacetyl acetyl 3094 H H H H acetyl H H acetyl acetyl H H 3095 H H H Hacetyl H H acetyl acetyl H acetyl 3096 H H H H acetyl H H acetyl acetylacetyl H 3097 H H H H acetyl H H acetyl acetyl acetyl acetyl 3098 H H HH acetyl H acetyl H H H H 3099 H H H H acetyl H acetyl H H H acetyl 3100H H H H acetyl H acetyl H H acetyl H 3101 H H H H acetyl H acetyl H Hacetyl acetyl 3102 H H H H acetyl H acetyl H acetyl H H 3103 H H H Hacetyl H acetyl H acetyl H acetyl 3104 H H H H acetyl H acetyl H acetylacetyl H 3105 H H H H acetyl H acetyl H acetyl acetyl acetyl 3106 H H HH acetyl H acetyl acetyl H H H 3107 H H H H acetyl H acetyl acetyl H Hacetyl 3108 H H H H acetyl H acetyl acetyl H acetyl H 3109 H H H Hacetyl H acetyl acetyl H acetyl acetyl 3110 H H H H acetyl H acetylacetyl acetyl H H 3111 H H H H acetyl H acetyl acetyl acetyl H acetyl3112 H H H H acetyl H acetyl acetyl acetyl acetyl H 3113 H H H H acetylH acetyl acetyl acetyl acetyl acetyl 3114 H H H H acetyl acetyl H H H HH 3115 H H H H acetyl acetyl H H H H acetyl 3116 H H H H acetyl acetyl HH H acetyl H 3117 H H H H acetyl acetyl H H H acetyl acetyl 3118 H H H Hacetyl acetyl H H acetyl H H 3119 H H H H acetyl acetyl H H acetyl Hacetyl 3120 H H H H acetyl acetyl H H acetyl acetyl H 3121 H H H Hacetyl acetyl H H acetyl acetyl acetyl 3122 H H H H acetyl acetyl Hacetyl H H H 3123 H H H H acetyl acetyl H acetyl H H acetyl 3124 H H H Hacetyl acetyl H acetyl H acetyl H 3125 H H H H acetyl acetyl H acetyl Hacetyl acetyl 3126 H H H H acetyl acetyl H acetyl acetyl H H 3127 H H HH acetyl acetyl H acetyl acetyl H acetyl 3128 H H H H acetyl acetyl Hacetyl acetyl acetyl H 3129 H H H H acetyl acetyl H acetyl acetyl acetylacetyl 3130 H H H H acetyl acetyl acetyl H H H H 3131 H H H H acetylacetyl acetyl H H H acetyl 3132 H H H H acetyl acetyl acetyl H H acetylH 3133 H H H H acetyl acetyl acetyl H H acetyl acetyl 3134 H H H Hacetyl acetyl acetyl H acetyl H H 3135 H H H H acetyl acetyl acetyl Hacetyl H acetyl 3136 H H H H acetyl acetyl acetyl H acetyl acetyl H 3137H H H H acetyl acetyl acetyl H acetyl acetyl acetyl 3138 H H H H acetylacetyl acetyl acetyl H H H 3139 H H H H acetyl acetyl acetyl acetyl H Hacetyl 3140 H H H H acetyl acetyl acetyl acetyl H acetyl H 3141 H H H Hacetyl acetyl acetyl acetyl H acetyl acetyl 3142 H H H H acetyl acetylacetyl acetyl acetyl H H 3143 H H H H acetyl acetyl acetyl acetyl acetylH acetyl 3144 H H H H acetyl acetyl acetyl acetyl acetyl acetyl H 3145 HH H H acetyl acetyl acetyl acetyl acetyl acetyl acetyl 3146 H H H acetylH H H H H H H 3147 H H H acetyl H H H H H H acetyl 3148 H H H acetyl H HH H H acetyl H 3149 H H H acetyl H H H H H acetyl acetyl 3150 H H Hacetyl H H H H acetyl H H 3151 H H H acetyl H H H H acetyl H acetyl 3152H H H acetyl H H H H acetyl acetyl H 3153 H H H acetyl H H H H acetylacetyl acetyl 3154 H H H acetyl H H H acetyl H H H 3155 H H H acetyl H HH acetyl H H acetyl 3156 H H H acetyl H H H acetyl H acetyl H 3157 H H Hacetyl H H H acetyl H acetyl acetyl 3158 H H H acetyl H H H acetylacetyl H H 3159 H H H acetyl H H H acetyl acetyl H acetyl 3160 H H Hacetyl H H H acetyl acetyl acetyl H 3161 H H H acetyl H H H acetylacetyl acetyl acetyl 3162 H H H acetyl H H acetyl H H H H 3163 H H Hacetyl H H acetyl H H H acetyl 3164 H H H acetyl H H acetyl H H acetyl H3165 H H H acetyl H H acetyl H H acetyl acetyl 3166 H H H acetyl H Hacetyl H acetyl H H 3167 H H H acetyl H H acetyl H acetyl H acetyl 3168H H H acetyl H H acetyl H acetyl acetyl H 3169 H H H acetyl H H acetyl Hacetyl acetyl acetyl 3170 H H H acetyl H H acetyl acetyl H H H 3171 H HH acetyl H H acetyl acetyl H H acetyl 3172 H H H acetyl H H acetylacetyl H acetyl H 3173 H H H acetyl H H acetyl acetyl H acetyl acetyl3174 H H H acetyl H H acetyl acetyl acetyl H H 3175 H H H acetyl H Hacetyl acetyl acetyl H acetyl 3176 H H H acetyl H H acetyl acetyl acetylacetyl H 3177 H H H acetyl H H acetyl acetyl acetyl acetyl acetyl 3178 HH H acetyl H acetyl H H H H H 3179 H H H acetyl H acetyl H H H H acetyl3180 H H H acetyl H acetyl H H H acetyl H 3181 H H H acetyl H acetyl H HH acetyl acetyl 3182 H H H acetyl H acetyl H H acetyl H H 3183 H H Hacetyl H acetyl H H acetyl H acetyl 3184 H H H acetyl H acetyl H Hacetyl acetyl H 3185 H H H acetyl H acetyl H H acetyl acetyl acetyl 3186H H H acetyl H acetyl H acetyl H H H 3187 H H H acetyl H acetyl H acetylH H acetyl 3188 H H H acetyl H acetyl H acetyl H acetyl H 3189 H H Hacetyl H acetyl H acetyl H acetyl acetyl 3190 H H H acetyl H acetyl Hacetyl acetyl H H 3191 H H H acetyl H acetyl H acetyl acetyl H acetyl3192 H H H acetyl H acetyl H acetyl acetyl acetyl H 3193 H H H acetyl Hacetyl H acetyl acetyl acetyl acetyl 3194 H H H acetyl H acetyl acetyl HH H H 3195 H H H acetyl H acetyl acetyl H H H acetyl 3196 H H H acetyl Hacetyl acetyl H H acetyl H 3197 H H H acetyl H acetyl acetyl H H acetylacetyl 3198 H H H acetyl H acetyl acetyl H acetyl H H 3199 H H H acetylH acetyl acetyl H acetyl H acetyl 3200 H H H acetyl H acetyl acetyl Hacetyl acetyl H 3201 H H H acetyl H acetyl acetyl H acetyl acetyl acetyl3202 H H H acetyl H acetyl acetyl acetyl H H H 3203 H H H acetyl Hacetyl acetyl acetyl H H acetyl 3204 H H H acetyl H acetyl acetyl acetylH acetyl H 3205 H H H acetyl H acetyl acetyl acetyl H acetyl acetyl 3206H H H acetyl H acetyl acetyl acetyl acetyl H H 3207 H H H acetyl Hacetyl acetyl acetyl acetyl H acetyl 3208 H H H acetyl H acetyl acetylacetyl acetyl acetyl H 3209 H H H acetyl H acetyl acetyl acetyl acetylacetyl acetyl 3210 H H H acetyl acetyl H H H H H H 3211 H H H acetylacetyl H H H H H acetyl 3212 H H H acetyl acetyl H H H H acetyl H 3213 HH H acetyl acetyl H H H H acetyl acetyl 3214 H H H acetyl acetyl H H Hacetyl H H 3215 H H H acetyl acetyl H H H acetyl H acetyl 3216 H H Hacetyl acetyl H H H acetyl acetyl H 3217 H H H acetyl acetyl H H Hacetyl acetyl acetyl 3218 H H H acetyl acetyl H H acetyl H H H 3219 H HH acetyl acetyl H H acetyl H H acetyl 3220 H H H acetyl acetyl H Hacetyl H acetyl H 3221 H H H acetyl acetyl H H acetyl H acetyl acetyl3222 H H H acetyl acetyl H H acetyl acetyl H H 3223 H H H acetyl acetylH H acetyl acetyl H acetyl 3224 H H H acetyl acetyl H H acetyl acetylacetyl H 3225 H H H acetyl acetyl H H acetyl acetyl acetyl acetyl 3226 HH H acetyl acetyl H acetyl H H H H 3227 H H H acetyl acetyl H acetyl H HH acetyl 3228 H H H acetyl acetyl H acetyl H H acetyl H 3229 H H Hacetyl acetyl H acetyl H H acetyl acetyl 3230 H H H acetyl acetyl Hacetyl H acetyl H H 3231 H H H acetyl acetyl H acetyl H acetyl H acetyl3232 H H H acetyl acetyl H acetyl H acetyl acetyl H 3233 H H H acetylacetyl H acetyl H acetyl acetyl acetyl 3234 H H H acetyl acetyl H acetylacetyl H H H 3235 H H H acetyl acetyl H acetyl acetyl H H acetyl 3236 HH H acetyl acetyl H acetyl acetyl H acetyl H 3237 H H H acetyl acetyl Hacetyl acetyl H acetyl acetyl 3238 H H H acetyl acetyl H acetyl acetylacetyl H H 3239 H H H acetyl acetyl H acetyl acetyl acetyl H acetyl 3240H H H acetyl acetyl H acetyl acetyl acetyl acetyl H 3241 H H H acetylacetyl H acetyl acetyl acetyl acetyl acetyl 3242 H H H acetyl acetylacetyl H H H H H 3243 H H H acetyl acetyl acetyl H H H H acetyl 3244 H HH acetyl acetyl acetyl H H H acetyl H 3245 H H H acetyl acetyl acetyl HH H acetyl acetyl 3246 H H H acetyl acetyl acetyl H H acetyl H H 3247 HH H acetyl acetyl acetyl H H acetyl H acetyl 3248 H H H acetyl acetylacetyl H H acetyl acetyl H 3249 H H H acetyl acetyl acetyl H H acetylacetyl acetyl 3250 H H H acetyl acetyl acetyl H acetyl H H H 3251 H H Hacetyl acetyl acetyl H acetyl H H acetyl 3252 H H H acetyl acetyl acetylH acetyl H acetyl H 3253 H H H acetyl acetyl acetyl H acetyl H acetylacetyl 3254 H H H acetyl acetyl acetyl H acetyl acetyl H H 3255 H H Hacetyl acetyl acetyl H acetyl acetyl H acetyl 3256 H H H acetyl acetylacetyl H acetyl acetyl acetyl H 3257 H H H acetyl acetyl acetyl H acetylacetyl acetyl acetyl 3258 H H H acetyl acetyl acetyl acetyl H H H H 3259H H H acetyl acetyl acetyl acetyl H H H acetyl 3260 H H H acetyl acetylacetyl acetyl H H acetyl H 3261 H H H acetyl acetyl acetyl acetyl H Hacetyl acetyl 3262 H H H acetyl acetyl acetyl acetyl H acetyl H H 3263 HH H acetyl acetyl acetyl acetyl H acetyl H acetyl 3264 H H H acetylacetyl acetyl acetyl H acetyl acetyl H 3265 H H H acetyl acetyl acetylacetyl H acetyl acetyl acetyl 3266 H H H acetyl acetyl acetyl acetylacetyl H H H 3267 H H H acetyl acetyl acetyl acetyl acetyl H H acetyl3268 H H H acetyl acetyl acetyl acetyl acetyl H acetyl H 3269 H H Hacetyl acetyl acetyl acetyl acetyl H acetyl acetyl 3270 H H H acetylacetyl acetyl acetyl acetyl acetyl H H 3271 H H H acetyl acetyl acetylacetyl acetyl acetyl H acetyl 3272 H H H acetyl acetyl acetyl acetylacetyl acetyl acetyl H 3273 H H H acetyl acetyl acetyl acetyl acetylacetyl acetyl acetyl 3274 H H acetyl H H H H H H H H 3275 H H acetyl H HH H H H H acetyl 3276 H H acetyl H H H H H H acetyl H 3277 H H acetyl HH H H H H acetyl acetyl 3278 H H acetyl H H H H H acetyl H H 3279 H Hacetyl H H H H H acetyl H acetyl 3280 H H acetyl H H H H H acetyl acetylH 3281 H H acetyl H H H H H acetyl acetyl acetyl 3282 H H acetyl H H H Hacetyl H H H 3283 H H acetyl H H H H acetyl H H acetyl 3284 H H acetyl HH H H acetyl H acetyl H 3285 H H acetyl H H H H acetyl H acetyl acetyl3286 H H acetyl H H H H acetyl acetyl H H 3287 H H acetyl H H H H acetylacetyl H acetyl 3288 H H acetyl H H H H acetyl acetyl acetyl H 3289 H Hacetyl H H H H acetyl acetyl acetyl acetyl 3290 H H acetyl H H H acetylH H H H 3291 H H acetyl H H H acetyl H H H acetyl 3292 H H acetyl H H Hacetyl H H acetyl H 3293 H H acetyl H H H acetyl H H acetyl acetyl 3294H H acetyl H H H acetyl H acetyl H H 3295 H H acetyl H H H acetyl Hacetyl H acetyl 3296 H H acetyl H H H acetyl H acetyl acetyl H 3297 H Hacetyl H H H acetyl H acetyl acetyl acetyl 3298 H H acetyl H H H acetylacetyl H H H 3299 H H acetyl H H H acetyl acetyl H H acetyl 3300 H Hacetyl H H H acetyl acetyl H acetyl H 3301 H H acetyl H H H acetylacetyl H acetyl acetyl 3302 H H acetyl H H H acetyl acetyl acetyl H H3303 H H acetyl H H H acetyl acetyl acetyl H acetyl 3304 H H acetyl H HH acetyl acetyl acetyl acetyl H 3305 H H acetyl H H H acetyl acetylacetyl acetyl acetyl 3306 H H acetyl H H acetyl H H H H H 3307 H Hacetyl H H acetyl H H H H acetyl 3308 H H acetyl H H acetyl H H H acetylH 3309 H H acetyl H H acetyl H H H acetyl acetyl 3310 H H acetyl H Hacetyl H H acetyl H H 3311 H H acetyl H H acetyl H H acetyl H acetyl3312 H H acetyl H H acetyl H H acetyl acetyl H 3313 H H acetyl H Hacetyl H H acetyl acetyl acetyl 3314 H H acetyl H H acetyl H acetyl H HH 3315 H H acetyl H H acetyl H acetyl H H acetyl 3316 H H acetyl H Hacetyl H acetyl H acetyl H 3317 H H acetyl H H acetyl H acetyl H acetylacetyl 3318 H H acetyl H H acetyl H acetyl acetyl H H 3319 H H acetyl HH acetyl H acetyl acetyl H acetyl 3320 H H acetyl H H acetyl H acetylacetyl acetyl H 3321 H H acetyl H H acetyl H acetyl acetyl acetyl acetyl3322 H H acetyl H H acetyl acetyl H H H H 3323 H H acetyl H H acetylacetyl H H H acetyl 3324 H H acetyl H H acetyl acetyl H H acetyl H 3325H H acetyl H H acetyl acetyl H H acetyl acetyl 3326 H H acetyl H Hacetyl acetyl H acetyl H H 3327 H H acetyl H H acetyl acetyl H acetyl Hacetyl 3328 H H acetyl H H acetyl acetyl H acetyl acetyl H 3329 H Hacetyl H H acetyl acetyl H acetyl acetyl acetyl 3330 H H acetyl H Hacetyl acetyl acetyl H H H 3331 H H acetyl H H acetyl acetyl acetyl H Hacetyl 3332 H H acetyl H H acetyl acetyl acetyl H acetyl H 3333 H Hacetyl H H acetyl acetyl acetyl H acetyl acetyl 3334 H H acetyl H Hacetyl acetyl acetyl acetyl H H 3335 H H acetyl H H acetyl acetyl acetylacetyl H acetyl 3336 H H acetyl H H acetyl acetyl acetyl acetyl acetyl H3337 H H acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl 3338 H Hacetyl H acetyl H H H H H H 3339 H H acetyl H acetyl H H H H H acetyl3340 H H acetyl H acetyl H H H H acetyl H 3341 H H acetyl H acetyl H H HH acetyl acetyl 3342 H H acetyl H acetyl H H H acetyl H H 3343 H Hacetyl H acetyl H H H acetyl H acetyl 3344 H H acetyl H acetyl H H Hacetyl acetyl H 3345 H H acetyl H acetyl H H H acetyl acetyl acetyl 3346H H acetyl H acetyl H H acetyl H H H 3347 H H acetyl H acetyl H H acetylH H acetyl 3348 H H acetyl H acetyl H H acetyl H acetyl H 3349 H Hacetyl H acetyl H H acetyl H acetyl acetyl 3350 H H acetyl H acetyl H Hacetyl acetyl H H 3351 H H acetyl H acetyl H H acetyl acetyl H acetyl3352 H H acetyl H acetyl H H acetyl acetyl acetyl H 3353 H H acetyl Hacetyl H H acetyl acetyl acetyl acetyl 3354 H H acetyl H acetyl H acetylH H H H 3355 H H acetyl H acetyl H acetyl H H H acetyl 3356 H H acetyl Hacetyl H acetyl H H acetyl H 3357 H H acetyl H acetyl H acetyl H Hacetyl acetyl 3358 H H acetyl H acetyl H acetyl H acetyl H H 3359 H Hacetyl H acetyl H acetyl H acetyl H acetyl 3360 H H acetyl H acetyl Hacetyl H acetyl acetyl H 3361 H H acetyl H acetyl H acetyl H acetylacetyl acetyl 3362 H H acetyl H acetyl H acetyl acetyl H H H 3363 H Hacetyl H acetyl H acetyl acetyl H H acetyl 3364 H H acetyl H acetyl Hacetyl acetyl H acetyl H 3365 H H acetyl H acetyl H acetyl acetyl Hacetyl acetyl 3366 H H acetyl H acetyl H acetyl acetyl acetyl H H 3367 HH acetyl H acetyl H acetyl acetyl acetyl H acetyl 3368 H H acetyl Hacetyl H acetyl acetyl acetyl acetyl H 3369 H H acetyl H acetyl H acetylacetyl acetyl acetyl acetyl 3370 H H acetyl H acetyl acetyl H H H H H3371 H H acetyl H acetyl acetyl H H H H acetyl 3372 H H acetyl H acetylacetyl H H H acetyl H 3373 H H acetyl H acetyl acetyl H H H acetylacetyl 3374 H H acetyl H acetyl acetyl H H acetyl H H 3375 H H acetyl Hacetyl acetyl H H acetyl H acetyl 3376 H H acetyl H acetyl acetyl H Hacetyl acetyl H 3377 H H acetyl H acetyl acetyl H H acetyl acetyl acetyl3378 H H acetyl H acetyl acetyl H acetyl H H H 3379 H H acetyl H acetylacetyl H acetyl H H acetyl 3380 H H acetyl H acetyl acetyl H acetyl Hacetyl H 3381 H H acetyl H acetyl acetyl H acetyl H acetyl acetyl 3382 HH acetyl H acetyl acetyl H acetyl acetyl H H 3383 H H acetyl H acetylacetyl H acetyl acetyl H acetyl 3384 H H acetyl H acetyl acetyl H acetylacetyl acetyl H 3385 H H acetyl H acetyl acetyl H acetyl acetyl acetylacetyl 3386 H H acetyl H acetyl acetyl acetyl H H H H 3387 H H acetyl Hacetyl acetyl acetyl H H H acetyl 3388 H H acetyl H acetyl acetyl acetylH H acetyl H 3389 H H acetyl H acetyl acetyl acetyl H H acetyl acetyl3390 H H acetyl H acetyl acetyl acetyl H acetyl H H 3391 H H acetyl Hacetyl acetyl acetyl H acetyl H acetyl 3392 H H acetyl H acetyl acetylacetyl H acetyl acetyl H 3393 H H acetyl H acetyl acetyl acetyl H acetylacetyl acetyl 3394 H H acetyl H acetyl acetyl acetyl acetyl H H H 3395 HH acetyl H acetyl acetyl acetyl acetyl H H acetyl 3396 H H acetyl Hacetyl acetyl acetyl acetyl H acetyl H 3397 H H acetyl H acetyl acetylacetyl acetyl H acetyl acetyl 3398 H H acetyl H acetyl acetyl acetylacetyl acetyl H H 3399 H H acetyl H acetyl acetyl acetyl acetyl acetyl Hacetyl 3400 H H acetyl H acetyl acetyl acetyl acetyl acetyl acetyl H3401 H H acetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl 3402H H acetyl acetyl H H H H H H H 3403 H H acetyl acetyl H H H H H Hacetyl 3404 H H acetyl acetyl H H H H H acetyl H 3405 H H acetyl acetylH H H H H acetyl acetyl 3406 H H acetyl acetyl H H H H acetyl H H 3407 HH acetyl acetyl H H H H acetyl H acetyl 3408 H H acetyl acetyl H H H Hacetyl acetyl H 3409 H H acetyl acetyl H H H H acetyl acetyl acetyl 3410H H acetyl acetyl H H H acetyl H H H 3411 H H acetyl acetyl H H H acetylH H acetyl 3412 H H acetyl acetyl H H H acetyl H acetyl H 3413 H Hacetyl acetyl H H H acetyl H acetyl acetyl 3414 H H acetyl acetyl H H Hacetyl acetyl H H 3415 H H acetyl acetyl H H H acetyl acetyl H acetyl3416 H H acetyl acetyl H H H acetyl acetyl acetyl H 3417 H H acetylacetyl H H H acetyl acetyl acetyl acetyl 3418 H H acetyl acetyl H Hacetyl H H H H 3419 H H acetyl acetyl H H acetyl H H H acetyl 3420 H Hacetyl acetyl H H acetyl H H acetyl H 3421 H H acetyl acetyl H H acetylH H acetyl acetyl 3422 H H acetyl acetyl H H acetyl H acetyl H H 3423 HH acetyl acetyl H H acetyl H acetyl H acetyl 3424 H H acetyl acetyl H Hacetyl H acetyl acetyl H 3425 H H acetyl acetyl H H acetyl H acetylacetyl acetyl 3426 H H acetyl acetyl H H acetyl acetyl H H H 3427 H Hacetyl acetyl H H acetyl acetyl H H acetyl 3428 H H acetyl acetyl H Hacetyl acetyl H acetyl H 3429 H H acetyl acetyl H H acetyl acetyl Hacetyl acetyl 3430 H H acetyl acetyl H H acetyl acetyl acetyl H H 3431 HH acetyl acetyl H H acetyl acetyl acetyl H acetyl 3432 H H acetyl acetylH H acetyl acetyl acetyl acetyl H 3433 H H acetyl acetyl H H acetylacetyl acetyl acetyl acetyl 3434 H H acetyl acetyl H acetyl H H H H H3435 H H acetyl acetyl H acetyl H H H H acetyl 3436 H H acetyl acetyl Hacetyl H H H acetyl H 3437 H H acetyl acetyl H acetyl H H H acetylacetyl 3438 H H acetyl acetyl H acetyl H H acetyl H H 3439 H H acetylacetyl H acetyl H H acetyl H acetyl 3440 H H acetyl acetyl H acetyl H Hacetyl acetyl H 3441 H H acetyl acetyl H acetyl H H acetyl acetyl acetyl3442 H H acetyl acetyl H acetyl H acetyl H H H 3443 H H acetyl acetyl Hacetyl H acetyl H H acetyl 3444 H H acetyl acetyl H acetyl H acetyl Hacetyl H 3445 H H acetyl acetyl H acetyl H acetyl H acetyl acetyl 3446 HH acetyl acetyl H acetyl H acetyl acetyl H H 3447 H H acetyl acetyl Hacetyl H acetyl acetyl H acetyl 3448 H H acetyl acetyl H acetyl H acetylacetyl acetyl H 3449 H H acetyl acetyl H acetyl H acetyl acetyl acetylacetyl 3450 H H acetyl acetyl H acetyl acetyl H H H H 3451 H H acetylacetyl H acetyl acetyl H H H acetyl 3452 H H acetyl acetyl H acetylacetyl H H acetyl H 3453 H H acetyl acetyl H acetyl acetyl H H acetylacetyl 3454 H H acetyl acetyl H acetyl acetyl H acetyl H H 3455 H Hacetyl acetyl H acetyl acetyl H acetyl H acetyl 3456 H H acetyl acetyl Hacetyl acetyl H acetyl acetyl H 3457 H H acetyl acetyl H acetyl acetyl Hacetyl acetyl acetyl 3458 H H acetyl acetyl H acetyl acetyl acetyl H H H3459 H H acetyl acetyl H acetyl acetyl acetyl H H acetyl 3460 H H acetylacetyl H acetyl acetyl acetyl H acetyl H 3461 H H acetyl acetyl H acetylacetyl acetyl H acetyl acetyl 3462 H H acetyl acetyl H acetyl acetylacetyl acetyl H H 3463 H H acetyl acetyl H acetyl acetyl acetyl acetyl Hacetyl 3464 H H acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H3465 H H acetyl acetyl H acetyl acetyl acetyl acetyl acetyl acetyl 3466H H acetyl acetyl acetyl H H H H H H 3467 H H acetyl acetyl acetyl H H HH H acetyl 3468 H H acetyl acetyl acetyl H H H H acetyl H 3469 H Hacetyl acetyl acetyl H H H H acetyl acetyl 3470 H H acetyl acetyl acetylH H H acetyl H H 3471 H H acetyl acetyl acetyl H H H acetyl H acetyl3472 H H acetyl acetyl acetyl H H H acetyl acetyl H 3473 H H acetylacetyl acetyl H H H acetyl acetyl acetyl 3474 H H acetyl acetyl acetyl HH acetyl H H H 3475 H H acetyl acetyl acetyl H H acetyl H H acetyl 3476H H acetyl acetyl acetyl H H acetyl H acetyl H 3477 H H acetyl acetylacetyl H H acetyl H acetyl acetyl 3478 H H acetyl acetyl acetyl H Hacetyl acetyl H H 3479 H H acetyl acetyl acetyl H H acetyl acetyl Hacetyl 3480 H H acetyl acetyl acetyl H H acetyl acetyl acetyl H 3481 H Hacetyl acetyl acetyl H H acetyl acetyl acetyl acetyl 3482 H H acetylacetyl acetyl H acetyl H H H H 3483 H H acetyl acetyl acetyl H acetyl HH H acetyl 3484 H H acetyl acetyl acetyl H acetyl H H acetyl H 3485 H Hacetyl acetyl acetyl H acetyl H H acetyl acetyl 3486 H H acetyl acetylacetyl H acetyl H acetyl H H 3487 H H acetyl acetyl acetyl H acetyl Hacetyl H acetyl 3488 H H acetyl acetyl acetyl H acetyl H acetyl acetyl H3489 H H acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl 3490 H Hacetyl acetyl acetyl H acetyl acetyl H H H 3491 H H acetyl acetyl acetylH acetyl acetyl H H acetyl 3492 H H acetyl acetyl acetyl H acetyl acetylH acetyl H 3493 H H acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl3494 H H acetyl acetyl acetyl H acetyl acetyl acetyl H H 3495 H H acetylacetyl acetyl H acetyl acetyl acetyl H acetyl 3496 H H acetyl acetylacetyl H acetyl acetyl acetyl acetyl H 3497 H H acetyl acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl 3498 H H acetyl acetyl acetyl acetylH H H H H 3499 H H acetyl acetyl acetyl acetyl H H H H acetyl 3500 H Hacetyl acetyl acetyl acetyl H H H acetyl H 3501 H H acetyl acetyl acetylacetyl H H H acetyl acetyl 3502 H H acetyl acetyl acetyl acetyl H Hacetyl H H 3503 H H acetyl acetyl acetyl acetyl H H acetyl H acetyl 3504H H acetyl acetyl acetyl acetyl H H acetyl acetyl H 3505 H H acetylacetyl acetyl acetyl H H acetyl acetyl acetyl 3506 H H acetyl acetylacetyl acetyl H acetyl H H H 3507 H H acetyl acetyl acetyl acetyl Hacetyl H H acetyl 3508 H H acetyl acetyl acetyl acetyl H acetyl H acetylH 3509 H H acetyl acetyl acetyl acetyl H acetyl H acetyl acetyl 3510 H Hacetyl acetyl acetyl acetyl H acetyl acetyl H H 3511 H H acetyl acetylacetyl acetyl H acetyl acetyl H acetyl 3512 H H acetyl acetyl acetylacetyl H acetyl acetyl acetyl H 3513 H H acetyl acetyl acetyl acetyl Hacetyl acetyl acetyl acetyl 3514 H H acetyl acetyl acetyl acetyl acetylH H H H 3515 H H acetyl acetyl acetyl acetyl acetyl H H H acetyl 3516 HH acetyl acetyl acetyl acetyl acetyl H H acetyl H 3517 H H acetyl acetylacetyl acetyl acetyl H H acetyl acetyl 3518 H H acetyl acetyl acetylacetyl acetyl H acetyl H H 3519 H H acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl 3520 H H acetyl acetyl acetyl acetyl acetyl H acetylacetyl H 3521 H H acetyl acetyl acetyl acetyl acetyl H acetyl acetylacetyl 3522 H H acetyl acetyl acetyl acetyl acetyl acetyl H H H 3523 H Hacetyl acetyl acetyl acetyl acetyl acetyl H H acetyl 3524 H H acetylacetyl acetyl acetyl acetyl acetyl H acetyl H 3525 H H acetyl acetylacetyl acetyl acetyl acetyl H acetyl acetyl 3526 H H acetyl acetylacetyl acetyl acetyl acetyl acetyl H H 3527 H H acetyl acetyl acetylacetyl acetyl acetyl acetyl H acetyl 3528 H H acetyl acetyl acetylacetyl acetyl acetyl acetyl acetyl H 3529 H H acetyl acetyl acetylacetyl acetyl acetyl acetyl acetyl acetyl 3530 H acetyl H H H H H H H HH 3531 H acetyl H H H H H H H H acetyl 3532 H acetyl H H H H H H Hacetyl H 3533 H acetyl H H H H H H H acetyl acetyl 3534 H acetyl H H H HH H acetyl H H 3535 H acetyl H H H H H H acetyl H acetyl 3536 H acetyl HH H H H H acetyl acetyl H 3537 H acetyl H H H H H H acetyl acetyl acetyl3538 H acetyl H H H H H acetyl H H H 3539 H acetyl H H H H H acetyl H Hacetyl 3540 H acetyl H H H H H acetyl H acetyl H 3541 H acetyl H H H H Hacetyl H acetyl acetyl 3542 H acetyl H H H H H acetyl acetyl H H 3543 Hacetyl H H H H H acetyl acetyl H acetyl 3544 H acetyl H H H H H acetylacetyl acetyl H 3545 H acetyl H H H H H acetyl acetyl acetyl acetyl 3546H acetyl H H H H acetyl H H H H 3547 H acetyl H H H H acetyl H H Hacetyl 3548 H acetyl H H H H acetyl H H acetyl H 3549 H acetyl H H H Hacetyl H H acetyl acetyl 3550 H acetyl H H H H acetyl H acetyl H H 3551H acetyl H H H H acetyl H acetyl H acetyl 3552 H acetyl H H H H acetyl Hacetyl acetyl H 3553 H acetyl H H H H acetyl H acetyl acetyl acetyl 3554H acetyl H H H H acetyl acetyl H H H 3555 H acetyl H H H H acetyl acetylH H acetyl 3556 H acetyl H H H H acetyl acetyl H acetyl H 3557 H acetylH H H H acetyl acetyl H acetyl acetyl 3558 H acetyl H H H H acetylacetyl acetyl H H 3559 H acetyl H H H H acetyl acetyl acetyl H acetyl3560 H acetyl H H H H acetyl acetyl acetyl acetyl H 3561 H acetyl H H HH acetyl acetyl acetyl acetyl acetyl 3562 H acetyl H H H acetyl H H H HH 3563 H acetyl H H H acetyl H H H H acetyl 3564 H acetyl H H H acetyl HH H acetyl H 3565 H acetyl H H H acetyl H H H acetyl acetyl 3566 Hacetyl H H H acetyl H H acetyl H H 3567 H acetyl H H H acetyl H H acetylH acetyl 3568 H acetyl H H H acetyl H H acetyl acetyl H 3569 H acetyl HH H acetyl H H acetyl acetyl acetyl 3570 H acetyl H H H acetyl H acetylH H H 3571 H acetyl H H H acetyl H acetyl H H acetyl 3572 H acetyl H H Hacetyl H acetyl H acetyl H 3573 H acetyl H H H acetyl H acetyl H acetylacetyl 3574 H acetyl H H H acetyl H acetyl acetyl H H 3575 H acetyl H HH acetyl H acetyl acetyl H acetyl 3576 H acetyl H H H acetyl H acetylacetyl acetyl H 3577 H acetyl H H H acetyl H acetyl acetyl acetyl acetyl3578 H acetyl H H H acetyl acetyl H H H H 3579 H acetyl H H H acetylacetyl H H H acetyl 3580 H acetyl H H H acetyl acetyl H H acetyl H 3581H acetyl H H H acetyl acetyl H H acetyl acetyl 3582 H acetyl H H Hacetyl acetyl H acetyl H H 3583 H acetyl H H H acetyl acetyl H acetyl Hacetyl 3584 H acetyl H H H acetyl acetyl H acetyl acetyl H 3585 H acetylH H H acetyl acetyl H acetyl acetyl acetyl 3586 H acetyl H H H acetylacetyl acetyl H H H 3587 H acetyl H H H acetyl acetyl acetyl H H acetyl3588 H acetyl H H H acetyl acetyl acetyl H acetyl H 3589 H acetyl H H Hacetyl acetyl acetyl H acetyl acetyl 3590 H acetyl H H H acetyl acetylacetyl acetyl H H 3591 H acetyl H H H acetyl acetyl acetyl acetyl Hacetyl 3592 H acetyl H H H acetyl acetyl acetyl acetyl acetyl H 3593 Hacetyl H H H acetyl acetyl acetyl acetyl acetyl acetyl 3594 H acetyl H Hacetyl H H H H H H 3595 H acetyl H H acetyl H H H H H acetyl 3596 Hacetyl H H acetyl H H H H acetyl H 3597 H acetyl H H acetyl H H H Hacetyl acetyl 3598 H acetyl H H acetyl H H H acetyl H H 3599 H acetyl HH acetyl H H H acetyl H acetyl 3600 H acetyl H H acetyl H H H acetylacetyl H 3601 H acetyl H H acetyl H H H acetyl acetyl acetyl 3602 Hacetyl H H acetyl H H acetyl H H H 3603 H acetyl H H acetyl H H acetyl HH acetyl 3604 H acetyl H H acetyl H H acetyl H acetyl H 3605 H acetyl HH acetyl H H acetyl H acetyl acetyl 3606 H acetyl H H acetyl H H acetylacetyl H H 3607 H acetyl H H acetyl H H acetyl acetyl H acetyl 3608 Hacetyl H H acetyl H H acetyl acetyl acetyl H 3609 H acetyl H H acetyl HH acetyl acetyl acetyl acetyl 3610 H acetyl H H acetyl H acetyl H H H H3611 H acetyl H H acetyl H acetyl H H H acetyl 3612 H acetyl H H acetylH acetyl H H acetyl H 3613 H acetyl H H acetyl H acetyl H H acetylacetyl 3614 H acetyl H H acetyl H acetyl H acetyl H H 3615 H acetyl H Hacetyl H acetyl H acetyl H acetyl 3616 H acetyl H H acetyl H acetyl Hacetyl acetyl H 3617 H acetyl H H acetyl H acetyl H acetyl acetyl acetyl3618 H acetyl H H acetyl H acetyl acetyl H H H 3619 H acetyl H H acetylH acetyl acetyl H H acetyl 3620 H acetyl H H acetyl H acetyl acetyl Hacetyl H 3621 H acetyl H H acetyl H acetyl acetyl H acetyl acetyl 3622 Hacetyl H H acetyl H acetyl acetyl acetyl H H 3623 H acetyl H H acetyl Hacetyl acetyl acetyl H acetyl 3624 H acetyl H H acetyl H acetyl acetylacetyl acetyl H 3625 H acetyl H H acetyl H acetyl acetyl acetyl acetylacetyl 3626 H acetyl H H acetyl acetyl H H H H H 3627 H acetyl H Hacetyl acetyl H H H H acetyl 3628 H acetyl H H acetyl acetyl H H Hacetyl H 3629 H acetyl H H acetyl acetyl H H H acetyl acetyl 3630 Hacetyl H H acetyl acetyl H H acetyl H H 3631 H acetyl H H acetyl acetylH H acetyl H acetyl 3632 H acetyl H H acetyl acetyl H H acetyl acetyl H3633 H acetyl H H acetyl acetyl H H acetyl acetyl acetyl 3634 H acetyl HH acetyl acetyl H acetyl H H H 3635 H acetyl H H acetyl acetyl H acetylH H acetyl 3636 H acetyl H H acetyl acetyl H acetyl H acetyl H 3637 Hacetyl H H acetyl acetyl H acetyl H acetyl acetyl 3638 H acetyl H Hacetyl acetyl H acetyl acetyl H H 3639 H acetyl H H acetyl acetyl Hacetyl acetyl H acetyl 3640 H acetyl H H acetyl acetyl H acetyl acetylacetyl H 3641 H acetyl H H acetyl acetyl H acetyl acetyl acetyl acetyl3642 H acetyl H H acetyl acetyl acetyl H H H H 3643 H acetyl H H acetylacetyl acetyl H H H acetyl 3644 H acetyl H H acetyl acetyl acetyl H Hacetyl H 3645 H acetyl H H acetyl acetyl acetyl H H acetyl acetyl 3646 Hacetyl H H acetyl acetyl acetyl H acetyl H H 3647 H acetyl H H acetylacetyl acetyl H acetyl H acetyl 3648 H acetyl H H acetyl acetyl acetyl Hacetyl acetyl H 3649 H acetyl H H acetyl acetyl acetyl H acetyl acetylacetyl 3650 H acetyl H H acetyl acetyl acetyl acetyl H H H 3651 H acetylH H acetyl acetyl acetyl acetyl H H acetyl 3652 H acetyl H H acetylacetyl acetyl acetyl H acetyl H 3653 H acetyl H H acetyl acetyl acetylacetyl H acetyl acetyl 3654 H acetyl H H acetyl acetyl acetyl acetylacetyl H H 3655 H acetyl H H acetyl acetyl acetyl acetyl acetyl H acetyl3656 H acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl H 3657 Hacetyl H H acetyl acetyl acetyl acetyl acetyl acetyl acetyl 3658 Hacetyl H acetyl H H H H H H H 3659 H acetyl H acetyl H H H H H H acetyl3660 H acetyl H acetyl H H H H H acetyl H 3661 H acetyl H acetyl H H H HH acetyl acetyl 3662 H acetyl H acetyl H H H H acetyl H H 3663 H acetylH acetyl H H H H acetyl H acetyl 3664 H acetyl H acetyl H H H H acetylacetyl H 3665 H acetyl H acetyl H H H H acetyl acetyl acetyl 3666 Hacetyl H acetyl H H H acetyl H H H 3667 H acetyl H acetyl H H H acetyl HH acetyl 3668 H acetyl H acetyl H H H acetyl H acetyl H 3669 H acetyl Hacetyl H H H acetyl H acetyl acetyl 3670 H acetyl H acetyl H H H acetylacetyl H H 3671 H acetyl H acetyl H H H acetyl acetyl H acetyl 3672 Hacetyl H acetyl H H H acetyl acetyl acetyl H 3673 H acetyl H acetyl H HH acetyl acetyl acetyl acetyl 3674 H acetyl H acetyl H H acetyl H H H H3675 H acetyl H acetyl H H acetyl H H H acetyl 3676 H acetyl H acetyl HH acetyl H H acetyl H 3677 H acetyl H acetyl H H acetyl H H acetylacetyl 3678 H acetyl H acetyl H H acetyl H acetyl H H 3679 H acetyl Hacetyl H H acetyl H acetyl H acetyl 3680 H acetyl H acetyl H H acetyl Hacetyl acetyl H 3681 H acetyl H acetyl H H acetyl H acetyl acetyl acetyl3682 H acetyl H acetyl H H acetyl acetyl H H H 3683 H acetyl H acetyl HH acetyl acetyl H H acetyl 3684 H acetyl H acetyl H H acetyl acetyl Hacetyl H 3685 H acetyl H acetyl H H acetyl acetyl H acetyl acetyl 3686 Hacetyl H acetyl H H acetyl acetyl acetyl H H 3687 H acetyl H acetyl H Hacetyl acetyl acetyl H acetyl 3688 H acetyl H acetyl H H acetyl acetylacetyl acetyl H 3689 H acetyl H acetyl H H acetyl acetyl acetyl acetylacetyl 3690 H acetyl H acetyl H acetyl H H H H H 3691 H acetyl H acetylH acetyl H H H H acetyl 3692 H acetyl H acetyl H acetyl H H H acetyl H3693 H acetyl H acetyl H acetyl H H H acetyl acetyl 3694 H acetyl Hacetyl H acetyl H H acetyl H H 3695 H acetyl H acetyl H acetyl H Hacetyl H acetyl 3696 H acetyl H acetyl H acetyl H H acetyl acetyl H 3697H acetyl H acetyl H acetyl H H acetyl acetyl acetyl 3698 H acetyl Hacetyl H acetyl H acetyl H H H 3699 H acetyl H acetyl H acetyl H acetylH H acetyl 3700 H acetyl H acetyl H acetyl H acetyl H acetyl H 3701 Hacetyl H acetyl H acetyl H acetyl H acetyl acetyl 3702 H acetyl H acetylH acetyl H acetyl acetyl H H 3703 H acetyl H acetyl H acetyl H acetylacetyl H acetyl 3704 H acetyl H acetyl H acetyl H acetyl acetyl acetyl H3705 H acetyl H acetyl H acetyl H acetyl acetyl acetyl acetyl 3706 Hacetyl H acetyl H acetyl acetyl H H H H 3707 H acetyl H acetyl H acetylacetyl H H H acetyl 3708 H acetyl H acetyl H acetyl acetyl H H acetyl H3709 H acetyl H acetyl H acetyl acetyl H H acetyl acetyl 3710 H acetyl Hacetyl H acetyl acetyl H acetyl H H 3711 H acetyl H acetyl H acetylacetyl H acetyl H acetyl 3712 H acetyl H acetyl H acetyl acetyl H acetylacetyl H 3713 H acetyl H acetyl H acetyl acetyl H acetyl acetyl acetyl3714 H acetyl H acetyl H acetyl acetyl acetyl H H H 3715 H acetyl Hacetyl H acetyl acetyl acetyl H H acetyl 3716 H acetyl H acetyl H acetylacetyl acetyl H acetyl H 3717 H acetyl H acetyl H acetyl acetyl acetyl Hacetyl acetyl 3718 H acetyl H acetyl H acetyl acetyl acetyl acetyl H H3719 H acetyl H acetyl H acetyl acetyl acetyl acetyl H acetyl 3720 Hacetyl H acetyl H acetyl acetyl acetyl acetyl acetyl H 3721 H acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl acetyl 3722 H acetyl Hacetyl acetyl H H H H H H 3723 H acetyl H acetyl acetyl H H H H H acetyl3724 H acetyl H acetyl acetyl H H H H acetyl H 3725 H acetyl H acetylacetyl H H H H acetyl acetyl 3726 H acetyl H acetyl acetyl H H H acetylH H 3727 H acetyl H acetyl acetyl H H H acetyl H acetyl 3728 H acetyl Hacetyl acetyl H H H acetyl acetyl H 3729 H acetyl H acetyl acetyl H H Hacetyl acetyl acetyl 3730 H acetyl H acetyl acetyl H H acetyl H H H 3731H acetyl H acetyl acetyl H H acetyl H H acetyl 3732 H acetyl H acetylacetyl H H acetyl H acetyl H 3733 H acetyl H acetyl acetyl H H acetyl Hacetyl acetyl 3734 H acetyl H acetyl acetyl H H acetyl acetyl H H 3735 Hacetyl H acetyl acetyl H H acetyl acetyl H acetyl 3736 H acetyl H acetylacetyl H H acetyl acetyl acetyl H 3737 H acetyl H acetyl acetyl H Hacetyl acetyl acetyl acetyl 3738 H acetyl H acetyl acetyl H acetyl H H HH 3739 H acetyl H acetyl acetyl H acetyl H H H acetyl 3740 H acetyl Hacetyl acetyl H acetyl H H acetyl H 3741 H acetyl H acetyl acetyl Hacetyl H H acetyl acetyl 3742 H acetyl H acetyl acetyl H acetyl H acetylH H 3743 H acetyl H acetyl acetyl H acetyl H acetyl H acetyl 3744 Hacetyl H acetyl acetyl H acetyl H acetyl acetyl H 3745 H acetyl H acetylacetyl H acetyl H acetyl acetyl acetyl 3746 H acetyl H acetyl acetyl Hacetyl acetyl H H H 3747 H acetyl H acetyl acetyl H acetyl acetyl H Hacetyl 3748 H acetyl H acetyl acetyl H acetyl acetyl H acetyl H 3749 Hacetyl H acetyl acetyl H acetyl acetyl H acetyl acetyl 3750 H acetyl Hacetyl acetyl H acetyl acetyl acetyl H H 3751 H acetyl H acetyl acetyl Hacetyl acetyl acetyl H acetyl 3752 H acetyl H acetyl acetyl H acetylacetyl acetyl acetyl H 3753 H acetyl H acetyl acetyl H acetyl acetylacetyl acetyl acetyl 3754 H acetyl H acetyl acetyl acetyl H H H H H 3755H acetyl H acetyl acetyl acetyl H H H H acetyl 3756 H acetyl H acetylacetyl acetyl H H H acetyl H 3757 H acetyl H acetyl acetyl acetyl H H Hacetyl acetyl 3758 H acetyl H acetyl acetyl acetyl H H acetyl H H 3759 Hacetyl H acetyl acetyl acetyl H H acetyl H acetyl 3760 H acetyl H acetylacetyl acetyl H H acetyl acetyl H 3761 H acetyl H acetyl acetyl acetyl HH acetyl acetyl acetyl 3762 H acetyl H acetyl acetyl acetyl H acetyl H HH 3763 H acetyl H acetyl acetyl acetyl H acetyl H H acetyl 3764 H acetylH acetyl acetyl acetyl H acetyl H acetyl H 3765 H acetyl H acetyl acetylacetyl H acetyl H acetyl acetyl 3766 H acetyl H acetyl acetyl acetyl Hacetyl acetyl H H 3767 H acetyl H acetyl acetyl acetyl H acetyl acetyl Hacetyl 3768 H acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl H3769 H acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl acetyl 3770H acetyl H acetyl acetyl acetyl acetyl H H H H 3771 H acetyl H acetylacetyl acetyl acetyl H H H acetyl 3772 H acetyl H acetyl acetyl acetylacetyl H H acetyl H 3773 H acetyl H acetyl acetyl acetyl acetyl H Hacetyl acetyl 3774 H acetyl H acetyl acetyl acetyl acetyl H acetyl H H3775 H acetyl H acetyl acetyl acetyl acetyl H acetyl H acetyl 3776 Hacetyl H acetyl acetyl acetyl acetyl H acetyl acetyl H 3777 H acetyl Hacetyl acetyl acetyl acetyl H acetyl acetyl acetyl 3778 H acetyl Hacetyl acetyl acetyl acetyl acetyl H H H 3779 H acetyl H acetyl acetylacetyl acetyl acetyl H H acetyl 3780 H acetyl H acetyl acetyl acetylacetyl acetyl H acetyl H 3781 H acetyl H acetyl acetyl acetyl acetylacetyl H acetyl acetyl 3782 H acetyl H acetyl acetyl acetyl acetylacetyl acetyl H H 3783 H acetyl H acetyl acetyl acetyl acetyl acetylacetyl H acetyl 3784 H acetyl H acetyl acetyl acetyl acetyl acetylacetyl acetyl H 3785 H acetyl H acetyl acetyl acetyl acetyl acetylacetyl acetyl acetyl 3786 H acetyl acetyl H H H H H H H H 3787 H acetylacetyl H H H H H H H acetyl 3788 H acetyl acetyl H H H H H H acetyl H3789 H acetyl acetyl H H H H H H acetyl acetyl 3790 H acetyl acetyl H HH H H acetyl H H 3791 H acetyl acetyl H H H H H acetyl H acetyl 3792 Hacetyl acetyl H H H H H acetyl acetyl H 3793 H acetyl acetyl H H H H Hacetyl acetyl acetyl 3794 H acetyl acetyl H H H H acetyl H H H 3795 Hacetyl acetyl H H H H acetyl H H acetyl 3796 H acetyl acetyl H H H Hacetyl H acetyl H 3797 H acetyl acetyl H H H H acetyl H acetyl acetyl3798 H acetyl acetyl H H H H acetyl acetyl H H 3799 H acetyl acetyl H HH H acetyl acetyl H acetyl 3800 H acetyl acetyl H H H H acetyl acetylacetyl H 3801 H acetyl acetyl H H H H acetyl acetyl acetyl acetyl 3802 Hacetyl acetyl H H H acetyl H H H H 3803 H acetyl acetyl H H H acetyl H HH acetyl 3804 H acetyl acetyl H H H acetyl H H acetyl H 3805 H acetylacetyl H H H acetyl H H acetyl acetyl 3806 H acetyl acetyl H H H acetylH acetyl H H 3807 H acetyl acetyl H H H acetyl H acetyl H acetyl 3808 Hacetyl acetyl H H H acetyl H acetyl acetyl H 3809 H acetyl acetyl H H Hacetyl H acetyl acetyl acetyl 3810 H acetyl acetyl H H H acetyl acetyl HH H 3811 H acetyl acetyl H H H acetyl acetyl H H acetyl 3812 H acetylacetyl H H H acetyl acetyl H acetyl H 3813 H acetyl acetyl H H H acetylacetyl H acetyl acetyl 3814 H acetyl acetyl H H H acetyl acetyl acetyl HH 3815 H acetyl acetyl H H H acetyl acetyl acetyl H acetyl 3816 H acetylacetyl H H H acetyl acetyl acetyl acetyl H 3817 H acetyl acetyl H H Hacetyl acetyl acetyl acetyl acetyl 3818 H acetyl acetyl H H acetyl H H HH H 3819 H acetyl acetyl H H acetyl H H H H acetyl 3820 H acetyl acetylH H acetyl H H H acetyl H 3821 H acetyl acetyl H H acetyl H H H acetylacetyl 3822 H acetyl acetyl H H acetyl H H acetyl H H 3823 H acetylacetyl H H acetyl H H acetyl H acetyl 3824 H acetyl acetyl H H acetyl HH acetyl acetyl H 3825 H acetyl acetyl H H acetyl H H acetyl acetylacetyl 3826 H acetyl acetyl H H acetyl H acetyl H H H 3827 H acetylacetyl H H acetyl H acetyl H H acetyl 3828 H acetyl acetyl H H acetyl Hacetyl H acetyl H 3829 H acetyl acetyl H H acetyl H acetyl H acetylacetyl 3830 H acetyl acetyl H H acetyl H acetyl acetyl H H 3831 H acetylacetyl H H acetyl H acetyl acetyl H acetyl 3832 H acetyl acetyl H Hacetyl H acetyl acetyl acetyl H 3833 H acetyl acetyl H H acetyl H acetylacetyl acetyl acetyl 3834 H acetyl acetyl H H acetyl acetyl H H H H 3835H acetyl acetyl H H acetyl acetyl H H H acetyl 3836 H acetyl acetyl H Hacetyl acetyl H H acetyl H 3837 H acetyl acetyl H H acetyl acetyl H Hacetyl acetyl 3838 H acetyl acetyl H H acetyl acetyl H acetyl H H 3839 Hacetyl acetyl H H acetyl acetyl H acetyl H acetyl 3840 H acetyl acetyl HH acetyl acetyl H acetyl acetyl H 3841 H acetyl acetyl H H acetyl acetylH acetyl acetyl acetyl 3842 H acetyl acetyl H H acetyl acetyl acetyl H HH 3843 H acetyl acetyl H H acetyl acetyl acetyl H H acetyl 3844 H acetylacetyl H H acetyl acetyl acetyl H acetyl H 3845 H acetyl acetyl H Hacetyl acetyl acetyl H acetyl acetyl 3846 H acetyl acetyl H H acetylacetyl acetyl acetyl H H 3847 H acetyl acetyl H H acetyl acetyl acetylacetyl H acetyl 3848 H acetyl acetyl H H acetyl acetyl acetyl acetylacetyl H 3849 H acetyl acetyl H H acetyl acetyl acetyl acetyl acetylacetyl 3850 H acetyl acetyl H acetyl H H H H H H 3851 H acetyl acetyl Hacetyl H H H H H acetyl 3852 H acetyl acetyl H acetyl H H H H acetyl H3853 H acetyl acetyl H acetyl H H H H acetyl acetyl 3854 H acetyl acetylH acetyl H H H acetyl H H 3855 H acetyl acetyl H acetyl H H H acetyl Hacetyl 3856 H acetyl acetyl H acetyl H H H acetyl acetyl H 3857 H acetylacetyl H acetyl H H H acetyl acetyl acetyl 3858 H acetyl acetyl H acetylH H acetyl H H H 3859 H acetyl acetyl H acetyl H H acetyl H H acetyl3860 H acetyl acetyl H acetyl H H acetyl H acetyl H 3861 H acetyl acetylH acetyl H H acetyl H acetyl acetyl 3862 H acetyl acetyl H acetyl H Hacetyl acetyl H H 3863 H acetyl acetyl H acetyl H H acetyl acetyl Hacetyl 3864 H acetyl acetyl H acetyl H H acetyl acetyl acetyl H 3865 Hacetyl acetyl H acetyl H H acetyl acetyl acetyl acetyl 3866 H acetylacetyl H acetyl H acetyl H H H H 3867 H acetyl acetyl H acetyl H acetylH H H acetyl 3868 H acetyl acetyl H acetyl H acetyl H H acetyl H 3869 Hacetyl acetyl H acetyl H acetyl H H acetyl acetyl 3870 H acetyl acetyl Hacetyl H acetyl H acetyl H H 3871 H acetyl acetyl H acetyl H acetyl Hacetyl H acetyl 3872 H acetyl acetyl H acetyl H acetyl H acetyl acetyl H3873 H acetyl acetyl H acetyl H acetyl H acetyl acetyl acetyl 3874 Hacetyl acetyl H acetyl H acetyl acetyl H H H 3875 H acetyl acetyl Hacetyl H acetyl acetyl H H acetyl 3876 H acetyl acetyl H acetyl H acetylacetyl H acetyl H 3877 H acetyl acetyl H acetyl H acetyl acetyl H acetylacetyl 3878 H acetyl acetyl H acetyl H acetyl acetyl acetyl H H 3879 Hacetyl acetyl H acetyl H acetyl acetyl acetyl H acetyl 3880 H acetylacetyl H acetyl H acetyl acetyl acetyl acetyl H 3881 H acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl 3882 H acetyl acetyl Hacetyl acetyl H H H H H 3883 H acetyl acetyl H acetyl acetyl H H H Hacetyl 3884 H acetyl acetyl H acetyl acetyl H H H acetyl H 3885 H acetylacetyl H acetyl acetyl H H H acetyl acetyl 3886 H acetyl acetyl H acetylacetyl H H acetyl H H 3887 H acetyl acetyl H acetyl acetyl H H acetyl Hacetyl 3888 H acetyl acetyl H acetyl acetyl H H acetyl acetyl H 3889 Hacetyl acetyl H acetyl acetyl H H acetyl acetyl acetyl 3890 H acetylacetyl H acetyl acetyl H acetyl H H H 3891 H acetyl acetyl H acetylacetyl H acetyl H H acetyl 3892 H acetyl acetyl H acetyl acetyl H acetylH acetyl H 3893 H acetyl acetyl H acetyl acetyl H acetyl H acetyl acetyl3894 H acetyl acetyl H acetyl acetyl H acetyl acetyl H H 3895 H acetylacetyl H acetyl acetyl H acetyl acetyl H acetyl 3896 H acetyl acetyl Hacetyl acetyl H acetyl acetyl acetyl H 3897 H acetyl acetyl H acetylacetyl H acetyl acetyl acetyl acetyl 3898 H acetyl acetyl H acetylacetyl acetyl H H H H 3899 H acetyl acetyl H acetyl acetyl acetyl H H Hacetyl 3900 H acetyl acetyl H acetyl acetyl acetyl H H acetyl H 3901 Hacetyl acetyl H acetyl acetyl acetyl H H acetyl acetyl 3902 H acetylacetyl H acetyl acetyl acetyl H acetyl H H 3903 H acetyl acetyl H acetylacetyl acetyl H acetyl H acetyl 3904 H acetyl acetyl H acetyl acetylacetyl H acetyl acetyl H 3905 H acetyl acetyl H acetyl acetyl acetyl Hacetyl acetyl acetyl 3906 H acetyl acetyl H acetyl acetyl acetyl acetylH H H 3907 H acetyl acetyl H acetyl acetyl acetyl acetyl H H acetyl 3908H acetyl acetyl H acetyl acetyl acetyl acetyl H acetyl H 3909 H acetylacetyl H acetyl acetyl acetyl acetyl H acetyl acetyl 3910 H acetylacetyl H acetyl acetyl acetyl acetyl acetyl H H 3911 H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl H acetyl 3912 H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H 3913 H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl 3914 H acetyl acetylacetyl H H H H H H H 3915 H acetyl acetyl acetyl H H H H H H acetyl 3916H acetyl acetyl acetyl H H H H H acetyl H 3917 H acetyl acetyl acetyl HH H H H acetyl acetyl 3918 H acetyl acetyl acetyl H H H H acetyl H H3919 H acetyl acetyl acetyl H H H H acetyl H acetyl 3920 H acetyl acetylacetyl H H H H acetyl acetyl H 3921 H acetyl acetyl acetyl H H H Hacetyl acetyl acetyl 3922 H acetyl acetyl acetyl H H H acetyl H H H 3923H acetyl acetyl acetyl H H H acetyl H H acetyl 3924 H acetyl acetylacetyl H H H acetyl H acetyl H 3925 H acetyl acetyl acetyl H H H acetylH acetyl acetyl 3926 H acetyl acetyl acetyl H H H acetyl acetyl H H 3927H acetyl acetyl acetyl H H H acetyl acetyl H acetyl 3928 H acetyl acetylacetyl H H H acetyl acetyl acetyl H 3929 H acetyl acetyl acetyl H H Hacetyl acetyl acetyl acetyl 3930 H acetyl acetyl acetyl H H acetyl H H HH 3931 H acetyl acetyl acetyl H H acetyl H H H acetyl 3932 H acetylacetyl acetyl H H acetyl H H acetyl H 3933 H acetyl acetyl acetyl H Hacetyl H H acetyl acetyl 3934 H acetyl acetyl acetyl H H acetyl H acetylH H 3935 H acetyl acetyl acetyl H H acetyl H acetyl H acetyl 3936 Hacetyl acetyl acetyl H H acetyl H acetyl acetyl H 3937 H acetyl acetylacetyl H H acetyl H acetyl acetyl acetyl 3938 H acetyl acetyl acetyl H Hacetyl acetyl H H H 3939 H acetyl acetyl acetyl H H acetyl acetyl H Hacetyl 3940 H acetyl acetyl acetyl H H acetyl acetyl H acetyl H 3941 Hacetyl acetyl acetyl H H acetyl acetyl H acetyl acetyl 3942 H acetylacetyl acetyl H H acetyl acetyl acetyl H H 3943 H acetyl acetyl acetyl HH acetyl acetyl acetyl H acetyl 3944 H acetyl acetyl acetyl H H acetylacetyl acetyl acetyl H 3945 H acetyl acetyl acetyl H H acetyl acetylacetyl acetyl acetyl 3946 H acetyl acetyl acetyl H acetyl H H H H H 3947H acetyl acetyl acetyl H acetyl H H H H acetyl 3948 H acetyl acetylacetyl H acetyl H H H acetyl H 3949 H acetyl acetyl acetyl H acetyl H HH acetyl acetyl 3950 H acetyl acetyl acetyl H acetyl H H acetyl H H 3951H acetyl acetyl acetyl H acetyl H H acetyl H acetyl 3952 H acetyl acetylacetyl H acetyl H H acetyl acetyl H 3953 H acetyl acetyl acetyl H acetylH H acetyl acetyl acetyl 3954 H acetyl acetyl acetyl H acetyl H acetyl HH H 3955 H acetyl acetyl acetyl H acetyl H acetyl H H acetyl 3956 Hacetyl acetyl acetyl H acetyl H acetyl H acetyl H 3957 H acetyl acetylacetyl H acetyl H acetyl H acetyl acetyl 3958 H acetyl acetyl acetyl Hacetyl H acetyl acetyl H H 3959 H acetyl acetyl acetyl H acetyl H acetylacetyl H acetyl 3960 H acetyl acetyl acetyl H acetyl H acetyl acetylacetyl H 3961 H acetyl acetyl acetyl H acetyl H acetyl acetyl acetylacetyl 3962 H acetyl acetyl acetyl H acetyl acetyl H H H H 3963 H acetylacetyl acetyl H acetyl acetyl H H H acetyl 3964 H acetyl acetyl acetyl Hacetyl acetyl H H acetyl H 3965 H acetyl acetyl acetyl H acetyl acetyl HH acetyl acetyl 3966 H acetyl acetyl acetyl H acetyl acetyl H acetyl H H3967 H acetyl acetyl acetyl H acetyl acetyl H acetyl H acetyl 3968 Hacetyl acetyl acetyl H acetyl acetyl H acetyl acetyl H 3969 H acetylacetyl acetyl H acetyl acetyl H acetyl acetyl acetyl 3970 H acetylacetyl acetyl H acetyl acetyl acetyl H H H 3971 H acetyl acetyl acetyl Hacetyl acetyl acetyl H H acetyl 3972 H acetyl acetyl acetyl H acetylacetyl acetyl H acetyl H 3973 H acetyl acetyl acetyl H acetyl acetylacetyl H acetyl acetyl 3974 H acetyl acetyl acetyl H acetyl acetylacetyl acetyl H H 3975 H acetyl acetyl acetyl H acetyl acetyl acetylacetyl H acetyl 3976 H acetyl acetyl acetyl H acetyl acetyl acetylacetyl acetyl H 3977 H acetyl acetyl acetyl H acetyl acetyl acetylacetyl acetyl acetyl 3978 H acetyl acetyl acetyl acetyl H H H H H H 3979H acetyl acetyl acetyl acetyl H H H H H acetyl 3980 H acetyl acetylacetyl acetyl H H H H acetyl H 3981 H acetyl acetyl acetyl acetyl H H HH acetyl acetyl 3982 H acetyl acetyl acetyl acetyl H H H acetyl H H 3983H acetyl acetyl acetyl acetyl H H H acetyl H acetyl 3984 H acetyl acetylacetyl acetyl H H H acetyl acetyl H 3985 H acetyl acetyl acetyl acetyl HH H acetyl acetyl acetyl 3986 H acetyl acetyl acetyl acetyl H H acetyl HH H 3987 H acetyl acetyl acetyl acetyl H H acetyl H H acetyl 3988 Hacetyl acetyl acetyl acetyl H H acetyl H acetyl H 3989 H acetyl acetylacetyl acetyl H H acetyl H acetyl acetyl 3990 H acetyl acetyl acetylacetyl H H acetyl acetyl H H 3991 H acetyl acetyl acetyl acetyl H Hacetyl acetyl H acetyl 3992 H acetyl acetyl acetyl acetyl H H acetylacetyl acetyl H 3993 H acetyl acetyl acetyl acetyl H H acetyl acetylacetyl acetyl 3994 H acetyl acetyl acetyl acetyl H acetyl H H H H 3995 Hacetyl acetyl acetyl acetyl H acetyl H H H acetyl 3996 H acetyl acetylacetyl acetyl H acetyl H H acetyl H 3997 H acetyl acetyl acetyl acetyl Hacetyl H H acetyl acetyl 3998 H acetyl acetyl acetyl acetyl H acetyl Hacetyl H H 3999 H acetyl acetyl acetyl acetyl H acetyl H acetyl H acetyl4000 H acetyl acetyl acetyl acetyl H acetyl H acetyl acetyl H 4001 Hacetyl acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl 4002 Hacetyl acetyl acetyl acetyl H acetyl acetyl H H H 4003 H acetyl acetylacetyl acetyl H acetyl acetyl H H acetyl 4004 H acetyl acetyl acetylacetyl H acetyl acetyl H acetyl H 4005 H acetyl acetyl acetyl acetyl Hacetyl acetyl H acetyl acetyl 4006 H acetyl acetyl acetyl acetyl Hacetyl acetyl acetyl H H 4007 H acetyl acetyl acetyl acetyl H acetylacetyl acetyl H acetyl 4008 H acetyl acetyl acetyl acetyl H acetylacetyl acetyl acetyl H 4009 H acetyl acetyl acetyl acetyl H acetylacetyl acetyl acetyl acetyl 4010 H acetyl acetyl acetyl acetyl acetyl HH H H H 4011 H acetyl acetyl acetyl acetyl acetyl H H H H acetyl 4012 Hacetyl acetyl acetyl acetyl acetyl H H H acetyl H 4013 H acetyl acetylacetyl acetyl acetyl H H H acetyl acetyl 4014 H acetyl acetyl acetylacetyl acetyl H H acetyl H H 4015 H acetyl acetyl acetyl acetyl acetyl HH acetyl H acetyl 4016 H acetyl acetyl acetyl acetyl acetyl H H acetylacetyl H 4017 H acetyl acetyl acetyl acetyl acetyl H H acetyl acetylacetyl 4018 H acetyl acetyl acetyl acetyl acetyl H acetyl H H H 4019 Hacetyl acetyl acetyl acetyl acetyl H acetyl H H acetyl 4020 H acetylacetyl acetyl acetyl acetyl H acetyl H acetyl H 4021 H acetyl acetylacetyl acetyl acetyl H acetyl H acetyl acetyl 4022 H acetyl acetylacetyl acetyl acetyl H acetyl acetyl H H 4023 H acetyl acetyl acetylacetyl acetyl H acetyl acetyl H acetyl 4024 H acetyl acetyl acetylacetyl acetyl H acetyl acetyl acetyl H 4025 H acetyl acetyl acetylacetyl acetyl H acetyl acetyl acetyl acetyl 4026 H acetyl acetyl acetylacetyl acetyl acetyl H H H H 4027 H acetyl acetyl acetyl acetyl acetylacetyl H H H acetyl 4028 H acetyl acetyl acetyl acetyl acetyl acetyl H Hacetyl H 4029 H acetyl acetyl acetyl acetyl acetyl acetyl H H acetylacetyl 4030 H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl H H4031 H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl H acetyl 4032H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl H 4033 Hacetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetyl 4034 Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl H H H 4035 H acetylacetyl acetyl acetyl acetyl acetyl acetyl H H acetyl 4036 H acetylacetyl acetyl acetyl acetyl acetyl acetyl H acetyl H 4037 H acetylacetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl 4038 H acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl H H 4039 H acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl 4040 H acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H 4041 H acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl 4042acetyl H H H H H H H H H H 4043 acetyl H H H H H H H H H acetyl 4044acetyl H H H H H H H H acetyl H 4045 acetyl H H H H H H H H acetylacetyl 4046 acetyl H H H H H H H acetyl H H 4047 acetyl H H H H H H Hacetyl H acetyl 4048 acetyl H H H H H H H acetyl acetyl H 4049 acetyl HH H H H H H acetyl acetyl acetyl 4050 acetyl H H H H H H acetyl H H H4051 acetyl H H H H H H acetyl H H acetyl 4052 acetyl H H H H H H acetylH acetyl H 4053 acetyl H H H H H H acetyl H acetyl acetyl 4054 acetyl HH H H H H acetyl acetyl H H 4055 acetyl H H H H H H acetyl acetyl Hacetyl 4056 acetyl H H H H H H acetyl acetyl acetyl H 4057 acetyl H H HH H H acetyl acetyl acetyl acetyl 4058 acetyl H H H H H acetyl H H H H4059 acetyl H H H H H acetyl H H H acetyl 4060 acetyl H H H H H acetyl HH acetyl H 4061 acetyl H H H H H acetyl H H acetyl acetyl 4062 acetyl HH H H H acetyl H acetyl H H 4063 acetyl H H H H H acetyl H acetyl Hacetyl 4064 acetyl H H H H H acetyl H acetyl acetyl H 4065 acetyl H H HH H acetyl H acetyl acetyl acetyl 4066 acetyl H H H H H acetyl acetyl HH H 4067 acetyl H H H H H acetyl acetyl H H acetyl 4068 acetyl H H H H Hacetyl acetyl H acetyl H 4069 acetyl H H H H H acetyl acetyl H acetylacetyl 4070 acetyl H H H H H acetyl acetyl acetyl H H 4071 acetyl H H HH H acetyl acetyl acetyl H acetyl 4072 acetyl H H H H H acetyl acetylacetyl acetyl H 4073 acetyl H H H H H acetyl acetyl acetyl acetyl acetyl4074 acetyl H H H H acetyl H H H H H 4075 acetyl H H H H acetyl H H H Hacetyl 4076 acetyl H H H H acetyl H H H acetyl H 4077 acetyl H H H Hacetyl H H H acetyl acetyl 4078 acetyl H H H H acetyl H H acetyl H H4079 acetyl H H H H acetyl H H acetyl H acetyl 4080 acetyl H H H Hacetyl H H acetyl acetyl H 4081 acetyl H H H H acetyl H H acetyl acetylacetyl 4082 acetyl H H H H acetyl H acetyl H H H 4083 acetyl H H H Hacetyl H acetyl H H acetyl 4084 acetyl H H H H acetyl H acetyl H acetylH 4085 acetyl H H H H acetyl H acetyl H acetyl acetyl 4086 acetyl H H HH acetyl H acetyl acetyl H H 4087 acetyl H H H H acetyl H acetyl acetylH acetyl 4088 acetyl H H H H acetyl H acetyl acetyl acetyl H 4089 acetylH H H H acetyl H acetyl acetyl acetyl acetyl 4090 acetyl H H H H acetylacetyl H H H H 4091 acetyl H H H H acetyl acetyl H H H acetyl 4092acetyl H H H H acetyl acetyl H H acetyl H 4093 acetyl H H H H acetylacetyl H H acetyl acetyl 4094 acetyl H H H H acetyl acetyl H acetyl H H4095 acetyl H H H H acetyl acetyl H acetyl H acetyl 4096 acetyl H H H Hacetyl acetyl H acetyl acetyl H 4097 acetyl H H H H acetyl acetyl Hacetyl acetyl acetyl 4098 acetyl H H H H acetyl acetyl acetyl H H H 4099acetyl H H H H acetyl acetyl acetyl H H acetyl 4100 acetyl H H H Hacetyl acetyl acetyl H acetyl H 4101 acetyl H H H H acetyl acetyl acetylH acetyl acetyl 4102 acetyl H H H H acetyl acetyl acetyl acetyl H H 4103acetyl H H H H acetyl acetyl acetyl acetyl H acetyl 4104 acetyl H H H Hacetyl acetyl acetyl acetyl acetyl H 4105 acetyl H H H H acetyl acetylacetyl acetyl acetyl acetyl 4106 acetyl H H H acetyl H H H H H H 4107acetyl H H H acetyl H H H H H acetyl 4108 acetyl H H H acetyl H H H Hacetyl H 4109 acetyl H H H acetyl H H H H acetyl acetyl 4110 acetyl H HH acetyl H H H acetyl H H 4111 acetyl H H H acetyl H H H acetyl H acetyl4112 acetyl H H H acetyl H H H acetyl acetyl H 4113 acetyl H H H acetylH H H acetyl acetyl acetyl 4114 acetyl H H H acetyl H H acetyl H H H4115 acetyl H H H acetyl H H acetyl H H acetyl 4116 acetyl H H H acetylH H acetyl H acetyl H 4117 acetyl H H H acetyl H H acetyl H acetylacetyl 4118 acetyl H H H acetyl H H acetyl acetyl H H 4119 acetyl H H Hacetyl H H acetyl acetyl H acetyl 4120 acetyl H H H acetyl H H acetylacetyl acetyl H 4121 acetyl H H H acetyl H H acetyl acetyl acetyl acetyl4122 acetyl H H H acetyl H acetyl H H H H 4123 acetyl H H H acetyl Hacetyl H H H acetyl 4124 acetyl H H H acetyl H acetyl H H acetyl H 4125acetyl H H H acetyl H acetyl H H acetyl acetyl 4126 acetyl H H H acetylH acetyl H acetyl H H 4127 acetyl H H H acetyl H acetyl H acetyl Hacetyl 4128 acetyl H H H acetyl H acetyl H acetyl acetyl H 4129 acetyl HH H acetyl H acetyl H acetyl acetyl acetyl 4130 acetyl H H H acetyl Hacetyl acetyl H H H 4131 acetyl H H H acetyl H acetyl acetyl H H acetyl4132 acetyl H H H acetyl H acetyl acetyl H acetyl H 4133 acetyl H H Hacetyl H acetyl acetyl H acetyl acetyl 4134 acetyl H H H acetyl H acetylacetyl acetyl H H 4135 acetyl H H H acetyl H acetyl acetyl acetyl Hacetyl 4136 acetyl H H H acetyl H acetyl acetyl acetyl acetyl H 4137acetyl H H H acetyl H acetyl acetyl acetyl acetyl acetyl 4138 acetyl H HH acetyl acetyl H H H H H 4139 acetyl H H H acetyl acetyl H H H H acetyl4140 acetyl H H H acetyl acetyl H H H acetyl H 4141 acetyl H H H acetylacetyl H H H acetyl acetyl 4142 acetyl H H H acetyl acetyl H H acetyl HH 4143 acetyl H H H acetyl acetyl H H acetyl H acetyl 4144 acetyl H H Hacetyl acetyl H H acetyl acetyl H 4145 acetyl H H H acetyl acetyl H Hacetyl acetyl acetyl 4146 acetyl H H H acetyl acetyl H acetyl H H H 4147acetyl H H H acetyl acetyl H acetyl H H acetyl 4148 acetyl H H H acetylacetyl H acetyl H acetyl H 4149 acetyl H H H acetyl acetyl H acetyl Hacetyl acetyl 4150 acetyl H H H acetyl acetyl H acetyl acetyl H H 4151acetyl H H H acetyl acetyl H acetyl acetyl H acetyl 4152 acetyl H H Hacetyl acetyl H acetyl acetyl acetyl H 4153 acetyl H H H acetyl acetyl Hacetyl acetyl acetyl acetyl 4154 acetyl H H H acetyl acetyl acetyl H H HH 4155 acetyl H H H acetyl acetyl acetyl H H H acetyl 4156 acetyl H H Hacetyl acetyl acetyl H H acetyl H 4157 acetyl H H H acetyl acetyl acetylH H acetyl acetyl 4158 acetyl H H H acetyl acetyl acetyl H acetyl H H4159 acetyl H H H acetyl acetyl acetyl H acetyl H acetyl 4160 acetyl H HH acetyl acetyl acetyl H acetyl acetyl H 4161 acetyl H H H acetyl acetylacetyl H acetyl acetyl acetyl 4162 acetyl H H H acetyl acetyl acetylacetyl H H H 4163 acetyl H H H acetyl acetyl acetyl acetyl H H acetyl4164 acetyl H H H acetyl acetyl acetyl acetyl H acetyl H 4165 acetyl H HH acetyl acetyl acetyl acetyl H acetyl acetyl 4166 acetyl H H H acetylacetyl acetyl acetyl acetyl H H 4167 acetyl H H H acetyl acetyl acetylacetyl acetyl H acetyl 4168 acetyl H H H acetyl acetyl acetyl acetylacetyl acetyl H 4169 acetyl H H H acetyl acetyl acetyl acetyl acetylacetyl acetyl 4170 acetyl H H acetyl H H H H H H H 4171 acetyl H Hacetyl H H H H H H acetyl 4172 acetyl H H acetyl H H H H H acetyl H 4173acetyl H H acetyl H H H H H acetyl acetyl 4174 acetyl H H acetyl H H H Hacetyl H H 4175 acetyl H H acetyl H H H H acetyl H acetyl 4176 acetyl HH acetyl H H H H acetyl acetyl H 4177 acetyl H H acetyl H H H H acetylacetyl acetyl 4178 acetyl H H acetyl H H H acetyl H H H 4179 acetyl H Hacetyl H H H acetyl H H acetyl 4180 acetyl H H acetyl H H H acetyl Hacetyl H 4181 acetyl H H acetyl H H H acetyl H acetyl acetyl 4182 acetylH H acetyl H H H acetyl acetyl H H 4183 acetyl H H acetyl H H H acetylacetyl H acetyl 4184 acetyl H H acetyl H H H acetyl acetyl acetyl H 4185acetyl H H acetyl H H H acetyl acetyl acetyl acetyl 4186 acetyl H Hacetyl H H acetyl H H H H 4187 acetyl H H acetyl H H acetyl H H H acetyl4188 acetyl H H acetyl H H acetyl H H acetyl H 4189 acetyl H H acetyl HH acetyl H H acetyl acetyl 4190 acetyl H H acetyl H H acetyl H acetyl HH 4191 acetyl H H acetyl H H acetyl H acetyl H acetyl 4192 acetyl H Hacetyl H H acetyl H acetyl acetyl H 4193 acetyl H H acetyl H H acetyl Hacetyl acetyl acetyl 4194 acetyl H H acetyl H H acetyl acetyl H H H 4195acetyl H H acetyl H H acetyl acetyl H H acetyl 4196 acetyl H H acetyl HH acetyl acetyl H acetyl H 4197 acetyl H H acetyl H H acetyl acetyl Hacetyl acetyl 4198 acetyl H H acetyl H H acetyl acetyl acetyl H H 4199acetyl H H acetyl H H acetyl acetyl acetyl H acetyl 4200 acetyl H Hacetyl H H acetyl acetyl acetyl acetyl H 4201 acetyl H H acetyl H Hacetyl acetyl acetyl acetyl acetyl 4202 acetyl H H acetyl H acetyl H H HH H 4203 acetyl H H acetyl H acetyl H H H H acetyl 4204 acetyl H Hacetyl H acetyl H H H acetyl H 4205 acetyl H H acetyl H acetyl H H Hacetyl acetyl 4206 acetyl H H acetyl H acetyl H H acetyl H H 4207 acetylH H acetyl H acetyl H H acetyl H acetyl 4208 acetyl H H acetyl H acetylH H acetyl acetyl H 4209 acetyl H H acetyl H acetyl H H acetyl acetylacetyl 4210 acetyl H H acetyl H acetyl H acetyl H H H 4211 acetyl H Hacetyl H acetyl H acetyl H H acetyl 4212 acetyl H H acetyl H acetyl Hacetyl H acetyl H 4213 acetyl H H acetyl H acetyl H acetyl H acetylacetyl 4214 acetyl H H acetyl H acetyl H acetyl acetyl H H 4215 acetyl HH acetyl H acetyl H acetyl acetyl H acetyl 4216 acetyl H H acetyl Hacetyl H acetyl acetyl acetyl H 4217 acetyl H H acetyl H acetyl H acetylacetyl acetyl acetyl 4218 acetyl H H acetyl H acetyl acetyl H H H H 4219acetyl H H acetyl H acetyl acetyl H H H acetyl 4220 acetyl H H acetyl Hacetyl acetyl H H acetyl H 4221 acetyl H H acetyl H acetyl acetyl H Hacetyl acetyl 4222 acetyl H H acetyl H acetyl acetyl H acetyl H H 4223acetyl H H acetyl H acetyl acetyl H acetyl H acetyl 4224 acetyl H Hacetyl H acetyl acetyl H acetyl acetyl H 4225 acetyl H H acetyl H acetylacetyl H acetyl acetyl acetyl 4226 acetyl H H acetyl H acetyl acetylacetyl H H H 4227 acetyl H H acetyl H acetyl acetyl acetyl H H acetyl4228 acetyl H H acetyl H acetyl acetyl acetyl H acetyl H 4229 acetyl H Hacetyl H acetyl acetyl acetyl H acetyl acetyl 4230 acetyl H H acetyl Hacetyl acetyl acetyl acetyl H H 4231 acetyl H H acetyl H acetyl acetylacetyl acetyl H acetyl 4232 acetyl H H acetyl H acetyl acetyl acetylacetyl acetyl H 4233 acetyl H H acetyl H acetyl acetyl acetyl acetylacetyl acetyl 4234 acetyl H H acetyl acetyl H H H H H H 4235 acetyl H Hacetyl acetyl H H H H H acetyl 4236 acetyl H H acetyl acetyl H H H Hacetyl H 4237 acetyl H H acetyl acetyl H H H H acetyl acetyl 4238 acetylH H acetyl acetyl H H H acetyl H H 4239 acetyl H H acetyl acetyl H H Hacetyl H acetyl 4240 acetyl H H acetyl acetyl H H H acetyl acetyl H 4241acetyl H H acetyl acetyl H H H acetyl acetyl acetyl 4242 acetyl H Hacetyl acetyl H H acetyl H H H 4243 acetyl H H acetyl acetyl H H acetylH H acetyl 4244 acetyl H H acetyl acetyl H H acetyl H acetyl H 4245acetyl H H acetyl acetyl H H acetyl H acetyl acetyl 4246 acetyl H Hacetyl acetyl H H acetyl acetyl H H 4247 acetyl H H acetyl acetyl H Hacetyl acetyl H acetyl 4248 acetyl H H acetyl acetyl H H acetyl acetylacetyl H 4249 acetyl H H acetyl acetyl H H acetyl acetyl acetyl acetyl4250 acetyl H H acetyl acetyl H acetyl H H H H 4251 acetyl H H acetylacetyl H acetyl H H H acetyl 4252 acetyl H H acetyl acetyl H acetyl H Hacetyl H 4253 acetyl H H acetyl acetyl H acetyl H H acetyl acetyl 4254acetyl H H acetyl acetyl H acetyl H acetyl H H 4255 acetyl H H acetylacetyl H acetyl H acetyl H acetyl 4256 acetyl H H acetyl acetyl H acetylH acetyl acetyl H 4257 acetyl H H acetyl acetyl H acetyl H acetyl acetylacetyl 4258 acetyl H H acetyl acetyl H acetyl acetyl H H H 4259 acetyl HH acetyl acetyl H acetyl acetyl H H acetyl 4260 acetyl H H acetyl acetylH acetyl acetyl H acetyl H 4261 acetyl H H acetyl acetyl H acetyl acetylH acetyl acetyl 4262 acetyl H H acetyl acetyl H acetyl acetyl acetyl H H4263 acetyl H H acetyl acetyl H acetyl acetyl acetyl H acetyl 4264acetyl H H acetyl acetyl H acetyl acetyl acetyl acetyl H 4265 acetyl H Hacetyl acetyl H acetyl acetyl acetyl acetyl acetyl 4266 acetyl H Hacetyl acetyl acetyl H H H H H 4267 acetyl H H acetyl acetyl acetyl H HH H acetyl 4268 acetyl H H acetyl acetyl acetyl H H H acetyl H 4269acetyl H H acetyl acetyl acetyl H H H acetyl acetyl 4270 acetyl H Hacetyl acetyl acetyl H H acetyl H H 4271 acetyl H H acetyl acetyl acetylH H acetyl H acetyl 4272 acetyl H H acetyl acetyl acetyl H H acetylacetyl H 4273 acetyl H H acetyl acetyl acetyl H H acetyl acetyl acetyl4274 acetyl H H acetyl acetyl acetyl H acetyl H H H 4275 acetyl H Hacetyl acetyl acetyl H acetyl H H acetyl 4276 acetyl H H acetyl acetylacetyl H acetyl H acetyl H 4277 acetyl H H acetyl acetyl acetyl H acetylH acetyl acetyl 4278 acetyl H H acetyl acetyl acetyl H acetyl acetyl H H4279 acetyl H H acetyl acetyl acetyl H acetyl acetyl H acetyl 4280acetyl H H acetyl acetyl acetyl H acetyl acetyl acetyl H 4281 acetyl H Hacetyl acetyl acetyl H acetyl acetyl acetyl acetyl 4282 acetyl H Hacetyl acetyl acetyl acetyl H H H H 4283 acetyl H H acetyl acetyl acetylacetyl H H H acetyl 4284 acetyl H H acetyl acetyl acetyl acetyl H Hacetyl H 4285 acetyl H H acetyl acetyl acetyl acetyl H H acetyl acetyl4286 acetyl H H acetyl acetyl acetyl acetyl H acetyl H H 4287 acetyl H Hacetyl acetyl acetyl acetyl H acetyl H acetyl 4288 acetyl H H acetylacetyl acetyl acetyl H acetyl acetyl H 4289 acetyl H H acetyl acetylacetyl acetyl H acetyl acetyl acetyl 4290 acetyl H H acetyl acetylacetyl acetyl acetyl H H H 4291 acetyl H H acetyl acetyl acetyl acetylacetyl H H acetyl 4292 acetyl H H acetyl acetyl acetyl acetyl acetyl Hacetyl H 4293 acetyl H H acetyl acetyl acetyl acetyl acetyl H acetylacetyl 4294 acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl H H4295 acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl 4296acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl acetyl H 4297acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl 4298acetyl H acetyl H H H H H H H H 4299 acetyl H acetyl H H H H H H Hacetyl 4300 acetyl H acetyl H H H H H H acetyl H 4301 acetyl H acetyl HH H H H H acetyl acetyl 4302 acetyl H acetyl H H H H H acetyl H H 4303acetyl H acetyl H H H H H acetyl H acetyl 4304 acetyl H acetyl H H H H Hacetyl acetyl H 4305 acetyl H acetyl H H H H H acetyl acetyl acetyl 4306acetyl H acetyl H H H H acetyl H H H 4307 acetyl H acetyl H H H H acetylH H acetyl 4308 acetyl H acetyl H H H H acetyl H acetyl H 4309 acetyl Hacetyl H H H H acetyl H acetyl acetyl 4310 acetyl H acetyl H H H Hacetyl acetyl H H 4311 acetyl H acetyl H H H H acetyl acetyl H acetyl4312 acetyl H acetyl H H H H acetyl acetyl acetyl H 4313 acetyl H acetylH H H H acetyl acetyl acetyl acetyl 4314 acetyl H acetyl H H H acetyl HH H H 4315 acetyl H acetyl H H H acetyl H H H acetyl 4316 acetyl Hacetyl H H H acetyl H H acetyl H 4317 acetyl H acetyl H H H acetyl H Hacetyl acetyl 4318 acetyl H acetyl H H H acetyl H acetyl H H 4319 acetylH acetyl H H H acetyl H acetyl H acetyl 4320 acetyl H acetyl H H Hacetyl H acetyl acetyl H 4321 acetyl H acetyl H H H acetyl H acetylacetyl acetyl 4322 acetyl H acetyl H H H acetyl acetyl H H H 4323 acetylH acetyl H H H acetyl acetyl H H acetyl 4324 acetyl H acetyl H H Hacetyl acetyl H acetyl H 4325 acetyl H acetyl H H H acetyl acetyl Hacetyl acetyl 4326 acetyl H acetyl H H H acetyl acetyl acetyl H H 4327acetyl H acetyl H H H acetyl acetyl acetyl H acetyl 4328 acetyl H acetylH H H acetyl acetyl acetyl acetyl H 4329 acetyl H acetyl H H H acetylacetyl acetyl acetyl acetyl 4330 acetyl H acetyl H H acetyl H H H H H4331 acetyl H acetyl H H acetyl H H H H acetyl 4332 acetyl H acetyl H Hacetyl H H H acetyl H 4333 acetyl H acetyl H H acetyl H H H acetylacetyl 4334 acetyl H acetyl H H acetyl H H acetyl H H 4335 acetyl Hacetyl H H acetyl H H acetyl H acetyl 4336 acetyl H acetyl H H acetyl HH acetyl acetyl H 4337 acetyl H acetyl H H acetyl H H acetyl acetylacetyl 4338 acetyl H acetyl H H acetyl H acetyl H H H 4339 acetyl Hacetyl H H acetyl H acetyl H H acetyl 4340 acetyl H acetyl H H acetyl Hacetyl H acetyl H 4341 acetyl H acetyl H H acetyl H acetyl H acetylacetyl 4342 acetyl H acetyl H H acetyl H acetyl acetyl H H 4343 acetyl Hacetyl H H acetyl H acetyl acetyl H acetyl 4344 acetyl H acetyl H Hacetyl H acetyl acetyl acetyl H 4345 acetyl H acetyl H H acetyl H acetylacetyl acetyl acetyl 4346 acetyl H acetyl H H acetyl acetyl H H H H 4347acetyl H acetyl H H acetyl acetyl H H H acetyl 4348 acetyl H acetyl H Hacetyl acetyl H H acetyl H 4349 acetyl H acetyl H H acetyl acetyl H Hacetyl acetyl 4350 acetyl H acetyl H H acetyl acetyl H acetyl H H 4351acetyl H acetyl H H acetyl acetyl H acetyl H acetyl 4352 acetyl H acetylH H acetyl acetyl H acetyl acetyl H 4353 acetyl H acetyl H H acetylacetyl H acetyl acetyl acetyl 4354 acetyl H acetyl H H acetyl acetylacetyl H H H 4355 acetyl H acetyl H H acetyl acetyl acetyl H H acetyl4356 acetyl H acetyl H H acetyl acetyl acetyl H acetyl H 4357 acetyl Hacetyl H H acetyl acetyl acetyl H acetyl acetyl 4358 acetyl H acetyl H Hacetyl acetyl acetyl acetyl H H 4359 acetyl H acetyl H H acetyl acetylacetyl acetyl H acetyl 4360 acetyl H acetyl H H acetyl acetyl acetylacetyl acetyl H 4361 acetyl H acetyl H H acetyl acetyl acetyl acetylacetyl acetyl 4362 acetyl H acetyl H acetyl H H H H H H 4363 acetyl Hacetyl H acetyl H H H H H acetyl 4364 acetyl H acetyl H acetyl H H H Hacetyl H 4365 acetyl H acetyl H acetyl H H H H acetyl acetyl 4366 acetylH acetyl H acetyl H H H acetyl H H 4367 acetyl H acetyl H acetyl H H Hacetyl H acetyl 4368 acetyl H acetyl H acetyl H H H acetyl acetyl H 4369acetyl H acetyl H acetyl H H H acetyl acetyl acetyl 4370 acetyl H acetylH acetyl H H acetyl H H H 4371 acetyl H acetyl H acetyl H H acetyl H Hacetyl 4372 acetyl H acetyl H acetyl H H acetyl H acetyl H 4373 acetyl Hacetyl H acetyl H H acetyl H acetyl acetyl 4374 acetyl H acetyl H acetylH H acetyl acetyl H H 4375 acetyl H acetyl H acetyl H H acetyl acetyl Hacetyl 4376 acetyl H acetyl H acetyl H H acetyl acetyl acetyl H 4377acetyl H acetyl H acetyl H H acetyl acetyl acetyl acetyl 4378 acetyl Hacetyl H acetyl H acetyl H H H H 4379 acetyl H acetyl H acetyl H acetylH H H acetyl 4380 acetyl H acetyl H acetyl H acetyl H H acetyl H 4381acetyl H acetyl H acetyl H acetyl H H acetyl acetyl 4382 acetyl H acetylH acetyl H acetyl H acetyl H H 4383 acetyl H acetyl H acetyl H acetyl Hacetyl H acetyl 4384 acetyl H acetyl H acetyl H acetyl H acetyl acetyl H4385 acetyl H acetyl H acetyl H acetyl H acetyl acetyl acetyl 4386acetyl H acetyl H acetyl H acetyl acetyl H H H 4387 acetyl H acetyl Hacetyl H acetyl acetyl H H acetyl 4388 acetyl H acetyl H acetyl H acetylacetyl H acetyl H 4389 acetyl H acetyl H acetyl H acetyl acetyl H acetylacetyl 4390 acetyl H acetyl H acetyl H acetyl acetyl acetyl H H 4391acetyl H acetyl H acetyl H acetyl acetyl acetyl H acetyl 4392 acetyl Hacetyl H acetyl H acetyl acetyl acetyl acetyl H 4393 acetyl H acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl 4394 acetyl H acetyl Hacetyl acetyl H H H H H 4395 acetyl H acetyl H acetyl acetyl H H H Hacetyl 4396 acetyl H acetyl H acetyl acetyl H H H acetyl H 4397 acetyl Hacetyl H acetyl acetyl H H H acetyl acetyl 4398 acetyl H acetyl H acetylacetyl H H acetyl H H 4399 acetyl H acetyl H acetyl acetyl H H acetyl Hacetyl 4400 acetyl H acetyl H acetyl acetyl H H acetyl acetyl H 4401acetyl H acetyl H acetyl acetyl H H acetyl acetyl acetyl 4402 acetyl Hacetyl H acetyl acetyl H acetyl H H H 4403 acetyl H acetyl H acetylacetyl H acetyl H H acetyl 4404 acetyl H acetyl H acetyl acetyl H acetylH acetyl H 4405 acetyl H acetyl H acetyl acetyl H acetyl H acetyl acetyl4406 acetyl H acetyl H acetyl acetyl H acetyl acetyl H H 4407 acetyl Hacetyl H acetyl acetyl H acetyl acetyl H acetyl 4408 acetyl H acetyl Hacetyl acetyl H acetyl acetyl acetyl H 4409 acetyl H acetyl H acetylacetyl H acetyl acetyl acetyl acetyl 4410 acetyl H acetyl H acetylacetyl acetyl H H H H 4411 acetyl H acetyl H acetyl acetyl acetyl H H Hacetyl 4412 acetyl H acetyl H acetyl acetyl acetyl H H acetyl H 4413acetyl H acetyl H acetyl acetyl acetyl H H acetyl acetyl 4414 acetyl Hacetyl H acetyl acetyl acetyl H acetyl H H 4415 acetyl H acetyl H acetylacetyl acetyl H acetyl H acetyl 4416 acetyl H acetyl H acetyl acetylacetyl H acetyl acetyl H 4417 acetyl H acetyl H acetyl acetyl acetyl Hacetyl acetyl acetyl 4418 acetyl H acetyl H acetyl acetyl acetyl acetylH H H 4419 acetyl H acetyl H acetyl acetyl acetyl acetyl H H acetyl 4420acetyl H acetyl H acetyl acetyl acetyl acetyl H acetyl H 4421 acetyl Hacetyl H acetyl acetyl acetyl acetyl H acetyl acetyl 4422 acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl H H 4423 acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl H acetyl 4424 acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H 4425 acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl 4426 acetyl H acetylacetyl H H H H H H H 4427 acetyl H acetyl acetyl H H H H H H acetyl 4428acetyl H acetyl acetyl H H H H H acetyl H 4429 acetyl H acetyl acetyl HH H H H acetyl acetyl 4430 acetyl H acetyl acetyl H H H H acetyl H H4431 acetyl H acetyl acetyl H H H H acetyl H acetyl 4432 acetyl H acetylacetyl H H H H acetyl acetyl H 4433 acetyl H acetyl acetyl H H H Hacetyl acetyl acetyl 4434 acetyl H acetyl acetyl H H H acetyl H H H 4435acetyl H acetyl acetyl H H H acetyl H H acetyl 4436 acetyl H acetylacetyl H H H acetyl H acetyl H 4437 acetyl H acetyl acetyl H H H acetylH acetyl acetyl 4438 acetyl H acetyl acetyl H H H acetyl acetyl H H 4439acetyl H acetyl acetyl H H H acetyl acetyl H acetyl 4440 acetyl H acetylacetyl H H H acetyl acetyl acetyl H 4441 acetyl H acetyl acetyl H H Hacetyl acetyl acetyl acetyl 4442 acetyl H acetyl acetyl H H acetyl H H HH 4443 acetyl H acetyl acetyl H H acetyl H H H acetyl 4444 acetyl Hacetyl acetyl H H acetyl H H acetyl H 4445 acetyl H acetyl acetyl H Hacetyl H H acetyl acetyl 4446 acetyl H acetyl acetyl H H acetyl H acetylH H 4447 acetyl H acetyl acetyl H H acetyl H acetyl H acetyl 4448 acetylH acetyl acetyl H H acetyl H acetyl acetyl H 4449 acetyl H acetyl acetylH H acetyl H acetyl acetyl acetyl 4450 acetyl H acetyl acetyl H H acetylacetyl H H H 4451 acetyl H acetyl acetyl H H acetyl acetyl H H acetyl4452 acetyl H acetyl acetyl H H acetyl acetyl H acetyl H 4453 acetyl Hacetyl acetyl H H acetyl acetyl H acetyl acetyl 4454 acetyl H acetylacetyl H H acetyl acetyl acetyl H H 4455 acetyl H acetyl acetyl H Hacetyl acetyl acetyl H acetyl 4456 acetyl H acetyl acetyl H H acetylacetyl acetyl acetyl H 4457 acetyl H acetyl acetyl H H acetyl acetylacetyl acetyl acetyl 4458 acetyl H acetyl acetyl H acetyl H H H H H 4459acetyl H acetyl acetyl H acetyl H H H H acetyl 4460 acetyl H acetylacetyl H acetyl H H H acetyl H 4461 acetyl H acetyl acetyl H acetyl H HH acetyl acetyl 4462 acetyl H acetyl acetyl H acetyl H H acetyl H H 4463acetyl H acetyl acetyl H acetyl H H acetyl H acetyl 4464 acetyl H acetylacetyl H acetyl H H acetyl acetyl H 4465 acetyl H acetyl acetyl H acetylH H acetyl acetyl acetyl 4466 acetyl H acetyl acetyl H acetyl H acetyl HH H 4467 acetyl H acetyl acetyl H acetyl H acetyl H H acetyl 4468 acetylH acetyl acetyl H acetyl H acetyl H acetyl H 4469 acetyl H acetyl acetylH acetyl H acetyl H acetyl acetyl 4470 acetyl H acetyl acetyl H acetyl Hacetyl acetyl H H 4471 acetyl H acetyl acetyl H acetyl H acetyl acetyl Hacetyl 4472 acetyl H acetyl acetyl H acetyl H acetyl acetyl acetyl H4473 acetyl H acetyl acetyl H acetyl H acetyl acetyl acetyl acetyl 4474acetyl H acetyl acetyl H acetyl acetyl H H H H 4475 acetyl H acetylacetyl H acetyl acetyl H H H acetyl 4476 acetyl H acetyl acetyl H acetylacetyl H H acetyl H 4477 acetyl H acetyl acetyl H acetyl acetyl H Hacetyl acetyl 4478 acetyl H acetyl acetyl H acetyl acetyl H acetyl H H4479 acetyl H acetyl acetyl H acetyl acetyl H acetyl H acetyl 4480acetyl H acetyl acetyl H acetyl acetyl H acetyl acetyl H 4481 acetyl Hacetyl acetyl H acetyl acetyl H acetyl acetyl acetyl 4482 acetyl Hacetyl acetyl H acetyl acetyl acetyl H H H 4483 acetyl H acetyl acetyl Hacetyl acetyl acetyl H H acetyl 4484 acetyl H acetyl acetyl H acetylacetyl acetyl H acetyl H 4485 acetyl H acetyl acetyl H acetyl acetylacetyl H acetyl acetyl 4486 acetyl H acetyl acetyl H acetyl acetylacetyl acetyl H H 4487 acetyl H acetyl acetyl H acetyl acetyl acetylacetyl H acetyl 4488 acetyl H acetyl acetyl H acetyl acetyl acetylacetyl acetyl H 4489 acetyl H acetyl acetyl H acetyl acetyl acetylacetyl acetyl acetyl 4490 acetyl H acetyl acetyl acetyl H H H H H H 4491acetyl H acetyl acetyl acetyl H H H H H acetyl 4492 acetyl H acetylacetyl acetyl H H H H acetyl H 4493 acetyl H acetyl acetyl acetyl H H HH acetyl acetyl 4494 acetyl H acetyl acetyl acetyl H H H acetyl H H 4495acetyl H acetyl acetyl acetyl H H H acetyl H acetyl 4496 acetyl H acetylacetyl acetyl H H H acetyl acetyl H 4497 acetyl H acetyl acetyl acetyl HH H acetyl acetyl acetyl 4498 acetyl H acetyl acetyl acetyl H H acetyl HH H 4499 acetyl H acetyl acetyl acetyl H H acetyl H H acetyl 4500 acetylH acetyl acetyl acetyl H H acetyl H acetyl H 4501 acetyl H acetyl acetylacetyl H H acetyl H acetyl acetyl 4502 acetyl H acetyl acetyl acetyl H Hacetyl acetyl H H 4503 acetyl H acetyl acetyl acetyl H H acetyl acetyl Hacetyl 4504 acetyl H acetyl acetyl acetyl H H acetyl acetyl acetyl H4505 acetyl H acetyl acetyl acetyl H H acetyl acetyl acetyl acetyl 4506acetyl H acetyl acetyl acetyl H acetyl H H H H 4507 acetyl H acetylacetyl acetyl H acetyl H H H acetyl 4508 acetyl H acetyl acetyl acetyl Hacetyl H H acetyl H 4509 acetyl H acetyl acetyl acetyl H acetyl H Hacetyl acetyl 4510 acetyl H acetyl acetyl acetyl H acetyl H acetyl H H4511 acetyl H acetyl acetyl acetyl H acetyl H acetyl H acetyl 4512acetyl H acetyl acetyl acetyl H acetyl H acetyl acetyl H 4513 acetyl Hacetyl acetyl acetyl H acetyl H acetyl acetyl acetyl 4514 acetyl Hacetyl acetyl acetyl H acetyl acetyl H H H 4515 acetyl H acetyl acetylacetyl H acetyl acetyl H H acetyl 4516 acetyl H acetyl acetyl acetyl Hacetyl acetyl H acetyl H 4517 acetyl H acetyl acetyl acetyl H acetylacetyl H acetyl acetyl 4518 acetyl H acetyl acetyl acetyl H acetylacetyl acetyl H H 4519 acetyl H acetyl acetyl acetyl H acetyl acetylacetyl H acetyl 4520 acetyl H acetyl acetyl acetyl H acetyl acetylacetyl acetyl H 4521 acetyl H acetyl acetyl acetyl H acetyl acetylacetyl acetyl acetyl 4522 acetyl H acetyl acetyl acetyl acetyl H H H H H4523 acetyl H acetyl acetyl acetyl acetyl H H H H acetyl 4524 acetyl Hacetyl acetyl acetyl acetyl H H H acetyl H 4525 acetyl H acetyl acetylacetyl acetyl H H H acetyl acetyl 4526 acetyl H acetyl acetyl acetylacetyl H H acetyl H H 4527 acetyl H acetyl acetyl acetyl acetyl H Hacetyl H acetyl 4528 acetyl H acetyl acetyl acetyl acetyl H H acetylacetyl H 4529 acetyl H acetyl acetyl acetyl acetyl H H acetyl acetylacetyl 4530 acetyl H acetyl acetyl acetyl acetyl H acetyl H H H 4531acetyl H acetyl acetyl acetyl acetyl H acetyl H H acetyl 4532 acetyl Hacetyl acetyl acetyl acetyl H acetyl H acetyl H 4533 acetyl H acetylacetyl acetyl acetyl H acetyl H acetyl acetyl 4534 acetyl H acetylacetyl acetyl acetyl H acetyl acetyl H H 4535 acetyl H acetyl acetylacetyl acetyl H acetyl acetyl H acetyl 4536 acetyl H acetyl acetylacetyl acetyl H acetyl acetyl acetyl H 4537 acetyl H acetyl acetylacetyl acetyl H acetyl acetyl acetyl acetyl 4538 acetyl H acetyl acetylacetyl acetyl acetyl H H H H 4539 acetyl H acetyl acetyl acetyl acetylacetyl H H H acetyl 4540 acetyl H acetyl acetyl acetyl acetyl acetyl H Hacetyl H 4541 acetyl H acetyl acetyl acetyl acetyl acetyl H H acetylacetyl 4542 acetyl H acetyl acetyl acetyl acetyl acetyl H acetyl H H4543 acetyl H acetyl acetyl acetyl acetyl acetyl H acetyl H acetyl 4544acetyl H acetyl acetyl acetyl acetyl acetyl H acetyl acetyl H 4545acetyl H acetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetyl 4546acetyl H acetyl acetyl acetyl acetyl acetyl acetyl H H H 4547 acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H H acetyl 4548 acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H acetyl H 4549 acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl 4550 acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl H H 4551 acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl 4552 acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H 4553 acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl 4554acetyl acetyl H H H H H H H H H 4555 acetyl acetyl H H H H H H H Hacetyl 4556 acetyl acetyl H H H H H H H acetyl H 4557 acetyl acetyl H HH H H H H acetyl acetyl 4558 acetyl acetyl H H H H H H acetyl H H 4559acetyl acetyl H H H H H H acetyl H acetyl 4560 acetyl acetyl H H H H H Hacetyl acetyl H 4561 acetyl acetyl H H H H H H acetyl acetyl acetyl 4562acetyl acetyl H H H H H acetyl H H H 4563 acetyl acetyl H H H H H acetylH H acetyl 4564 acetyl acetyl H H H H H acetyl H acetyl H 4565 acetylacetyl H H H H H acetyl H acetyl acetyl 4566 acetyl acetyl H H H H Hacetyl acetyl H H 4567 acetyl acetyl H H H H H acetyl acetyl H acetyl4568 acetyl acetyl H H H H H acetyl acetyl acetyl H 4569 acetyl acetyl HH H H H acetyl acetyl acetyl acetyl 4570 acetyl acetyl H H H H acetyl HH H H 4571 acetyl acetyl H H H H acetyl H H H acetyl 4572 acetyl acetylH H H H acetyl H H acetyl H 4573 acetyl acetyl H H H H acetyl H H acetylacetyl 4574 acetyl acetyl H H H H acetyl H acetyl H H 4575 acetyl acetylH H H H acetyl H acetyl H acetyl 4576 acetyl acetyl H H H H acetyl Hacetyl acetyl H 4577 acetyl acetyl H H H H acetyl H acetyl acetyl acetyl4578 acetyl acetyl H H H H acetyl acetyl H H H 4579 acetyl acetyl H H HH acetyl acetyl H H acetyl 4580 acetyl acetyl H H H H acetyl acetyl Hacetyl H 4581 acetyl acetyl H H H H acetyl acetyl H acetyl acetyl 4582acetyl acetyl H H H H acetyl acetyl acetyl H H 4583 acetyl acetyl H H HH acetyl acetyl acetyl H acetyl 4584 acetyl acetyl H H H H acetyl acetylacetyl acetyl H 4585 acetyl acetyl H H H H acetyl acetyl acetyl acetylacetyl 4586 acetyl acetyl H H H acetyl H H H H H 4587 acetyl acetyl H HH acetyl H H H H acetyl 4588 acetyl acetyl H H H acetyl H H H acetyl H4589 acetyl acetyl H H H acetyl H H H acetyl acetyl 4590 acetyl acetyl HH H acetyl H H acetyl H H 4591 acetyl acetyl H H H acetyl H H acetyl Hacetyl 4592 acetyl acetyl H H H acetyl H H acetyl acetyl H 4593 acetylacetyl H H H acetyl H H acetyl acetyl acetyl 4594 acetyl acetyl H H Hacetyl H acetyl H H H 4595 acetyl acetyl H H H acetyl H acetyl H Hacetyl 4596 acetyl acetyl H H H acetyl H acetyl H acetyl H 4597 acetylacetyl H H H acetyl H acetyl H acetyl acetyl 4598 acetyl acetyl H H Hacetyl H acetyl acetyl H H 4599 acetyl acetyl H H H acetyl H acetylacetyl H acetyl 4600 acetyl acetyl H H H acetyl H acetyl acetyl acetyl H4601 acetyl acetyl H H H acetyl H acetyl acetyl acetyl acetyl 4602acetyl acetyl H H H acetyl acetyl H H H H 4603 acetyl acetyl H H Hacetyl acetyl H H H acetyl 4604 acetyl acetyl H H H acetyl acetyl H Hacetyl H 4605 acetyl acetyl H H H acetyl acetyl H H acetyl acetyl 4606acetyl acetyl H H H acetyl acetyl H acetyl H H 4607 acetyl acetyl H H Hacetyl acetyl H acetyl H acetyl 4608 acetyl acetyl H H H acetyl acetyl Hacetyl acetyl H 4609 acetyl acetyl H H H acetyl acetyl H acetyl acetylacetyl 4610 acetyl acetyl H H H acetyl acetyl acetyl H H H 4611 acetylacetyl H H H acetyl acetyl acetyl H H acetyl 4612 acetyl acetyl H H Hacetyl acetyl acetyl H acetyl H 4613 acetyl acetyl H H H acetyl acetylacetyl H acetyl acetyl 4614 acetyl acetyl H H H acetyl acetyl acetylacetyl H H 4615 acetyl acetyl H H H acetyl acetyl acetyl acetyl H acetyl4616 acetyl acetyl H H H acetyl acetyl acetyl acetyl acetyl H 4617acetyl acetyl H H H acetyl acetyl acetyl acetyl acetyl acetyl 4618acetyl acetyl H H acetyl H H H H H H 4619 acetyl acetyl H H acetyl H H HH H acetyl 4620 acetyl acetyl H H acetyl H H H H acetyl H 4621 acetylacetyl H H acetyl H H H H acetyl acetyl 4622 acetyl acetyl H H acetyl HH H acetyl H H 4623 acetyl acetyl H H acetyl H H H acetyl H acetyl 4624acetyl acetyl H H acetyl H H H acetyl acetyl H 4625 acetyl acetyl H Hacetyl H H H acetyl acetyl acetyl 4626 acetyl acetyl H H acetyl H Hacetyl H H H 4627 acetyl acetyl H H acetyl H H acetyl H H acetyl 4628acetyl acetyl H H acetyl H H acetyl H acetyl H 4629 acetyl acetyl H Hacetyl H H acetyl H acetyl acetyl 4630 acetyl acetyl H H acetyl H Hacetyl acetyl H H 4631 acetyl acetyl H H acetyl H H acetyl acetyl Hacetyl 4632 acetyl acetyl H H acetyl H H acetyl acetyl acetyl H 4633acetyl acetyl H H acetyl H H acetyl acetyl acetyl acetyl 4634 acetylacetyl H H acetyl H acetyl H H H H 4635 acetyl acetyl H H acetyl Hacetyl H H H acetyl 4636 acetyl acetyl H H acetyl H acetyl H H acetyl H4637 acetyl acetyl H H acetyl H acetyl H H acetyl acetyl 4638 acetylacetyl H H acetyl H acetyl H acetyl H H 4639 acetyl acetyl H H acetyl Hacetyl H acetyl H acetyl 4640 acetyl acetyl H H acetyl H acetyl H acetylacetyl H 4641 acetyl acetyl H H acetyl H acetyl H acetyl acetyl acetyl4642 acetyl acetyl H H acetyl H acetyl acetyl H H H 4643 acetyl acetyl HH acetyl H acetyl acetyl H H acetyl 4644 acetyl acetyl H H acetyl Hacetyl acetyl H acetyl H 4645 acetyl acetyl H H acetyl H acetyl acetyl Hacetyl acetyl 4646 acetyl acetyl H H acetyl H acetyl acetyl acetyl H H4647 acetyl acetyl H H acetyl H acetyl acetyl acetyl H acetyl 4648acetyl acetyl H H acetyl H acetyl acetyl acetyl acetyl H 4649 acetylacetyl H H acetyl H acetyl acetyl acetyl acetyl acetyl 4650 acetylacetyl H H acetyl acetyl H H H H H 4651 acetyl acetyl H H acetyl acetylH H H H acetyl 4652 acetyl acetyl H H acetyl acetyl H H H acetyl H 4653acetyl acetyl H H acetyl acetyl H H H acetyl acetyl 4654 acetyl acetyl HH acetyl acetyl H H acetyl H H 4655 acetyl acetyl H H acetyl acetyl H Hacetyl H acetyl 4656 acetyl acetyl H H acetyl acetyl H H acetyl acetyl H4657 acetyl acetyl H H acetyl acetyl H H acetyl acetyl acetyl 4658acetyl acetyl H H acetyl acetyl H acetyl H H H 4659 acetyl acetyl H Hacetyl acetyl H acetyl H H acetyl 4660 acetyl acetyl H H acetyl acetyl Hacetyl H acetyl H 4661 acetyl acetyl H H acetyl acetyl H acetyl H acetylacetyl 4662 acetyl acetyl H H acetyl acetyl H acetyl acetyl H H 4663acetyl acetyl H H acetyl acetyl H acetyl acetyl H acetyl 4664 acetylacetyl H H acetyl acetyl H acetyl acetyl acetyl H 4665 acetyl acetyl H Hacetyl acetyl H acetyl acetyl acetyl acetyl 4666 acetyl acetyl H Hacetyl acetyl acetyl H H H H 4667 acetyl acetyl H H acetyl acetyl acetylH H H acetyl 4668 acetyl acetyl H H acetyl acetyl acetyl H H acetyl H4669 acetyl acetyl H H acetyl acetyl acetyl H H acetyl acetyl 4670acetyl acetyl H H acetyl acetyl acetyl H acetyl H H 4671 acetyl acetyl HH acetyl acetyl acetyl H acetyl H acetyl 4672 acetyl acetyl H H acetylacetyl acetyl H acetyl acetyl H 4673 acetyl acetyl H H acetyl acetylacetyl H acetyl acetyl acetyl 4674 acetyl acetyl H H acetyl acetylacetyl acetyl H H H 4675 acetyl acetyl H H acetyl acetyl acetyl acetyl HH acetyl 4676 acetyl acetyl H H acetyl acetyl acetyl acetyl H acetyl H4677 acetyl acetyl H H acetyl acetyl acetyl acetyl H acetyl acetyl 4678acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl H H 4679 acetylacetyl H H acetyl acetyl acetyl acetyl acetyl H acetyl 4680 acetylacetyl H H acetyl acetyl acetyl acetyl acetyl acetyl H 4681 acetylacetyl H H acetyl acetyl acetyl acetyl acetyl acetyl acetyl 4682 acetylacetyl H acetyl H H H H H H H 4683 acetyl acetyl H acetyl H H H H H Hacetyl 4684 acetyl acetyl H acetyl H H H H H acetyl H 4685 acetyl acetylH acetyl H H H H H acetyl acetyl 4686 acetyl acetyl H acetyl H H H Hacetyl H H 4687 acetyl acetyl H acetyl H H H H acetyl H acetyl 4688acetyl acetyl H acetyl H H H H acetyl acetyl H 4689 acetyl acetyl Hacetyl H H H H acetyl acetyl acetyl 4690 acetyl acetyl H acetyl H H Hacetyl H H H 4691 acetyl acetyl H acetyl H H H acetyl H H acetyl 4692acetyl acetyl H acetyl H H H acetyl H acetyl H 4693 acetyl acetyl Hacetyl H H H acetyl H acetyl acetyl 4694 acetyl acetyl H acetyl H H Hacetyl acetyl H H 4695 acetyl acetyl H acetyl H H H acetyl acetyl Hacetyl 4696 acetyl acetyl H acetyl H H H acetyl acetyl acetyl H 4697acetyl acetyl H acetyl H H H acetyl acetyl acetyl acetyl 4698 acetylacetyl H acetyl H H acetyl H H H H 4699 acetyl acetyl H acetyl H Hacetyl H H H acetyl 4700 acetyl acetyl H acetyl H H acetyl H H acetyl H4701 acetyl acetyl H acetyl H H acetyl H H acetyl acetyl 4702 acetylacetyl H acetyl H H acetyl H acetyl H H 4703 acetyl acetyl H acetyl H Hacetyl H acetyl H acetyl 4704 acetyl acetyl H acetyl H H acetyl H acetylacetyl H 4705 acetyl acetyl H acetyl H H acetyl H acetyl acetyl acetyl4706 acetyl acetyl H acetyl H H acetyl acetyl H H H 4707 acetyl acetyl Hacetyl H H acetyl acetyl H H acetyl 4708 acetyl acetyl H acetyl H Hacetyl acetyl H acetyl H 4709 acetyl acetyl H acetyl H H acetyl acetyl Hacetyl acetyl 4710 acetyl acetyl H acetyl H H acetyl acetyl acetyl H H4711 acetyl acetyl H acetyl H H acetyl acetyl acetyl H acetyl 4712acetyl acetyl H acetyl H H acetyl acetyl acetyl acetyl H 4713 acetylacetyl H acetyl H H acetyl acetyl acetyl acetyl acetyl 4714 acetylacetyl H acetyl H acetyl H H H H H 4715 acetyl acetyl H acetyl H acetylH H H H acetyl 4716 acetyl acetyl H acetyl H acetyl H H H acetyl H 4717acetyl acetyl H acetyl H acetyl H H H acetyl acetyl 4718 acetyl acetyl Hacetyl H acetyl H H acetyl H H 4719 acetyl acetyl H acetyl H acetyl H Hacetyl H acetyl 4720 acetyl acetyl H acetyl H acetyl H H acetyl acetyl H4721 acetyl acetyl H acetyl H acetyl H H acetyl acetyl acetyl 4722acetyl acetyl H acetyl H acetyl H acetyl H H H 4723 acetyl acetyl Hacetyl H acetyl H acetyl H H acetyl 4724 acetyl acetyl H acetyl H acetylH acetyl H acetyl H 4725 acetyl acetyl H acetyl H acetyl H acetyl Hacetyl acetyl 4726 acetyl acetyl H acetyl H acetyl H acetyl acetyl H H4727 acetyl acetyl H acetyl H acetyl H acetyl acetyl H acetyl 4728acetyl acetyl H acetyl H acetyl H acetyl acetyl acetyl H 4729 acetylacetyl H acetyl H acetyl H acetyl acetyl acetyl acetyl 4730 acetylacetyl H acetyl H acetyl acetyl H H H H 4731 acetyl acetyl H acetyl Hacetyl acetyl H H H acetyl 4732 acetyl acetyl H acetyl H acetyl acetyl HH acetyl H 4733 acetyl acetyl H acetyl H acetyl acetyl H H acetyl acetyl4734 acetyl acetyl H acetyl H acetyl acetyl H acetyl H H 4735 acetylacetyl H acetyl H acetyl acetyl H acetyl H acetyl 4736 acetyl acetyl Hacetyl H acetyl acetyl H acetyl acetyl H 4737 acetyl acetyl H acetyl Hacetyl acetyl H acetyl acetyl acetyl 4738 acetyl acetyl H acetyl Hacetyl acetyl acetyl H H H 4739 acetyl acetyl H acetyl H acetyl acetylacetyl H H acetyl 4740 acetyl acetyl H acetyl H acetyl acetyl acetyl Hacetyl H 4741 acetyl acetyl H acetyl H acetyl acetyl acetyl H acetylacetyl 4742 acetyl acetyl H acetyl H acetyl acetyl acetyl acetyl H H4743 acetyl acetyl H acetyl H acetyl acetyl acetyl acetyl H acetyl 4744acetyl acetyl H acetyl H acetyl acetyl acetyl acetyl acetyl H 4745acetyl acetyl H acetyl H acetyl acetyl acetyl acetyl acetyl acetyl 4746acetyl acetyl H acetyl acetyl H H H H H H 4747 acetyl acetyl H acetylacetyl H H H H H acetyl 4748 acetyl acetyl H acetyl acetyl H H H Hacetyl H 4749 acetyl acetyl H acetyl acetyl H H H H acetyl acetyl 4750acetyl acetyl H acetyl acetyl H H H acetyl H H 4751 acetyl acetyl Hacetyl acetyl H H H acetyl H acetyl 4752 acetyl acetyl H acetyl acetyl HH H acetyl acetyl H 4753 acetyl acetyl H acetyl acetyl H H H acetylacetyl acetyl 4754 acetyl acetyl H acetyl acetyl H H acetyl H H H 4755acetyl acetyl H acetyl acetyl H H acetyl H H acetyl 4756 acetyl acetyl Hacetyl acetyl H H acetyl H acetyl H 4757 acetyl acetyl H acetyl acetyl HH acetyl H acetyl acetyl 4758 acetyl acetyl H acetyl acetyl H H acetylacetyl H H 4759 acetyl acetyl H acetyl acetyl H H acetyl acetyl H acetyl4760 acetyl acetyl H acetyl acetyl H H acetyl acetyl acetyl H 4761acetyl acetyl H acetyl acetyl H H acetyl acetyl acetyl acetyl 4762acetyl acetyl H acetyl acetyl H acetyl H H H H 4763 acetyl acetyl Hacetyl acetyl H acetyl H H H acetyl 4764 acetyl acetyl H acetyl acetyl Hacetyl H H acetyl H 4765 acetyl acetyl H acetyl acetyl H acetyl H Hacetyl acetyl 4766 acetyl acetyl H acetyl acetyl H acetyl H acetyl H H4767 acetyl acetyl H acetyl acetyl H acetyl H acetyl H acetyl 4768acetyl acetyl H acetyl acetyl H acetyl H acetyl acetyl H 4769 acetylacetyl H acetyl acetyl H acetyl H acetyl acetyl acetyl 4770 acetylacetyl H acetyl acetyl H acetyl acetyl H H H 4771 acetyl acetyl H acetylacetyl H acetyl acetyl H H acetyl 4772 acetyl acetyl H acetyl acetyl Hacetyl acetyl H acetyl H 4773 acetyl acetyl H acetyl acetyl H acetylacetyl H acetyl acetyl 4774 acetyl acetyl H acetyl acetyl H acetylacetyl acetyl H H 4775 acetyl acetyl H acetyl acetyl H acetyl acetylacetyl H acetyl 4776 acetyl acetyl H acetyl acetyl H acetyl acetylacetyl acetyl H 4777 acetyl acetyl H acetyl acetyl H acetyl acetylacetyl acetyl acetyl 4778 acetyl acetyl H acetyl acetyl acetyl H H H H H4779 acetyl acetyl H acetyl acetyl acetyl H H H H acetyl 4780 acetylacetyl H acetyl acetyl acetyl H H H acetyl H 4781 acetyl acetyl H acetylacetyl acetyl H H H acetyl acetyl 4782 acetyl acetyl H acetyl acetylacetyl H H acetyl H H 4783 acetyl acetyl H acetyl acetyl acetyl H Hacetyl H acetyl 4784 acetyl acetyl H acetyl acetyl acetyl H H acetylacetyl H 4785 acetyl acetyl H acetyl acetyl acetyl H H acetyl acetylacetyl 4786 acetyl acetyl H acetyl acetyl acetyl H acetyl H H H 4787acetyl acetyl H acetyl acetyl acetyl H acetyl H H acetyl 4788 acetylacetyl H acetyl acetyl acetyl H acetyl H acetyl H 4789 acetyl acetyl Hacetyl acetyl acetyl H acetyl H acetyl acetyl 4790 acetyl acetyl Hacetyl acetyl acetyl H acetyl acetyl H H 4791 acetyl acetyl H acetylacetyl acetyl H acetyl acetyl H acetyl 4792 acetyl acetyl H acetylacetyl acetyl H acetyl acetyl acetyl H 4793 acetyl acetyl H acetylacetyl acetyl H acetyl acetyl acetyl acetyl 4794 acetyl acetyl H acetylacetyl acetyl acetyl H H H H 4795 acetyl acetyl H acetyl acetyl acetylacetyl H H H acetyl 4796 acetyl acetyl H acetyl acetyl acetyl acetyl H Hacetyl H 4797 acetyl acetyl H acetyl acetyl acetyl acetyl H H acetylacetyl 4798 acetyl acetyl H acetyl acetyl acetyl acetyl H acetyl H H4799 acetyl acetyl H acetyl acetyl acetyl acetyl H acetyl H acetyl 4800acetyl acetyl H acetyl acetyl acetyl acetyl H acetyl acetyl H 4801acetyl acetyl H acetyl acetyl acetyl acetyl H acetyl acetyl acetyl 4802acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H H H 4803 acetylacetyl H acetyl acetyl acetyl acetyl acetyl H H acetyl 4804 acetylacetyl H acetyl acetyl acetyl acetyl acetyl H acetyl H 4805 acetylacetyl H acetyl acetyl acetyl acetyl acetyl H acetyl acetyl 4806 acetylacetyl H acetyl acetyl acetyl acetyl acetyl acetyl H H 4807 acetylacetyl H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl 4808 acetylacetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl H 4809 acetylacetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl 4810acetyl acetyl acetyl H H H H H H H H 4811 acetyl acetyl acetyl H H H H HH H acetyl 4812 acetyl acetyl acetyl H H H H H H acetyl H 4813 acetylacetyl acetyl H H H H H H acetyl acetyl 4814 acetyl acetyl acetyl H H HH H acetyl H H 4815 acetyl acetyl acetyl H H H H H acetyl H acetyl 4816acetyl acetyl acetyl H H H H H acetyl acetyl H 4817 acetyl acetyl acetylH H H H H acetyl acetyl acetyl 4818 acetyl acetyl acetyl H H H H acetylH H H 4819 acetyl acetyl acetyl H H H H acetyl H H acetyl 4820 acetylacetyl acetyl H H H H acetyl H acetyl H 4821 acetyl acetyl acetyl H H HH acetyl H acetyl acetyl 4822 acetyl acetyl acetyl H H H H acetyl acetylH H 4823 acetyl acetyl acetyl H H H H acetyl acetyl H acetyl 4824 acetylacetyl acetyl H H H H acetyl acetyl acetyl H 4825 acetyl acetyl acetyl HH H H acetyl acetyl acetyl acetyl 4826 acetyl acetyl acetyl H H H acetylH H H H 4827 acetyl acetyl acetyl H H H acetyl H H H acetyl 4828 acetylacetyl acetyl H H H acetyl H H acetyl H 4829 acetyl acetyl acetyl H H Hacetyl H H acetyl acetyl 4830 acetyl acetyl acetyl H H H acetyl H acetylH H 4831 acetyl acetyl acetyl H H H acetyl H acetyl H acetyl 4832 acetylacetyl acetyl H H H acetyl H acetyl acetyl H 4833 acetyl acetyl acetyl HH H acetyl H acetyl acetyl acetyl 4834 acetyl acetyl acetyl H H H acetylacetyl H H H 4835 acetyl acetyl acetyl H H H acetyl acetyl H H acetyl4836 acetyl acetyl acetyl H H H acetyl acetyl H acetyl H 4837 acetylacetyl acetyl H H H acetyl acetyl H acetyl acetyl 4838 acetyl acetylacetyl H H H acetyl acetyl acetyl H H 4839 acetyl acetyl acetyl H H Hacetyl acetyl acetyl H acetyl 4840 acetyl acetyl acetyl H H H acetylacetyl acetyl acetyl H 4841 acetyl acetyl acetyl H H H acetyl acetylacetyl acetyl acetyl 4842 acetyl acetyl acetyl H H acetyl H H H H H 4843acetyl acetyl acetyl H H acetyl H H H H acetyl 4844 acetyl acetyl acetylH H acetyl H H H acetyl H 4845 acetyl acetyl acetyl H H acetyl H H Hacetyl acetyl 4846 acetyl acetyl acetyl H H acetyl H H acetyl H H 4847acetyl acetyl acetyl H H acetyl H H acetyl H acetyl 4848 acetyl acetylacetyl H H acetyl H H acetyl acetyl H 4849 acetyl acetyl acetyl H Hacetyl H H acetyl acetyl acetyl 4850 acetyl acetyl acetyl H H acetyl Hacetyl H H H 4851 acetyl acetyl acetyl H H acetyl H acetyl H H acetyl4852 acetyl acetyl acetyl H H acetyl H acetyl H acetyl H 4853 acetylacetyl acetyl H H acetyl H acetyl H acetyl acetyl 4854 acetyl acetylacetyl H H acetyl H acetyl acetyl H H 4855 acetyl acetyl acetyl H Hacetyl H acetyl acetyl H acetyl 4856 acetyl acetyl acetyl H H acetyl Hacetyl acetyl acetyl H 4857 acetyl acetyl acetyl H H acetyl H acetylacetyl acetyl acetyl 4858 acetyl acetyl acetyl H H acetyl acetyl H H H H4859 acetyl acetyl acetyl H H acetyl acetyl H H H acetyl 4860 acetylacetyl acetyl H H acetyl acetyl H H acetyl H 4861 acetyl acetyl acetyl HH acetyl acetyl H H acetyl acetyl 4862 acetyl acetyl acetyl H H acetylacetyl H acetyl H H 4863 acetyl acetyl acetyl H H acetyl acetyl H acetylH acetyl 4864 acetyl acetyl acetyl H H acetyl acetyl H acetyl acetyl H4865 acetyl acetyl acetyl H H acetyl acetyl H acetyl acetyl acetyl 4866acetyl acetyl acetyl H H acetyl acetyl acetyl H H H 4867 acetyl acetylacetyl H H acetyl acetyl acetyl H H acetyl 4868 acetyl acetyl acetyl H Hacetyl acetyl acetyl H acetyl H 4869 acetyl acetyl acetyl H H acetylacetyl acetyl H acetyl acetyl 4870 acetyl acetyl acetyl H H acetylacetyl acetyl acetyl H H 4871 acetyl acetyl acetyl H H acetyl acetylacetyl acetyl H acetyl 4872 acetyl acetyl acetyl H H acetyl acetylacetyl acetyl acetyl H 4873 acetyl acetyl acetyl H H acetyl acetylacetyl acetyl acetyl acetyl 4874 acetyl acetyl acetyl H acetyl H H H H HH 4875 acetyl acetyl acetyl H acetyl H H H H H acetyl 4876 acetyl acetylacetyl H acetyl H H H H acetyl H 4877 acetyl acetyl acetyl H acetyl H HH H acetyl acetyl 4878 acetyl acetyl acetyl H acetyl H H H acetyl H H4879 acetyl acetyl acetyl H acetyl H H H acetyl H acetyl 4880 acetylacetyl acetyl H acetyl H H H acetyl acetyl H 4881 acetyl acetyl acetyl Hacetyl H H H acetyl acetyl acetyl 4882 acetyl acetyl acetyl H acetyl H Hacetyl H H H 4883 acetyl acetyl acetyl H acetyl H H acetyl H H acetyl4884 acetyl acetyl acetyl H acetyl H H acetyl H acetyl H 4885 acetylacetyl acetyl H acetyl H H acetyl H acetyl acetyl 4886 acetyl acetylacetyl H acetyl H H acetyl acetyl H H 4887 acetyl acetyl acetyl H acetylH H acetyl acetyl H acetyl 4888 acetyl acetyl acetyl H acetyl H H acetylacetyl acetyl H 4889 acetyl acetyl acetyl H acetyl H H acetyl acetylacetyl acetyl 4890 acetyl acetyl acetyl H acetyl H acetyl H H H H 4891acetyl acetyl acetyl H acetyl H acetyl H H H acetyl 4892 acetyl acetylacetyl H acetyl H acetyl H H acetyl H 4893 acetyl acetyl acetyl H acetylH acetyl H H acetyl acetyl 4894 acetyl acetyl acetyl H acetyl H acetyl Hacetyl H H 4895 acetyl acetyl acetyl H acetyl H acetyl H acetyl H acetyl4896 acetyl acetyl acetyl H acetyl H acetyl H acetyl acetyl H 4897acetyl acetyl acetyl H acetyl H acetyl H acetyl acetyl acetyl 4898acetyl acetyl acetyl H acetyl H acetyl acetyl H H H 4899 acetyl acetylacetyl H acetyl H acetyl acetyl H H acetyl 4900 acetyl acetyl acetyl Hacetyl H acetyl acetyl H acetyl H 4901 acetyl acetyl acetyl H acetyl Hacetyl acetyl H acetyl acetyl 4902 acetyl acetyl acetyl H acetyl Hacetyl acetyl acetyl H H 4903 acetyl acetyl acetyl H acetyl H acetylacetyl acetyl H acetyl 4904 acetyl acetyl acetyl H acetyl H acetylacetyl acetyl acetyl H 4905 acetyl acetyl acetyl H acetyl H acetylacetyl acetyl acetyl acetyl 4906 acetyl acetyl acetyl H acetyl acetyl HH H H H 4907 acetyl acetyl acetyl H acetyl acetyl H H H H acetyl 4908acetyl acetyl acetyl H acetyl acetyl H H H acetyl H 4909 acetyl acetylacetyl H acetyl acetyl H H H acetyl acetyl 4910 acetyl acetyl acetyl Hacetyl acetyl H H acetyl H H 4911 acetyl acetyl acetyl H acetyl acetyl HH acetyl H acetyl 4912 acetyl acetyl acetyl H acetyl acetyl H H acetylacetyl H 4913 acetyl acetyl acetyl H acetyl acetyl H H acetyl acetylacetyl 4914 acetyl acetyl acetyl H acetyl acetyl H acetyl H H H 4915acetyl acetyl acetyl H acetyl acetyl H acetyl H H acetyl 4916 acetylacetyl acetyl H acetyl acetyl H acetyl H acetyl H 4917 acetyl acetylacetyl H acetyl acetyl H acetyl H acetyl acetyl 4918 acetyl acetylacetyl H acetyl acetyl H acetyl acetyl H H 4919 acetyl acetyl acetyl Hacetyl acetyl H acetyl acetyl H acetyl 4920 acetyl acetyl acetyl Hacetyl acetyl H acetyl acetyl acetyl H 4921 acetyl acetyl acetyl Hacetyl acetyl H acetyl acetyl acetyl acetyl 4922 acetyl acetyl acetyl Hacetyl acetyl acetyl H H H H 4923 acetyl acetyl acetyl H acetyl acetylacetyl H H H acetyl 4924 acetyl acetyl acetyl H acetyl acetyl acetyl H Hacetyl H 4925 acetyl acetyl acetyl H acetyl acetyl acetyl H H acetylacetyl 4926 acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl H H4927 acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl H acetyl 4928acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl H 4929acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl 4930acetyl acetyl acetyl H acetyl acetyl acetyl acetyl H H H 4931 acetylacetyl acetyl H acetyl acetyl acetyl acetyl H H acetyl 4932 acetylacetyl acetyl H acetyl acetyl acetyl acetyl H acetyl H 4933 acetylacetyl acetyl H acetyl acetyl acetyl acetyl H acetyl acetyl 4934 acetylacetyl acetyl H acetyl acetyl acetyl acetyl acetyl H H 4935 acetylacetyl acetyl H acetyl acetyl acetyl acetyl acetyl H acetyl 4936 acetylacetyl acetyl H acetyl acetyl acetyl acetyl acetyl acetyl H 4937 acetylacetyl acetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl 4938acetyl acetyl acetyl acetyl H H H H H H H 4939 acetyl acetyl acetylacetyl H H H H H H acetyl 4940 acetyl acetyl acetyl acetyl H H H H Hacetyl H 4941 acetyl acetyl acetyl acetyl H H H H H acetyl acetyl 4942acetyl acetyl acetyl acetyl H H H H acetyl H H 4943 acetyl acetyl acetylacetyl H H H H acetyl H acetyl 4944 acetyl acetyl acetyl acetyl H H H Hacetyl acetyl H 4945 acetyl acetyl acetyl acetyl H H H H acetyl acetylacetyl 4946 acetyl acetyl acetyl acetyl H H H acetyl H H H 4947 acetylacetyl acetyl acetyl H H H acetyl H H acetyl 4948 acetyl acetyl acetylacetyl H H H acetyl H acetyl H 4949 acetyl acetyl acetyl acetyl H H Hacetyl H acetyl acetyl 4950 acetyl acetyl acetyl acetyl H H H acetylacetyl H H 4951 acetyl acetyl acetyl acetyl H H H acetyl acetyl H acetyl4952 acetyl acetyl acetyl acetyl H H H acetyl acetyl acetyl H 4953acetyl acetyl acetyl acetyl H H H acetyl acetyl acetyl acetyl 4954acetyl acetyl acetyl acetyl H H acetyl H H H H 4955 acetyl acetyl acetylacetyl H H acetyl H H H acetyl 4956 acetyl acetyl acetyl acetyl H Hacetyl H H acetyl H 4957 acetyl acetyl acetyl acetyl H H acetyl H Hacetyl acetyl 4958 acetyl acetyl acetyl acetyl H H acetyl H acetyl H H4959 acetyl acetyl acetyl acetyl H H acetyl H acetyl H acetyl 4960acetyl acetyl acetyl acetyl H H acetyl H acetyl acetyl H 4961 acetylacetyl acetyl acetyl H H acetyl H acetyl acetyl acetyl 4962 acetylacetyl acetyl acetyl H H acetyl acetyl H H H 4963 acetyl acetyl acetylacetyl H H acetyl acetyl H H acetyl 4964 acetyl acetyl acetyl acetyl H Hacetyl acetyl H acetyl H 4965 acetyl acetyl acetyl acetyl H H acetylacetyl H acetyl acetyl 4966 acetyl acetyl acetyl acetyl H H acetylacetyl acetyl H H 4967 acetyl acetyl acetyl acetyl H H acetyl acetylacetyl H acetyl 4968 acetyl acetyl acetyl acetyl H H acetyl acetylacetyl acetyl H 4969 acetyl acetyl acetyl acetyl H H acetyl acetylacetyl acetyl acetyl 4970 acetyl acetyl acetyl acetyl H acetyl H H H H H4971 acetyl acetyl acetyl acetyl H acetyl H H H H acetyl 4972 acetylacetyl acetyl acetyl H acetyl H H H acetyl H 4973 acetyl acetyl acetylacetyl H acetyl H H H acetyl acetyl 4974 acetyl acetyl acetyl acetyl Hacetyl H H acetyl H H 4975 acetyl acetyl acetyl acetyl H acetyl H Hacetyl H acetyl 4976 acetyl acetyl acetyl acetyl H acetyl H H acetylacetyl H 4977 acetyl acetyl acetyl acetyl H acetyl H H acetyl acetylacetyl 4978 acetyl acetyl acetyl acetyl H acetyl H acetyl H H H 4979acetyl acetyl acetyl acetyl H acetyl H acetyl H H acetyl 4980 acetylacetyl acetyl acetyl H acetyl H acetyl H acetyl H 4981 acetyl acetylacetyl acetyl H acetyl H acetyl H acetyl acetyl 4982 acetyl acetylacetyl acetyl H acetyl H acetyl acetyl H H 4983 acetyl acetyl acetylacetyl H acetyl H acetyl acetyl H acetyl 4984 acetyl acetyl acetylacetyl H acetyl H acetyl acetyl acetyl H 4985 acetyl acetyl acetylacetyl H acetyl H acetyl acetyl acetyl acetyl 4986 acetyl acetyl acetylacetyl H acetyl acetyl H H H H 4987 acetyl acetyl acetyl acetyl H acetylacetyl H H H acetyl 4988 acetyl acetyl acetyl acetyl H acetyl acetyl H Hacetyl H 4989 acetyl acetyl acetyl acetyl H acetyl acetyl H H acetylacetyl 4990 acetyl acetyl acetyl acetyl H acetyl acetyl H acetyl H H4991 acetyl acetyl acetyl acetyl H acetyl acetyl H acetyl H acetyl 4992acetyl acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl H 4993acetyl acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl acetyl 4994acetyl acetyl acetyl acetyl H acetyl acetyl acetyl H H H 4995 acetylacetyl acetyl acetyl H acetyl acetyl acetyl H H acetyl 4996 acetylacetyl acetyl acetyl H acetyl acetyl acetyl H acetyl H 4997 acetylacetyl acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl 4998 acetylacetyl acetyl acetyl H acetyl acetyl acetyl acetyl H H 4999 acetylacetyl acetyl acetyl H acetyl acetyl acetyl acetyl H acetyl 5000 acetylacetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H 5001 acetylacetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl acetyl 5002acetyl acetyl acetyl acetyl acetyl H H H H H H 5003 acetyl acetyl acetylacetyl acetyl H H H H H acetyl 5004 acetyl acetyl acetyl acetyl acetyl HH H H acetyl H 5005 acetyl acetyl acetyl acetyl acetyl H H H H acetylacetyl 5006 acetyl acetyl acetyl acetyl acetyl H H H acetyl H H 5007acetyl acetyl acetyl acetyl acetyl H H H acetyl H acetyl 5008 acetylacetyl acetyl acetyl acetyl H H H acetyl acetyl H 5009 acetyl acetylacetyl acetyl acetyl H H H acetyl acetyl acetyl 5010 acetyl acetylacetyl acetyl acetyl H H acetyl H H H 5011 acetyl acetyl acetyl acetylacetyl H H acetyl H H acetyl 5012 acetyl acetyl acetyl acetyl acetyl H Hacetyl H acetyl H 5013 acetyl acetyl acetyl acetyl acetyl H H acetyl Hacetyl acetyl 5014 acetyl acetyl acetyl acetyl acetyl H H acetyl acetylH H 5015 acetyl acetyl acetyl acetyl acetyl H H acetyl acetyl H acetyl5016 acetyl acetyl acetyl acetyl acetyl H H acetyl acetyl acetyl H 5017acetyl acetyl acetyl acetyl acetyl H H acetyl acetyl acetyl acetyl 5018acetyl acetyl acetyl acetyl acetyl H acetyl H H H H 5019 acetyl acetylacetyl acetyl acetyl H acetyl H H H acetyl 5020 acetyl acetyl acetylacetyl acetyl H acetyl H H acetyl H 5021 acetyl acetyl acetyl acetylacetyl H acetyl H H acetyl acetyl 5022 acetyl acetyl acetyl acetylacetyl H acetyl H acetyl H H 5023 acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl H acetyl 5024 acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl acetyl H 5025 acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl acetyl acetyl 5026 acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl H H H 5027 acetyl acetyl acetyl acetyl acetyl H acetylacetyl H H acetyl 5028 acetyl acetyl acetyl acetyl acetyl H acetylacetyl H acetyl H 5029 acetyl acetyl acetyl acetyl acetyl H acetylacetyl H acetyl acetyl 5030 acetyl acetyl acetyl acetyl acetyl H acetylacetyl acetyl H H 5031 acetyl acetyl acetyl acetyl acetyl H acetylacetyl acetyl H acetyl 5032 acetyl acetyl acetyl acetyl acetyl H acetylacetyl acetyl acetyl H 5033 acetyl acetyl acetyl acetyl acetyl H acetylacetyl acetyl acetyl acetyl 5034 acetyl acetyl acetyl acetyl acetylacetyl H H H H H 5035 acetyl acetyl acetyl acetyl acetyl acetyl H H H Hacetyl 5036 acetyl acetyl acetyl acetyl acetyl acetyl H H H acetyl H5037 acetyl acetyl acetyl acetyl acetyl acetyl H H H acetyl acetyl 5038acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl H H 5039 acetylacetyl acetyl acetyl acetyl acetyl H H acetyl H acetyl 5040 acetylacetyl acetyl acetyl acetyl acetyl H H acetyl acetyl H 5041 acetylacetyl acetyl acetyl acetyl acetyl H H acetyl acetyl acetyl 5042 acetylacetyl acetyl acetyl acetyl acetyl H acetyl H H H 5043 acetyl acetylacetyl acetyl acetyl acetyl H acetyl H H acetyl 5044 acetyl acetylacetyl acetyl acetyl acetyl H acetyl H acetyl H 5045 acetyl acetylacetyl acetyl acetyl acetyl H acetyl H acetyl acetyl 5046 acetyl acetylacetyl acetyl acetyl acetyl H acetyl acetyl H H 5047 acetyl acetylacetyl acetyl acetyl acetyl H acetyl acetyl H acetyl 5048 acetyl acetylacetyl acetyl acetyl acetyl H acetyl acetyl acetyl H 5049 acetyl acetylacetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetyl 5050 acetylacetyl acetyl acetyl acetyl acetyl acetyl H H H H 5051 acetyl acetylacetyl acetyl acetyl acetyl acetyl H H H acetyl 5052 acetyl acetylacetyl acetyl acetyl acetyl acetyl H H acetyl H 5053 acetyl acetylacetyl acetyl acetyl acetyl acetyl H H acetyl acetyl 5054 acetyl acetylacetyl acetyl acetyl acetyl acetyl H acetyl H H 5055 acetyl acetylacetyl acetyl acetyl acetyl acetyl H acetyl H acetyl 5056 acetyl acetylacetyl acetyl acetyl acetyl acetyl H acetyl acetyl H 5057 acetyl acetylacetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetyl 5058 acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl H H H 5059 acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl 5060 acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl H 5061 acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl 5062acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H H 5063acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl5064 acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetylacetyl H

TABLE 9 (duodecasaccharides) (Y is either H or a carrier) n10; n11, R2n1, R1 n2, R1 n3, R1 n4, R1 n5, R1 n6, R1 n7, R1 n8, R1 n9, R1 R1 R15065 H H H H H H H H H H H acetyl 5066 H H H H H H H H H H acetyl H 5067H H H H H H H H H H acetyl acetyl 5068 H H H H H H H H H acetyl H H 5069H H H H H H H H H acetyl H acetyl 5070 H H H H H H H H H acetyl acetyl H5071 H H H H H H H H H acetyl acetyl acetyl 5072 H H H H H H H H acetylH H H 5073 H H H H H H H H acetyl H H acetyl 5074 H H H H H H H H acetylH acetyl H 5075 H H H H H H H H acetyl H acetyl acetyl 5076 H H H H H HH H acetyl acetyl H H 5077 H H H H H H H H acetyl acetyl H Acetyl 5078 HH H H H H H H acetyl acetyl acetyl H 5079 H H H H H H H H acetyl acetylacetyl Acetyl 5080 H H H H H H H acetyl H H H H 5081 H H H H H H Hacetyl H H H Acetyl 5082 H H H H H H H acetyl H H acetyl H 5083 H H H HH H H acetyl H H acetyl acetyl 5084 H H H H H H H acetyl H acetyl H H5085 H H H H H H H acetyl H acetyl H acetyl 5086 H H H H H H H acetyl Hacetyl acetyl H 5087 H H H H H H H acetyl H acetyl acetyl acetyl 5088 HH H H H H H acetyl acetyl H H H 5089 H H H H H H H acetyl acetyl H Hacetyl 5090 H H H H H H H acetyl acetyl H acetyl H 5091 H H H H H H Hacetyl acetyl H acetyl acetyl 5092 H H H H H H H acetyl acetyl acetyl HH 5093 H H H H H H H acetyl acetyl acetyl H acetyl 5094 H H H H H H Hacetyl acetyl acetyl acetyl H 5095 H H H H H H H acetyl acetyl acetylacetyl acetyl 5096 H H H H H H acetyl H H H H H 5097 H H H H H H acetylH H H H acetyl 5098 H H H H H H acetyl H H H acetyl H 5099 H H H H H Hacetyl H H H acetyl acetyl 5100 H H H H H H acetyl H H acetyl H H 5101 HH H H H H acetyl H H acetyl H acetyl 5102 H H H H H H acetyl H H acetylacetyl H 5103 H H H H H H acetyl H H acetyl acetyl acetyl 5104 H H H H HH acetyl H acetyl H H H 5105 H H H H H H acetyl H acetyl H H acetyl 5106H H H H H H acetyl H acetyl H acetyl H 5107 H H H H H H acetyl H acetylH acetyl acetyl 5108 H H H H H H acetyl H acetyl acetyl H H 5109 H H H HH H acetyl H acetyl acetyl H acetyl 5110 H H H H H H acetyl H acetylacetyl acetyl H 5111 H H H H H H acetyl H acetyl acetyl acetyl acetyl5112 H H H H H H acetyl acetyl H H H H 5113 H H H H H H acetyl acetyl HH H acetyl 5114 H H H H H H acetyl acetyl H H acetyl H 5115 H H H H H Hacetyl acetyl H H acetyl acetyl 5116 H H H H H H acetyl acetyl H acetylH H 5117 H H H H H H acetyl acetyl H acetyl H acetyl 5118 H H H H H Hacetyl acetyl H acetyl acetyl H 5119 H H H H H H acetyl acetyl H acetylacetyl acetyl 5120 H H H H H H acetyl acetyl acetyl H H H 5121 H H H H HH acetyl acetyl acetyl H H acetyl 5122 H H H H H H acetyl acetyl acetylH acetyl H 5123 H H H H H H acetyl acetyl acetyl H acetyl acetyl 5124 HH H H H H acetyl acetyl acetyl acetyl H H 5125 H H H H H H acetyl acetylacetyl acetyl H acetyl 5126 H H H H H H acetyl acetyl acetyl acetylacetyl H 5127 H H H H H H acetyl acetyl acetyl acetyl acetyl acetyl 5128H H H H H acetyl H H H H H H 5129 H H H H H acetyl H H H H H acetyl 5130H H H H H acetyl H H H H acetyl H 5131 H H H H H acetyl H H H H acetylacetyl 5132 H H H H H acetyl H H H acetyl H H 5133 H H H H H acetyl H HH acetyl H acetyl 5134 H H H H H acetyl H H H acetyl acetyl H 5135 H H HH H acetyl H H H acetyl acetyl acetyl 5136 H H H H H acetyl H H acetyl HH H 5137 H H H H H acetyl H H acetyl H H acetyl 5138 H H H H H acetyl HH acetyl H acetyl H 5139 H H H H H acetyl H H acetyl H acetyl acetyl5140 H H H H H acetyl H H acetyl acetyl H H 5141 H H H H H acetyl H Hacetyl acetyl H acetyl 5142 H H H H H acetyl H H acetyl acetyl acetyl H5143 H H H H H acetyl H H acetyl acetyl acetyl acetyl 5144 H H H H Hacetyl H acetyl H H H H 5145 H H H H H acetyl H acetyl H H H acetyl 5146H H H H H acetyl H acetyl H H acetyl H 5147 H H H H H acetyl H acetyl HH acetyl acetyl 5148 H H H H H acetyl H acetyl H acetyl H H 5149 H H H HH acetyl H acetyl H acetyl H acetyl 5150 H H H H H acetyl H acetyl Hacetyl acetyl H 5151 H H H H H acetyl H acetyl H acetyl acetyl acetyl5152 H H H H H acetyl H acetyl acetyl H H H 5153 H H H H H acetyl Hacetyl acetyl H H acetyl 5154 H H H H H acetyl H acetyl acetyl H acetylH 5155 H H H H H acetyl H acetyl acetyl H acetyl acetyl 5156 H H H H Hacetyl H acetyl acetyl acetyl H H 5157 H H H H H acetyl H acetyl acetylacetyl H acetyl 5158 H H H H H acetyl H acetyl acetyl acetyl acetyl H5159 H H H H H acetyl H acetyl acetyl acetyl acetyl acetyl 5160 H H H HH acetyl acetyl H H H H H 5161 H H H H H acetyl acetyl H H H H acetyl5162 H H H H H acetyl acetyl H H H acetyl H 5163 H H H H H acetyl acetylH H H acetyl acetyl 5164 H H H H H acetyl acetyl H H acetyl H H 5165 H HH H H acetyl acetyl H H acetyl H acetyl 5166 H H H H H acetyl acetyl H Hacetyl acetyl H 5167 H H H H H acetyl acetyl H H acetyl acetyl acetyl5168 H H H H H acetyl acetyl H acetyl H H H 5169 H H H H H acetyl acetylH acetyl H H acetyl 5170 H H H H H acetyl acetyl H acetyl H acetyl H5171 H H H H H acetyl acetyl H acetyl H acetyl acetyl 5172 H H H H Hacetyl acetyl H acetyl acetyl H H 5173 H H H H H acetyl acetyl H acetylacetyl H acetyl 5174 H H H H H acetyl acetyl H acetyl acetyl acetyl H5175 H H H H H acetyl acetyl H acetyl acetyl acetyl acetyl 5176 H H H HH acetyl acetyl acetyl H H H H 5177 H H H H H acetyl acetyl acetyl H H Hacetyl 5178 H H H H H acetyl acetyl acetyl H H acetyl H 5179 H H H H Hacetyl acetyl acetyl H H acetyl acetyl 5180 H H H H H acetyl acetylacetyl H acetyl H H 5181 H H H H H acetyl acetyl acetyl H acetyl Hacetyl 5182 H H H H H acetyl acetyl acetyl H acetyl acetyl H 5183 H H HH H acetyl acetyl acetyl H acetyl acetyl acetyl 5184 H H H H H acetylacetyl acetyl acetyl H H H 5185 H H H H H acetyl acetyl acetyl acetyl HH acetyl 5186 H H H H H acetyl acetyl acetyl acetyl H acetyl H 5187 H HH H H acetyl acetyl acetyl acetyl H acetyl acetyl 5188 H H H H H acetylacetyl acetyl acetyl acetyl H H 5189 H H H H H acetyl acetyl acetylacetyl acetyl H acetyl 5190 H H H H H acetyl acetyl acetyl acetyl acetylacetyl H 5191 H H H H H acetyl acetyl acetyl acetyl acetyl acetyl acetyl5192 H H H H acetyl H H H H H H H 5193 H H H H acetyl H H H H H H acetyl5194 H H H H acetyl H H H H H acetyl H 5195 H H H H acetyl H H H H Hacetyl acetyl 5196 H H H H acetyl H H H H acetyl H H 5197 H H H H acetylH H H H acetyl H acetyl 5198 H H H H acetyl H H H H acetyl acetyl H 5199H H H H acetyl H H H H acetyl acetyl acetyl 5200 H H H H acetyl H H Hacetyl H H H 5201 H H H H acetyl H H H acetyl H H acetyl 5202 H H H Hacetyl H H H acetyl H acetyl H 5203 H H H H acetyl H H H acetyl H acetylacetyl 5204 H H H H acetyl H H H acetyl acetyl H H 5205 H H H H acetyl HH H acetyl acetyl H acetyl 5206 H H H H acetyl H H H acetyl acetylacetyl H 5207 H H H H acetyl H H H acetyl acetyl acetyl acetyl 5208 H HH H acetyl H H acetyl H H H H 5209 H H H H acetyl H H acetyl H H Hacetyl 5210 H H H H acetyl H H acetyl H H acetyl H 5211 H H H H acetyl HH acetyl H H acetyl acetyl 5212 H H H H acetyl H H acetyl H acetyl H H5213 H H H H acetyl H H acetyl H acetyl H acetyl 5214 H H H H acetyl H Hacetyl H acetyl acetyl H 5215 H H H H acetyl H H acetyl H acetyl acetylacetyl 5216 H H H H acetyl H H acetyl acetyl H H H 5217 H H H H acetyl HH acetyl acetyl H H acetyl 5218 H H H H acetyl H H acetyl acetyl Hacetyl H 5219 H H H H acetyl H H acetyl acetyl H acetyl acetyl 5220 H HH H acetyl H H acetyl acetyl acetyl H H 5221 H H H H acetyl H H acetylacetyl acetyl H acetyl 5222 H H H H acetyl H H acetyl acetyl acetylacetyl H 5223 H H H H acetyl H H acetyl acetyl acetyl acetyl acetyl 5224H H H H acetyl H acetyl H H H H H 5225 H H H H acetyl H acetyl H H H Hacetyl 5226 H H H H acetyl H acetyl H H H acetyl H 5227 H H H H acetyl Hacetyl H H H acetyl acetyl 5228 H H H H acetyl H acetyl H H acetyl H H5229 H H H H acetyl H acetyl H H acetyl H acetyl 5230 H H H H acetyl Hacetyl H H acetyl acetyl H 5231 H H H H acetyl H acetyl H H acetylacetyl acetyl 5232 H H H H acetyl H acetyl H acetyl H H H 5233 H H H Hacetyl H acetyl H acetyl H H acetyl 5234 H H H H acetyl H acetyl Hacetyl H acetyl H 5235 H H H H acetyl H acetyl H acetyl H acetyl acetyl5236 H H H H acetyl H acetyl H acetyl acetyl H H 5237 H H H H acetyl Hacetyl H acetyl acetyl H acetyl 5238 H H H H acetyl H acetyl H acetylacetyl acetyl H 5239 H H H H acetyl H acetyl H acetyl acetyl acetylacetyl 5240 H H H H acetyl H acetyl acetyl H H H H 5241 H H H H acetyl Hacetyl acetyl H H H acetyl 5242 H H H H acetyl H acetyl acetyl H Hacetyl H 5243 H H H H acetyl H acetyl acetyl H H acetyl acetyl 5244 H HH H acetyl H acetyl acetyl H acetyl H H 5245 H H H H acetyl H acetylacetyl H acetyl H acetyl 5246 H H H H acetyl H acetyl acetyl H acetylacetyl H 5247 H H H H acetyl H acetyl acetyl H acetyl acetyl acetyl 5248H H H H acetyl H acetyl acetyl acetyl H H H 5249 H H H H acetyl H acetylacetyl acetyl H H acetyl 5250 H H H H acetyl H acetyl acetyl acetyl Hacetyl H 5251 H H H H acetyl H acetyl acetyl acetyl H acetyl acetyl 5252H H H H acetyl H acetyl acetyl acetyl acetyl H H 5253 H H H H acetyl Hacetyl acetyl acetyl acetyl H acetyl 5254 H H H H acetyl H acetyl acetylacetyl acetyl acetyl H 5255 H H H H acetyl H acetyl acetyl acetyl acetylacetyl acetyl 5256 H H H H acetyl acetyl H H H H H H 5257 H H H H acetylacetyl H H H H H acetyl 5258 H H H H acetyl acetyl H H H H acetyl H 5259H H H H acetyl acetyl H H H H acetyl acetyl 5260 H H H H acetyl acetyl HH H acetyl H H 5261 H H H H acetyl acetyl H H H acetyl H acetyl 5262 H HH H acetyl acetyl H H H acetyl acetyl H 5263 H H H H acetyl acetyl H H Hacetyl acetyl acetyl 5264 H H H H acetyl acetyl H H acetyl H H H 5265 HH H H acetyl acetyl H H acetyl H H acetyl 5266 H H H H acetyl acetyl H Hacetyl H acetyl H 5267 H H H H acetyl acetyl H H acetyl H acetyl acetyl5268 H H H H acetyl acetyl H H acetyl acetyl H H 5269 H H H H acetylacetyl H H acetyl acetyl H acetyl 5270 H H H H acetyl acetyl H H acetylacetyl acetyl H 5271 H H H H acetyl acetyl H H acetyl acetyl acetylacetyl 5272 H H H H acetyl acetyl H acetyl H H H H 5273 H H H H acetylacetyl H acetyl H H H acetyl 5274 H H H H acetyl acetyl H acetyl H Hacetyl H 5275 H H H H acetyl acetyl H acetyl H H acetyl acetyl 5276 H HH H acetyl acetyl H acetyl H acetyl H H 5277 H H H H acetyl acetyl Hacetyl H acetyl H acetyl 5278 H H H H acetyl acetyl H acetyl H acetylacetyl H 5279 H H H H acetyl acetyl H acetyl H acetyl acetyl acetyl 5280H H H H acetyl acetyl H acetyl acetyl H H H 5281 H H H H acetyl acetyl Hacetyl acetyl H H acetyl 5282 H H H H acetyl acetyl H acetyl acetyl Hacetyl H 5283 H H H H acetyl acetyl H acetyl acetyl H acetyl acetyl 5284H H H H acetyl acetyl H acetyl acetyl acetyl H H 5285 H H H H acetylacetyl H acetyl acetyl acetyl H acetyl 5286 H H H H acetyl acetyl Hacetyl acetyl acetyl acetyl H 5287 H H H H acetyl acetyl H acetyl acetylacetyl acetyl acetyl 5288 H H H H acetyl acetyl acetyl H H H H H 5289 HH H H acetyl acetyl acetyl H H H H acetyl 5290 H H H H acetyl acetylacetyl H H H acetyl H 5291 H H H H acetyl acetyl acetyl H H H acetylacetyl 5292 H H H H acetyl acetyl acetyl H H acetyl H H 5293 H H H Hacetyl acetyl acetyl H H acetyl H acetyl 5294 H H H H acetyl acetylacetyl H H acetyl acetyl H 5295 H H H H acetyl acetyl acetyl H H acetylacetyl acetyl 5296 H H H H acetyl acetyl acetyl H acetyl H H H 5297 H HH H acetyl acetyl acetyl H acetyl H H acetyl 5298 H H H H acetyl acetylacetyl H acetyl H acetyl H 5299 H H H H acetyl acetyl acetyl H acetyl Hacetyl acetyl 5300 H H H H acetyl acetyl acetyl H acetyl acetyl H H 5301H H H H acetyl acetyl acetyl H acetyl acetyl H acetyl 5302 H H H Hacetyl acetyl acetyl H acetyl acetyl acetyl H 5303 H H H H acetyl acetylacetyl H acetyl acetyl acetyl acetyl 5304 H H H H acetyl acetyl acetylacetyl H H H H 5305 H H H H acetyl acetyl acetyl acetyl H H H acetyl5306 H H H H acetyl acetyl acetyl acetyl H H acetyl H 5307 H H H Hacetyl acetyl acetyl acetyl H H acetyl acetyl 5308 H H H H acetyl acetylacetyl acetyl H acetyl H H 5309 H H H H acetyl acetyl acetyl acetyl Hacetyl H acetyl 5310 H H H H acetyl acetyl acetyl acetyl H acetyl acetylH 5311 H H H H acetyl acetyl acetyl acetyl H acetyl acetyl acetyl 5312 HH H H acetyl acetyl acetyl acetyl acetyl H H H 5313 H H H H acetylacetyl acetyl acetyl acetyl H H acetyl 5314 H H H H acetyl acetyl acetylacetyl acetyl H acetyl H 5315 H H H H acetyl acetyl acetyl acetyl acetylH acetyl acetyl 5316 H H H H acetyl acetyl acetyl acetyl acetyl acetyl HH 5317 H H H H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl 5318 HH H H acetyl acetyl acetyl acetyl acetyl acetyl acetyl H 5319 H H H Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl 5320 H H Hacetyl H H H H H H H H 5321 H H H acetyl H H H H H H H acetyl 5322 H H Hacetyl H H H H H H acetyl H 5323 H H H acetyl H H H H H H acetyl acetyl5324 H H H acetyl H H H H H acetyl H H 5325 H H H acetyl H H H H Hacetyl H acetyl 5326 H H H acetyl H H H H H acetyl acetyl H 5327 H H Hacetyl H H H H H acetyl acetyl acetyl 5328 H H H acetyl H H H H acetyl HH H 5329 H H H acetyl H H H H acetyl H H acetyl 5330 H H H acetyl H H HH acetyl H acetyl H 5331 H H H acetyl H H H H acetyl H acetyl acetyl5332 H H H acetyl H H H H acetyl acetyl H H 5333 H H H acetyl H H H Hacetyl acetyl H acetyl 5334 H H H acetyl H H H H acetyl acetyl acetyl H5335 H H H acetyl H H H H acetyl acetyl acetyl acetyl 5336 H H H acetylH H H acetyl H H H H 5337 H H H acetyl H H H acetyl H H H acetyl 5338 HH H acetyl H H H acetyl H H acetyl H 5339 H H H acetyl H H H acetyl H Hacetyl acetyl 5340 H H H acetyl H H H acetyl H acetyl H H 5341 H H Hacetyl H H H acetyl H acetyl H acetyl 5342 H H H acetyl H H H acetyl Hacetyl acetyl H 5343 H H H acetyl H H H acetyl H acetyl acetyl acetyl5344 H H H acetyl H H H acetyl acetyl H H H 5345 H H H acetyl H H Hacetyl acetyl H H acetyl 5346 H H H acetyl H H H acetyl acetyl H acetylH 5347 H H H acetyl H H H acetyl acetyl H acetyl acetyl 5348 H H Hacetyl H H H acetyl acetyl acetyl H H 5349 H H H acetyl H H H acetylacetyl acetyl H acetyl 5350 H H H acetyl H H H acetyl acetyl acetylacetyl H 5351 H H H acetyl H H H acetyl acetyl acetyl acetyl acetyl 5352H H H acetyl H H acetyl H H H H H 5353 H H H acetyl H H acetyl H H H Hacetyl 5354 H H H acetyl H H acetyl H H H acetyl H 5355 H H H acetyl H Hacetyl H H H acetyl acetyl 5356 H H H acetyl H H acetyl H H acetyl H H5357 H H H acetyl H H acetyl H H acetyl H acetyl 5358 H H H acetyl H Hacetyl H H acetyl acetyl H 5359 H H H acetyl H H acetyl H H acetylacetyl acetyl 5360 H H H acetyl H H acetyl H acetyl H H H 5361 H H Hacetyl H H acetyl H acetyl H H acetyl 5362 H H H acetyl H H acetyl Hacetyl H acetyl H 5363 H H H acetyl H H acetyl H acetyl H acetyl acetyl5364 H H H acetyl H H acetyl H acetyl acetyl H H 5365 H H H acetyl H Hacetyl H acetyl acetyl H acetyl 5366 H H H acetyl H H acetyl H acetylacetyl acetyl H 5367 H H H acetyl H H acetyl H acetyl acetyl acetylacetyl 5368 H H H acetyl H H acetyl acetyl H H H H 5369 H H H acetyl H Hacetyl acetyl H H H acetyl 5370 H H H acetyl H H acetyl acetyl H Hacetyl H 5371 H H H acetyl H H acetyl acetyl H H acetyl acetyl 5372 H HH acetyl H H acetyl acetyl H acetyl H H 5373 H H H acetyl H H acetylacetyl H acetyl H acetyl 5374 H H H acetyl H H acetyl acetyl H acetylacetyl H 5375 H H H acetyl H H acetyl acetyl H acetyl acetyl acetyl 5376H H H acetyl H H acetyl acetyl acetyl H H H 5377 H H H acetyl H H acetylacetyl acetyl H H acetyl 5378 H H H acetyl H H acetyl acetyl acetyl Hacetyl H 5379 H H H acetyl H H acetyl acetyl acetyl H acetyl acetyl 5380H H H acetyl H H acetyl acetyl acetyl acetyl H H 5381 H H H acetyl H Hacetyl acetyl acetyl acetyl H acetyl 5382 H H H acetyl H H acetyl acetylacetyl acetyl acetyl H 5383 H H H acetyl H H acetyl acetyl acetyl acetylacetyl acetyl 5384 H H H acetyl H acetyl H H H H H H 5385 H H H acetyl Hacetyl H H H H H acetyl 5386 H H H acetyl H acetyl H H H H acetyl H 5387H H H acetyl H acetyl H H H H acetyl acetyl 5388 H H H acetyl H acetyl HH H acetyl H H 5389 H H H acetyl H acetyl H H H acetyl H acetyl 5390 H HH acetyl H acetyl H H H acetyl acetyl H 5391 H H H acetyl H acetyl H H Hacetyl acetyl acetyl 5392 H H H acetyl H acetyl H H acetyl H H H 5393 HH H acetyl H acetyl H H acetyl H H acetyl 5394 H H H acetyl H acetyl H Hacetyl H acetyl H 5395 H H H acetyl H acetyl H H acetyl H acetyl acetyl5396 H H H acetyl H acetyl H H acetyl acetyl H H 5397 H H H acetyl Hacetyl H H acetyl acetyl H acetyl 5398 H H H acetyl H acetyl H H acetylacetyl acetyl H 5399 H H H acetyl H acetyl H H acetyl acetyl acetylacetyl 5400 H H H acetyl H acetyl H acetyl H H H H 5401 H H H acetyl Hacetyl H acetyl H H H acetyl 5402 H H H acetyl H acetyl H acetyl H Hacetyl H 5403 H H H acetyl H acetyl H acetyl H H acetyl acetyl 5404 H HH acetyl H acetyl H acetyl H acetyl H H 5405 H H H acetyl H acetyl Hacetyl H acetyl H acetyl 5406 H H H acetyl H acetyl H acetyl H acetylacetyl H 5407 H H H acetyl H acetyl H acetyl H acetyl acetyl acetyl 5408H H H acetyl H acetyl H acetyl acetyl H H H 5409 H H H acetyl H acetyl Hacetyl acetyl H H acetyl 5410 H H H acetyl H acetyl H acetyl acetyl Hacetyl H 5411 H H H acetyl H acetyl H acetyl acetyl H acetyl acetyl 5412H H H acetyl H acetyl H acetyl acetyl acetyl H H 5413 H H H acetyl Hacetyl H acetyl acetyl acetyl H acetyl 5414 H H H acetyl H acetyl Hacetyl acetyl acetyl acetyl H 5415 H H H acetyl H acetyl H acetyl acetylacetyl acetyl acetyl 5416 H H H acetyl H acetyl acetyl H H H H H 5417 HH H acetyl H acetyl acetyl H H H H acetyl 5418 H H H acetyl H acetylacetyl H H H acetyl H 5419 H H H acetyl H acetyl acetyl H H H acetylacetyl 5420 H H H acetyl H acetyl acetyl H H acetyl H H 5421 H H Hacetyl H acetyl acetyl H H acetyl H acetyl 5422 H H H acetyl H acetylacetyl H H acetyl acetyl H 5423 H H H acetyl H acetyl acetyl H H acetylacetyl acetyl 5424 H H H acetyl H acetyl acetyl H acetyl H H H 5425 H HH acetyl H acetyl acetyl H acetyl H H acetyl 5426 H H H acetyl H acetylacetyl H acetyl H acetyl H 5427 H H H acetyl H acetyl acetyl H acetyl Hacetyl acetyl 5428 H H H acetyl H acetyl acetyl H acetyl acetyl H H 5429H H H acetyl H acetyl acetyl H acetyl acetyl H acetyl 5430 H H H acetylH acetyl acetyl H acetyl acetyl acetyl H 5431 H H H acetyl H acetylacetyl H acetyl acetyl acetyl acetyl 5432 H H H acetyl H acetyl acetylacetyl H H H H 5433 H H H acetyl H acetyl acetyl acetyl H H H acetyl5434 H H H acetyl H acetyl acetyl acetyl H H acetyl H 5435 H H H acetylH acetyl acetyl acetyl H H acetyl acetyl 5436 H H H acetyl H acetylacetyl acetyl H acetyl H H 5437 H H H acetyl H acetyl acetyl acetyl Hacetyl H acetyl 5438 H H H acetyl H acetyl acetyl acetyl H acetyl acetylH 5439 H H H acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl 5440 HH H acetyl H acetyl acetyl acetyl acetyl H H H 5441 H H H acetyl Hacetyl acetyl acetyl acetyl H H acetyl 5442 H H H acetyl H acetyl acetylacetyl acetyl H acetyl H 5443 H H H acetyl H acetyl acetyl acetyl acetylH acetyl acetyl 5444 H H H acetyl H acetyl acetyl acetyl acetyl acetyl HH 5445 H H H acetyl H acetyl acetyl acetyl acetyl acetyl H acetyl 5446 HH H acetyl H acetyl acetyl acetyl acetyl acetyl acetyl H 5447 H H Hacetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl 5448 H H Hacetyl acetyl H H H H H H H 5449 H H H acetyl acetyl H H H H H H acetyl5450 H H H acetyl acetyl H H H H H acetyl H 5451 H H H acetyl acetyl H HH H H acetyl acetyl 5452 H H H acetyl acetyl H H H H acetyl H H 5453 H HH acetyl acetyl H H H H acetyl H acetyl 5454 H H H acetyl acetyl H H H Hacetyl acetyl H 5455 H H H acetyl acetyl H H H H acetyl acetyl acetyl5456 H H H acetyl acetyl H H H acetyl H H H 5457 H H H acetyl acetyl H HH acetyl H H acetyl 5458 H H H acetyl acetyl H H H acetyl H acetyl H5459 H H H acetyl acetyl H H H acetyl H acetyl acetyl 5460 H H H acetylacetyl H H H acetyl acetyl H H 5461 H H H acetyl acetyl H H H acetylacetyl H acetyl 5462 H H H acetyl acetyl H H H acetyl acetyl acetyl H5463 H H H acetyl acetyl H H H acetyl acetyl acetyl acetyl 5464 H H Hacetyl acetyl H H acetyl H H H H 5465 H H H acetyl acetyl H H acetyl H HH acetyl 5466 H H H acetyl acetyl H H acetyl H H acetyl H 5467 H H Hacetyl acetyl H H acetyl H H acetyl acetyl 5468 H H H acetyl acetyl H Hacetyl H acetyl H H 5469 H H H acetyl acetyl H H acetyl H acetyl Hacetyl 5470 H H H acetyl acetyl H H acetyl H acetyl acetyl H 5471 H H Hacetyl acetyl H H acetyl H acetyl acetyl acetyl 5472 H H H acetyl acetylH H acetyl acetyl H H H 5473 H H H acetyl acetyl H H acetyl acetyl H Hacetyl 5474 H H H acetyl acetyl H H acetyl acetyl H acetyl H 5475 H H Hacetyl acetyl H H acetyl acetyl H acetyl acetyl 5476 H H H acetyl acetylH H acetyl acetyl acetyl H H 5477 H H H acetyl acetyl H H acetyl acetylacetyl H acetyl 5478 H H H acetyl acetyl H H acetyl acetyl acetyl acetylH 5479 H H H acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl 5480 HH H acetyl acetyl H acetyl H H H H H 5481 H H H acetyl acetyl H acetyl HH H H acetyl 5482 H H H acetyl acetyl H acetyl H H H acetyl H 5483 H H Hacetyl acetyl H acetyl H H H acetyl acetyl 5484 H H H acetyl acetyl Hacetyl H H acetyl H H 5485 H H H acetyl acetyl H acetyl H H acetyl Hacetyl 5486 H H H acetyl acetyl H acetyl H H acetyl acetyl H 5487 H H Hacetyl acetyl H acetyl H H acetyl acetyl acetyl 5488 H H H acetyl acetylH acetyl H acetyl H H H 5489 H H H acetyl acetyl H acetyl H acetyl H Hacetyl 5490 H H H acetyl acetyl H acetyl H acetyl H acetyl H 5491 H H Hacetyl acetyl H acetyl H acetyl H acetyl acetyl 5492 H H H acetyl acetylH acetyl H acetyl acetyl H H 5493 H H H acetyl acetyl H acetyl H acetylacetyl H acetyl 5494 H H H acetyl acetyl H acetyl H acetyl acetyl acetylH 5495 H H H acetyl acetyl H acetyl H acetyl acetyl acetyl acetyl 5496 HH H acetyl acetyl H acetyl acetyl H H H H 5497 H H H acetyl acetyl Hacetyl acetyl H H H acetyl 5498 H H H acetyl acetyl H acetyl acetyl H Hacetyl H 5499 H H H acetyl acetyl H acetyl acetyl H H acetyl acetyl 5500H H H acetyl acetyl H acetyl acetyl H acetyl H H 5501 H H H acetylacetyl H acetyl acetyl H acetyl H acetyl 5502 H H H acetyl acetyl Hacetyl acetyl H acetyl acetyl H 5503 H H H acetyl acetyl H acetyl acetylH acetyl acetyl acetyl 5504 H H H acetyl acetyl H acetyl acetyl acetyl HH H 5505 H H H acetyl acetyl H acetyl acetyl acetyl H H acetyl 5506 H HH acetyl acetyl H acetyl acetyl acetyl H acetyl H 5507 H H H acetylacetyl H acetyl acetyl acetyl H acetyl acetyl 5508 H H H acetyl acetyl Hacetyl acetyl acetyl acetyl H H 5509 H H H acetyl acetyl H acetyl acetylacetyl acetyl H acetyl 5510 H H H acetyl acetyl H acetyl acetyl acetylacetyl acetyl H 5511 H H H acetyl acetyl H acetyl acetyl acetyl acetylacetyl acetyl 5512 H H H acetyl acetyl acetyl H H H H H H 5513 H H Hacetyl acetyl acetyl H H H H H acetyl 5514 H H H acetyl acetyl acetyl HH H H acetyl H 5515 H H H acetyl acetyl acetyl H H H H acetyl acetyl5516 H H H acetyl acetyl acetyl H H H acetyl H H 5517 H H H acetylacetyl acetyl H H H acetyl H acetyl 5518 H H H acetyl acetyl acetyl H HH acetyl acetyl H 5519 H H H acetyl acetyl acetyl H H H acetyl acetylacetyl 5520 H H H acetyl acetyl acetyl H H acetyl H H H 5521 H H Hacetyl acetyl acetyl H H acetyl H H acetyl 5522 H H H acetyl acetylacetyl H H acetyl H acetyl H 5523 H H H acetyl acetyl acetyl H H acetylH acetyl acetyl 5524 H H H acetyl acetyl acetyl H H acetyl acetyl H H5525 H H H acetyl acetyl acetyl H H acetyl acetyl H acetyl 5526 H H Hacetyl acetyl acetyl H H acetyl acetyl acetyl H 5527 H H H acetyl acetylacetyl H H acetyl acetyl acetyl acetyl 5528 H H H acetyl acetyl acetyl Hacetyl H H H H 5529 H H H acetyl acetyl acetyl H acetyl H H H acetyl5530 H H H acetyl acetyl acetyl H acetyl H H acetyl H 5531 H H H acetylacetyl acetyl H acetyl H H acetyl acetyl 5532 H H H acetyl acetyl acetylH acetyl H acetyl H H 5533 H H H acetyl acetyl acetyl H acetyl H acetylH acetyl 5534 H H H acetyl acetyl acetyl H acetyl H acetyl acetyl H 5535H H H acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl 5536 H H Hacetyl acetyl acetyl H acetyl acetyl H H H 5537 H H H acetyl acetylacetyl H acetyl acetyl H H acetyl 5538 H H H acetyl acetyl acetyl Hacetyl acetyl H acetyl H 5539 H H H acetyl acetyl acetyl H acetyl acetylH acetyl acetyl 5540 H H H acetyl acetyl acetyl H acetyl acetyl acetyl HH 5541 H H H acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl 5542 HH H acetyl acetyl acetyl H acetyl acetyl acetyl acetyl H 5543 H H Hacetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl 5544 H H Hacetyl acetyl acetyl acetyl H H H H H 5545 H H H acetyl acetyl acetylacetyl H H H H acetyl 5546 H H H acetyl acetyl acetyl acetyl H H Hacetyl H 5547 H H H acetyl acetyl acetyl acetyl H H H acetyl acetyl 5548H H H acetyl acetyl acetyl acetyl H H acetyl H H 5549 H H H acetylacetyl acetyl acetyl H H acetyl H acetyl 5550 H H H acetyl acetyl acetylacetyl H H acetyl acetyl H 5551 H H H acetyl acetyl acetyl acetyl H Hacetyl acetyl acetyl 5552 H H H acetyl acetyl acetyl acetyl H acetyl H HH 5553 H H H acetyl acetyl acetyl acetyl H acetyl H H acetyl 5554 H H Hacetyl acetyl acetyl acetyl H acetyl H acetyl H 5555 H H H acetyl acetylacetyl acetyl H acetyl H acetyl acetyl 5556 H H H acetyl acetyl acetylacetyl H acetyl acetyl H H 5557 H H H acetyl acetyl acetyl acetyl Hacetyl acetyl H acetyl 5558 H H H acetyl acetyl acetyl acetyl H acetylacetyl acetyl H 5559 H H H acetyl acetyl acetyl acetyl H acetyl acetylacetyl acetyl 5560 H H H acetyl acetyl acetyl acetyl acetyl H H H H 5561H H H acetyl acetyl acetyl acetyl acetyl H H H acetyl 5562 H H H acetylacetyl acetyl acetyl acetyl H H acetyl H 5563 H H H acetyl acetyl acetylacetyl acetyl H H acetyl acetyl 5564 H H H acetyl acetyl acetyl acetylacetyl H acetyl H H 5565 H H H acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl 5566 H H H acetyl acetyl acetyl acetyl acetyl H acetylacetyl H 5567 H H H acetyl acetyl acetyl acetyl acetyl H acetyl acetylacetyl 5568 H H H acetyl acetyl acetyl acetyl acetyl acetyl H H H 5569 HH H acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl 5570 H H Hacetyl acetyl acetyl acetyl acetyl acetyl H acetyl H 5571 H H H acetylacetyl acetyl acetyl acetyl acetyl H acetyl acetyl 5572 H H H acetylacetyl acetyl acetyl acetyl acetyl acetyl H H 5573 H H H acetyl acetylacetyl acetyl acetyl acetyl acetyl H acetyl 5574 H H H acetyl acetylacetyl acetyl acetyl acetyl acetyl acetyl H 5575 H H H acetyl acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl 5576 H H acetyl H H H HH H H H H 5577 H H acetyl H H H H H H H H acetyl 5578 H H acetyl H H H HH H H acetyl H 5579 H H acetyl H H H H H H H acetyl acetyl 5580 H Hacetyl H H H H H H acetyl H H 5581 H H acetyl H H H H H H acetyl Hacetyl 5582 H H acetyl H H H H H H acetyl acetyl H 5583 H H acetyl H H HH H H acetyl acetyl acetyl 5584 H H acetyl H H H H H acetyl H H H 5585 HH acetyl H H H H H acetyl H H acetyl 5586 H H acetyl H H H H H acetyl Hacetyl H 5587 H H acetyl H H H H H acetyl H acetyl acetyl 5588 H Hacetyl H H H H H acetyl acetyl H H 5589 H H acetyl H H H H H acetylacetyl H acetyl 5590 H H acetyl H H H H H acetyl acetyl acetyl H 5591 HH acetyl H H H H H acetyl acetyl acetyl acetyl 5592 H H acetyl H H H Hacetyl H H H H 5593 H H acetyl H H H H acetyl H H H acetyl 5594 H Hacetyl H H H H acetyl H H acetyl H 5595 H H acetyl H H H H acetyl H Hacetyl acetyl 5596 H H acetyl H H H H acetyl H acetyl H H 5597 H Hacetyl H H H H acetyl H acetyl H acetyl 5598 H H acetyl H H H H acetyl Hacetyl acetyl H 5599 H H acetyl H H H H acetyl H acetyl acetyl acetyl5600 H H acetyl H H H H acetyl acetyl H H H 5601 H H acetyl H H H Hacetyl acetyl H H acetyl 5602 H H acetyl H H H H acetyl acetyl H acetylH 5603 H H acetyl H H H H acetyl acetyl H acetyl acetyl 5604 H H acetylH H H H acetyl acetyl acetyl H H 5605 H H acetyl H H H H acetyl acetylacetyl H acetyl 5606 H H acetyl H H H H acetyl acetyl acetyl acetyl H5607 H H acetyl H H H H acetyl acetyl acetyl acetyl acetyl 5608 H Hacetyl H H H acetyl H H H H H 5609 H H acetyl H H H acetyl H H H Hacetyl 5610 H H acetyl H H H acetyl H H H acetyl H 5611 H H acetyl H H Hacetyl H H H acetyl acetyl 5612 H H acetyl H H H acetyl H H acetyl H H5613 H H acetyl H H H acetyl H H acetyl H acetyl 5614 H H acetyl H H Hacetyl H H acetyl acetyl H 5615 H H acetyl H H H acetyl H H acetylacetyl acetyl 5616 H H acetyl H H H acetyl H acetyl H H H 5617 H Hacetyl H H H acetyl H acetyl H H acetyl 5618 H H acetyl H H H acetyl Hacetyl H acetyl H 5619 H H acetyl H H H acetyl H acetyl H acetyl acetyl5620 H H acetyl H H H acetyl H acetyl acetyl H H 5621 H H acetyl H H Hacetyl H acetyl acetyl H acetyl 5622 H H acetyl H H H acetyl H acetylacetyl acetyl H 5623 H H acetyl H H H acetyl H acetyl acetyl acetylacetyl 5624 H H acetyl H H H acetyl acetyl H H H H 5625 H H acetyl H H Hacetyl acetyl H H H acetyl 5626 H H acetyl H H H acetyl acetyl H Hacetyl H 5627 H H acetyl H H H acetyl acetyl H H acetyl acetyl 5628 H Hacetyl H H H acetyl acetyl H acetyl H H 5629 H H acetyl H H H acetylacetyl H acetyl H acetyl 5630 H H acetyl H H H acetyl acetyl H acetylacetyl H 5631 H H acetyl H H H acetyl acetyl H acetyl acetyl acetyl 5632H H acetyl H H H acetyl acetyl acetyl H H H 5633 H H acetyl H H H acetylacetyl acetyl H H acetyl 5634 H H acetyl H H H acetyl acetyl acetyl Hacetyl H 5635 H H acetyl H H H acetyl acetyl acetyl H acetyl acetyl 5636H H acetyl H H H acetyl acetyl acetyl acetyl H H 5637 H H acetyl H H Hacetyl acetyl acetyl acetyl H acetyl 5638 H H acetyl H H H acetyl acetylacetyl acetyl acetyl H 5639 H H acetyl H H H acetyl acetyl acetyl acetylacetyl acetyl 5640 H H acetyl H H acetyl H H H H H H 5641 H H acetyl H Hacetyl H H H H H acetyl 5642 H H acetyl H H acetyl H H H H acetyl H 5643H H acetyl H H acetyl H H H H acetyl acetyl 5644 H H acetyl H H acetyl HH H acetyl H H 5645 H H acetyl H H acetyl H H H acetyl H acetyl 5646 H Hacetyl H H acetyl H H H acetyl acetyl H 5647 H H acetyl H H acetyl H H Hacetyl acetyl acetyl 5648 H H acetyl H H acetyl H H acetyl H H H 5649 HH acetyl H H acetyl H H acetyl H H acetyl 5650 H H acetyl H H acetyl H Hacetyl H acetyl H 5651 H H acetyl H H acetyl H H acetyl H acetyl acetyl5652 H H acetyl H H acetyl H H acetyl acetyl H H 5653 H H acetyl H Hacetyl H H acetyl acetyl H acetyl 5654 H H acetyl H H acetyl H H acetylacetyl acetyl H 5655 H H acetyl H H acetyl H H acetyl acetyl acetylacetyl 5656 H H acetyl H H acetyl H acetyl H H H H 5657 H H acetyl H Hacetyl H acetyl H H H acetyl 5658 H H acetyl H H acetyl H acetyl H Hacetyl H 5659 H H acetyl H H acetyl H acetyl H H acetyl acetyl 5660 H Hacetyl H H acetyl H acetyl H acetyl H H 5661 H H acetyl H H acetyl Hacetyl H acetyl H acetyl 5662 H H acetyl H H acetyl H acetyl H acetylacetyl H 5663 H H acetyl H H acetyl H acetyl H acetyl acetyl acetyl 5664H H acetyl H H acetyl H acetyl acetyl H H H 5665 H H acetyl H H acetyl Hacetyl acetyl H H acetyl 5666 H H acetyl H H acetyl H acetyl acetyl Hacetyl H 5667 H H acetyl H H acetyl H acetyl acetyl H acetyl acetyl 5668H H acetyl H H acetyl H acetyl acetyl acetyl H H 5669 H H acetyl H Hacetyl H acetyl acetyl acetyl H acetyl 5670 H H acetyl H H acetyl Hacetyl acetyl acetyl acetyl H 5671 H H acetyl H H acetyl H acetyl acetylacetyl acetyl acetyl 5672 H H acetyl H H acetyl acetyl H H H H H 5673 HH acetyl H H acetyl acetyl H H H H acetyl 5674 H H acetyl H H acetylacetyl H H H acetyl H 5675 H H acetyl H H acetyl acetyl H H H acetylacetyl 5676 H H acetyl H H acetyl acetyl H H acetyl H H 5677 H H acetylH H acetyl acetyl H H acetyl H acetyl 5678 H H acetyl H H acetyl acetylH H acetyl acetyl H 5679 H H acetyl H H acetyl acetyl H H acetyl acetylacetyl 5680 H H acetyl H H acetyl acetyl H acetyl H H H 5681 H H acetylH H acetyl acetyl H acetyl H H acetyl 5682 H H acetyl H H acetyl acetylH acetyl H acetyl H 5683 H H acetyl H H acetyl acetyl H acetyl H acetylacetyl 5684 H H acetyl H H acetyl acetyl H acetyl acetyl H H 5685 H Hacetyl H H acetyl acetyl H acetyl acetyl H acetyl 5686 H H acetyl H Hacetyl acetyl H acetyl acetyl acetyl H 5687 H H acetyl H H acetyl acetylH acetyl acetyl acetyl acetyl 5688 H H acetyl H H acetyl acetyl acetyl HH H H 5689 H H acetyl H H acetyl acetyl acetyl H H H acetyl 5690 H Hacetyl H H acetyl acetyl acetyl H H acetyl H 5691 H H acetyl H H acetylacetyl acetyl H H acetyl acetyl 5692 H H acetyl H H acetyl acetyl acetylH acetyl H H 5693 H H acetyl H H acetyl acetyl acetyl H acetyl H acetyl5694 H H acetyl H H acetyl acetyl acetyl H acetyl acetyl H 5695 H Hacetyl H H acetyl acetyl acetyl H acetyl acetyl acetyl 5696 H H acetyl HH acetyl acetyl acetyl acetyl H H H 5697 H H acetyl H H acetyl acetylacetyl acetyl H H acetyl 5698 H H acetyl H H acetyl acetyl acetyl acetylH acetyl H 5699 H H acetyl H H acetyl acetyl acetyl acetyl H acetylacetyl 5700 H H acetyl H H acetyl acetyl acetyl acetyl acetyl H H 5701 HH acetyl H H acetyl acetyl acetyl acetyl acetyl H acetyl 5702 H H acetylH H acetyl acetyl acetyl acetyl acetyl acetyl H 5703 H H acetyl H Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl 5704 H H acetyl Hacetyl H H H H H H H 5705 H H acetyl H acetyl H H H H H H acetyl 5706 HH acetyl H acetyl H H H H H acetyl H 5707 H H acetyl H acetyl H H H H Hacetyl acetyl 5708 H H acetyl H acetyl H H H H acetyl H H 5709 H Hacetyl H acetyl H H H H acetyl H acetyl 5710 H H acetyl H acetyl H H H Hacetyl acetyl H 5711 H H acetyl H acetyl H H H H acetyl acetyl acetyl5712 H H acetyl H acetyl H H H acetyl H H H 5713 H H acetyl H acetyl H HH acetyl H H acetyl 5714 H H acetyl H acetyl H H H acetyl H acetyl H5715 H H acetyl H acetyl H H H acetyl H acetyl acetyl 5716 H H acetyl Hacetyl H H H acetyl acetyl H H 5717 H H acetyl H acetyl H H H acetylacetyl H acetyl 5718 H H acetyl H acetyl H H H acetyl acetyl acetyl H5719 H H acetyl H acetyl H H H acetyl acetyl acetyl acetyl 5720 H Hacetyl H acetyl H H acetyl H H H H 5721 H H acetyl H acetyl H H acetyl HH H acetyl 5722 H H acetyl H acetyl H H acetyl H H acetyl H 5723 H Hacetyl H acetyl H H acetyl H H acetyl acetyl 5724 H H acetyl H acetyl HH acetyl H acetyl H H 5725 H H acetyl H acetyl H H acetyl H acetyl Hacetyl 5726 H H acetyl H acetyl H H acetyl H acetyl acetyl H 5727 H Hacetyl H acetyl H H acetyl H acetyl acetyl acetyl 5728 H H acetyl Hacetyl H H acetyl acetyl H H H 5729 H H acetyl H acetyl H H acetylacetyl H H acetyl 5730 H H acetyl H acetyl H H acetyl acetyl H acetyl H5731 H H acetyl H acetyl H H acetyl acetyl H acetyl acetyl 5732 H Hacetyl H acetyl H H acetyl acetyl acetyl H H 5733 H H acetyl H acetyl HH acetyl acetyl acetyl H acetyl 5734 H H acetyl H acetyl H H acetylacetyl acetyl acetyl H 5735 H H acetyl H acetyl H H acetyl acetyl acetylacetyl acetyl 5736 H H acetyl H acetyl H acetyl H H H H H 5737 H Hacetyl H acetyl H acetyl H H H H acetyl 5738 H H acetyl H acetyl Hacetyl H H H acetyl H 5739 H H acetyl H acetyl H acetyl H H H acetylacetyl 5740 H H acetyl H acetyl H acetyl H H acetyl H H 5741 H H acetylH acetyl H acetyl H H acetyl H acetyl 5742 H H acetyl H acetyl H acetylH H acetyl acetyl H 5743 H H acetyl H acetyl H acetyl H H acetyl acetylacetyl 5744 H H acetyl H acetyl H acetyl H acetyl H H H 5745 H H acetylH acetyl H acetyl H acetyl H H acetyl 5746 H H acetyl H acetyl H acetylH acetyl H acetyl H 5747 H H acetyl H acetyl H acetyl H acetyl H acetylacetyl 5748 H H acetyl H acetyl H acetyl H acetyl acetyl H H 5749 H Hacetyl H acetyl H acetyl H acetyl acetyl H acetyl 5750 H H acetyl Hacetyl H acetyl H acetyl acetyl acetyl H 5751 H H acetyl H acetyl Hacetyl H acetyl acetyl acetyl acetyl 5752 H H acetyl H acetyl H acetylacetyl H H H H 5753 H H acetyl H acetyl H acetyl acetyl H H H acetyl5754 H H acetyl H acetyl H acetyl acetyl H H acetyl H 5755 H H acetyl Hacetyl H acetyl acetyl H H acetyl acetyl 5756 H H acetyl H acetyl Hacetyl acetyl H acetyl H H 5757 H H acetyl H acetyl H acetyl acetyl Hacetyl H acetyl 5758 H H acetyl H acetyl H acetyl acetyl H acetyl acetylH 5759 H H acetyl H acetyl H acetyl acetyl H acetyl acetyl acetyl 5760 HH acetyl H acetyl H acetyl acetyl acetyl H H H 5761 H H acetyl H acetylH acetyl acetyl acetyl H H acetyl 5762 H H acetyl H acetyl H acetylacetyl acetyl H acetyl H 5763 H H acetyl H acetyl H acetyl acetyl acetylH acetyl acetyl 5764 H H acetyl H acetyl H acetyl acetyl acetyl acetyl HH 5765 H H acetyl H acetyl H acetyl acetyl acetyl acetyl H acetyl 5766 HH acetyl H acetyl H acetyl acetyl acetyl acetyl acetyl H 5767 H H acetylH acetyl H acetyl acetyl acetyl acetyl acetyl acetyl 5768 H H acetyl Hacetyl acetyl H H H H H H 5769 H H acetyl H acetyl acetyl H H H H Hacetyl 5770 H H acetyl H acetyl acetyl H H H H acetyl H 5771 H H acetylH acetyl acetyl H H H H acetyl acetyl 5772 H H acetyl H acetyl acetyl HH H acetyl H H 5773 H H acetyl H acetyl acetyl H H H acetyl H acetyl5774 H H acetyl H acetyl acetyl H H H acetyl acetyl H 5775 H H acetyl Hacetyl acetyl H H H acetyl acetyl acetyl 5776 H H acetyl H acetyl acetylH H acetyl H H H 5777 H H acetyl H acetyl acetyl H H acetyl H H acetyl5778 H H acetyl H acetyl acetyl H H acetyl H acetyl H 5779 H H acetyl Hacetyl acetyl H H acetyl H acetyl acetyl 5780 H H acetyl H acetyl acetylH H acetyl acetyl H H 5781 H H acetyl H acetyl acetyl H H acetyl acetylH acetyl 5782 H H acetyl H acetyl acetyl H H acetyl acetyl acetyl H 5783H H acetyl H acetyl acetyl H H acetyl acetyl acetyl acetyl 5784 H Hacetyl H acetyl acetyl H acetyl H H H H 5785 H H acetyl H acetyl acetylH acetyl H H H acetyl 5786 H H acetyl H acetyl acetyl H acetyl H Hacetyl H 5787 H H acetyl H acetyl acetyl H acetyl H H acetyl acetyl 5788H H acetyl H acetyl acetyl H acetyl H acetyl H H 5789 H H acetyl Hacetyl acetyl H acetyl H acetyl H acetyl 5790 H H acetyl H acetyl acetylH acetyl H acetyl acetyl H 5791 H H acetyl H acetyl acetyl H acetyl Hacetyl acetyl acetyl 5792 H H acetyl H acetyl acetyl H acetyl acetyl H HH 5793 H H acetyl H acetyl acetyl H acetyl acetyl H H acetyl 5794 H Hacetyl H acetyl acetyl H acetyl acetyl H acetyl H 5795 H H acetyl Hacetyl acetyl H acetyl acetyl H acetyl acetyl 5796 H H acetyl H acetylacetyl H acetyl acetyl acetyl H H 5797 H H acetyl H acetyl acetyl Hacetyl acetyl acetyl H acetyl 5798 H H acetyl H acetyl acetyl H acetylacetyl acetyl acetyl H 5799 H H acetyl H acetyl acetyl H acetyl acetylacetyl acetyl acetyl 5800 H H acetyl H acetyl acetyl acetyl H H H H H5801 H H acetyl H acetyl acetyl acetyl H H H H acetyl 5802 H H acetyl Hacetyl acetyl acetyl H H H acetyl H 5803 H H acetyl H acetyl acetylacetyl H H H acetyl acetyl 5804 H H acetyl H acetyl acetyl acetyl H Hacetyl H H 5805 H H acetyl H acetyl acetyl acetyl H H acetyl H acetyl5806 H H acetyl H acetyl acetyl acetyl H H acetyl acetyl H 5807 H Hacetyl H acetyl acetyl acetyl H H acetyl acetyl acetyl 5808 H H acetyl Hacetyl acetyl acetyl H acetyl H H H 5809 H H acetyl H acetyl acetylacetyl H acetyl H H acetyl 5810 H H acetyl H acetyl acetyl acetyl Hacetyl H acetyl H 5811 H H acetyl H acetyl acetyl acetyl H acetyl Hacetyl acetyl 5812 H H acetyl H acetyl acetyl acetyl H acetyl acetyl H H5813 H H acetyl H acetyl acetyl acetyl H acetyl acetyl H acetyl 5814 H Hacetyl H acetyl acetyl acetyl H acetyl acetyl acetyl H 5815 H H acetyl Hacetyl acetyl acetyl H acetyl acetyl acetyl acetyl 5816 H H acetyl Hacetyl acetyl acetyl acetyl H H H H 5817 H H acetyl H acetyl acetylacetyl acetyl H H H acetyl 5818 H H acetyl H acetyl acetyl acetyl acetylH H acetyl H 5819 H H acetyl H acetyl acetyl acetyl acetyl H H acetylacetyl 5820 H H acetyl H acetyl acetyl acetyl acetyl H acetyl H H 5821 HH acetyl H acetyl acetyl acetyl acetyl H acetyl H acetyl 5822 H H acetylH acetyl acetyl acetyl acetyl H acetyl acetyl H 5823 H H acetyl H acetylacetyl acetyl acetyl H acetyl acetyl acetyl 5824 H H acetyl H acetylacetyl acetyl acetyl acetyl H H H 5825 H H acetyl H acetyl acetyl acetylacetyl acetyl H H acetyl 5826 H H acetyl H acetyl acetyl acetyl acetylacetyl H acetyl H 5827 H H acetyl H acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl 5828 H H acetyl H acetyl acetyl acetyl acetyl acetylacetyl H H 5829 H H acetyl H acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl 5830 H H acetyl H acetyl acetyl acetyl acetyl acetyl acetylacetyl H 5831 H H acetyl H acetyl acetyl acetyl acetyl acetyl acetylacetyl acetyl 5832 H H acetyl acetyl H H H H H H H H 5833 H H acetylacetyl H H H H H H H acetyl 5834 H H acetyl acetyl H H H H H H acetyl H5835 H H acetyl acetyl H H H H H H acetyl acetyl 5836 H H acetyl acetylH H H H H acetyl H H 5837 H H acetyl acetyl H H H H H acetyl H acetyl5838 H H acetyl acetyl H H H H H acetyl acetyl H 5839 H H acetyl acetylH H H H H acetyl acetyl acetyl 5840 H H acetyl acetyl H H H H acetyl H HH 5841 H H acetyl acetyl H H H H acetyl H H acetyl 5842 H H acetylacetyl H H H H acetyl H acetyl H 5843 H H acetyl acetyl H H H H acetyl Hacetyl acetyl 5844 H H acetyl acetyl H H H H acetyl acetyl H H 5845 H Hacetyl acetyl H H H H acetyl acetyl H acetyl 5846 H H acetyl acetyl H HH H acetyl acetyl acetyl H 5847 H H acetyl acetyl H H H H acetyl acetylacetyl acetyl 5848 H H acetyl acetyl H H H acetyl H H H H 5849 H Hacetyl acetyl H H H acetyl H H H acetyl 5850 H H acetyl acetyl H H Hacetyl H H acetyl H 5851 H H acetyl acetyl H H H acetyl H H acetylacetyl 5852 H H acetyl acetyl H H H acetyl H acetyl H H 5853 H H acetylacetyl H H H acetyl H acetyl H acetyl 5854 H H acetyl acetyl H H Hacetyl H acetyl acetyl H 5855 H H acetyl acetyl H H H acetyl H acetylacetyl acetyl 5856 H H acetyl acetyl H H H acetyl acetyl H H H 5857 H Hacetyl acetyl H H H acetyl acetyl H H acetyl 5858 H H acetyl acetyl H HH acetyl acetyl H acetyl H 5859 H H acetyl acetyl H H H acetyl acetyl Hacetyl acetyl 5860 H H acetyl acetyl H H H acetyl acetyl acetyl H H 5861H H acetyl acetyl H H H acetyl acetyl acetyl H acetyl 5862 H H acetylacetyl H H H acetyl acetyl acetyl acetyl H 5863 H H acetyl acetyl H H Hacetyl acetyl acetyl acetyl acetyl 5864 H H acetyl acetyl H H acetyl H HH H H 5865 H H acetyl acetyl H H acetyl H H H H acetyl 5866 H H acetylacetyl H H acetyl H H H acetyl H 5867 H H acetyl acetyl H H acetyl H H Hacetyl acetyl 5868 H H acetyl acetyl H H acetyl H H acetyl H H 5869 H Hacetyl acetyl H H acetyl H H acetyl H acetyl 5870 H H acetyl acetyl H Hacetyl H H acetyl acetyl H 5871 H H acetyl acetyl H H acetyl H H acetylacetyl acetyl 5872 H H acetyl acetyl H H acetyl H acetyl H H H 5873 H Hacetyl acetyl H H acetyl H acetyl H H acetyl 5874 H H acetyl acetyl H Hacetyl H acetyl H acetyl H 5875 H H acetyl acetyl H H acetyl H acetyl Hacetyl acetyl 5876 H H acetyl acetyl H H acetyl H acetyl acetyl H H 5877H H acetyl acetyl H H acetyl H acetyl acetyl H acetyl 5878 H H acetylacetyl H H acetyl H acetyl acetyl acetyl H 5879 H H acetyl acetyl H Hacetyl H acetyl acetyl acetyl acetyl 5880 H H acetyl acetyl H H acetylacetyl H H H H 5881 H H acetyl acetyl H H acetyl acetyl H H H acetyl5882 H H acetyl acetyl H H acetyl acetyl H H acetyl H 5883 H H acetylacetyl H H acetyl acetyl H H acetyl acetyl 5884 H H acetyl acetyl H Hacetyl acetyl H acetyl H H 5885 H H acetyl acetyl H H acetyl acetyl Hacetyl H acetyl 5886 H H acetyl acetyl H H acetyl acetyl H acetyl acetylH 5887 H H acetyl acetyl H H acetyl acetyl H acetyl acetyl acetyl 5888 HH acetyl acetyl H H acetyl acetyl acetyl H H H 5889 H H acetyl acetyl HH acetyl acetyl acetyl H H acetyl 5890 H H acetyl acetyl H H acetylacetyl acetyl H acetyl H 5891 H H acetyl acetyl H H acetyl acetyl acetylH acetyl acetyl 5892 H H acetyl acetyl H H acetyl acetyl acetyl acetyl HH 5893 H H acetyl acetyl H H acetyl acetyl acetyl acetyl H acetyl 5894 HH acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl H 5895 H H acetylacetyl H H acetyl acetyl acetyl acetyl acetyl acetyl 5896 H H acetylacetyl H acetyl H H H H H H 5897 H H acetyl acetyl H acetyl H H H H Hacetyl 5898 H H acetyl acetyl H acetyl H H H H acetyl H 5899 H H acetylacetyl H acetyl H H H H acetyl acetyl 5900 H H acetyl acetyl H acetyl HH H acetyl H H 5901 H H acetyl acetyl H acetyl H H H acetyl H acetyl5902 H H acetyl acetyl H acetyl H H H acetyl acetyl H 5903 H H acetylacetyl H acetyl H H H acetyl acetyl acetyl 5904 H H acetyl acetyl Hacetyl H H acetyl H H H 5905 H H acetyl acetyl H acetyl H H acetyl H Hacetyl 5906 H H acetyl acetyl H acetyl H H acetyl H acetyl H 5907 H Hacetyl acetyl H acetyl H H acetyl H acetyl acetyl 5908 H H acetyl acetylH acetyl H H acetyl acetyl H H 5909 H H acetyl acetyl H acetyl H Hacetyl acetyl H acetyl 5910 H H acetyl acetyl H acetyl H H acetyl acetylacetyl H 5911 H H acetyl acetyl H acetyl H H acetyl acetyl acetyl acetyl5912 H H acetyl acetyl H acetyl H acetyl H H H H 5913 H H acetyl acetylH acetyl H acetyl H H H acetyl 5914 H H acetyl acetyl H acetyl H acetylH H acetyl H 5915 H H acetyl acetyl H acetyl H acetyl H H acetyl acetyl5916 H H acetyl acetyl H acetyl H acetyl H acetyl H H 5917 H H acetylacetyl H acetyl H acetyl H acetyl H acetyl 5918 H H acetyl acetyl Hacetyl H acetyl H acetyl acetyl H 5919 H H acetyl acetyl H acetyl Hacetyl H acetyl acetyl acetyl 5920 H H acetyl acetyl H acetyl H acetylacetyl H H H 5921 H H acetyl acetyl H acetyl H acetyl acetyl H H acetyl5922 H H acetyl acetyl H acetyl H acetyl acetyl H acetyl H 5923 H Hacetyl acetyl H acetyl H acetyl acetyl H acetyl acetyl 5924 H H acetylacetyl H acetyl H acetyl acetyl acetyl H H 5925 H H acetyl acetyl Hacetyl H acetyl acetyl acetyl H acetyl 5926 H H acetyl acetyl H acetyl Hacetyl acetyl acetyl acetyl H 5927 H H acetyl acetyl H acetyl H acetylacetyl acetyl acetyl acetyl 5928 H H acetyl acetyl H acetyl acetyl H H HH H 5929 H H acetyl acetyl H acetyl acetyl H H H H acetyl 5930 H Hacetyl acetyl H acetyl acetyl H H H acetyl H 5931 H H acetyl acetyl Hacetyl acetyl H H H acetyl acetyl 5932 H H acetyl acetyl H acetyl acetylH H acetyl H H 5933 H H acetyl acetyl H acetyl acetyl H H acetyl Hacetyl 5934 H H acetyl acetyl H acetyl acetyl H H acetyl acetyl H 5935 HH acetyl acetyl H acetyl acetyl H H acetyl acetyl acetyl 5936 H H acetylacetyl H acetyl acetyl H acetyl H H H 5937 H H acetyl acetyl H acetylacetyl H acetyl H H acetyl 5938 H H acetyl acetyl H acetyl acetyl Hacetyl H acetyl H 5939 H H acetyl acetyl H acetyl acetyl H acetyl Hacetyl acetyl 5940 H H acetyl acetyl H acetyl acetyl H acetyl acetyl H H5941 H H acetyl acetyl H acetyl acetyl H acetyl acetyl H acetyl 5942 H Hacetyl acetyl H acetyl acetyl H acetyl acetyl acetyl H 5943 H H acetylacetyl H acetyl acetyl H acetyl acetyl acetyl acetyl 5944 H H acetylacetyl H acetyl acetyl acetyl H H H H 5945 H H acetyl acetyl H acetylacetyl acetyl H H H acetyl 5946 H H acetyl acetyl H acetyl acetyl acetylH H acetyl H 5947 H H acetyl acetyl H acetyl acetyl acetyl H H acetylacetyl 5948 H H acetyl acetyl H acetyl acetyl acetyl H acetyl H H 5949 HH acetyl acetyl H acetyl acetyl acetyl H acetyl H acetyl 5950 H H acetylacetyl H acetyl acetyl acetyl H acetyl acetyl H 5951 H H acetyl acetyl Hacetyl acetyl acetyl H acetyl acetyl acetyl 5952 H H acetyl acetyl Hacetyl acetyl acetyl acetyl H H H 5953 H H acetyl acetyl H acetyl acetylacetyl acetyl H H acetyl 5954 H H acetyl acetyl H acetyl acetyl acetylacetyl H acetyl H 5955 H H acetyl acetyl H acetyl acetyl acetyl acetyl Hacetyl acetyl 5956 H H acetyl acetyl H acetyl acetyl acetyl acetylacetyl H H 5957 H H acetyl acetyl H acetyl acetyl acetyl acetyl acetyl Hacetyl 5958 H H acetyl acetyl H acetyl acetyl acetyl acetyl acetylacetyl H 5959 H H acetyl acetyl H acetyl acetyl acetyl acetyl acetylacetyl acetyl 5960 H H acetyl acetyl acetyl H H H H H H H 5961 H Hacetyl acetyl acetyl H H H H H H acetyl 5962 H H acetyl acetyl acetyl HH H H H acetyl H 5963 H H acetyl acetyl acetyl H H H H H acetyl acetyl5964 H H acetyl acetyl acetyl H H H H acetyl H H 5965 H H acetyl acetylacetyl H H H H acetyl H acetyl 5966 H H acetyl acetyl acetyl H H H Hacetyl acetyl H 5967 H H acetyl acetyl acetyl H H H H acetyl acetylacetyl 5968 H H acetyl acetyl acetyl H H H acetyl H H H 5969 H H acetylacetyl acetyl H H H acetyl H H acetyl 5970 H H acetyl acetyl acetyl H HH acetyl H acetyl H 5971 H H acetyl acetyl acetyl H H H acetyl H acetylacetyl 5972 H H acetyl acetyl acetyl H H H acetyl acetyl H H 5973 H Hacetyl acetyl acetyl H H H acetyl acetyl H acetyl 5974 H H acetyl acetylacetyl H H H acetyl acetyl acetyl H 5975 H H acetyl acetyl acetyl H H Hacetyl acetyl acetyl acetyl 5976 H H acetyl acetyl acetyl H H acetyl H HH H 5977 H H acetyl acetyl acetyl H H acetyl H H H acetyl 5978 H Hacetyl acetyl acetyl H H acetyl H H acetyl H 5979 H H acetyl acetylacetyl H H acetyl H H acetyl acetyl 5980 H H acetyl acetyl acetyl H Hacetyl H acetyl H H 5981 H H acetyl acetyl acetyl H H acetyl H acetyl Hacetyl 5982 H H acetyl acetyl acetyl H H acetyl H acetyl acetyl H 5983 HH acetyl acetyl acetyl H H acetyl H acetyl acetyl acetyl 5984 H H acetylacetyl acetyl H H acetyl acetyl H H H 5985 H H acetyl acetyl acetyl H Hacetyl acetyl H H acetyl 5986 H H acetyl acetyl acetyl H H acetyl acetylH acetyl H 5987 H H acetyl acetyl acetyl H H acetyl acetyl H acetylacetyl 5988 H H acetyl acetyl acetyl H H acetyl acetyl acetyl H H 5989 HH acetyl acetyl acetyl H H acetyl acetyl acetyl H acetyl 5990 H H acetylacetyl acetyl H H acetyl acetyl acetyl acetyl H 5991 H H acetyl acetylacetyl H H acetyl acetyl acetyl acetyl acetyl 5992 H H acetyl acetylacetyl H acetyl H H H H H 5993 H H acetyl acetyl acetyl H acetyl H H H Hacetyl 5994 H H acetyl acetyl acetyl H acetyl H H H acetyl H 5995 H Hacetyl acetyl acetyl H acetyl H H H acetyl acetyl 5996 H H acetyl acetylacetyl H acetyl H H acetyl H H 5997 H H acetyl acetyl acetyl H acetyl HH acetyl H acetyl 5998 H H acetyl acetyl acetyl H acetyl H H acetylacetyl H 5999 H H acetyl acetyl acetyl H acetyl H H acetyl acetyl acetyl6000 H H acetyl acetyl acetyl H acetyl H acetyl H H H 6001 H H acetylacetyl acetyl H acetyl H acetyl H H acetyl 6002 H H acetyl acetyl acetylH acetyl H acetyl H acetyl H 6003 H H acetyl acetyl acetyl H acetyl Hacetyl H acetyl acetyl 6004 H H acetyl acetyl acetyl H acetyl H acetylacetyl H H 6005 H H acetyl acetyl acetyl H acetyl H acetyl acetyl Hacetyl 6006 H H acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl H6007 H H acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl acetyl6008 H H acetyl acetyl acetyl H acetyl acetyl H H H H 6009 H H acetylacetyl acetyl H acetyl acetyl H H H acetyl 6010 H H acetyl acetyl acetylH acetyl acetyl H H acetyl H 6011 H H acetyl acetyl acetyl H acetylacetyl H H acetyl acetyl 6012 H H acetyl acetyl acetyl H acetyl acetyl Hacetyl H H 6013 H H acetyl acetyl acetyl H acetyl acetyl H acetyl Hacetyl 6014 H H acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl H6015 H H acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl acetyl6016 H H acetyl acetyl acetyl H acetyl acetyl acetyl H H H 6017 H Hacetyl acetyl acetyl H acetyl acetyl acetyl H H acetyl 6018 H H acetylacetyl acetyl H acetyl acetyl acetyl H acetyl H 6019 H H acetyl acetylacetyl H acetyl acetyl acetyl H acetyl acetyl 6020 H H acetyl acetylacetyl H acetyl acetyl acetyl acetyl H H 6021 H H acetyl acetyl acetyl Hacetyl acetyl acetyl acetyl H acetyl 6022 H H acetyl acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl H 6023 H H acetyl acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl 6024 H H acetyl acetyl acetylacetyl H H H H H H 6025 H H acetyl acetyl acetyl acetyl H H H H H acetyl6026 H H acetyl acetyl acetyl acetyl H H H H acetyl H 6027 H H acetylacetyl acetyl acetyl H H H H acetyl acetyl 6028 H H acetyl acetyl acetylacetyl H H H acetyl H H 6029 H H acetyl acetyl acetyl acetyl H H Hacetyl H acetyl 6030 H H acetyl acetyl acetyl acetyl H H H acetyl acetylH 6031 H H acetyl acetyl acetyl acetyl H H H acetyl acetyl acetyl 6032 HH acetyl acetyl acetyl acetyl H H acetyl H H H 6033 H H acetyl acetylacetyl acetyl H H acetyl H H acetyl 6034 H H acetyl acetyl acetyl acetylH H acetyl H acetyl H 6035 H H acetyl acetyl acetyl acetyl H H acetyl Hacetyl acetyl 6036 H H acetyl acetyl acetyl acetyl H H acetyl acetyl H H6037 H H acetyl acetyl acetyl acetyl H H acetyl acetyl H acetyl 6038 H Hacetyl acetyl acetyl acetyl H H acetyl acetyl acetyl H 6039 H H acetylacetyl acetyl acetyl H H acetyl acetyl acetyl acetyl 6040 H H acetylacetyl acetyl acetyl H acetyl H H H H 6041 H H acetyl acetyl acetylacetyl H acetyl H H H acetyl 6042 H H acetyl acetyl acetyl acetyl Hacetyl H H acetyl H 6043 H H acetyl acetyl acetyl acetyl H acetyl H Hacetyl acetyl 6044 H H acetyl acetyl acetyl acetyl H acetyl H acetyl H H6045 H H acetyl acetyl acetyl acetyl H acetyl H acetyl H acetyl 6046 H Hacetyl acetyl acetyl acetyl H acetyl H acetyl acetyl H 6047 H H acetylacetyl acetyl acetyl H acetyl H acetyl acetyl acetyl 6048 H H acetylacetyl acetyl acetyl H acetyl acetyl H H H 6049 H H acetyl acetyl acetylacetyl H acetyl acetyl H H acetyl 6050 H H acetyl acetyl acetyl acetyl Hacetyl acetyl H acetyl H 6051 H H acetyl acetyl acetyl acetyl H acetylacetyl H acetyl acetyl 6052 H H acetyl acetyl acetyl acetyl H acetylacetyl acetyl H H 6053 H H acetyl acetyl acetyl acetyl H acetyl acetylacetyl H acetyl 6054 H H acetyl acetyl acetyl acetyl H acetyl acetylacetyl acetyl H 6055 H H acetyl acetyl acetyl acetyl H acetyl acetylacetyl acetyl acetyl 6056 H H acetyl acetyl acetyl acetyl acetyl H H H HH 6057 H H acetyl acetyl acetyl acetyl acetyl H H H H acetyl 6058 H Hacetyl acetyl acetyl acetyl acetyl H H H acetyl H 6059 H H acetyl acetylacetyl acetyl acetyl H H H acetyl acetyl 6060 H H acetyl acetyl acetylacetyl acetyl H H acetyl H H 6061 H H acetyl acetyl acetyl acetyl acetylH H acetyl H acetyl 6062 H H acetyl acetyl acetyl acetyl acetyl H Hacetyl acetyl H 6063 H H acetyl acetyl acetyl acetyl acetyl H H acetylacetyl acetyl 6064 H H acetyl acetyl acetyl acetyl acetyl H acetyl H H H6065 H H acetyl acetyl acetyl acetyl acetyl H acetyl H H acetyl 6066 H Hacetyl acetyl acetyl acetyl acetyl H acetyl H acetyl H 6067 H H acetylacetyl acetyl acetyl acetyl H acetyl H acetyl acetyl 6068 H H acetylacetyl acetyl acetyl acetyl H acetyl acetyl H H 6069 H H acetyl acetylacetyl acetyl acetyl H acetyl acetyl H acetyl 6070 H H acetyl acetylacetyl acetyl acetyl H acetyl acetyl acetyl H 6071 H H acetyl acetylacetyl acetyl acetyl H acetyl acetyl acetyl acetyl 6072 H H acetylacetyl acetyl acetyl acetyl acetyl H H H H 6073 H H acetyl acetyl acetylacetyl acetyl acetyl H H H acetyl 6074 H H acetyl acetyl acetyl acetylacetyl acetyl H H acetyl H 6075 H H acetyl acetyl acetyl acetyl acetylacetyl H H acetyl acetyl 6076 H H acetyl acetyl acetyl acetyl acetylacetyl H acetyl H H 6077 H H acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl 6078 H H acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl H 6079 H H acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl acetyl 6080 H H acetyl acetyl acetyl acetyl acetyl acetylacetyl H H H 6081 H H acetyl acetyl acetyl acetyl acetyl acetyl acetyl HH acetyl 6082 H H acetyl acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl H 6083 H H acetyl acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl 6084 H H acetyl acetyl acetyl acetyl acetyl acetyl acetylacetyl H H 6085 H H acetyl acetyl acetyl acetyl acetyl acetyl acetylacetyl H acetyl 6086 H H acetyl acetyl acetyl acetyl acetyl acetylacetyl acetyl acetyl H 6087 H H acetyl acetyl acetyl acetyl acetylacetyl acetyl acetyl acetyl acetyl 6088 H acetyl H H H H H H H H H H6089 H acetyl H H H H H H H H H acetyl 6090 H acetyl H H H H H H H Hacetyl H 6091 H acetyl H H H H H H H H acetyl acetyl 6092 H acetyl H H HH H H H acetyl H H 6093 H acetyl H H H H H H H acetyl H acetyl 6094 Hacetyl H H H H H H H acetyl acetyl H 6095 H acetyl H H H H H H H acetylacetyl acetyl 6096 H acetyl H H H H H H acetyl H H H 6097 H acetyl H H HH H H acetyl H H acetyl 6098 H acetyl H H H H H H acetyl H acetyl H 6099H acetyl H H H H H H acetyl H acetyl acetyl 6100 H acetyl H H H H H Hacetyl acetyl H H 6101 H acetyl H H H H H H acetyl acetyl H acetyl 6102H acetyl H H H H H H acetyl acetyl acetyl H 6103 H acetyl H H H H H Hacetyl acetyl acetyl acetyl 6104 H acetyl H H H H H acetyl H H H H 6105H acetyl H H H H H acetyl H H H acetyl 6106 H acetyl H H H H H acetyl HH acetyl H 6107 H acetyl H H H H H acetyl H H acetyl acetyl 6108 Hacetyl H H H H H acetyl H acetyl H H 6109 H acetyl H H H H H acetyl Hacetyl H acetyl 6110 H acetyl H H H H H acetyl H acetyl acetyl H 6111 Hacetyl H H H H H acetyl H acetyl acetyl acetyl 6112 H acetyl H H H H Hacetyl acetyl H H H 6113 H acetyl H H H H H acetyl acetyl H H acetyl6114 H acetyl H H H H H acetyl acetyl H acetyl H 6115 H acetyl H H H H Hacetyl acetyl H acetyl acetyl 6116 H acetyl H H H H H acetyl acetylacetyl H H 6117 H acetyl H H H H H acetyl acetyl acetyl H acetyl 6118 Hacetyl H H H H H acetyl acetyl acetyl acetyl H 6119 H acetyl H H H H Hacetyl acetyl acetyl acetyl acetyl 6120 H acetyl H H H H acetyl H H H HH 6121 H acetyl H H H H acetyl H H H H acetyl 6122 H acetyl H H H Hacetyl H H H acetyl H 6123 H acetyl H H H H acetyl H H H acetyl acetyl6124 H acetyl H H H H acetyl H H acetyl H H 6125 H acetyl H H H H acetylH H acetyl H acetyl 6126 H acetyl H H H H acetyl H H acetyl acetyl H6127 H acetyl H H H H acetyl H H acetyl acetyl acetyl 6128 H acetyl H HH H acetyl H acetyl H H H 6129 H acetyl H H H H acetyl H acetyl H Hacetyl 6130 H acetyl H H H H acetyl H acetyl H acetyl H 6131 H acetyl HH H H acetyl H acetyl H acetyl acetyl 6132 H acetyl H H H H acetyl Hacetyl acetyl H H 6133 H acetyl H H H H acetyl H acetyl acetyl H acetyl6134 H acetyl H H H H acetyl H acetyl acetyl acetyl H 6135 H acetyl H HH H acetyl H acetyl acetyl acetyl acetyl 6136 H acetyl H H H H acetylacetyl H H H H 6137 H acetyl H H H H acetyl acetyl H H H acetyl 6138 Hacetyl H H H H acetyl acetyl H H acetyl H 6139 H acetyl H H H H acetylacetyl H H acetyl acetyl 6140 H acetyl H H H H acetyl acetyl H acetyl HH 6141 H acetyl H H H H acetyl acetyl H acetyl H acetyl 6142 H acetyl HH H H acetyl acetyl H acetyl acetyl H 6143 H acetyl H H H H acetylacetyl H acetyl acetyl acetyl 6144 H acetyl H H H H acetyl acetyl acetylH H H 6145 H acetyl H H H H acetyl acetyl acetyl H H acetyl 6146 Hacetyl H H H H acetyl acetyl acetyl H acetyl H 6147 H acetyl H H H Hacetyl acetyl acetyl H acetyl acetyl 6148 H acetyl H H H H acetyl acetylacetyl acetyl H H 6149 H acetyl H H H H acetyl acetyl acetyl acetyl Hacetyl 6150 H acetyl H H H H acetyl acetyl acetyl acetyl acetyl H 6151 Hacetyl H H H H acetyl acetyl acetyl acetyl acetyl acetyl 6152 H acetyl HH H acetyl H H H H H H 6153 H acetyl H H H acetyl H H H H H acetyl 6154H acetyl H H H acetyl H H H H acetyl H 6155 H acetyl H H H acetyl H H HH acetyl acetyl 6156 H acetyl H H H acetyl H H H acetyl H H 6157 Hacetyl H H H acetyl H H H acetyl H acetyl 6158 H acetyl H H H acetyl H HH acetyl acetyl H 6159 H acetyl H H H acetyl H H H acetyl acetyl acetyl6160 H acetyl H H H acetyl H H acetyl H H H 6161 H acetyl H H H acetyl HH acetyl H H acetyl 6162 H acetyl H H H acetyl H H acetyl H acetyl H6163 H acetyl H H H acetyl H H acetyl H acetyl acetyl 6164 H acetyl H HH acetyl H H acetyl acetyl H H 6165 H acetyl H H H acetyl H H acetylacetyl H acetyl 6166 H acetyl H H H acetyl H H acetyl acetyl acetyl H6167 H acetyl H H H acetyl H H acetyl acetyl acetyl acetyl 6168 H acetylH H H acetyl H acetyl H H H H 6169 H acetyl H H H acetyl H acetyl H H Hacetyl 6170 H acetyl H H H acetyl H acetyl H H acetyl H 6171 H acetyl HH H acetyl H acetyl H H acetyl acetyl 6172 H acetyl H H H acetyl Hacetyl H acetyl H H 6173 H acetyl H H H acetyl H acetyl H acetyl Hacetyl 6174 H acetyl H H H acetyl H acetyl H acetyl acetyl H 6175 Hacetyl H H H acetyl H acetyl H acetyl acetyl acetyl 6176 H acetyl H H Hacetyl H acetyl acetyl H H H 6177 H acetyl H H H acetyl H acetyl acetylH H acetyl 6178 H acetyl H H H acetyl H acetyl acetyl H acetyl H 6179 Hacetyl H H H acetyl H acetyl acetyl H acetyl acetyl 6180 H acetyl H H Hacetyl H acetyl acetyl acetyl H H 6181 H acetyl H H H acetyl H acetylacetyl acetyl H acetyl 6182 H acetyl H H H acetyl H acetyl acetyl acetylacetyl H 6183 H acetyl H H H acetyl H acetyl acetyl acetyl acetyl acetyl6184 H acetyl H H H acetyl acetyl H H H H H 6185 H acetyl H H H acetylacetyl H H H H acetyl 6186 H acetyl H H H acetyl acetyl H H H acetyl H6187 H acetyl H H H acetyl acetyl H H H acetyl acetyl 6188 H acetyl H HH acetyl acetyl H H acetyl H H 6189 H acetyl H H H acetyl acetyl H Hacetyl H acetyl 6190 H acetyl H H H acetyl acetyl H H acetyl acetyl H6191 H acetyl H H H acetyl acetyl H H acetyl acetyl acetyl 6192 H acetylH H H acetyl acetyl H acetyl H H H 6193 H acetyl H H H acetyl acetyl Hacetyl H H acetyl 6194 H acetyl H H H acetyl acetyl H acetyl H acetyl H6195 H acetyl H H H acetyl acetyl H acetyl H acetyl acetyl 6196 H acetylH H H acetyl acetyl H acetyl acetyl H H 6197 H acetyl H H H acetylacetyl H acetyl acetyl H acetyl 6198 H acetyl H H H acetyl acetyl Hacetyl acetyl acetyl H 6199 H acetyl H H H acetyl acetyl H acetyl acetylacetyl acetyl 6200 H acetyl H H H acetyl acetyl acetyl H H H H 6201 Hacetyl H H H acetyl acetyl acetyl H H H acetyl 6202 H acetyl H H Hacetyl acetyl acetyl H H acetyl H 6203 H acetyl H H H acetyl acetylacetyl H H acetyl acetyl 6204 H acetyl H H H acetyl acetyl acetyl Hacetyl H H 6205 H acetyl H H H acetyl acetyl acetyl H acetyl H acetyl6206 H acetyl H H H acetyl acetyl acetyl H acetyl acetyl H 6207 H acetylH H H acetyl acetyl acetyl H acetyl acetyl acetyl 6208 H acetyl H H Hacetyl acetyl acetyl acetyl H H H 6209 H acetyl H H H acetyl acetylacetyl acetyl H H acetyl 6210 H acetyl H H H acetyl acetyl acetyl acetylH acetyl H 6211 H acetyl H H H acetyl acetyl acetyl acetyl H acetylacetyl 6212 H acetyl H H H acetyl acetyl acetyl acetyl acetyl H H 6213 Hacetyl H H H acetyl acetyl acetyl acetyl acetyl H acetyl 6214 H acetyl HH H acetyl acetyl acetyl acetyl acetyl acetyl H 6215 H acetyl H H Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl 6216 H acetyl H Hacetyl H H H H H H H 6217 H acetyl H H acetyl H H H H H H acetyl 6218 Hacetyl H H acetyl H H H H H acetyl H 6219 H acetyl H H acetyl H H H H Hacetyl acetyl 6220 H acetyl H H acetyl H H H H acetyl H H 6221 H acetylH H acetyl H H H H acetyl H acetyl 6222 H acetyl H H acetyl H H H Hacetyl acetyl H 6223 H acetyl H H acetyl H H H H acetyl acetyl acetyl6224 H acetyl H H acetyl H H H acetyl H H H 6225 H acetyl H H acetyl H HH acetyl H H acetyl 6226 H acetyl H H acetyl H H H acetyl H acetyl H6227 H acetyl H H acetyl H H H acetyl H acetyl acetyl 6228 H acetyl H Hacetyl H H H acetyl acetyl H H 6229 H acetyl H H acetyl H H H acetylacetyl H acetyl 6230 H acetyl H H acetyl H H H acetyl acetyl acetyl H6231 H acetyl H H acetyl H H H acetyl acetyl acetyl acetyl 6232 H acetylH H acetyl H H acetyl H H H H 6233 H acetyl H H acetyl H H acetyl H H Hacetyl 6234 H acetyl H H acetyl H H acetyl H H acetyl H 6235 H acetyl HH acetyl H H acetyl H H acetyl acetyl 6236 H acetyl H H acetyl H Hacetyl H acetyl H H 6237 H acetyl H H acetyl H H acetyl H acetyl Hacetyl 6238 H acetyl H H acetyl H H acetyl H acetyl acetyl H 6239 Hacetyl H H acetyl H H acetyl H acetyl acetyl acetyl 6240 H acetyl H Hacetyl H H acetyl acetyl H H H 6241 H acetyl H H acetyl H H acetylacetyl H H acetyl 6242 H acetyl H H acetyl H H acetyl acetyl H acetyl H6243 H acetyl H H acetyl H H acetyl acetyl H acetyl acetyl 6244 H acetylH H acetyl H H acetyl acetyl acetyl H H 6245 H acetyl H H acetyl H Hacetyl acetyl acetyl H acetyl 6246 H acetyl H H acetyl H H acetyl acetylacetyl acetyl H 6247 H acetyl H H acetyl H H acetyl acetyl acetyl acetylacetyl 6248 H acetyl H H acetyl H acetyl H H H H H 6249 H acetyl H Hacetyl H acetyl H H H H acetyl 6250 H acetyl H H acetyl H acetyl H H Hacetyl H 6251 H acetyl H H acetyl H acetyl H H H acetyl acetyl 6252 Hacetyl H H acetyl H acetyl H H acetyl H H 6253 H acetyl H H acetyl Hacetyl H H acetyl H acetyl 6254 H acetyl H H acetyl H acetyl H H acetylacetyl H 6255 H acetyl H H acetyl H acetyl H H acetyl acetyl acetyl 6256H acetyl H H acetyl H acetyl H acetyl H H H 6257 H acetyl H H acetyl Hacetyl H acetyl H H acetyl 6258 H acetyl H H acetyl H acetyl H acetyl Hacetyl H 6259 H acetyl H H acetyl H acetyl H acetyl H acetyl acetyl 6260H acetyl H H acetyl H acetyl H acetyl acetyl H H 6261 H acetyl H Hacetyl H acetyl H acetyl acetyl H acetyl 6262 H acetyl H H acetyl Hacetyl H acetyl acetyl acetyl H 6263 H acetyl H H acetyl H acetyl Hacetyl acetyl acetyl acetyl 6264 H acetyl H H acetyl H acetyl acetyl H HH H 6265 H acetyl H H acetyl H acetyl acetyl H H H acetyl 6266 H acetylH H acetyl H acetyl acetyl H H acetyl H 6267 H acetyl H H acetyl Hacetyl acetyl H H acetyl acetyl 6268 H acetyl H H acetyl H acetyl acetylH acetyl H H 6269 H acetyl H H acetyl H acetyl acetyl H acetyl H acetyl6270 H acetyl H H acetyl H acetyl acetyl H acetyl acetyl H 6271 H acetylH H acetyl H acetyl acetyl H acetyl acetyl acetyl 6272 H acetyl H Hacetyl H acetyl acetyl acetyl H H H 6273 H acetyl H H acetyl H acetylacetyl acetyl H H acetyl 6274 H acetyl H H acetyl H acetyl acetyl acetylH acetyl H 6275 H acetyl H H acetyl H acetyl acetyl acetyl H acetylacetyl 6276 H acetyl H H acetyl H acetyl acetyl acetyl acetyl H H 6277 Hacetyl H H acetyl H acetyl acetyl acetyl acetyl H acetyl 6278 H acetyl HH acetyl H acetyl acetyl acetyl acetyl acetyl H 6279 H acetyl H H acetylH acetyl acetyl acetyl acetyl acetyl acetyl 6280 H acetyl H H acetylacetyl H H H H H H 6281 H acetyl H H acetyl acetyl H H H H H acetyl 6282H acetyl H H acetyl acetyl H H H H acetyl H 6283 H acetyl H H acetylacetyl H H H H acetyl acetyl 6284 H acetyl H H acetyl acetyl H H Hacetyl H H 6285 H acetyl H H acetyl acetyl H H H acetyl H acetyl 6286 Hacetyl H H acetyl acetyl H H H acetyl acetyl H 6287 H acetyl H H acetylacetyl H H H acetyl acetyl acetyl 6288 H acetyl H H acetyl acetyl H Hacetyl H H H 6289 H acetyl H H acetyl acetyl H H acetyl H H acetyl 6290H acetyl H H acetyl acetyl H H acetyl H acetyl H 6291 H acetyl H Hacetyl acetyl H H acetyl H acetyl acetyl 6292 H acetyl H H acetyl acetylH H acetyl acetyl H H 6293 H acetyl H H acetyl acetyl H H acetyl acetylH acetyl 6294 H acetyl H H acetyl acetyl H H acetyl acetyl acetyl H 6295H acetyl H H acetyl acetyl H H acetyl acetyl acetyl acetyl 6296 H acetylH H acetyl acetyl H acetyl H H H H 6297 H acetyl H H acetyl acetyl Hacetyl H H H acetyl 6298 H acetyl H H acetyl acetyl H acetyl H H acetylH 6299 H acetyl H H acetyl acetyl H acetyl H H acetyl acetyl 6300 Hacetyl H H acetyl acetyl H acetyl H acetyl H H 6301 H acetyl H H acetylacetyl H acetyl H acetyl H acetyl 6302 H acetyl H H acetyl acetyl Hacetyl H acetyl acetyl H 6303 H acetyl H H acetyl acetyl H acetyl Hacetyl acetyl acetyl 6304 H acetyl H H acetyl acetyl H acetyl acetyl H HH 6305 H acetyl H H acetyl acetyl H acetyl acetyl H H acetyl 6306 Hacetyl H H acetyl acetyl H acetyl acetyl H acetyl H 6307 H acetyl H Hacetyl acetyl H acetyl acetyl H acetyl acetyl 6308 H acetyl H H acetylacetyl H acetyl acetyl acetyl H H 6309 H acetyl H H acetyl acetyl Hacetyl acetyl acetyl H acetyl 6310 H acetyl H H acetyl acetyl H acetylacetyl acetyl acetyl H 6311 H acetyl H H acetyl acetyl H acetyl acetylacetyl acetyl acetyl 6312 H acetyl H H acetyl acetyl acetyl H H H H H6313 H acetyl H H acetyl acetyl acetyl H H H H acetyl 6314 H acetyl H Hacetyl acetyl acetyl H H H acetyl H 6315 H acetyl H H acetyl acetylacetyl H H H acetyl acetyl 6316 H acetyl H H acetyl acetyl acetyl H Hacetyl H H 6317 H acetyl H H acetyl acetyl acetyl H H acetyl H acetyl6318 H acetyl H H acetyl acetyl acetyl H H acetyl acetyl H 6319 H acetylH H acetyl acetyl acetyl H H acetyl acetyl acetyl 6320 H acetyl H Hacetyl acetyl acetyl H acetyl H H H 6321 H acetyl H H acetyl acetylacetyl H acetyl H H acetyl 6322 H acetyl H H acetyl acetyl acetyl Hacetyl H acetyl H 6323 H acetyl H H acetyl acetyl acetyl H acetyl Hacetyl acetyl 6324 H acetyl H H acetyl acetyl acetyl H acetyl acetyl H H6325 H acetyl H H acetyl acetyl acetyl H acetyl acetyl H acetyl 6326 Hacetyl H H acetyl acetyl acetyl H acetyl acetyl acetyl H 6327 H acetyl HH acetyl acetyl acetyl H acetyl acetyl acetyl acetyl 6328 H acetyl H Hacetyl acetyl acetyl acetyl H H H H 6329 H acetyl H H acetyl acetylacetyl acetyl H H H acetyl 6330 H acetyl H H acetyl acetyl acetyl acetylH H acetyl H 6331 H acetyl H H acetyl acetyl acetyl acetyl H H acetylacetyl 6332 H acetyl H H acetyl acetyl acetyl acetyl H acetyl H H 6333 Hacetyl H H acetyl acetyl acetyl acetyl H acetyl H acetyl 6334 H acetyl HH acetyl acetyl acetyl acetyl H acetyl acetyl H 6335 H acetyl H H acetylacetyl acetyl acetyl H acetyl acetyl acetyl 6336 H acetyl H H acetylacetyl acetyl acetyl acetyl H H H 6337 H acetyl H H acetyl acetyl acetylacetyl acetyl H H acetyl 6338 H acetyl H H acetyl acetyl acetyl acetylacetyl H acetyl H 6339 H acetyl H H acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl 6340 H acetyl H H acetyl acetyl acetyl acetyl acetylacetyl H H 6341 H acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl 6342 H acetyl H H acetyl acetyl acetyl acetyl acetyl acetylacetyl H 6343 H acetyl H H acetyl acetyl acetyl acetyl acetyl acetylacetyl acetyl 6344 H acetyl H acetyl H H H H H H H H 6345 H acetyl Hacetyl H H H H H H H acetyl 6346 H acetyl H acetyl H H H H H H acetyl H6347 H acetyl H acetyl H H H H H H acetyl acetyl 6348 H acetyl H acetylH H H H H acetyl H H 6349 H acetyl H acetyl H H H H H acetyl H acetyl6350 H acetyl H acetyl H H H H H acetyl acetyl H 6351 H acetyl H acetylH H H H H acetyl acetyl acetyl 6352 H acetyl H acetyl H H H H acetyl H HH 6353 H acetyl H acetyl H H H H acetyl H H acetyl 6354 H acetyl Hacetyl H H H H acetyl H acetyl H 6355 H acetyl H acetyl H H H H acetyl Hacetyl acetyl 6356 H acetyl H acetyl H H H H acetyl acetyl H H 6357 Hacetyl H acetyl H H H H acetyl acetyl H acetyl 6358 H acetyl H acetyl HH H H acetyl acetyl acetyl H 6359 H acetyl H acetyl H H H H acetylacetyl acetyl acetyl 6360 H acetyl H acetyl H H H acetyl H H H H 6361 Hacetyl H acetyl H H H acetyl H H H acetyl 6362 H acetyl H acetyl H H Hacetyl H H acetyl H 6363 H acetyl H acetyl H H H acetyl H H acetylacetyl 6364 H acetyl H acetyl H H H acetyl H acetyl H H 6365 H acetyl Hacetyl H H H acetyl H acetyl H acetyl 6366 H acetyl H acetyl H H Hacetyl H acetyl acetyl H 6367 H acetyl H acetyl H H H acetyl H acetylacetyl acetyl 6368 H acetyl H acetyl H H H ,acetyl acetyl H H H 6369 Hacetyl H acetyl H H H acetyl acetyl H H acetyl 6370 H acetyl H acetyl HH H acetyl acetyl H acetyl H 6371 H acetyl H acetyl H H H acetyl acetylH acetyl acetyl 6372 H acetyl H acetyl H H H acetyl acetyl acetyl H H6373 H acetyl H acetyl H H H acetyl acetyl acetyl H acetyl 6374 H acetylH acetyl H H H acetyl acetyl acetyl acetyl H 6375 H acetyl H acetyl H HH acetyl acetyl acetyl acetyl acetyl 6376 H acetyl H acetyl H H acetyl HH H H H 6377 H acetyl H acetyl H H acetyl H H H H acetyl 6378 H acetyl Hacetyl H H acetyl H H H acetyl H 6379 H acetyl H acetyl H H acetyl H H Hacetyl acetyl 6380 H acetyl H acetyl H H acetyl H H acetyl H H 6381 Hacetyl H acetyl H H acetyl H H acetyl H acetyl 6382 H acetyl H acetyl HH acetyl H H acetyl acetyl H 6383 H acetyl H acetyl H H acetyl H Hacetyl acetyl acetyl 6384 H acetyl H acetyl H H acetyl H acetyl H H H6385 H acetyl H acetyl H H acetyl H acetyl H H acetyl 6386 H acetyl Hacetyl H H acetyl H acetyl H acetyl H 6387 H acetyl H acetyl H H acetylH acetyl H acetyl acetyl 6388 H acetyl H acetyl H H acetyl H acetylacetyl H H 6389 H acetyl H acetyl H H acetyl H acetyl acetyl H acetyl6390 H acetyl H acetyl H H acetyl H acetyl acetyl acetyl H 6391 H acetylH acetyl H H acetyl H acetyl acetyl acetyl acetyl 6392 H acetyl H acetylH H acetyl acetyl H H H H 6393 H acetyl H acetyl H H acetyl acetyl H H Hacetyl 6394 H acetyl H acetyl H H acetyl acetyl H H acetyl H 6395 Hacetyl H acetyl H H acetyl acetyl H H acetyl acetyl 6396 H acetyl Hacetyl H H acetyl acetyl H acetyl H H 6397 H acetyl H acetyl H H acetylacetyl H acetyl H acetyl 6398 H acetyl H acetyl H H acetyl acetyl Hacetyl acetyl H 6399 H acetyl H acetyl H H acetyl acetyl H acetyl acetylacetyl 6400 H acetyl H acetyl H H acetyl acetyl acetyl H H H 6401 Hacetyl H acetyl H H acetyl acetyl acetyl H H acetyl 6402 H acetyl Hacetyl H H acetyl acetyl acetyl H acetyl H 6403 H acetyl H acetyl H Hacetyl acetyl acetyl H acetyl acetyl 6404 H acetyl H acetyl H H acetylacetyl acetyl acetyl H H 6405 H acetyl H acetyl H H acetyl acetyl acetylacetyl H acetyl 6406 H acetyl H acetyl H H acetyl acetyl acetyl acetylacetyl H 6407 H acetyl H acetyl H H, acetyl acetyl acetyl acetyl acetylacetyl 6408 H acetyl H acetyl H acetyl H H H H H H 6409 H acetyl Hacetyl H acetyl H H H H H acetyl 6410 H acetyl H acetyl H acetyl H H H Hacetyl H 6411 H acetyl H acetyl H acetyl H H H H acetyl acetyl 6412 Hacetyl H acetyl H acetyl H H H acetyl H H 6413 H acetyl H acetyl Hacetyl H H H acetyl H acetyl 6414 H acetyl H acetyl H acetyl H H Hacetyl acetyl H 6415 H acetyl H acetyl H acetyl H H H acetyl acetylacetyl 6416 H acetyl H acetyl H acetyl H H acetyl H H H 6417 H acetyl Hacetyl H acetyl H H acetyl H H acetyl 6418 H acetyl H acetyl H acetyl HH acetyl H acetyl H 6419 H acetyl H acetyl H acetyl H H acetyl H acetylacetyl 6420 H acetyl H acetyl H acetyl H H acetyl acetyl H H 6421 Hacetyl H acetyl H acetyl H H acetyl acetyl H acetyl 6422 H acetyl Hacetyl H acetyl H H acetyl acetyl acetyl H 6423 H acetyl H acetyl Hacetyl H H acetyl acetyl acetyl acetyl 6424 H acetyl H acetyl H acetyl Hacetyl H H H H 6425 H acetyl H acetyl H acetyl H acetyl H H H acetyl6426 H acetyl H acetyl H acetyl H acetyl H H acetyl H 6427 H acetyl Hacetyl H acetyl H acetyl H H acetyl acetyl 6428 H acetyl H acetyl Hacetyl H acetyl H acetyl H H 6429 H acetyl H acetyl H acetyl H acetyl Hacetyl H acetyl 6430 H acetyl H acetyl H acetyl H acetyl H acetyl acetylH 6431 H acetyl H acetyl H acetyl H acetyl H acetyl acetyl acetyl 6432 Hacetyl H acetyl H acetyl H acetyl acetyl H H H 6433 H acetyl H acetyl Hacetyl H acetyl acetyl H H acetyl 6434 H acetyl H acetyl H acetyl Hacetyl acetyl H acetyl H 6435 H acetyl H acetyl H acetyl H acetyl acetylH acetyl acetyl 6436 H acetyl H acetyl H acetyl H acetyl acetyl acetyl HH 6437 H acetyl H acetyl H acetyl H acetyl acetyl acetyl H acetyl 6438 Hacetyl H acetyl H acetyl H acetyl acetyl acetyl acetyl H 6439 H acetyl Hacetyl H acetyl H acetyl acetyl acetyl acetyl acetyl 6440 H acetyl Hacetyl H acetyl acetyl H H H H H 6441 H acetyl H acetyl H acetyl acetylH H H H acetyl 6442 H acetyl H acetyl H acetyl acetyl H H H acetyl H6443 H acetyl H acetyl H acetyl acetyl H H H acetyl acetyl 6444 H acetylH acetyl H acetyl acetyl H H acetyl H H 6445 H acetyl H acetyl H acetylacetyl H H acetyl H acetyl 6446 H acetyl H acetyl H acetyl acetyl H Hacetyl acetyl H 6447 H acetyl H acetyl H acetyl acetyl H H acetyl acetylacetyl 6448 H acetyl H acetyl H acetyl acetyl H acetyl H H H 6449 Hacetyl H acetyl H acetyl acetyl H acetyl H H acetyl 6450 H acetyl Hacetyl H acetyl acetyl H acetyl H acetyl H 6451 H acetyl H acetyl Hacetyl acetyl H acetyl H acetyl acetyl 6452 H acetyl H acetyl H acetylacetyl H acetyl acetyl H H 6453 H acetyl H acetyl H acetyl acetyl Hacetyl acetyl H acetyl 6454 H acetyl H acetyl H acetyl acetyl H acetylacetyl acetyl H 6455 H acetyl H acetyl H acetyl acetyl H acetyl acetylacetyl acetyl 6456 H acetyl H acetyl H acetyl acetyl acetyl H H H H 6457H acetyl H acetyl H acetyl acetyl acetyl H H H acetyl 6458 H acetyl Hacetyl H acetyl acetyl acetyl H H acetyl H 6459 H acetyl H acetyl Hacetyl acetyl acetyl H H acetyl acetyl 6460 H acetyl H acetyl H acetylacetyl acetyl H acetyl H H 6461 H acetyl H acetyl H acetyl acetyl acetylH acetyl H acetyl 6462 H acetyl H acetyl H acetyl acetyl acetyl H acetylacetyl H 6463 H acetyl H acetyl H acetyl acetyl acetyl H acetyl acetylacetyl 6464 H acetyl H acetyl H acetyl acetyl acetyl acetyl H H H 6465 Hacetyl H acetyl H acetyl acetyl acetyl acetyl H H acetyl 6466 H acetyl Hacetyl H acetyl acetyl acetyl acetyl H acetyl H 6467 H acetyl H acetyl Hacetyl acetyl acetyl acetyl H acetyl acetyl 6468 H acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl H H 6469 H acetyl H acetyl H acetylacetyl acetyl acetyl acetyl H acetyl 6470 H acetyl H acetyl H acetylacetyl acetyl acetyl acetyl acetyl H 6471 H acetyl H acetyl H acetylacetyl acetyl acetyl acetyl acetyl acetyl 6472 H acetyl H acetyl acetylH H H H H H H 6473 H acetyl H acetyl acetyl H H H H H H acetyl 6474 Hacetyl H acetyl acetyl H H H H H acetyl H 6475 H acetyl H acetyl acetylH H H H H acetyl acetyl 6476 H acetyl H acetyl acetyl H H H H acetyl H H6477 H acetyl H acetyl acetyl H H H H acetyl H acetyl 6478 H acetyl Hacetyl acetyl H H H H acetyl acetyl H 6479 H acetyl H acetyl acetyl H HH H acetyl acetyl acetyl 6480 H acetyl H acetyl acetyl H H H acetyl H HH 6481 H acetyl H acetyl acetyl H H H acetyl H H acetyl 6482 H acetyl Hacetyl acetyl H H H acetyl H acetyl H 6483 H acetyl H acetyl acetyl H HH acetyl H acetyl acetyl 6484 H acetyl H acetyl acetyl H H H acetylacetyl H H 6485 H acetyl H acetyl acetyl H H H acetyl acetyl H acetyl6486 H acetyl H acetyl acetyl H H H acetyl acetyl acetyl H 6487 H acetylH acetyl acetyl H H H acetyl acetyl acetyl acetyl 6488 H acetyl H acetylacetyl H H acetyl H H H H 6489 H acetyl H acetyl acetyl H H acetyl H H Hacetyl 6490 H acetyl H acetyl acetyl H H acetyl H H acetyl H 6491 Hacetyl H acetyl acetyl H H acetyl H H acetyl acetyl 6492 H acetyl Hacetyl acetyl H H acetyl H acetyl H H 6493 H acetyl H acetyl acetyl H Hacetyl H acetyl H acetyl 6494 H acetyl H acetyl acetyl H H acetyl Hacetyl acetyl H 6495 H acetyl H acetyl acetyl H H acetyl H acetyl acetylacetyl 6496 H acetyl H acetyl acetyl H H acetyl acetyl H H H 6497 Hacetyl H acetyl acetyl H H acetyl acetyl H H acetyl 6498 H acetyl Hacetyl acetyl H H acetyl acetyl H acetyl H 6499 H acetyl H acetyl acetylH H acetyl acetyl H acetyl acetyl 6500 H acetyl H acetyl acetyl H Hacetyl acetyl acetyl H H 6501 H acetyl H acetyl acetyl H H acetyl acetylacetyl H acetyl 6502 H acetyl H acetyl acetyl H H acetyl acetyl acetylacetyl H 6503 H acetyl H acetyl acetyl H H acetyl acetyl acetyl acetylacetyl 6504 H acetyl H acetyl acetyl H acetyl H H H H H 6505 H acetyl Hacetyl acetyl H acetyl H H H H acetyl 6506 H acetyl H acetyl acetyl Hacetyl H H H acetyl H 6507 H acetyl H acetyl acetyl H acetyl H H Hacetyl acetyl 6508 H acetyl H acetyl acetyl H acetyl H H acetyl H H 6509H acetyl H acetyl acetyl H acetyl H H acetyl H acetyl 6510 H acetyl Hacetyl acetyl H acetyl H H acetyl acetyl H 6511 H acetyl H acetyl acetylH acetyl H H acetyl acetyl acetyl 6512 H acetyl H acetyl acetyl H acetylH acetyl H H H 6513 H acetyl H acetyl acetyl H acetyl H acetyl H Hacetyl 6514 H acetyl H acetyl acetyl H acetyl H acetyl H acetyl H 6515 Hacetyl H acetyl acetyl H acetyl H acetyl H acetyl acetyl 6516 H acetyl Hacetyl acetyl H acetyl H acetyl acetyl H H 6517 H acetyl H acetyl acetylH acetyl H acetyl acetyl H acetyl 6518 H acetyl H acetyl acetyl H acetylH acetyl acetyl acetyl H 6519 H acetyl H acetyl acetyl H acetyl H acetylacetyl acetyl acetyl 6520 H acetyl H acetyl acetyl H acetyl acetyl H H HH 6521 H acetyl H acetyl acetyl H acetyl acetyl H H H acetyl 6522 Hacetyl H acetyl acetyl H acetyl acetyl H H acetyl H 6523 H acetyl Hacetyl acetyl H acetyl acetyl H H acetyl acetyl 6524 H acetyl H acetylacetyl H acetyl acetyl H acetyl H H 6525 H acetyl H acetyl acetyl Hacetyl acetyl H acetyl H acetyl 6526 H acetyl H acetyl acetyl H acetylacetyl H acetyl acetyl H 6527 H acetyl H acetyl acetyl H acetyl acetyl Hacetyl acetyl acetyl 6528 H acetyl H acetyl acetyl H acetyl acetylacetyl H H H 6529 H acetyl H acetyl acetyl H acetyl acetyl acetyl H Hacetyl 6530 H acetyl H acetyl acetyl H acetyl acetyl acetyl H acetyl H6531 H acetyl H acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl6532 H acetyl H acetyl acetyl H acetyl acetyl acetyl acetyl H H 6533 Hacetyl H acetyl acetyl H acetyl acetyl acetyl acetyl H acetyl 6534 Hacetyl H acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H 6535 Hacetyl H acetyl acetyl H acetyl acetyl acetyl acetyl acetyl acetyl 6536H acetyl H acetyl acetyl acetyl H H H H H H 6537 H acetyl H acetylacetyl acetyl H H H H H acetyl 6538 H acetyl H acetyl acetyl acetyl H HH H acetyl H 6539 H acetyl H acetyl acetyl acetyl H H H H acetyl acetyl6540 H acetyl H acetyl acetyl acetyl H H H acetyl H H 6541 H acetyl Hacetyl acetyl acetyl H H H acetyl H acetyl 6542 H acetyl H acetyl acetylacetyl H H H acetyl acetyl H 6543 H acetyl H acetyl acetyl acetyl H H Hacetyl acetyl acetyl 6544 H acetyl H acetyl acetyl acetyl H H acetyl H HH 6545 H acetyl H acetyl acetyl acetyl H H acetyl H H acetyl 6546 Hacetyl H acetyl acetyl acetyl H H acetyl H acetyl H 6547 H acetyl Hacetyl acetyl acetyl H H acetyl H acetyl acetyl 6548 H acetyl H acetylacetyl acetyl H H acetyl acetyl H H 6549 H acetyl H acetyl acetyl acetylH H acetyl acetyl H acetyl 6550 H acetyl H acetyl acetyl acetyl H Hacetyl acetyl acetyl H 6551 H acetyl H acetyl acetyl acetyl H H acetylacetyl acetyl acetyl 6552 H acetyl H acetyl acetyl acetyl H acetyl H H HH 6553 H acetyl H acetyl acetyl acetyl H acetyl H H H acetyl 6554 Hacetyl H acetyl acetyl acetyl H acetyl H H acetyl H 6555 H acetyl Hacetyl acetyl acetyl H acetyl H H acetyl acetyl 6556 H acetyl H acetylacetyl acetyl H acetyl H acetyl H H 6557 H acetyl H acetyl acetyl acetylH acetyl H acetyl H acetyl 6558 H acetyl H acetyl acetyl acetyl H acetylH acetyl acetyl H 6559 H acetyl H acetyl acetyl acetyl H acetyl H acetylacetyl acetyl 6560 H acetyl H acetyl acetyl acetyl H acetyl acetyl H H H6561 H acetyl H acetyl acetyl acetyl H acetyl acetyl H H acetyl 6562 Hacetyl H acetyl acetyl acetyl H acetyl acetyl H acetyl H 6563 H acetyl Hacetyl acetyl acetyl H acetyl acetyl H acetyl acetyl 6564 H acetyl Hacetyl acetyl acetyl H acetyl acetyl acetyl H H 6565 H acetyl H acetylacetyl acetyl H acetyl acetyl acetyl H acetyl 6566 H acetyl H acetylacetyl acetyl H acetyl acetyl acetyl acetyl H 6567 H acetyl H acetylacetyl acetyl H acetyl acetyl acetyl acetyl acetyl 6568 H acetyl Hacetyl acetyl acetyl acetyl H H H H H 6569 H acetyl H acetyl acetylacetyl acetyl H H H H acetyl 6570 H acetyl H acetyl acetyl acetyl acetylH H H acetyl H 6571 H acetyl H acetyl acetyl acetyl acetyl H H H acetylacetyl 6572 H acetyl H acetyl acetyl acetyl acetyl H H acetyl H H 6573 Hacetyl H acetyl acetyl acetyl acetyl H H acetyl H acetyl 6574 H acetyl Hacetyl acetyl acetyl acetyl H H acetyl acetyl H 6575 H acetyl H acetylacetyl acetyl acetyl H H acetyl acetyl acetyl 6576 H acetyl H acetylacetyl acetyl acetyl H acetyl H H H 6577 H acetyl H acetyl acetyl acetylacetyl H acetyl H H acetyl 6578 H acetyl H acetyl acetyl acetyl acetyl Hacetyl H acetyl H 6579 H acetyl H acetyl acetyl acetyl acetyl H acetyl Hacetyl acetyl 6580 H acetyl H acetyl acetyl acetyl acetyl H acetylacetyl H H 6581 H acetyl H acetyl acetyl acetyl acetyl H acetyl acetyl Hacetyl 6582 H acetyl H acetyl acetyl acetyl acetyl H acetyl acetylacetyl H 6583 H acetyl H acetyl acetyl acetyl acetyl H acetyl acetylacetyl acetyl 6584 H acetyl H acetyl acetyl acetyl acetyl acetyl H H H H6585 H acetyl H acetyl acetyl acetyl acetyl acetyl H H H acetyl 6586 Hacetyl H acetyl acetyl acetyl acetyl acetyl H H acetyl H 6587 H acetyl Hacetyl acetyl acetyl acetyl acetyl H H acetyl acetyl 6588 H acetyl Hacetyl acetyl acetyl acetyl acetyl H acetyl H H 6589 H acetyl H acetylacetyl acetyl acetyl acetyl H acetyl H acetyl 6590 H acetyl H acetylacetyl acetyl acetyl acetyl H acetyl acetyl H 6591 H acetyl H acetylacetyl acetyl acetyl acetyl H acetyl acetyl acetyl 6592 H acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H H H 6593 H acetyl H acetylacetyl acetyl acetyl acetyl acetyl H H acetyl 6594 H acetyl H acetylacetyl acetyl acetyl acetyl acetyl H acetyl H 6595 H acetyl H acetylacetyl acetyl acetyl acetyl acetyl H acetyl acetyl 6596 H acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl H H 6597 H acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl 6598 H acetylH acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H 6599 Hacetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl6600 H acetyl acetyl H H H H H H H H H 6601 H acetyl acetyl H H H H H HH H acetyl 6602 H acetyl acetyl H H H H H H H acetyl H 6603 H acetylacetyl H H H H H H H acetyl acetyl 6604 H acetyl acetyl H H H H H Hacetyl H H 6605 H acetyl acetyl H H H H H H acetyl H acetyl 6606 Hacetyl acetyl H H H H H H acetyl acetyl H 6607 H acetyl acetyl H H H H HH acetyl acetyl acetyl 6608 H acetyl acetyl H H H H H acetyl H H H 6609H acetyl acetyl H H H H H acetyl H H acetyl 6610 H acetyl acetyl H H H HH acetyl H acetyl H 6611 H acetyl acetyl H H H H H acetyl H acetylacetyl 6612 H acetyl acetyl H H H H H acetyl acetyl H H 6613 H acetylacetyl H H H H H acetyl acetyl H acetyl 6614 H acetyl acetyl H H H H Hacetyl acetyl acetyl H 6615 H acetyl acetyl H H H H H acetyl acetylacetyl acetyl 6616 H acetyl acetyl H H H H acetyl H H H H 6617 H acetylacetyl H H H H acetyl H H H acetyl 6618 H acetyl acetyl H H H H acetyl HH acetyl H 6619 H acetyl acetyl H H H H acetyl H H acetyl acetyl 6620 Hacetyl acetyl H H H H acetyl H acetyl H H 6621 H acetyl acetyl H H H Hacetyl H acetyl H acetyl 6622 H acetyl acetyl H H H H acetyl H acetylacetyl H 6623 H acetyl acetyl H H H H acetyl H acetyl acetyl acetyl 6624H acetyl acetyl H H H H acetyl acetyl H H H 6625 H acetyl acetyl H H H Hacetyl acetyl H H acetyl 6626 H acetyl acetyl H H H H acetyl acetyl Hacetyl H 6627 H acetyl acetyl H H H H acetyl acetyl H acetyl acetyl 6628H acetyl acetyl H H H H acetyl acetyl acetyl H H 6629 H acetyl acetyl HH H H acetyl acetyl acetyl H acetyl 6630 H acetyl acetyl H H H H acetylacetyl acetyl acetyl H 6631 H acetyl acetyl H H H H acetyl acetyl acetylacetyl acetyl 6632 H acetyl acetyl H H H acetyl H H H H H 6633 H acetylacetyl H H H acetyl H H H H acetyl 6634 H acetyl acetyl H H H acetyl H HH acetyl H 6635 H acetyl acetyl H H H acetyl H H H acetyl acetyl 6636 Hacetyl acetyl H H H acetyl H H acetyl H H 6637 H acetyl acetyl H H Hacetyl H H acetyl H acetyl 6638 H acetyl acetyl H H H acetyl H H acetylacetyl H 6639 H acetyl acetyl H H H acetyl H H acetyl acetyl acetyl 6640H acetyl acetyl H H H acetyl H acetyl H H H 6641 H acetyl acetyl H H Hacetyl H acetyl H H acetyl 6642 H acetyl acetyl H H H acetyl H acetyl Hacetyl H 6643 H acetyl acetyl H H H acetyl H acetyl H acetyl acetyl 6644H acetyl acetyl H H H acetyl H acetyl acetyl H H 6645 H acetyl acetyl HH H acetyl H acetyl acetyl H acetyl 6646 H acetyl acetyl H H H acetyl Hacetyl acetyl acetyl H 6647 H acetyl acetyl H H H acetyl H acetyl acetylacetyl acetyl 6648 H acetyl acetyl H H H acetyl acetyl H H H H 6649 Hacetyl acetyl H H H acetyl acetyl H H H acetyl 6650 H acetyl acetyl H HH acetyl acetyl H H acetyl H 6651 H acetyl acetyl H H H acetyl acetyl HH acetyl acetyl 6652 H acetyl acetyl H H H acetyl acetyl H acetyl H H6653 H acetyl acetyl H H H acetyl acetyl H acetyl H acetyl 6654 H acetylacetyl H H H acetyl acetyl H acetyl acetyl H 6655 H acetyl acetyl H H Hacetyl acetyl H acetyl acetyl acetyl 6656 H acetyl acetyl H H H acetylacetyl acetyl H H H 6657 H acetyl acetyl H H H acetyl acetyl acetyl H Hacetyl 6658 H acetyl acetyl H H H acetyl acetyl acetyl H acetyl H 6659 Hacetyl acetyl H H H acetyl acetyl acetyl H acetyl acetyl 6660 H acetylacetyl H H H acetyl acetyl acetyl acetyl H H 6661 H acetyl acetyl H H Hacetyl acetyl acetyl acetyl H acetyl 6662 H acetyl acetyl H H H acetylacetyl acetyl acetyl acetyl H 6663 H acetyl acetyl H H H acetyl acetylacetyl acetyl acetyl acetyl 6664 H acetyl acetyl H H acetyl H H H H H H6665 H acetyl acetyl H H acetyl H H H H H acetyl 6666 H acetyl acetyl HH acetyl H H H H acetyl H 6667 H acetyl acetyl H H acetyl H H H H acetylacetyl 6668 H acetyl acetyl H H acetyl H H H acetyl H H 6669 H acetylacetyl H H acetyl H H H acetyl H acetyl 6670 H acetyl acetyl H H acetylH H H acetyl acetyl H 6671 H acetyl acetyl H H acetyl H H H acetylacetyl acetyl 6672 H acetyl acetyl H H acetyl H H acetyl H H H 6673 Hacetyl acetyl H H acetyl H H acetyl H H acetyl 6674 H acetyl acetyl H Hacetyl H H acetyl H acetyl H 6675 H acetyl acetyl H H acetyl H H acetylH acetyl acetyl 6676 H acetyl acetyl H H acetyl H H acetyl acetyl H H6677 H acetyl acetyl H H acetyl H H acetyl acetyl H acetyl 6678 H acetylacetyl H H acetyl H H acetyl acetyl acetyl H 6679 H acetyl acetyl H Hacetyl H H acetyl acetyl acetyl acetyl 6680 H acetyl acetyl H H acetyl Hacetyl H H H H 6681 H acetyl acetyl H H acetyl H acetyl H H H acetyl6682 H acetyl acetyl H H acetyl H acetyl H H acetyl H 6683 H acetylacetyl H H acetyl H acetyl H H acetyl acetyl 6684 H acetyl acetyl H Hacetyl H acetyl H acetyl H H 6685 H acetyl acetyl H H acetyl H acetyl Hacetyl H acetyl 6686 H acetyl acetyl H H acetyl H acetyl H acetyl acetylH 6687 H acetyl acetyl H H acetyl H acetyl H acetyl acetyl acetyl 6688 Hacetyl acetyl H H acetyl H acetyl acetyl H H H 6689 H acetyl acetyl H Hacetyl H acetyl acetyl H H acetyl 6690 H acetyl acetyl H H acetyl Hacetyl acetyl H acetyl H 6691 H acetyl acetyl H H acetyl H acetyl acetylH acetyl acetyl 6692 H acetyl acetyl H H acetyl H acetyl acetyl acetyl HH 6693 H acetyl acetyl H H acetyl H acetyl acetyl acetyl H acetyl 6694 Hacetyl acetyl H H acetyl H acetyl acetyl acetyl acetyl H 6695 H acetylacetyl H H acetyl H acetyl acetyl acetyl acetyl acetyl 6696 H acetylacetyl H H acetyl acetyl H H H H H 6697 H acetyl acetyl H H acetylacetyl H H H H acetyl 6698 H acetyl acetyl H H acetyl acetyl H H Hacetyl H 6699 H acetyl acetyl H H acetyl acetyl H H H acetyl acetyl 6700H acetyl acetyl H H acetyl acetyl H H acetyl H H 6701 H acetyl acetyl HH acetyl acetyl H H acetyl H acetyl 6702 H acetyl acetyl H H acetylacetyl H H acetyl acetyl H 6703 H acetyl acetyl H H acetyl acetyl H Hacetyl acetyl acetyl 6704 H acetyl acetyl H H acetyl acetyl H acetyl H HH 6705 H acetyl acetyl H H acetyl acetyl H acetyl H H acetyl 6706 Hacetyl acetyl H H acetyl acetyl H acetyl H acetyl H 6707 H acetyl acetylH H acetyl acetyl H acetyl H acetyl acetyl 6708 H acetyl acetyl H Hacetyl acetyl H acetyl acetyl H H 6709 H acetyl acetyl H H acetyl acetylH acetyl acetyl H acetyl 6710 H acetyl acetyl H H acetyl acetyl H acetylacetyl acetyl H 6711 H acetyl acetyl H H acetyl acetyl H acetyl acetylacetyl acetyl 6712 H acetyl acetyl H H acetyl acetyl acetyl H H H H 6713H acetyl acetyl H H acetyl acetyl acetyl H H H acetyl 6714 H acetylacetyl H H acetyl acetyl acetyl H H acetyl H 6715 H acetyl acetyl H Hacetyl acetyl acetyl H H acetyl acetyl 6716 H acetyl acetyl H H acetylacetyl acetyl H acetyl H H 6717 H acetyl acetyl H H acetyl acetyl acetylH acetyl H acetyl 6718 H acetyl acetyl H H acetyl acetyl acetyl H acetylacetyl H 6719 H acetyl acetyl H H acetyl acetyl acetyl H acetyl acetylacetyl 6720 H acetyl acetyl H H acetyl acetyl acetyl acetyl H H H 6721 Hacetyl acetyl H H acetyl acetyl acetyl acetyl H H acetyl 6722 H acetylacetyl H H acetyl acetyl acetyl acetyl H acetyl H 6723 H acetyl acetyl HH acetyl acetyl acetyl acetyl H acetyl acetyl 6724 H acetyl acetyl H Hacetyl acetyl acetyl acetyl acetyl H H 6725 H acetyl acetyl H H acetylacetyl acetyl acetyl acetyl H acetyl 6726 H acetyl acetyl H H acetylacetyl acetyl acetyl acetyl acetyl H 6727 H acetyl acetyl H H acetylacetyl acetyl acetyl acetyl acetyl acetyl 6728 H acetyl acetyl H acetylH H H H H H H 6729 H acetyl acetyl H acetyl H H H H H H acetyl 6730 Hacetyl acetyl H acetyl H H H H H acetyl H 6731 H acetyl acetyl H acetylH H H H H acetyl acetyl 6732 H acetyl acetyl H acetyl H H H H acetyl H H6733 H acetyl acetyl H acetyl H H H H acetyl H acetyl 6734 H acetylacetyl H acetyl H H H H acetyl acetyl H 6735 H acetyl acetyl H acetyl HH H H acetyl acetyl acetyl 6736 H acetyl acetyl H acetyl H H H acetyl HH H 6737 H acetyl acetyl H acetyl H H H acetyl H H acetyl 6738 H acetylacetyl H acetyl H H H acetyl H acetyl H 6739 H acetyl acetyl H acetyl HH H acetyl H acetyl acetyl 6740 H acetyl acetyl H acetyl H H H acetylacetyl H H 6741 H acetyl acetyl H acetyl H H H acetyl acetyl H acetyl6742 H acetyl acetyl H acetyl H H H acetyl acetyl acetyl H 6743 H acetylacetyl H acetyl H H H acetyl acetyl acetyl acetyl 6744 H acetyl acetyl Hacetyl H H acetyl H H H H 6745 H acetyl acetyl H acetyl H H acetyl H H Hacetyl 6746 H acetyl acetyl H acetyl H H acetyl H H acetyl H 6747 Hacetyl acetyl H acetyl H H acetyl H H acetyl acetyl 6748 H acetyl acetylH acetyl H H acetyl H acetyl H H 6749 H acetyl acetyl H acetyl H Hacetyl H acetyl H acetyl 6750 H acetyl acetyl H acetyl H H acetyl Hacetyl acetyl H 6751 H acetyl acetyl H acetyl H H acetyl H acetyl acetylacetyl 6752 H acetyl acetyl H acetyl H H acetyl acetyl H H H 6753 Hacetyl acetyl H acetyl H H acetyl acetyl H H acetyl 6754 H acetyl acetylH acetyl H H acetyl acetyl H acetyl H 6755 H acetyl acetyl H acetyl H Hacetyl acetyl H acetyl acetyl 6756 H acetyl acetyl H acetyl H H acetylacetyl acetyl H H 6757 H acetyl acetyl H acetyl H H acetyl acetyl acetylH acetyl 6758 H acetyl acetyl H acetyl H H acetyl acetyl acetyl acetyl H6759 H acetyl acetyl H acetyl H H acetyl acetyl acetyl acetyl acetyl6760 H acetyl acetyl H acetyl H acetyl H H H H H 6761 H acetyl acetyl Hacetyl H acetyl H H H H acetyl 6762 H acetyl acetyl H acetyl H acetyl HH H acetyl H 6763 H acetyl acetyl H acetyl H acetyl H H H acetyl acetyl6764 H acetyl acetyl H acetyl H acetyl H H acetyl H H 6765 H acetylacetyl H acetyl H acetyl H H acetyl H acetyl 6766 H acetyl acetyl Hacetyl H acetyl H H acetyl acetyl H 6767 H acetyl acetyl H acetyl Hacetyl H H acetyl acetyl acetyl 6768 H acetyl acetyl H acetyl H acetyl Hacetyl H H H 6769 H acetyl acetyl H acetyl H acetyl H acetyl H H acetyl6770 H acetyl acetyl H acetyl H acetyl H acetyl H acetyl H 6771 H acetylacetyl H acetyl H acetyl H acetyl H acetyl acetyl 6772 H acetyl acetyl Hacetyl H acetyl H acetyl acetyl H H 6773 H acetyl acetyl H acetyl Hacetyl H acetyl acetyl H acetyl 6774 H acetyl acetyl H acetyl H acetyl Hacetyl acetyl acetyl H 6775 H acetyl acetyl H acetyl H acetyl H acetylacetyl acetyl acetyl 6776 H acetyl acetyl H acetyl H acetyl acetyl H H HH 6777 H acetyl acetyl H acetyl H acetyl acetyl H H H acetyl 6778 Hacetyl acetyl H acetyl H acetyl acetyl H H acetyl H 6779 H acetyl acetylH acetyl H acetyl acetyl H H acetyl acetyl 6780 H acetyl acetyl H acetylH acetyl acetyl H acetyl H H 6781 H acetyl acetyl H acetyl H acetylacetyl H acetyl H acetyl 6782 H acetyl acetyl H acetyl H acetyl acetyl Hacetyl acetyl H 6783 H acetyl acetyl H acetyl H acetyl acetyl H acetylacetyl acetyl 6784 H acetyl acetyl H acetyl H acetyl acetyl acetyl H H H6785 H acetyl acetyl H acetyl H acetyl acetyl acetyl H H acetyl 6786 Hacetyl acetyl H acetyl H acetyl acetyl acetyl H acetyl H 6787 H acetylacetyl H acetyl H acetyl acetyl acetyl H acetyl acetyl 6788 H acetylacetyl H acetyl H acetyl acetyl acetyl acetyl H H 6789 H acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl H acetyl 6790 H acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl H 6791 H acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl acetyl 6792 H acetyl acetylH acetyl acetyl H H H H H H 6793 H acetyl acetyl H acetyl acetyl H H H HH acetyl 6794 H acetyl acetyl H acetyl acetyl H H H H acetyl H 6795 Hacetyl acetyl H acetyl acetyl H H H H acetyl acetyl 6796 H acetyl acetylH acetyl acetyl H H H acetyl H H 6797 H acetyl acetyl H acetyl acetyl HH H acetyl H acetyl 6798 H acetyl acetyl H acetyl acetyl H H H acetylacetyl H 6799 H acetyl acetyl H acetyl acetyl H H H acetyl acetyl acetyl6800 H acetyl acetyl H acetyl acetyl H H acetyl H H H 6801 H acetylacetyl H acetyl acetyl H H acetyl H H acetyl 6802 H acetyl acetyl Hacetyl acetyl H H acetyl H acetyl H 6803 H acetyl acetyl H acetyl acetylH H acetyl H acetyl acetyl 6804 H acetyl acetyl H acetyl acetyl H Hacetyl acetyl H H 6805 H acetyl acetyl H acetyl acetyl H H acetyl acetylH acetyl 6806 H acetyl acetyl H acetyl acetyl H H acetyl acetyl acetyl H6807 H acetyl acetyl H acetyl acetyl H H acetyl acetyl acetyl acetyl6808 H acetyl acetyl H acetyl acetyl H acetyl H H H H 6809 H acetylacetyl H acetyl acetyl H acetyl H H H acetyl 6810 H acetyl acetyl Hacetyl acetyl H acetyl H H acetyl H 6811 H acetyl acetyl H acetyl acetylH acetyl H H acetyl acetyl 6812 H acetyl acetyl H acetyl acetyl H acetylH acetyl H H 6813 H acetyl acetyl H acetyl acetyl H acetyl H acetyl Hacetyl 6814 H acetyl acetyl H acetyl acetyl H acetyl H acetyl acetyl H6815 H acetyl acetyl H acetyl acetyl H acetyl H acetyl acetyl acetyl6816 H acetyl acetyl H acetyl acetyl H acetyl acetyl H H H 6817 H acetylacetyl H acetyl acetyl H acetyl acetyl H H acetyl 6818 H acetyl acetyl Hacetyl acetyl H acetyl acetyl H acetyl H 6819 H acetyl acetyl H acetylacetyl H acetyl acetyl H acetyl acetyl 6820 H acetyl acetyl H acetylacetyl H acetyl acetyl acetyl H H 6821 H acetyl acetyl H acetyl acetyl Hacetyl acetyl acetyl H acetyl 6822 H acetyl acetyl H acetyl acetyl Hacetyl acetyl acetyl acetyl H 6823 H acetyl acetyl H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl 6824 H acetyl acetyl H acetyl acetylacetyl H H H H H 6825 H acetyl acetyl H acetyl acetyl acetyl H H H Hacetyl 6826 H acetyl acetyl H acetyl acetyl acetyl H H H acetyl H 6827 Hacetyl acetyl H acetyl acetyl acetyl H H H acetyl acetyl 6828 H acetylacetyl H acetyl acetyl acetyl H H acetyl H H 6829 H acetyl acetyl Hacetyl acetyl acetyl H H acetyl H acetyl 6830 H acetyl acetyl H acetylacetyl acetyl H H acetyl acetyl H 6831 H acetyl acetyl H acetyl acetylacetyl H H acetyl acetyl acetyl 6832 H acetyl acetyl H acetyl acetylacetyl H acetyl H H H 6833 H acetyl acetyl H acetyl acetyl acetyl Hacetyl H H acetyl 6834 H acetyl acetyl H acetyl acetyl acetyl H acetyl Hacetyl H 6835 H acetyl acetyl H acetyl acetyl acetyl H acetyl H acetylacetyl 6836 H acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl H H6837 H acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl H acetyl6838 H acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl H6839 H acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl acetylacetyl 6840 H acetyl acetyl H acetyl acetyl acetyl acetyl H H H H 6841 Hacetyl acetyl H acetyl acetyl acetyl acetyl H H H acetyl 6842 H acetylacetyl H acetyl acetyl acetyl acetyl H H acetyl H 6843 H acetyl acetyl Hacetyl acetyl acetyl acetyl H H acetyl acetyl 6844 H acetyl acetyl Hacetyl acetyl acetyl acetyl H acetyl H H 6845 H acetyl acetyl H acetylacetyl acetyl acetyl H acetyl H acetyl 6846 H acetyl acetyl H acetylacetyl acetyl acetyl H acetyl acetyl H 6847 H acetyl acetyl H acetylacetyl acetyl acetyl H acetyl acetyl acetyl 6848 H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl H H H 6849 H acetyl acetyl H acetylacetyl acetyl acetyl acetyl H H acetyl 6850 H acetyl acetyl H acetylacetyl acetyl acetyl acetyl H acetyl H 6851 H acetyl acetyl H acetylacetyl acetyl acetyl acetyl H acetyl acetyl 6852 H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H H 6853 H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H acetyl 6854 H acetyl acetylH acetyl acetyl acetyl acetyl acetyl acetyl acetyl H 6855 H acetylacetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl 6856 Hacetyl acetyl acetyl H H H H H H H H 6857 H acetyl acetyl acetyl H H H HH H H acetyl 6858 H acetyl acetyl acetyl H H H H H H acetyl H 6859 Hacetyl acetyl acetyl H H H H H H acetyl acetyl 6860 H acetyl acetylacetyl H H H H H acetyl H H 6861 H acetyl acetyl acetyl H H H H H acetylH acetyl 6862 H acetyl acetyl acetyl H H H H H acetyl acetyl H 6863 Hacetyl acetyl acetyl H H H H H acetyl acetyl acetyl 6864 H acetyl acetylacetyl H H H H acetyl H H H 6865 H acetyl acetyl acetyl H H H H acetyl HH acetyl 6866 H acetyl acetyl acetyl H H H H acetyl H acetyl H 6867 Hacetyl acetyl acetyl H H H H acetyl H acetyl acetyl 6868 H acetyl acetylacetyl H H H H acetyl acetyl H H 6869 H acetyl acetyl acetyl H H H Hacetyl acetyl H acetyl 6870 H acetyl acetyl acetyl H H H H acetyl acetylacetyl H 6871 H acetyl acetyl acetyl H H H H acetyl acetyl acetyl acetyl6872 H acetyl acetyl acetyl H H H acetyl H H H H 6873 H acetyl acetylacetyl H H H acetyl H H H acetyl 6874 H acetyl acetyl acetyl H H Hacetyl H H acetyl H 6875 H acetyl acetyl acetyl H H H acetyl H H acetylacetyl 6876 H acetyl acetyl acetyl H H H acetyl H acetyl H H 6877 Hacetyl acetyl acetyl H H H acetyl H acetyl H acetyl 6878 H acetyl acetylacetyl H H H acetyl H acetyl acetyl H 6879 H acetyl acetyl acetyl H H Hacetyl H acetyl acetyl acetyl 6880 H acetyl acetyl acetyl H H H acetylacetyl H H H 6881 H acetyl acetyl acetyl H H H acetyl acetyl H H acetyl6882 H acetyl acetyl acetyl H H H acetyl acetyl H acetyl H 6883 H acetylacetyl acetyl H H H acetyl acetyl H acetyl acetyl 6884 H acetyl acetylacetyl H H H acetyl acetyl acetyl H H 6885 H acetyl acetyl acetyl H H Hacetyl acetyl acetyl H acetyl 6886 H acetyl acetyl acetyl H H H acetylacetyl acetyl acetyl H 6887 H acetyl acetyl acetyl H H H acetyl acetylacetyl acetyl acetyl 6888 H acetyl acetyl acetyl H H acetyl H H H H H6889 H acetyl acetyl acetyl H H acetyl H H H H acetyl 6890 H acetylacetyl acetyl H H acetyl H H H acetyl H 6891 H acetyl acetyl acetyl H Hacetyl H H H acetyl acetyl 6892 H acetyl acetyl acetyl H H acetyl H Hacetyl H H 6893 H acetyl acetyl acetyl H H acetyl H H acetyl H acetyl6894 H acetyl acetyl acetyl H H acetyl H H acetyl acetyl H 6895 H acetylacetyl acetyl H H acetyl H H acetyl acetyl acetyl 6896 H acetyl acetylacetyl H H acetyl H acetyl H H H 6897 H acetyl acetyl acetyl H H acetylH acetyl H H acetyl 6898 H acetyl acetyl acetyl H H acetyl H acetyl Hacetyl H 6899 H acetyl acetyl acetyl H H acetyl H acetyl H acetyl acetyl6900 H acetyl acetyl acetyl H H acetyl H acetyl acetyl H H 6901 H acetylacetyl acetyl H H acetyl H acetyl acetyl H acetyl 6902 H acetyl acetylacetyl H H acetyl H acetyl acetyl acetyl H 6903 H acetyl acetyl acetyl HH acetyl H acetyl acetyl acetyl acetyl 6904 H acetyl acetyl acetyl H Hacetyl acetyl H H H H 6905 H acetyl acetyl acetyl H H acetyl acetyl H HH acetyl 6906 H acetyl acetyl acetyl H H acetyl acetyl H H acetyl H 6907H acetyl acetyl acetyl H H acetyl acetyl H H acetyl acetyl 6908 H acetylacetyl acetyl H H acetyl acetyl H acetyl H H 6909 H acetyl acetyl acetylH H acetyl acetyl H acetyl H acetyl 6910 H acetyl acetyl acetyl H Hacetyl acetyl H acetyl acetyl H 6911 H acetyl acetyl acetyl H H acetylacetyl H acetyl acetyl acetyl 6912 H acetyl acetyl acetyl H H acetylacetyl acetyl H H H 6913 H acetyl acetyl acetyl H H acetyl acetyl acetylH H acetyl 6914 H acetyl acetyl acetyl H H acetyl acetyl acetyl H acetylH 6915 H acetyl acetyl acetyl H H acetyl acetyl acetyl H acetyl acetyl6916 H acetyl acetyl acetyl H H acetyl acetyl acetyl acetyl H H 6917 Hacetyl acetyl acetyl H H acetyl acetyl acetyl acetyl H acetyl 6918 Hacetyl acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl H 6919 Hacetyl acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl 6920H acetyl acetyl acetyl H acetyl H H H H H H 6921 H acetyl acetyl acetylH acetyl H H H H H acetyl 6922 H acetyl acetyl acetyl H acetyl H H H Hacetyl H 6923 H acetyl acetyl acetyl H acetyl H H H H acetyl acetyl 6924H acetyl acetyl acetyl H acetyl H H H acetyl H H 6925 H acetyl acetylacetyl H acetyl H H H acetyl H acetyl 6926 H acetyl acetyl acetyl Hacetyl H H H acetyl acetyl H 6927 H acetyl acetyl acetyl H acetyl H H Hacetyl acetyl acetyl 6928 H acetyl acetyl acetyl H acetyl H H acetyl H HH 6929 H acetyl acetyl acetyl H acetyl H H acetyl H H acetyl 6930 Hacetyl acetyl acetyl H acetyl H H acetyl H acetyl H 6931 H acetyl acetylacetyl H acetyl H H acetyl H acetyl acetyl 6932 H acetyl acetyl acetyl Hacetyl H H acetyl acetyl H H 6933 H acetyl acetyl acetyl H acetyl H Hacetyl acetyl H acetyl 6934 H acetyl acetyl acetyl H acetyl H H acetylacetyl acetyl H 6935 H acetyl acetyl acetyl H acetyl H H acetyl acetylacetyl acetyl 6936 H acetyl acetyl acetyl H acetyl H acetyl H H H H 6937H acetyl acetyl acetyl H acetyl H acetyl H H H acetyl 6938 H acetylacetyl acetyl H acetyl H acetyl H H acetyl H 6939 H acetyl acetyl acetylH acetyl H acetyl H H acetyl acetyl 6940 H acetyl acetyl acetyl H acetylH acetyl H acetyl H H 6941 H acetyl acetyl acetyl H acetyl H acetyl Hacetyl H acetyl 6942 H acetyl acetyl acetyl H acetyl H acetyl H acetylacetyl H 6943 H acetyl acetyl acetyl H acetyl H acetyl H acetyl acetylacetyl 6944 H acetyl acetyl acetyl H acetyl H acetyl acetyl H H H 6945 Hacetyl acetyl acetyl H acetyl H acetyl acetyl H H acetyl 6946 H acetylacetyl acetyl H acetyl H acetyl acetyl H acetyl H 6947 H acetyl acetylacetyl H acetyl H acetyl acetyl H acetyl acetyl 6948 H acetyl acetylacetyl H acetyl H acetyl acetyl acetyl H H 6949 H acetyl acetyl acetyl Hacetyl H acetyl acetyl acetyl H acetyl 6950 H acetyl acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl H 6951 H acetyl acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl 6952 H acetyl acetyl acetylH acetyl acetyl H H H H H 6953 H acetyl acetyl acetyl H acetyl acetyl HH H H acetyl 6954 H acetyl acetyl acetyl H acetyl acetyl H H H acetyl H6955 H acetyl acetyl acetyl H acetyl acetyl H H H acetyl acetyl 6956 Hacetyl acetyl acetyl H acetyl acetyl H H acetyl H H 6957 H acetyl acetylacetyl H acetyl acetyl H H acetyl H acetyl 6958 H acetyl acetyl acetyl Hacetyl acetyl H H acetyl acetyl H 6959 H acetyl acetyl acetyl H acetylacetyl H H acetyl acetyl acetyl 6960 H acetyl acetyl acetyl H acetylacetyl H acetyl H H H 6961 H acetyl acetyl acetyl H acetyl acetyl Hacetyl H H acetyl 6962 H acetyl acetyl acetyl H acetyl acetyl H acetyl Hacetyl H 6963 H acetyl acetyl acetyl H acetyl acetyl H acetyl H acetylacetyl 6964 H acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl H H6965 H acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl H acetyl6966 H acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl acetyl H6967 H acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl acetylacetyl 6968 H acetyl acetyl acetyl H acetyl acetyl acetyl H H H H 6969 Hacetyl acetyl acetyl H acetyl acetyl acetyl H H H acetyl 6970 H acetylacetyl acetyl H acetyl acetyl acetyl H H acetyl H 6971 H acetyl acetylacetyl H acetyl acetyl acetyl H H acetyl acetyl 6972 H acetyl acetylacetyl H acetyl acetyl acetyl H acetyl H H 6973 H acetyl acetyl acetyl Hacetyl acetyl acetyl H acetyl H acetyl 6974 H acetyl acetyl acetyl Hacetyl acetyl acetyl H acetyl acetyl H 6975 H acetyl acetyl acetyl Hacetyl acetyl acetyl H acetyl acetyl acetyl 6976 H acetyl acetyl acetylH acetyl acetyl acetyl acetyl H H H 6977 H acetyl acetyl acetyl H acetylacetyl acetyl acetyl H H acetyl 6978 H acetyl acetyl acetyl H acetylacetyl acetyl acetyl H acetyl H 6979 H acetyl acetyl acetyl H acetylacetyl acetyl acetyl H acetyl acetyl 6980 H acetyl acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl H H 6981 H acetyl acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl H acetyl 6982 H acetyl acetyl acetylH acetyl acetyl acetyl acetyl acetyl acetyl H 6983 H acetyl acetylacetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl 6984 H acetylacetyl acetyl acetyl H H H H H H H 6985 H acetyl acetyl acetyl acetyl HH H H H H acetyl 6986 H acetyl acetyl acetyl acetyl H H H H H acetyl H6987 H acetyl acetyl acetyl acetyl H H H H H acetyl acetyl 6988 H acetylacetyl acetyl acetyl H H H H acetyl H H 6989 H acetyl acetyl acetylacetyl H H H H acetyl H acetyl 6990 H acetyl acetyl acetyl acetyl H H HH acetyl acetyl H 6991 H acetyl acetyl acetyl acetyl H H H H acetylacetyl acetyl 6992 H acetyl acetyl acetyl acetyl H H H acetyl H H H 6993H acetyl acetyl acetyl acetyl H H H acetyl H H acetyl 6994 H acetylacetyl acetyl acetyl H H H acetyl H acetyl H 6995 H acetyl acetyl acetylacetyl H H H acetyl H acetyl acetyl 6996 H acetyl acetyl acetyl acetyl HH H acetyl acetyl H H 6997 H acetyl acetyl acetyl acetyl H H H acetylacetyl H acetyl 6998 H acetyl acetyl acetyl acetyl H H H acetyl acetylacetyl H 6999 H acetyl acetyl acetyl acetyl H H H acetyl acetyl acetylacetyl 7000 H acetyl acetyl acetyl acetyl H H acetyl H H H H 7001 Hacetyl acetyl acetyl acetyl H H acetyl H H H acetyl 7002 H acetyl acetylacetyl acetyl H H acetyl H H acetyl H 7003 H acetyl acetyl acetyl acetylH H acetyl H H acetyl acetyl 7004 H acetyl acetyl acetyl acetyl H Hacetyl H acetyl H H 7005 H acetyl acetyl acetyl acetyl H H acetyl Hacetyl H acetyl 7006 H acetyl acetyl acetyl acetyl H H acetyl H acetylacetyl H 7007 H acetyl acetyl acetyl acetyl H H acetyl H acetyl acetylacetyl 7008 H acetyl acetyl acetyl acetyl H H acetyl acetyl H H H 7009 Hacetyl acetyl acetyl acetyl H H acetyl acetyl H H acetyl 7010 H acetylacetyl acetyl acetyl H H acetyl acetyl H acetyl H 7011 H acetyl acetylacetyl acetyl H H acetyl acetyl H acetyl acetyl 7012 H acetyl acetylacetyl acetyl H H acetyl acetyl acetyl H H 7013 H acetyl acetyl acetylacetyl H H acetyl acetyl acetyl H acetyl 7014 H acetyl acetyl acetylacetyl H H acetyl acetyl acetyl acetyl H 7015 H acetyl acetyl acetylacetyl H H acetyl acetyl acetyl acetyl acetyl 7016 H acetyl acetylacetyl acetyl H acetyl H H H H H 7017 H acetyl acetyl acetyl acetyl Hacetyl H H H H acetyl 7018 H acetyl acetyl acetyl acetyl H acetyl H H Hacetyl H 7019 H acetyl acetyl acetyl acetyl H acetyl H H H acetyl acetyl7020 H acetyl acetyl acetyl acetyl H acetyl H H acetyl H H 7021 H acetylacetyl acetyl acetyl H acetyl H H acetyl H acetyl 7022 H acetyl acetylacetyl acetyl H acetyl H H acetyl acetyl H 7023 H acetyl acetyl acetylacetyl H acetyl H H acetyl acetyl acetyl 7024 H acetyl acetyl acetylacetyl H acetyl H acetyl H H H 7025 H acetyl acetyl acetyl acetyl Hacetyl H acetyl H H acetyl 7026 H acetyl acetyl acetyl acetyl H acetyl Hacetyl H acetyl H 7027 H acetyl acetyl acetyl acetyl H acetyl H acetyl Hacetyl acetyl 7028 H acetyl acetyl acetyl acetyl H acetyl H acetylacetyl H H 7029 H acetyl acetyl acetyl acetyl H acetyl H acetyl acetyl Hacetyl 7030 H acetyl acetyl acetyl acetyl H acetyl H acetyl acetylacetyl H 7031 H acetyl acetyl acetyl acetyl H acetyl H acetyl acetylacetyl acetyl 7032 H acetyl acetyl acetyl acetyl H acetyl acetyl H H H H7033 H acetyl acetyl acetyl acetyl H acetyl acetyl H H H acetyl 7034 Hacetyl acetyl acetyl acetyl H acetyl acetyl H H acetyl H 7035 H acetylacetyl acetyl acetyl H acetyl acetyl H H acetyl acetyl 7036 H acetylacetyl acetyl acetyl H acetyl acetyl H acetyl H H 7037 H acetyl acetylacetyl acetyl H acetyl acetyl H acetyl H acetyl 7038 H acetyl acetylacetyl acetyl H acetyl acetyl H acetyl acetyl H 7039 H acetyl acetylacetyl acetyl H acetyl acetyl H acetyl acetyl acetyl 7040 H acetylacetyl acetyl acetyl H acetyl acetyl acetyl H H H 7041 H acetyl acetylacetyl acetyl H acetyl acetyl acetyl H H acetyl 7042 H acetyl acetylacetyl acetyl H acetyl acetyl acetyl H acetyl H 7043 H acetyl acetylacetyl acetyl H acetyl acetyl acetyl H acetyl acetyl 7044 H acetylacetyl acetyl acetyl H acetyl acetyl acetyl acetyl H H 7045 H acetylacetyl acetyl acetyl H acetyl acetyl acetyl acetyl H acetyl 7046 Hacetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H 7047H acetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetylacetyl 7048 H acetyl acetyl acetyl acetyl acetyl H H H H H H 7049 Hacetyl acetyl acetyl acetyl acetyl H H H H H acetyl 7050 H acetyl acetylacetyl acetyl acetyl H H H H acetyl H 7051 H acetyl acetyl acetyl acetylacetyl H H H H acetyl acetyl 7052 H acetyl acetyl acetyl acetyl acetyl HH H acetyl H H 7053 H acetyl acetyl acetyl acetyl acetyl H H H acetyl Hacetyl 7054 H acetyl acetyl acetyl acetyl acetyl H H H acetyl acetyl H7055 H acetyl acetyl acetyl acetyl acetyl H H H acetyl acetyl acetyl7056 H acetyl acetyl acetyl acetyl acetyl H H acetyl H H H 7057 H acetylacetyl acetyl acetyl acetyl H H acetyl H H acetyl 7058 H acetyl acetylacetyl acetyl acetyl H H acetyl H acetyl H 7059 H acetyl acetyl acetylacetyl acetyl H H acetyl H acetyl acetyl 7060 H acetyl acetyl acetylacetyl acetyl H H acetyl acetyl H H 7061 H acetyl acetyl acetyl acetylacetyl H H acetyl acetyl H acetyl 7062 H acetyl acetyl acetyl acetylacetyl H H acetyl acetyl acetyl H 7063 H acetyl acetyl acetyl acetylacetyl H H acetyl acetyl acetyl acetyl 7064 H acetyl acetyl acetylacetyl acetyl H acetyl H H H H 7065 H acetyl acetyl acetyl acetyl acetylH acetyl H H H acetyl 7066 H acetyl acetyl acetyl acetyl acetyl H acetylH H acetyl H 7067 H acetyl acetyl acetyl acetyl acetyl H acetyl H Hacetyl acetyl 7068 H acetyl acetyl acetyl acetyl acetyl H acetyl Hacetyl H H 7069 H acetyl acetyl acetyl acetyl acetyl H acetyl H acetyl Hacetyl 7070 H acetyl acetyl acetyl acetyl acetyl H acetyl H acetylacetyl H 7071 H acetyl acetyl acetyl acetyl acetyl H acetyl H acetylacetyl acetyl 7072 H acetyl acetyl acetyl acetyl acetyl H acetyl acetylH H H 7073 H acetyl acetyl acetyl acetyl acetyl H acetyl acetyl H Hacetyl 7074 H acetyl acetyl acetyl acetyl acetyl H acetyl acetyl Hacetyl H 7075 H acetyl acetyl acetyl acetyl acetyl H acetyl acetyl Hacetyl acetyl 7076 H acetyl acetyl acetyl acetyl acetyl H acetyl acetylacetyl H H 7077 H acetyl acetyl acetyl acetyl acetyl H acetyl acetylacetyl H acetyl 7078 H acetyl acetyl acetyl acetyl acetyl H acetylacetyl acetyl acetyl H 7079 H acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl 7080 H acetyl acetyl acetyl acetylacetyl acetyl H H H H H 7081 H acetyl acetyl acetyl acetyl acetyl acetylH H H H acetyl 7082 H acetyl acetyl acetyl acetyl acetyl acetyl H H Hacetyl H 7083 H acetyl acetyl acetyl acetyl acetyl acetyl H H H acetylacetyl 7084 H acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl H H7085 H acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl H acetyl7086 H acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl acetyl H7087 H acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl acetylacetyl 7088 H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl H H H7089 H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl H H acetyl7090 H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl H acetyl H7091 H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl H acetylacetyl 7092 H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetylH H 7093 H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl Hacetyl 7094 H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetylacetyl H 7095 H acetyl acetyl acetyl acetyl acetyl acetyl H acetylacetyl acetyl acetyl 7096 H acetyl acetyl acetyl acetyl acetyl acetylacetyl H H H H 7097 H acetyl acetyl acetyl acetyl acetyl acetyl acetyl HH H acetyl 7098 H acetyl acetyl acetyl acetyl acetyl acetyl acetyl H Hacetyl H 7099 H acetyl acetyl acetyl acetyl acetyl acetyl acetyl H Hacetyl acetyl 7100 H acetyl acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl H H 7101 H acetyl acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl 7102 H acetyl acetyl acetyl acetyl acetyl acetyl acetylH acetyl acetyl H 7103 H acetyl acetyl acetyl acetyl acetyl acetylacetyl H acetyl acetyl acetyl 7104 H acetyl acetyl acetyl acetyl acetylacetyl acetyl acetyl H H H 7105 H acetyl acetyl acetyl acetyl acetylacetyl acetyl acetyl H H acetyl 7106 H acetyl acetyl acetyl acetylacetyl acetyl acetyl acetyl H acetyl H 7107 H acetyl acetyl acetylacetyl acetyl acetyl acetyl acetyl H acetyl acetyl 7108 H acetyl acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl H H 7109 H acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl 7110 Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H7111 H acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetylacetyl acetyl 7112 acetyl H H H H H H H H H H H 7113 acetyl H H H H H HH H H H acetyl 7114 acetyl H H H H H H H H H acetyl H 7115 acetyl H H HH H H H H H acetyl acetyl 7116 acetyl H H H H H H H H acetyl H H 7117acetyl H H H H H H H H acetyl H acetyl 7118 acetyl H H H H H H H Hacetyl acetyl H 7119 acetyl H H H H H H H H acetyl acetyl acetyl 7120acetyl H H H H H H H acetyl H H H 7121 acetyl H H H H H H H acetyl H Hacetyl 7122 acetyl H H H H H H H acetyl H acetyl H 7123 acetyl H H H H HH H acetyl H acetyl acetyl 7124 acetyl H H H H H H H acetyl acetyl H H7125 acetyl H H H H H H H acetyl acetyl H acetyl 7126 acetyl H H H H H HH acetyl acetyl acetyl H 7127 acetyl H H H H H H H acetyl acetyl acetylacetyl 7128 acetyl H H H H H H acetyl H H H H 7129 acetyl H H H H H Hacetyl H H H acetyl 7130 acetyl H H H H H H acetyl H H acetyl H 7131acetyl H H H H H H acetyl H H acetyl acetyl 7132 acetyl H H H H H Hacetyl H acetyl H H 7133 acetyl H H H H H H acetyl H acetyl H acetyl7134 acetyl H H H H H H acetyl H acetyl acetyl H 7135 acetyl H H H H H Hacetyl H acetyl acetyl acetyl 7136 acetyl H H H H H H acetyl acetyl H HH 7137 acetyl H H H H H H acetyl acetyl H H acetyl 7138 acetyl H H H H HH acetyl acetyl H acetyl H 7139 acetyl H H H H H H acetyl acetyl Hacetyl acetyl 7140 acetyl H H H H H H acetyl acetyl acetyl H H 7141acetyl H H H H H H acetyl acetyl acetyl H acetyl 7142 acetyl H H H H H Hacetyl acetyl acetyl acetyl H 7143 acetyl H H H H H H acetyl acetylacetyl acetyl acetyl 7144 acetyl H H H H H acetyl H H H H H 7145 acetylH H H H H acetyl H H H H acetyl 7146 acetyl H H H H H acetyl H H Hacetyl H 7147 acetyl H H H H H acetyl H H H acetyl acetyl 7148 acetyl HH H H H acetyl H H acetyl H H 7149 acetyl H H H H H acetyl H H acetyl Hacetyl 7150 acetyl H H H H H acetyl H H acetyl acetyl H 7151 acetyl H HH H H acetyl H H acetyl acetyl acetyl 7152 acetyl H H H H H acetyl Hacetyl H H H 7153 acetyl H H H H H acetyl H acetyl H H acetyl 7154acetyl H H H H H acetyl H acetyl H acetyl H 7155 acetyl H H H H H acetylH acetyl H acetyl acetyl 7156 acetyl H H H H H acetyl H acetyl acetyl HH 7157 acetyl H H H H H acetyl H acetyl acetyl H acetyl 7158 acetyl H HH H H acetyl H acetyl acetyl acetyl H 7159 acetyl H H H H H acetyl Hacetyl acetyl acetyl acetyl 7160 acetyl H H H H H acetyl acetyl H H H H7161 acetyl H H H H H acetyl acetyl H H H acetyl 7162 acetyl H H H H Hacetyl acetyl H H acetyl H 7163 acetyl H H H H H acetyl acetyl H Hacetyl acetyl 7164 acetyl H H H H H acetyl acetyl H acetyl H H 7165acetyl H H H H H acetyl acetyl H acetyl H acetyl 7166 acetyl H H H H Hacetyl acetyl H acetyl acetyl H 7167 acetyl H H H H H acetyl acetyl Hacetyl acetyl acetyl 7168 acetyl H H H H H acetyl acetyl acetyl H H H7169 acetyl H H H H H acetyl acetyl acetyl H H acetyl 7170 acetyl H H HH H acetyl acetyl acetyl H acetyl H 7171 acetyl H H H H H acetyl acetylacetyl H acetyl acetyl 7172 acetyl H H H H H acetyl acetyl acetyl acetylH H 7173 acetyl H H H H H acetyl acetyl acetyl acetyl H acetyl 7174acetyl H H H H H acetyl acetyl acetyl acetyl acetyl H 7175 acetyl H H HH H acetyl acetyl acetyl acetyl acetyl acetyl 7176 acetyl H H H H acetylH H H H H H 7177 acetyl H H H H acetyl H H H H H acetyl 7178 acetyl H HH H acetyl H H H H acetyl H 7179 acetyl H H H H acetyl H H H H acetylacetyl 7180 acetyl H H H H acetyl H H H acetyl H H 7181 acetyl H H H Hacetyl H H H acetyl H acetyl 7182 acetyl H H H H acetyl H H H acetylacetyl H 7183 acetyl H H H H acetyl H H H acetyl acetyl acetyl 7184acetyl H H H H acetyl H H acetyl H H H 7185 acetyl H H H H acetyl H Hacetyl H H acetyl 7186 acetyl H H H H acetyl H H acetyl H acetyl H 7187acetyl H H H H acetyl H H acetyl H acetyl acetyl 7188 acetyl H H H Hacetyl H H acetyl acetyl H H 7189 acetyl H H H H acetyl H H acetylacetyl H acetyl 7190 acetyl H H H H acetyl H H acetyl acetyl acetyl H7191 acetyl H H H H acetyl H H acetyl acetyl acetyl acetyl 7192 acetyl HH H H acetyl H acetyl H H H H 7193 acetyl H H H H acetyl H acetyl H H Hacetyl 7194 acetyl H H H H acetyl H acetyl H H acetyl H 7195 acetyl H HH H acetyl H acetyl H H acetyl acetyl 7196 acetyl H H H H acetyl Hacetyl H acetyl H H 7197 acetyl H H H H acetyl H acetyl H acetyl Hacetyl 7198 acetyl H H H H acetyl H acetyl H acetyl acetyl H 7199 acetylH H H H acetyl H acetyl H acetyl acetyl acetyl 7200 acetyl H H H Hacetyl H acetyl acetyl H H H 7201 acetyl H H H H acetyl H acetyl acetylH H acetyl 7202 acetyl H H H H acetyl H acetyl acetyl H acetyl H 7203acetyl H H H H acetyl H acetyl acetyl H acetyl acetyl 7204 acetyl H H HH acetyl H acetyl acetyl acetyl H H 7205 acetyl H H H H acetyl H acetylacetyl acetyl H acetyl 7206 acetyl H H H H acetyl H acetyl acetyl acetylacetyl H 7207 acetyl H H H H acetyl H acetyl acetyl acetyl acetyl acetyl7208 acetyl H H H H acetyl acetyl H H H H H 7209 acetyl H H H H acetylacetyl H H H H acetyl 7210 acetyl H H H H acetyl acetyl H H H acetyl H7211 acetyl H H H H acetyl acetyl H H H acetyl acetyl 7212 acetyl H H HH acetyl acetyl H H acetyl H H 7213 acetyl H H H H acetyl acetyl H Hacetyl H acetyl 7214 acetyl H H H H acetyl acetyl H H acetyl acetyl H7215 acetyl H H H H acetyl acetyl H H acetyl acetyl acetyl 7216 acetyl HH H H acetyl acetyl H acetyl H H H 7217 acetyl H H H H acetyl acetyl Hacetyl H H acetyl 7218 acetyl H H H H acetyl acetyl H acetyl H acetyl H7219 acetyl H H H H acetyl acetyl H acetyl H acetyl acetyl 7220 acetyl HH H H acetyl acetyl H acetyl acetyl H H 7221 acetyl H H H H acetylacetyl H acetyl acetyl H acetyl 7222 acetyl H H H H acetyl acetyl Hacetyl acetyl acetyl H 7223 acetyl H H H H acetyl acetyl H acetyl acetylacetyl acetyl 7224 acetyl H H H H acetyl acetyl acetyl H H H H 7225acetyl H H H H acetyl acetyl acetyl H H H acetyl 7226 acetyl H H H Hacetyl acetyl acetyl H H acetyl H 7227 acetyl H H H H acetyl acetylacetyl H H acetyl acetyl 7228 acetyl H H H H acetyl acetyl acetyl Hacetyl H H 7229 acetyl H H H H acetyl acetyl acetyl H acetyl H acetyl7230 acetyl H H H H acetyl acetyl acetyl H acetyl acetyl H 7231 acetyl HH H H acetyl acetyl acetyl H acetyl acetyl acetyl 7232 acetyl H H H Hacetyl acetyl acetyl acetyl H H H 7233 acetyl H H H H acetyl acetylacetyl acetyl H H acetyl 7234 acetyl H H H H acetyl acetyl acetyl acetylH acetyl H 7235 acetyl H H H H acetyl acetyl acetyl acetyl H acetylacetyl 7236 acetyl H H H H acetyl acetyl acetyl acetyl acetyl H H 7237acetyl H H H H acetyl acetyl acetyl acetyl acetyl H acetyl 7238 acetyl HH H H acetyl acetyl acetyl acetyl acetyl acetyl H 7239 acetyl H H H Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl 7240 acetyl H H Hacetyl H H H H H H H 7241 acetyl H H H acetyl H H H H H H acetyl 7242acetyl H H H acetyl H H H H H acetyl H 7243 acetyl H H H acetyl H H H HH acetyl acetyl 7244 acetyl H H H acetyl H H H H acetyl H H 7245 acetylH H H acetyl H H H H acetyl H acetyl 7246 acetyl H H H acetyl H H H Hacetyl acetyl H 7247 acetyl H H H acetyl H H H H acetyl acetyl acetyl7248 acetyl H H H acetyl H H H acetyl H H H 7249 acetyl H H H acetyl H HH acetyl H H acetyl 7250 acetyl H H H acetyl H H H acetyl H acetyl H7251 acetyl H H H acetyl H H H acetyl H acetyl acetyl 7252 acetyl H H Hacetyl H H H acetyl acetyl H H 7253 acetyl H H H acetyl H H H acetylacetyl H acetyl 7254 acetyl H H H acetyl H H H acetyl acetyl acetyl H7255 acetyl H H H acetyl H H H acetyl acetyl acetyl acetyl 7256 acetyl HH H acetyl H H acetyl H H H H 7257 acetyl H H H acetyl H H acetyl H H Hacetyl 7258 acetyl H H H acetyl H H acetyl H H acetyl H 7259 acetyl H HH acetyl H H acetyl H H acetyl acetyl 7260 acetyl H H H acetyl H Hacetyl H acetyl H H 7261 acetyl H H H acetyl H H acetyl H acetyl Hacetyl 7262 acetyl H H H acetyl H H acetyl H acetyl acetyl H 7263 acetylH H H acetyl H H acetyl H acetyl acetyl acetyl 7264 acetyl H H H acetylH H acetyl acetyl H H H 7265 acetyl H H H acetyl H H acetyl acetyl H Hacetyl 7266 acetyl H H H acetyl H H acetyl acetyl H acetyl H 7267 acetylH H H acetyl H H acetyl acetyl H acetyl acetyl 7268 acetyl H H H acetylH H acetyl acetyl acetyl H H 7269 acetyl H H H acetyl H H acetyl acetylacetyl H acetyl 7270 acetyl H H H acetyl H H acetyl acetyl acetyl acetylH 7271 acetyl H H H acetyl H H acetyl acetyl acetyl acetyl acetyl 7272acetyl H H H acetyl H acetyl H H H H H 7273 acetyl H H H acetyl H acetylH H H H acetyl 7274 acetyl H H H acetyl H acetyl H H H acetyl H 7275acetyl H H H acetyl H acetyl H H H acetyl acetyl 7276 acetyl H H Hacetyl H acetyl H H acetyl H H 7277 acetyl H H H acetyl H acetyl H Hacetyl H acetyl 7278 acetyl H H H acetyl H acetyl H H acetyl acetyl H7279 acetyl H H H acetyl H acetyl H H acetyl acetyl acetyl 7280 acetyl HH H acetyl H acetyl H acetyl H H H 7281 acetyl H H H acetyl H acetyl Hacetyl H H acetyl 7282 acetyl H H H acetyl H acetyl H acetyl H acetyl H7283 acetyl H H H acetyl H acetyl H acetyl H acetyl acetyl 7284 acetyl HH H acetyl H acetyl H acetyl acetyl H H 7285 acetyl H H H acetyl Hacetyl H acetyl acetyl H acetyl 7286 acetyl H H H acetyl H acetyl Hacetyl acetyl acetyl H 7287 acetyl H H H acetyl H acetyl H acetyl acetylacetyl acetyl 7288 acetyl H H H acetyl H acetyl acetyl H H H H 7289acetyl H H H acetyl H acetyl acetyl H H H acetyl 7290 acetyl H H Hacetyl H acetyl acetyl H H acetyl H 7291 acetyl H H H acetyl H acetylacetyl H H acetyl acetyl 7292 acetyl H H H acetyl H acetyl acetyl Hacetyl H H 7293 acetyl H H H acetyl H acetyl acetyl H acetyl H acetyl7294 acetyl H H H acetyl H acetyl acetyl H acetyl acetyl H 7295 acetyl HH H acetyl H acetyl acetyl H acetyl acetyl acetyl 7296 acetyl H H Hacetyl H acetyl acetyl acetyl H H H 7297 acetyl H H H acetyl H acetylacetyl acetyl H H acetyl 7298 acetyl H H H acetyl H acetyl acetyl acetylH acetyl H 7299 acetyl H H H acetyl H acetyl acetyl acetyl H acetylacetyl 7300 acetyl H H H acetyl H acetyl acetyl acetyl acetyl H H 7301acetyl H H H acetyl H acetyl acetyl acetyl acetyl H acetyl 7302 acetyl HH H acetyl H acetyl acetyl acetyl acetyl acetyl H 7303 acetyl H H Hacetyl H acetyl acetyl acetyl acetyl acetyl acetyl 7304 acetyl H H Hacetyl acetyl H H H H H H 7305 acetyl H H H acetyl acetyl H H H H Hacetyl 7306 acetyl H H H acetyl acetyl H H H H acetyl H 7307 acetyl H HH acetyl acetyl H H H H acetyl acetyl 7308 acetyl H H H acetyl acetyl HH H acetyl H H 7309 acetyl H H H acetyl acetyl H H H acetyl H acetyl7310 acetyl H H H acetyl acetyl H H H acetyl acetyl H 7311 acetyl H H Hacetyl acetyl H H H acetyl acetyl acetyl 7312 acetyl H H H acetyl acetylH H acetyl H H H 7313 acetyl H H H acetyl acetyl H H acetyl H H acetyl7314 acetyl H H H acetyl acetyl H H acetyl H acetyl H 7315 acetyl H H Hacetyl acetyl H H acetyl H acetyl acetyl 7316 acetyl H H H acetyl acetylH H acetyl acetyl H H 7317 acetyl H H H acetyl acetyl H H acetyl acetylH acetyl 7318 acetyl H H H acetyl acetyl H H acetyl acetyl acetyl H 7319acetyl H H H acetyl acetyl H H acetyl acetyl acetyl acetyl 7320 acetyl HH H acetyl acetyl H acetyl H H H H 7321 acetyl H H H acetyl acetyl Hacetyl H H H acetyl 7322 acetyl H H H acetyl acetyl H acetyl H H acetylH 7323 acetyl H H H acetyl acetyl H acetyl H H acetyl acetyl 7324 acetylH H H acetyl acetyl H acetyl H acetyl H H 7325 acetyl H H H acetylacetyl H acetyl H acetyl H acetyl 7326 acetyl H H H acetyl acetyl Hacetyl H acetyl acetyl H 7327 acetyl H H H acetyl acetyl H acetyl Hacetyl acetyl acetyl 7328 acetyl H H H acetyl acetyl H acetyl acetyl H HH 7329 acetyl H H H acetyl acetyl H acetyl acetyl H H acetyl 7330 acetylH H H acetyl acetyl H acetyl acetyl H acetyl H 7331 acetyl H H H acetylacetyl H acetyl acetyl H acetyl acetyl 7332 acetyl H H H acetyl acetyl Hacetyl acetyl acetyl H H 7333 acetyl H H H acetyl acetyl H acetyl acetylacetyl H acetyl 7334 acetyl H H H acetyl acetyl H acetyl acetyl acetylacetyl H 7335 acetyl H H H acetyl acetyl H acetyl acetyl acetyl acetylacetyl 7336 acetyl H H H acetyl acetyl acetyl H H H H H 7337 acetyl H HH acetyl acetyl acetyl H H H H acetyl 7338 acetyl H H H acetyl acetylacetyl H H H acetyl H 7339 acetyl H H H acetyl acetyl acetyl H H Hacetyl acetyl 7340 acetyl H H H acetyl acetyl acetyl H H acetyl H H 7341acetyl H H H acetyl acetyl acetyl H H acetyl H acetyl 7342 acetyl H H Hacetyl acetyl acetyl H H acetyl acetyl H 7343 acetyl H H H acetyl acetylacetyl H H acetyl acetyl acetyl 7344 acetyl H H H acetyl acetyl acetyl Hacetyl H H H 7345 acetyl H H H acetyl acetyl acetyl H acetyl H H acetyl7346 acetyl H H H acetyl acetyl acetyl H acetyl H acetyl H 7347 acetyl HH H acetyl acetyl acetyl H acetyl H acetyl acetyl 7348 acetyl H H Hacetyl acetyl acetyl H acetyl acetyl H H 7349 acetyl H H H acetyl acetylacetyl H acetyl acetyl H acetyl 7350 acetyl H H H acetyl acetyl acetyl Hacetyl acetyl acetyl H 7351 acetyl H H H acetyl acetyl acetyl H acetylacetyl acetyl acetyl 7352 acetyl H H H acetyl acetyl acetyl acetyl H H HH 7353 acetyl H H H acetyl acetyl acetyl acetyl H H H acetyl 7354 acetylH H H acetyl acetyl acetyl acetyl H H acetyl H 7355 acetyl H H H acetylacetyl acetyl acetyl H H acetyl acetyl 7356 acetyl H H H acetyl acetylacetyl acetyl H acetyl H H 7357 acetyl H H H acetyl acetyl acetyl acetylH acetyl H acetyl 7358 acetyl H H H acetyl acetyl acetyl acetyl H acetylacetyl H 7359 acetyl H H H acetyl acetyl acetyl acetyl H acetyl acetylacetyl 7360 acetyl H H H acetyl acetyl acetyl acetyl acetyl H H H 7361acetyl H H H acetyl acetyl acetyl acetyl acetyl H H acetyl 7362 acetyl HH H acetyl acetyl acetyl acetyl acetyl H acetyl H 7363 acetyl H H Hacetyl acetyl acetyl acetyl acetyl H acetyl acetyl 7364 acetyl H H Hacetyl acetyl acetyl acetyl acetyl acetyl H H 7365 acetyl H H H acetylacetyl acetyl acetyl acetyl acetyl H acetyl 7366 acetyl H H H acetylacetyl acetyl acetyl acetyl acetyl acetyl H 7367 acetyl H H H acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl 7368 acetyl H H acetylH H H H H H H H 7369 acetyl H H acetyl H H H H H H H acetyl 7370 acetylH H acetyl H H H H H H acetyl H 7371 acetyl H H acetyl H H H H H Hacetyl acetyl 7372 acetyl H H acetyl H H H H H acetyl H H 7373 acetyl HH acetyl H H H H H acetyl H acetyl 7374 acetyl H H acetyl H H H H Hacetyl acetyl H 7375 acetyl H H acetyl H H H H H acetyl acetyl acetyl7376 acetyl H H acetyl H H H H acetyl H H H 7377 acetyl H H acetyl H H HH acetyl H H acetyl 7378 acetyl H H acetyl H H H H acetyl H acetyl H7379 acetyl H H acetyl H H H H acetyl H acetyl acetyl 7380 acetyl H Hacetyl H H H H acetyl acetyl H H 7381 acetyl H H acetyl H H H H acetylacetyl H acetyl 7382 acetyl H H acetyl H H H H acetyl acetyl acetyl H7383 acetyl H H acetyl H H H H acetyl acetyl acetyl acetyl 7384 acetyl HH acetyl H H H acetyl H H H H 7385 acetyl H H acetyl H H H acetyl H H Hacetyl 7386 acetyl H H acetyl H H H acetyl H H acetyl H 7387 acetyl H Hacetyl H H H acetyl H H acetyl acetyl 7388 acetyl H H acetyl H H Hacetyl H acetyl H H 7389 acetyl H H acetyl H H H acetyl H acetyl Hacetyl 7390 acetyl H H acetyl H H H acetyl H acetyl acetyl H 7391 acetylH H acetyl H H H acetyl H acetyl acetyl acetyl 7392 acetyl H H acetyl HH H acetyl acetyl H H H 7393 acetyl H H acetyl H H H acetyl acetyl H Hacetyl 7394 acetyl H H acetyl H H H acetyl acetyl H acetyl H 7395 acetylH H acetyl H H H acetyl acetyl H acetyl acetyl 7396 acetyl H H acetyl HH H acetyl acetyl acetyl H H 7397 acetyl H H acetyl H H H acetyl acetylacetyl H acetyl 7398 acetyl H H acetyl H H H acetyl acetyl acetyl acetylH 7399 acetyl H H acetyl H H H acetyl acetyl acetyl acetyl acetyl 7400acetyl H H acetyl H H acetyl H H H H H 7401 acetyl H H acetyl H H acetylH H H H acetyl 7402 acetyl H H acetyl H H acetyl H H H acetyl H 7403acetyl H H acetyl H H acetyl H H H acetyl acetyl 7404 acetyl H H acetylH H acetyl H H acetyl H H 7405 acetyl H H acetyl H H acetyl H H acetyl Hacetyl 7406 acetyl H H acetyl H H acetyl H H acetyl acetyl H 7407 acetylH H acetyl H H acetyl H H acetyl acetyl acetyl 7408 acetyl H H acetyl HH acetyl H acetyl H H H 7409 acetyl H H acetyl H H acetyl H acetyl H Hacetyl 7410 acetyl H H acetyl H H acetyl H acetyl H acetyl H 7411 acetylH H acetyl H H acetyl H acetyl H acetyl acetyl 7412 acetyl H H acetyl HH acetyl H acetyl acetyl H H 7413 acetyl H H acetyl H H acetyl H acetylacetyl H acetyl 7414 acetyl H H acetyl H H acetyl H acetyl acetyl acetylH 7415 acetyl H H acetyl H H acetyl H acetyl acetyl acetyl acetyl 7416acetyl H H acetyl H H acetyl acetyl H H H H 7417 acetyl H H acetyl H Hacetyl acetyl H H H acetyl 7418 acetyl H H acetyl H H acetyl acetyl H Hacetyl H 7419 acetyl H H acetyl H H acetyl acetyl H H acetyl acetyl 7420acetyl H H acetyl H H acetyl acetyl H acetyl H H 7421 acetyl H H acetylH H acetyl acetyl H acetyl H acetyl 7422 acetyl H H acetyl H H acetylacetyl H acetyl acetyl H 7423 acetyl H H acetyl H H acetyl acetyl Hacetyl acetyl acetyl 7424 acetyl H H acetyl H H acetyl acetyl acetyl H HH 7425 acetyl H H acetyl H H acetyl acetyl acetyl H H acetyl 7426 acetylH H acetyl H H acetyl acetyl acetyl H acetyl H 7427 acetyl H H acetyl HH acetyl acetyl acetyl H acetyl acetyl 7428 acetyl H H acetyl H H acetylacetyl acetyl acetyl H H 7429 acetyl H H acetyl H H acetyl acetyl acetylacetyl H acetyl 7430 acetyl H H acetyl H H acetyl acetyl acetyl acetylacetyl H 7431 acetyl H H acetyl H H acetyl acetyl acetyl acetyl acetylacetyl 7432 acetyl H H acetyl H acetyl H H H H H H 7433 acetyl H Hacetyl H acetyl H H H H H acetyl 7434 acetyl H H acetyl H acetyl H H H Hacetyl H 7435 acetyl H H acetyl H acetyl H H H H acetyl acetyl 7436acetyl H H acetyl H acetyl H H H acetyl H H 7437 acetyl H H acetyl Hacetyl H H H acetyl H acetyl 7438 acetyl H H acetyl H acetyl H H Hacetyl acetyl H 7439 acetyl H H acetyl H acetyl H H H acetyl acetylacetyl 7440 acetyl H H acetyl H acetyl H H acetyl H H H 7441 acetyl H Hacetyl H acetyl H H acetyl H H acetyl 7442 acetyl H H acetyl H acetyl HH acetyl H acetyl H 7443 acetyl H H acetyl H acetyl H H acetyl H acetylacetyl 7444 acetyl H H acetyl H acetyl H H acetyl acetyl H H 7445 acetylH H acetyl H acetyl H H acetyl acetyl H acetyl 7446 acetyl H H acetyl Hacetyl H H acetyl acetyl acetyl H 7447 acetyl H H acetyl H acetyl H Hacetyl acetyl acetyl acetyl 7448 acetyl H H acetyl H acetyl H acetyl H HH H 7449 acetyl H H acetyl H acetyl H acetyl H H H acetyl 7450 acetyl HH acetyl H acetyl H acetyl H H acetyl H 7451 acetyl H H acetyl H acetylH acetyl H H acetyl acetyl 7452 acetyl H H acetyl H acetyl H acetyl Hacetyl H H 7453 acetyl H H acetyl H acetyl H acetyl H acetyl H acetyl7454 acetyl H H acetyl H acetyl H acetyl H acetyl acetyl H 7455 acetyl HH acetyl H acetyl H acetyl H acetyl acetyl acetyl 7456 acetyl H H acetylH acetyl H acetyl acetyl H H H 7457 acetyl H H acetyl H acetyl H acetylacetyl H H acetyl 7458 acetyl H H acetyl H acetyl H acetyl acetyl Hacetyl H 7459 acetyl H H acetyl H acetyl H acetyl acetyl H acetyl acetyl7460 acetyl H H acetyl H acetyl H acetyl acetyl acetyl H H 7461 acetyl HH acetyl H acetyl H acetyl acetyl acetyl H acetyl 7462 acetyl H H acetylH acetyl H acetyl acetyl acetyl acetyl H 7463 acetyl H H acetyl H acetylH acetyl acetyl acetyl acetyl acetyl 7464 acetyl H H acetyl H acetylacetyl H H H H H 7465 acetyl H H acetyl H acetyl acetyl H H H H acetyl7466 acetyl H H acetyl H acetyl acetyl H H H acetyl H 7467 acetyl H Hacetyl H acetyl acetyl H H H acetyl acetyl 7468 acetyl H H acetyl Hacetyl acetyl H H acetyl H H 7469 acetyl H H acetyl H acetyl acetyl H Hacetyl H acetyl 7470 acetyl H H acetyl H acetyl acetyl H H acetyl acetylH 7471 acetyl H H acetyl H acetyl acetyl H H acetyl acetyl acetyl 7472acetyl H H acetyl H acetyl acetyl H acetyl H H H 7473 acetyl H H acetylH acetyl acetyl H acetyl H H acetyl 7474 acetyl H H acetyl H acetylacetyl H acetyl H acetyl H 7475 acetyl H H acetyl H acetyl acetyl Hacetyl H acetyl acetyl 7476 acetyl H H acetyl H acetyl acetyl H acetylacetyl H H 7477 acetyl H H acetyl H acetyl acetyl H acetyl acetyl Hacetyl 7478 acetyl H H acetyl H acetyl acetyl H acetyl acetyl acetyl H7479 acetyl H H acetyl H acetyl acetyl H acetyl acetyl acetyl acetyl7480 acetyl H H acetyl H acetyl acetyl acetyl H H H H 7481 acetyl H Hacetyl H acetyl acetyl acetyl H H H acetyl 7482 acetyl H H acetyl Hacetyl acetyl acetyl H H acetyl H 7483 acetyl H H acetyl H acetyl acetylacetyl H H acetyl acetyl 7484 acetyl H H acetyl H acetyl acetyl acetyl Hacetyl H H 7485 acetyl H H acetyl H acetyl acetyl acetyl H acetyl Hacetyl 7486 acetyl H H acetyl H acetyl acetyl acetyl H acetyl acetyl H7487 acetyl H H acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl7488 acetyl H H acetyl H acetyl acetyl acetyl acetyl H H H 7489 acetyl HH acetyl H acetyl acetyl acetyl acetyl H H acetyl 7490 acetyl H H acetylH acetyl acetyl acetyl acetyl H acetyl H 7491 acetyl H H acetyl H acetylacetyl acetyl acetyl H acetyl acetyl 7492 acetyl H H acetyl H acetylacetyl acetyl acetyl acetyl H H 7493 acetyl H H acetyl H acetyl acetylacetyl acetyl acetyl H acetyl 7494 acetyl H H acetyl H acetyl acetylacetyl acetyl acetyl acetyl H 7495 acetyl H H acetyl H acetyl acetylacetyl acetyl acetyl acetyl acetyl 7496 acetyl H H acetyl acetyl H H H HH H H 7497 acetyl H H acetyl acetyl H H H H H H acetyl 7498 acetyl H Hacetyl acetyl H H H H H acetyl H 7499 acetyl H H acetyl acetyl H H H H Hacetyl acetyl 7500 acetyl H H acetyl acetyl H H H H acetyl H H 7501acetyl H H acetyl acetyl H H H H acetyl H acetyl 7502 acetyl H H acetylacetyl H H H H acetyl acetyl H 7503 acetyl H H acetyl acetyl H H H Hacetyl acetyl acetyl 7504 acetyl H H acetyl acetyl H H H acetyl H H H7505 acetyl H H acetyl acetyl H H H acetyl H H acetyl 7506 acetyl H Hacetyl acetyl H H H acetyl H acetyl H 7507 acetyl H H acetyl acetyl H HH acetyl H acetyl acetyl 7508 acetyl H H acetyl acetyl H H H acetylacetyl H H 7509 acetyl H H acetyl acetyl H H H acetyl acetyl H acetyl7510 acetyl H H acetyl acetyl H H H acetyl acetyl acetyl H 7511 acetyl HH acetyl acetyl H H H acetyl acetyl acetyl acetyl 7512 acetyl H H acetylacetyl H H acetyl H H H H 7513 acetyl H H acetyl acetyl H H acetyl H H Hacetyl 7514 acetyl H H acetyl acetyl H H acetyl H H acetyl H 7515 acetylH H acetyl acetyl H H acetyl H H acetyl acetyl 7516 acetyl H H acetylacetyl H H acetyl H acetyl H H 7517 acetyl H H acetyl acetyl H H acetylH acetyl H acetyl 7518 acetyl H H acetyl acetyl H H acetyl H acetylacetyl H 7519 acetyl H H acetyl acetyl H H acetyl H acetyl acetyl acetyl7520 acetyl H H acetyl acetyl H H acetyl acetyl H H H 7521 acetyl H Hacetyl acetyl H H acetyl acetyl H H acetyl 7522 acetyl H H acetyl acetylH H acetyl acetyl H acetyl H 7523 acetyl H H acetyl acetyl H H acetylacetyl H acetyl acetyl 7524 acetyl H H acetyl acetyl H H acetyl acetylacetyl H H 7525 acetyl H H acetyl acetyl H H acetyl acetyl acetyl Hacetyl 7526 acetyl H H acetyl acetyl H H acetyl acetyl acetyl acetyl H7527 acetyl H H acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl7528 acetyl H H acetyl acetyl H acetyl H H H H H 7529 acetyl H H acetylacetyl H acetyl H H H H acetyl 7530 acetyl H H acetyl acetyl H acetyl HH H acetyl H 7531 acetyl H H acetyl acetyl H acetyl H H H acetyl acetyl7532 acetyl H H acetyl acetyl H acetyl H H acetyl H H 7533 acetyl H Hacetyl acetyl H acetyl H H acetyl H acetyl 7534 acetyl H H acetyl acetylH acetyl H H acetyl acetyl H 7535 acetyl H H acetyl acetyl H acetyl H Hacetyl acetyl acetyl 7536 acetyl H H acetyl acetyl H acetyl H acetyl H HH 7537 acetyl H H acetyl acetyl H acetyl H acetyl H H acetyl 7538 acetylH H acetyl acetyl H acetyl H acetyl H acetyl H 7539 acetyl H H acetylacetyl H acetyl H acetyl H acetyl acetyl 7540 acetyl H H acetyl acetyl Hacetyl H acetyl acetyl H H 7541 acetyl H H acetyl acetyl H acetyl Hacetyl acetyl H acetyl 7542 acetyl H H acetyl acetyl H acetyl H acetylacetyl acetyl H 7543 acetyl H H acetyl acetyl H acetyl H acetyl acetylacetyl acetyl 7544 acetyl H H acetyl acetyl H acetyl acetyl H H H H 7545acetyl H H acetyl acetyl H acetyl acetyl H H H acetyl 7546 acetyl H Hacetyl acetyl H acetyl acetyl H H acetyl H 7547 acetyl H H acetyl acetylH acetyl acetyl H H acetyl acetyl 7548 acetyl H H acetyl acetyl H acetylacetyl H acetyl H H 7549 acetyl H H acetyl acetyl H acetyl acetyl Hacetyl H acetyl 7550 acetyl H H acetyl acetyl H acetyl acetyl H acetylacetyl H 7551 acetyl H H acetyl acetyl H acetyl acetyl H acetyl acetylacetyl 7552 acetyl H H acetyl acetyl H acetyl acetyl acetyl H H H 7553acetyl H H acetyl acetyl H acetyl acetyl acetyl H H acetyl 7554 acetyl HH acetyl acetyl H acetyl acetyl acetyl H acetyl H 7555 acetyl H H acetylacetyl H acetyl acetyl acetyl H acetyl acetyl 7556 acetyl H H acetylacetyl H acetyl acetyl acetyl acetyl H H 7557 acetyl H H acetyl acetyl Hacetyl acetyl acetyl acetyl H acetyl 7558 acetyl H H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl H 7559 acetyl H H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl 7560 acetyl H H acetyl acetylacetyl H H H H H H 7561 acetyl H H acetyl acetyl acetyl H H H H H acetyl7562 acetyl H H acetyl acetyl acetyl H H H H acetyl H 7563 acetyl H Hacetyl acetyl acetyl H H H H acetyl acetyl 7564 acetyl H H acetyl acetylacetyl H H H acetyl H H 7565 acetyl H H acetyl acetyl acetyl H H Hacetyl H acetyl 7566 acetyl H H acetyl acetyl acetyl H H H acetyl acetylH 7567 acetyl H H acetyl acetyl acetyl H H H acetyl acetyl acetyl 7568acetyl H H acetyl acetyl acetyl H H acetyl H H H 7569 acetyl H H acetylacetyl acetyl H H acetyl H H acetyl 7570 acetyl H H acetyl acetyl acetylH H acetyl H acetyl H 7571 acetyl H H acetyl acetyl acetyl H H acetyl Hacetyl acetyl 7572 acetyl H H acetyl acetyl acetyl H H acetyl acetyl H H7573 acetyl H H acetyl acetyl acetyl H H acetyl acetyl H acetyl 7574acetyl H H acetyl acetyl acetyl H H acetyl acetyl acetyl H 7575 acetyl HH acetyl acetyl acetyl H H acetyl acetyl acetyl acetyl 7576 acetyl H Hacetyl acetyl acetyl H acetyl H H H H 7577 acetyl H H acetyl acetylacetyl H acetyl H H H acetyl 7578 acetyl H H acetyl acetyl acetyl Hacetyl H H acetyl H 7579 acetyl H H acetyl acetyl acetyl H acetyl H Hacetyl acetyl 7580 acetyl H H acetyl acetyl acetyl H acetyl H acetyl H H7581 acetyl H H acetyl acetyl acetyl H acetyl H acetyl H acetyl 7582acetyl H H acetyl acetyl acetyl H acetyl H acetyl acetyl H 7583 acetyl HH acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl 7584 acetyl H Hacetyl acetyl acetyl H acetyl acetyl H H H 7585 acetyl H H acetyl acetylacetyl H acetyl acetyl H H acetyl 7586 acetyl H H acetyl acetyl acetyl Hacetyl acetyl H acetyl H 7587 acetyl H H acetyl acetyl acetyl H acetylacetyl H acetyl acetyl 7588 acetyl H H acetyl acetyl acetyl H acetylacetyl acetyl H H 7589 acetyl H H acetyl acetyl acetyl H acetyl acetylacetyl H acetyl 7590 acetyl H H acetyl acetyl acetyl H acetyl acetylacetyl acetyl H 7591 acetyl H H acetyl acetyl acetyl H acetyl acetylacetyl acetyl acetyl 7592 acetyl H H acetyl acetyl acetyl acetyl H H H HH 7593 acetyl H H acetyl acetyl acetyl acetyl H H H H acetyl 7594 acetylH H acetyl acetyl acetyl acetyl H H H acetyl H 7595 acetyl H H acetylacetyl acetyl acetyl H H H acetyl acetyl 7596 acetyl H H acetyl acetylacetyl acetyl H H acetyl H H 7597 acetyl H H acetyl acetyl acetyl acetylH H acetyl H acetyl 7598 acetyl H H acetyl acetyl acetyl acetyl H Hacetyl acetyl H 7599 acetyl H H acetyl acetyl acetyl acetyl H H acetylacetyl acetyl 7600 acetyl H H acetyl acetyl acetyl acetyl H acetyl H H H7601 acetyl H H acetyl acetyl acetyl acetyl H acetyl H H acetyl 7602acetyl H H acetyl acetyl acetyl acetyl H acetyl H acetyl H 7603 acetyl HH acetyl acetyl acetyl acetyl H acetyl H acetyl acetyl 7604 acetyl H Hacetyl acetyl acetyl acetyl H acetyl acetyl H H 7605 acetyl H H acetylacetyl acetyl acetyl H acetyl acetyl H acetyl 7606 acetyl H H acetylacetyl acetyl acetyl H acetyl acetyl acetyl H 7607 acetyl H H acetylacetyl acetyl acetyl H acetyl acetyl acetyl acetyl 7608 acetyl H Hacetyl acetyl acetyl acetyl acetyl H H H H 7609 acetyl H H acetyl acetylacetyl acetyl acetyl H H H acetyl 7610 acetyl H H acetyl acetyl acetylacetyl acetyl H H acetyl H 7611 acetyl H H acetyl acetyl acetyl acetylacetyl H H acetyl acetyl 7612 acetyl H H acetyl acetyl acetyl acetylacetyl H acetyl H H 7613 acetyl H H acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl 7614 acetyl H H acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl H 7615 acetyl H H acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl acetyl 7616 acetyl H H acetyl acetyl acetyl acetyl acetylacetyl H H H 7617 acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl HH acetyl 7618 acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl H 7619 acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl 7620 acetyl H H acetyl acetyl acetyl acetyl acetyl acetylacetyl H H 7621 acetyl H H acetyl acetyl acetyl acetyl acetyl acetylacetyl H acetyl 7622 acetyl H H acetyl acetyl acetyl acetyl acetylacetyl acetyl acetyl H 7623 acetyl H H acetyl acetyl acetyl acetylacetyl acetyl acetyl acetyl acetyl 7624 acetyl H acetyl H H H H H H H HH 7625 acetyl H acetyl H H H H H H H H acetyl 7626 acetyl H acetyl H H HH H H H acetyl H 7627 acetyl H acetyl H H H H H H H acetyl acetyl 7628acetyl H acetyl H H H H H H acetyl H H 7629 acetyl H acetyl H H H H H Hacetyl H acetyl 7630 acetyl H acetyl H H H H H H acetyl acetyl H 7631acetyl H acetyl H H H H H H acetyl acetyl acetyl 7632 acetyl H acetyl HH H H H acetyl H H H 7633 acetyl H acetyl H H H H H acetyl H H acetyl7634 acetyl H acetyl H H H H H acetyl H acetyl H 7635 acetyl H acetyl HH H H H acetyl H acetyl acetyl 7636 acetyl H acetyl H H H H H acetylacetyl H H 7637 acetyl H acetyl H H H H H acetyl acetyl H acetyl 7638acetyl H acetyl H H H H H acetyl acetyl acetyl H 7639 acetyl H acetyl HH H H H acetyl acetyl acetyl acetyl 7640 acetyl H acetyl H H H H acetylH H H H 7641 acetyl H acetyl H H H H acetyl H H H acetyl 7642 acetyl Hacetyl H H H H acetyl H H acetyl H 7643 acetyl H acetyl H H H H acetyl HH acetyl acetyl 7644 acetyl H acetyl H H H H acetyl H acetyl H H 7645acetyl H acetyl H H H H acetyl H acetyl H acetyl 7646 acetyl H acetyl HH H H acetyl H acetyl acetyl H 7647 acetyl H acetyl H H H H acetyl Hacetyl acetyl acetyl 7648 acetyl H acetyl H H H H acetyl acetyl H H H7649 acetyl H acetyl H H H H acetyl acetyl H H acetyl 7650 acetyl Hacetyl H H H H acetyl acetyl H acetyl H 7651 acetyl H acetyl H H H Hacetyl acetyl H acetyl acetyl 7652 acetyl H acetyl H H H H acetyl acetylacetyl H H 7653 acetyl H acetyl H H H H acetyl acetyl acetyl H acetyl7654 acetyl H acetyl H H H H acetyl acetyl acetyl acetyl H 7655 acetyl Hacetyl H H H H acetyl acetyl acetyl acetyl acetyl 7656 acetyl H acetyl HH H acetyl H H H H H 7657 acetyl H acetyl H H H acetyl H H H H acetyl7658 acetyl H acetyl H H H acetyl H H H acetyl H 7659 acetyl H acetyl HH H acetyl H H H acetyl acetyl 7660 acetyl H acetyl H H H acetyl H Hacetyl H H 7661 acetyl H acetyl H H H acetyl H H acetyl H acetyl 7662acetyl H acetyl H H H acetyl H H acetyl acetyl H 7663 acetyl H acetyl HH H acetyl H H acetyl acetyl acetyl 7664 acetyl H acetyl H H H acetyl Hacetyl H H H 7665 acetyl H acetyl H H H acetyl H acetyl H H acetyl 7666acetyl H acetyl H H H acetyl H acetyl H acetyl H 7667 acetyl H acetyl HH H acetyl H acetyl H acetyl acetyl 7668 acetyl H acetyl H H H acetyl Hacetyl acetyl H H 7669 acetyl H acetyl H H H acetyl H acetyl acetyl Hacetyl 7670 acetyl H acetyl H H H acetyl H acetyl acetyl acetyl H 7671acetyl H acetyl H H H acetyl H acetyl acetyl acetyl acetyl 7672 acetyl Hacetyl H H H acetyl acetyl H H H H 7673 acetyl H acetyl H H H acetylacetyl H H H acetyl 7674 acetyl H acetyl H H H acetyl acetyl H H acetylH 7675 acetyl H acetyl H H H acetyl acetyl H H acetyl acetyl 7676 acetylH acetyl H H H acetyl acetyl H acetyl H H 7677 acetyl H acetyl H H Hacetyl acetyl H acetyl H acetyl 7678 acetyl H acetyl H H H acetyl acetylH acetyl acetyl H 7679 acetyl H acetyl H H H acetyl acetyl H acetylacetyl acetyl 7680 acetyl H acetyl H H H acetyl acetyl acetyl H H H 7681acetyl H acetyl H H H acetyl acetyl acetyl H H acetyl 7682 acetyl Hacetyl H H H acetyl acetyl acetyl H acetyl H 7683 acetyl H acetyl H H Hacetyl acetyl acetyl H acetyl acetyl 7684 acetyl H acetyl H H H acetylacetyl acetyl acetyl H H 7685 acetyl H acetyl H H H acetyl acetyl acetylacetyl H acetyl 7686 acetyl H acetyl H H H acetyl acetyl acetyl acetylacetyl H 7687 acetyl H acetyl H H H acetyl acetyl acetyl acetyl acetylacetyl 7688 acetyl H acetyl H H acetyl H H H H H H 7689 acetyl H acetylH H acetyl H H H H H acetyl 7690 acetyl H acetyl H H acetyl H H H Hacetyl H 7691 acetyl H acetyl H H acetyl H H H H acetyl acetyl 7692acetyl H acetyl H H acetyl H H H acetyl H H 7693 acetyl H acetyl H Hacetyl H H H acetyl H acetyl 7694 acetyl H acetyl H H acetyl H H Hacetyl acetyl H 7695 acetyl H acetyl H H acetyl H H H acetyl acetylacetyl 7696 acetyl H acetyl H H acetyl H H acetyl H H H 7697 acetyl Hacetyl H H acetyl H H acetyl H H acetyl 7698 acetyl H acetyl H H acetylH H acetyl H acetyl H 7699 acetyl H acetyl H H acetyl H H acetyl Hacetyl acetyl 7700 acetyl H acetyl H H acetyl H H acetyl acetyl H H 7701acetyl H acetyl H H acetyl H H acetyl acetyl H acetyl 7702 acetyl Hacetyl H H acetyl H H acetyl acetyl acetyl H 7703 acetyl H acetyl H Hacetyl H H acetyl acetyl acetyl acetyl 7704 acetyl H acetyl H H acetyl Hacetyl H H H H 7705 acetyl H acetyl H H acetyl H acetyl H H H acetyl7706 acetyl H acetyl H H acetyl H acetyl H H acetyl H 7707 acetyl Hacetyl H H acetyl H acetyl H H acetyl acetyl 7708 acetyl H acetyl H Hacetyl H acetyl H acetyl H H 7709 acetyl H acetyl H H acetyl H acetyl Hacetyl H acetyl 7710 acetyl H acetyl H H acetyl H acetyl H acetyl acetylH 7711 acetyl H acetyl H H acetyl H acetyl H acetyl acetyl acetyl 7712acetyl H acetyl H H acetyl H acetyl acetyl H H H 7713 acetyl H acetyl HH acetyl H acetyl acetyl H H acetyl 7714 acetyl H acetyl H H acetyl Hacetyl acetyl H acetyl H 7715 acetyl H acetyl H H acetyl H acetyl acetylH acetyl acetyl 7716 acetyl H acetyl H H acetyl H acetyl acetyl acetyl HH 7717 acetyl H acetyl H H acetyl H acetyl acetyl acetyl H acetyl 7718acetyl H acetyl H H acetyl H acetyl acetyl acetyl acetyl H 7719 acetyl Hacetyl H H acetyl H acetyl acetyl acetyl acetyl acetyl 7720 acetyl Hacetyl H H acetyl acetyl H H H H H 7721 acetyl H acetyl H H acetylacetyl H H H H acetyl 7722 acetyl H acetyl H H acetyl acetyl H H Hacetyl H 7723 acetyl H acetyl H H acetyl acetyl H H H acetyl acetyl 7724acetyl H acetyl H H acetyl acetyl H H acetyl H H 7725 acetyl H acetyl HH acetyl acetyl H H acetyl H acetyl 7726 acetyl H acetyl H H acetylacetyl H H acetyl acetyl H 7727 acetyl H acetyl H H acetyl acetyl H Hacetyl acetyl acetyl 7728 acetyl H acetyl H H acetyl acetyl H acetyl H HH 7729 acetyl H acetyl H H acetyl acetyl H acetyl H H acetyl 7730 acetylH acetyl H H acetyl acetyl H acetyl H acetyl H 7731 acetyl H acetyl H Hacetyl acetyl H acetyl H acetyl acetyl 7732 acetyl H acetyl H H acetylacetyl H acetyl acetyl H H 7733 acetyl H acetyl H H acetyl acetyl Hacetyl acetyl H acetyl 7734 acetyl H acetyl H H acetyl acetyl H acetylacetyl acetyl H 7735 acetyl H acetyl H H acetyl acetyl H acetyl acetylacetyl acetyl 7736 acetyl H acetyl H H acetyl acetyl acetyl H H H H 7737acetyl H acetyl H H acetyl acetyl acetyl H H H acetyl 7738 acetyl Hacetyl H H acetyl acetyl acetyl H H acetyl H 7739 acetyl H acetyl H Hacetyl acetyl acetyl H H acetyl acetyl 7740 acetyl H acetyl H H acetylacetyl acetyl H acetyl H H 7741 acetyl H acetyl H H acetyl acetyl acetylH acetyl H acetyl 7742 acetyl H acetyl H H acetyl acetyl acetyl H acetylacetyl H 7743 acetyl H acetyl H H acetyl acetyl acetyl H acetyl acetylacetyl 7744 acetyl H acetyl H H acetyl acetyl acetyl acetyl H H H 7745acetyl H acetyl H H acetyl acetyl acetyl acetyl H H acetyl 7746 acetyl Hacetyl H H acetyl acetyl acetyl acetyl H acetyl H 7747 acetyl H acetyl HH acetyl acetyl acetyl acetyl H acetyl acetyl 7748 acetyl H acetyl H Hacetyl acetyl acetyl acetyl acetyl H H 7749 acetyl H acetyl H H acetylacetyl acetyl acetyl acetyl H acetyl 7750 acetyl H acetyl H H acetylacetyl acetyl acetyl acetyl acetyl H 7751 acetyl H acetyl H H acetylacetyl acetyl acetyl acetyl acetyl acetyl 7752 acetyl H acetyl H acetylH H H H H H H 7753 acetyl H acetyl H acetyl H H H H H H acetyl 7754acetyl H acetyl H acetyl H H H H H acetyl H 7755 acetyl H acetyl Hacetyl H H H H H acetyl acetyl 7756 acetyl H acetyl H acetyl H H H Hacetyl H H 7757 acetyl H acetyl H acetyl H H H H acetyl H acetyl 7758acetyl H acetyl H acetyl H H H H acetyl acetyl H 7759 acetyl H acetyl Hacetyl H H H H acetyl acetyl acetyl 7760 acetyl H acetyl H acetyl H H Hacetyl H H H 7761 acetyl H acetyl H acetyl H H H acetyl H H acetyl 7762acetyl H acetyl H acetyl H H H acetyl H acetyl H 7763 acetyl H acetyl Hacetyl H H H acetyl H acetyl acetyl 7764 acetyl H acetyl H acetyl H H Hacetyl acetyl H H 7765 acetyl H acetyl H acetyl H H H acetyl acetyl Hacetyl 7766 acetyl H acetyl H acetyl H H H acetyl acetyl acetyl H 7767acetyl H acetyl H acetyl H H H acetyl acetyl acetyl acetyl 7768 acetyl Hacetyl H acetyl H H acetyl H H H H 7769 acetyl H acetyl H acetyl H Hacetyl H H H acetyl 7770 acetyl H acetyl H acetyl H H acetyl H H acetylH 7771 acetyl H acetyl H acetyl H H acetyl H H acetyl acetyl 7772 acetylH acetyl H acetyl H H acetyl H acetyl H H 7773 acetyl H acetyl H acetylH H acetyl H acetyl H acetyl 7774 acetyl H acetyl H acetyl H H acetyl Hacetyl acetyl H 7775 acetyl H acetyl H acetyl H H acetyl H acetyl acetylacetyl 7776 acetyl H acetyl H acetyl H H acetyl acetyl H H H 7777 acetylH acetyl H acetyl H H acetyl acetyl H H acetyl 7778 acetyl H acetyl Hacetyl H H acetyl acetyl H acetyl H 7779 acetyl H acetyl H acetyl H Hacetyl acetyl H acetyl acetyl 7780 acetyl H acetyl H acetyl H H acetylacetyl acetyl H H 7781 acetyl H acetyl H acetyl H H acetyl acetyl acetylH acetyl 7782 acetyl H acetyl H acetyl H H acetyl acetyl acetyl acetyl H7783 acetyl H acetyl H acetyl H H acetyl acetyl acetyl acetyl acetyl7784 acetyl H acetyl H acetyl H acetyl H H H H H 7785 acetyl H acetyl Hacetyl H acetyl H H H H acetyl 7786 acetyl H acetyl H acetyl H acetyl HH H acetyl H 7787 acetyl H acetyl H acetyl H acetyl H H H acetyl acetyl7788 acetyl H acetyl H acetyl H acetyl H H acetyl H H 7789 acetyl Hacetyl H acetyl H acetyl H H acetyl H acetyl 7790 acetyl H acetyl Hacetyl H acetyl H H acetyl acetyl H 7791 acetyl H acetyl H acetyl Hacetyl H H acetyl acetyl acetyl 7792 acetyl H acetyl H acetyl H acetyl Hacetyl H H H 7793 acetyl H acetyl H acetyl H acetyl H acetyl H H acetyl7794 acetyl H acetyl H acetyl H acetyl H acetyl H acetyl H 7795 acetyl Hacetyl H acetyl H acetyl H acetyl H acetyl acetyl 7796 acetyl H acetyl Hacetyl H acetyl H acetyl acetyl H H 7797 acetyl H acetyl H acetyl Hacetyl H acetyl acetyl H acetyl 7798 acetyl H acetyl H acetyl H acetyl Hacetyl acetyl acetyl H 7799 acetyl H acetyl H acetyl H acetyl H acetylacetyl acetyl acetyl 7800 acetyl H acetyl H acetyl H acetyl acetyl H H HH 7801 acetyl H acetyl H acetyl H acetyl acetyl H H H acetyl 7802 acetylH acetyl H acetyl H acetyl acetyl H H acetyl H 7803 acetyl H acetyl Hacetyl H acetyl acetyl H H acetyl acetyl 7804 acetyl H acetyl H acetyl Hacetyl acetyl H acetyl H H 7805 acetyl H acetyl H acetyl H acetyl acetylH acetyl H acetyl 7806 acetyl H acetyl H acetyl H acetyl acetyl H acetylacetyl H 7807 acetyl H acetyl H acetyl H acetyl acetyl H acetyl acetylacetyl 7808 acetyl H acetyl H acetyl H acetyl acetyl acetyl H H H 7809acetyl H acetyl H acetyl H acetyl acetyl acetyl H H acetyl 7810 acetyl Hacetyl H acetyl H acetyl acetyl acetyl H acetyl H 7811 acetyl H acetyl Hacetyl H acetyl acetyl acetyl H acetyl acetyl 7812 acetyl H acetyl Hacetyl H acetyl acetyl acetyl acetyl H H 7813 acetyl H acetyl H acetyl Hacetyl acetyl acetyl acetyl H acetyl 7814 acetyl H acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl H 7815 acetyl H acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl 7816 acetyl H acetyl H acetylacetyl H H H H H H 7817 acetyl H acetyl H acetyl acetyl H H H H H acetyl7818 acetyl H acetyl H acetyl acetyl H H H H acetyl H 7819 acetyl Hacetyl H acetyl acetyl H H H H acetyl acetyl 7820 acetyl H acetyl Hacetyl acetyl H H H acetyl H H 7821 acetyl H acetyl H acetyl acetyl H HH acetyl H acetyl 7822 acetyl H acetyl H acetyl acetyl H H H acetylacetyl H 7823 acetyl H acetyl H acetyl acetyl H H H acetyl acetyl acetyl7824 acetyl H acetyl H acetyl acetyl H H acetyl H H H 7825 acetyl Hacetyl H acetyl acetyl H H acetyl H H acetyl 7826 acetyl H acetyl Hacetyl acetyl H H acetyl H acetyl H 7827 acetyl H acetyl H acetyl acetylH H acetyl H acetyl acetyl 7828 acetyl H acetyl H acetyl acetyl H Hacetyl acetyl H H 7829 acetyl H acetyl H acetyl acetyl H H acetyl acetylH acetyl 7830 acetyl H acetyl H acetyl acetyl H H acetyl acetyl acetyl H7831 acetyl H acetyl H acetyl acetyl H H acetyl acetyl acetyl acetyl7832 acetyl H acetyl H acetyl acetyl H acetyl H H H H 7833 acetyl Hacetyl H acetyl acetyl H acetyl H H H acetyl 7834 acetyl H acetyl Hacetyl acetyl H acetyl H H acetyl H 7835 acetyl H acetyl H acetyl acetylH acetyl H H acetyl acetyl 7836 acetyl H acetyl H acetyl acetyl H acetylH acetyl H H 7837 acetyl H acetyl H acetyl acetyl H acetyl H acetyl Hacetyl 7838 acetyl H acetyl H acetyl acetyl H acetyl H acetyl acetyl H7839 acetyl H acetyl H acetyl acetyl H acetyl H acetyl acetyl acetyl7840 acetyl H acetyl H acetyl acetyl H acetyl acetyl H H H 7841 acetyl Hacetyl H acetyl acetyl H acetyl acetyl H H acetyl 7842 acetyl H acetyl Hacetyl acetyl H acetyl acetyl H acetyl H 7843 acetyl H acetyl H acetylacetyl H acetyl acetyl H acetyl acetyl 7844 acetyl H acetyl H acetylacetyl H acetyl acetyl acetyl H H 7845 acetyl H acetyl H acetyl acetyl Hacetyl acetyl acetyl H acetyl 7846 acetyl H acetyl H acetyl acetyl Hacetyl acetyl acetyl acetyl H 7847 acetyl H acetyl H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl 7848 acetyl H acetyl H acetyl acetylacetyl H H H H H 7849 acetyl H acetyl H acetyl acetyl acetyl H H H Hacetyl 7850 acetyl H acetyl H acetyl acetyl acetyl H H H acetyl H 7851acetyl H acetyl H acetyl acetyl acetyl H H H acetyl acetyl 7852 acetyl Hacetyl H acetyl acetyl acetyl H H acetyl H H 7853 acetyl H acetyl Hacetyl acetyl acetyl H H acetyl H acetyl 7854 acetyl H acetyl H acetylacetyl acetyl H H acetyl acetyl H 7855 acetyl H acetyl H acetyl acetylacetyl H H acetyl acetyl acetyl 7856 acetyl H acetyl H acetyl acetylacetyl H acetyl H H H 7857 acetyl H acetyl H acetyl acetyl acetyl Hacetyl H H acetyl 7858 acetyl H acetyl H acetyl acetyl acetyl H acetyl Hacetyl H 7859 acetyl H acetyl H acetyl acetyl acetyl H acetyl H acetylacetyl 7860 acetyl H acetyl H acetyl acetyl acetyl H acetyl acetyl H H7861 acetyl H acetyl H acetyl acetyl acetyl H acetyl acetyl H acetyl7862 acetyl H acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl H7863 acetyl H acetyl H acetyl acetyl acetyl H acetyl acetyl acetylacetyl 7864 acetyl H acetyl H acetyl acetyl acetyl acetyl H H H H 7865acetyl H acetyl H acetyl acetyl acetyl acetyl H H H acetyl 7866 acetyl Hacetyl H acetyl acetyl acetyl acetyl H H acetyl H 7867 acetyl H acetyl Hacetyl acetyl acetyl acetyl H H acetyl acetyl 7868 acetyl H acetyl Hacetyl acetyl acetyl acetyl H acetyl H H 7869 acetyl H acetyl H acetylacetyl acetyl acetyl H acetyl H acetyl 7870 acetyl H acetyl H acetylacetyl acetyl acetyl H acetyl acetyl H 7871 acetyl H acetyl H acetylacetyl acetyl acetyl H acetyl acetyl acetyl 7872 acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl H H H 7873 acetyl H acetyl H acetylacetyl acetyl acetyl acetyl H H acetyl 7874 acetyl H acetyl H acetylacetyl acetyl acetyl acetyl H acetyl H 7875 acetyl H acetyl H acetylacetyl acetyl acetyl acetyl H acetyl acetyl 7876 acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H H 7877 acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl H acetyl 7878 acetyl H acetylH acetyl acetyl acetyl acetyl acetyl acetyl acetyl H 7879 acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl 7880acetyl H acetyl acetyl H H H H H H H H 7881 acetyl H acetyl acetyl H H HH H H H acetyl 7882 acetyl H acetyl acetyl H H H H H H acetyl H 7883acetyl H acetyl acetyl H H H H H H acetyl acetyl 7884 acetyl H acetylacetyl H H H H H acetyl H H 7885 acetyl H acetyl acetyl H H H H H acetylH acetyl 7886 acetyl H acetyl acetyl H H H H H acetyl acetyl H 7887acetyl H acetyl acetyl H H H H H acetyl acetyl acetyl 7888 acetyl Hacetyl acetyl H H H H acetyl H H H 7889 acetyl H acetyl acetyl H H H Hacetyl H H acetyl 7890 acetyl H acetyl acetyl H H H H acetyl H acetyl H7891 acetyl H acetyl acetyl H H H H acetyl H acetyl acetyl 7892 acetyl Hacetyl acetyl H H H H acetyl acetyl H H 7893 acetyl H acetyl acetyl H HH H acetyl acetyl H acetyl 7894 acetyl H acetyl acetyl H H H H acetylacetyl acetyl H 7895 acetyl H acetyl acetyl H H H H acetyl acetyl acetylacetyl 7896 acetyl H acetyl acetyl H H H acetyl H H H H 7897 acetyl Hacetyl acetyl H H H acetyl H H H acetyl 7898 acetyl H acetyl acetyl H HH acetyl H H acetyl H 7899 acetyl H acetyl acetyl H H H acetyl H Hacetyl acetyl 7900 acetyl H acetyl acetyl H H H acetyl H acetyl H H 7901acetyl H acetyl acetyl H H H acetyl H acetyl H acetyl 7902 acetyl Hacetyl acetyl H H H acetyl H acetyl acetyl H 7903 acetyl H acetyl acetylH H H acetyl H acetyl acetyl acetyl 7904 acetyl H acetyl acetyl H H Hacetyl acetyl H H H 7905 acetyl H acetyl acetyl H H H acetyl acetyl H Hacetyl 7906 acetyl H acetyl acetyl H H H acetyl acetyl H acetyl H 7907acetyl H acetyl acetyl H H H acetyl acetyl H acetyl acetyl 7908 acetyl Hacetyl acetyl H H H acetyl acetyl acetyl H H 7909 acetyl H acetyl acetylH H H acetyl acetyl acetyl H acetyl 7910 acetyl H acetyl acetyl H H Hacetyl acetyl acetyl acetyl H 7911 acetyl H acetyl acetyl H H H acetylacetyl acetyl acetyl acetyl 7912 acetyl H acetyl acetyl H H acetyl H H HH H 7913 acetyl H acetyl acetyl H H acetyl H H H H acetyl 7914 acetyl Hacetyl acetyl H H acetyl H H H acetyl H 7915 acetyl H acetyl acetyl H Hacetyl H H H acetyl acetyl 7916 acetyl H acetyl acetyl H H acetyl H Hacetyl H H 7917 acetyl H acetyl acetyl H H acetyl H H acetyl H acetyl7918 acetyl H acetyl acetyl H H acetyl H H acetyl acetyl H 7919 acetyl Hacetyl acetyl H H acetyl H H acetyl acetyl acetyl 7920 acetyl H acetylacetyl H H acetyl H acetyl H H H 7921 acetyl H acetyl acetyl H H acetylH acetyl H H acetyl 7922 acetyl H acetyl acetyl H H acetyl H acetyl Hacetyl H 7923 acetyl H acetyl acetyl H H acetyl H acetyl H acetyl acetyl7924 acetyl H acetyl acetyl H H acetyl H acetyl acetyl H H 7925 acetyl Hacetyl acetyl H H acetyl H acetyl acetyl H acetyl 7926 acetyl H acetylacetyl H H acetyl H acetyl acetyl acetyl H 7927 acetyl H acetyl acetyl HH acetyl H acetyl acetyl acetyl acetyl 7928 acetyl H acetyl acetyl H Hacetyl acetyl H H H H 7929 acetyl H acetyl acetyl H H acetyl acetyl H HH acetyl 7930 acetyl H acetyl acetyl H H acetyl acetyl H H acetyl H 7931acetyl H acetyl acetyl H H acetyl acetyl H H acetyl acetyl 7932 acetyl Hacetyl acetyl H H acetyl acetyl H acetyl H H 7933 acetyl H acetyl acetylH H acetyl acetyl H acetyl H acetyl 7934 acetyl H acetyl acetyl H Hacetyl acetyl H acetyl acetyl H 7935 acetyl H acetyl acetyl H H acetylacetyl H acetyl acetyl acetyl 7936 acetyl H acetyl acetyl H H acetylacetyl acetyl H H H 7937 acetyl H acetyl acetyl H H acetyl acetyl acetylH H acetyl 7938 acetyl H acetyl acetyl H H acetyl acetyl acetyl H acetylH 7939 acetyl H acetyl acetyl H H acetyl acetyl acetyl H acetyl acetyl7940 acetyl H acetyl acetyl H H acetyl acetyl acetyl acetyl H H 7941acetyl H acetyl acetyl H H acetyl acetyl acetyl acetyl H acetyl 7942acetyl H acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl H 7943acetyl H acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl acetyl7944 acetyl H acetyl acetyl H acetyl H H H H H H 7945 acetyl H acetylacetyl H acetyl H H H H H acetyl 7946 acetyl H acetyl acetyl H acetyl HH H H acetyl H 7947 acetyl H acetyl acetyl H acetyl H H H H acetylacetyl 7948 acetyl H acetyl acetyl H acetyl H H H acetyl H H 7949 acetylH acetyl acetyl H acetyl H H H acetyl H acetyl 7950 acetyl H acetylacetyl H acetyl H H H acetyl acetyl H 7951 acetyl H acetyl acetyl Hacetyl H H H acetyl acetyl acetyl 7952 acetyl H acetyl acetyl H acetyl HH acetyl H H H 7953 acetyl H acetyl acetyl H acetyl H H acetyl H Hacetyl 7954 acetyl H acetyl acetyl H acetyl H H acetyl H acetyl H 7955acetyl H acetyl acetyl H acetyl H H acetyl H acetyl acetyl 7956 acetyl Hacetyl acetyl H acetyl H H acetyl acetyl H H 7957 acetyl H acetyl acetylH acetyl H H acetyl acetyl H acetyl 7958 acetyl H acetyl acetyl H acetylH H acetyl acetyl acetyl H 7959 acetyl H acetyl acetyl H acetyl H Hacetyl acetyl acetyl acetyl 7960 acetyl H acetyl acetyl H acetyl Hacetyl H H H H 7961 acetyl H acetyl acetyl H acetyl H acetyl H H Hacetyl 7962 acetyl H acetyl acetyl H acetyl H acetyl H H acetyl H 7963acetyl H acetyl acetyl H acetyl H acetyl H H acetyl acetyl 7964 acetyl Hacetyl acetyl H acetyl H acetyl H acetyl H H 7965 acetyl H acetyl acetylH acetyl H acetyl H acetyl H acetyl 7966 acetyl H acetyl acetyl H acetylH acetyl H acetyl acetyl H 7967 acetyl H acetyl acetyl H acetyl H acetylH acetyl acetyl acetyl 7968 acetyl H acetyl acetyl H acetyl H acetylacetyl H H H 7969 acetyl H acetyl acetyl H acetyl H acetyl acetyl H Hacetyl 7970 acetyl H acetyl acetyl H acetyl H acetyl acetyl H acetyl H7971 acetyl H acetyl acetyl H acetyl H acetyl acetyl H acetyl acetyl7972 acetyl H acetyl acetyl H acetyl H acetyl acetyl acetyl H H 7973acetyl H acetyl acetyl H acetyl H acetyl acetyl acetyl H acetyl 7974acetyl H acetyl acetyl H acetyl H acetyl acetyl acetyl acetyl H 7975acetyl H acetyl acetyl H acetyl H acetyl acetyl acetyl acetyl acetyl7976 acetyl H acetyl acetyl H acetyl acetyl H H H H H 7977 acetyl Hacetyl acetyl H acetyl acetyl H H H H acetyl 7978 acetyl H acetyl acetylH acetyl acetyl H H H acetyl H 7979 acetyl H acetyl acetyl H acetylacetyl H H H acetyl acetyl 7980 acetyl H acetyl acetyl H acetyl acetyl HH acetyl H H 7981 acetyl H acetyl acetyl H acetyl acetyl H H acetyl Hacetyl 7982 acetyl H acetyl acetyl H acetyl acetyl H H acetyl acetyl H7983 acetyl H acetyl acetyl H acetyl acetyl H H acetyl acetyl acetyl7984 acetyl H acetyl acetyl H acetyl acetyl H acetyl H H H 7985 acetyl Hacetyl acetyl H acetyl acetyl H acetyl H H acetyl 7986 acetyl H acetylacetyl H acetyl acetyl H acetyl H acetyl H 7987 acetyl H acetyl acetyl Hacetyl acetyl H acetyl H acetyl acetyl 7988 acetyl H acetyl acetyl Hacetyl acetyl H acetyl acetyl H H 7989 acetyl H acetyl acetyl H acetylacetyl H acetyl acetyl H acetyl 7990 acetyl H acetyl acetyl H acetylacetyl H acetyl acetyl acetyl H 7991 acetyl H acetyl acetyl H acetylacetyl H acetyl acetyl acetyl acetyl 7992 acetyl H acetyl acetyl Hacetyl acetyl acetyl H H H H 7993 acetyl H acetyl acetyl H acetyl acetylacetyl H H H acetyl 7994 acetyl H acetyl acetyl H acetyl acetyl acetyl HH acetyl H 7995 acetyl H acetyl acetyl H acetyl acetyl acetyl H H acetylacetyl 7996 acetyl H acetyl acetyl H acetyl acetyl acetyl H acetyl H H7997 acetyl H acetyl acetyl H acetyl acetyl acetyl H acetyl H acetyl7998 acetyl H acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl H7999 acetyl H acetyl acetyl H acetyl acetyl acetyl H acetyl acetylacetyl 8000 acetyl H acetyl acetyl H acetyl acetyl acetyl acetyl H H H8001 acetyl H acetyl acetyl H acetyl acetyl acetyl acetyl H H acetyl8002 acetyl H acetyl acetyl H acetyl acetyl acetyl acetyl H acetyl H8003 acetyl H acetyl acetyl H acetyl acetyl acetyl acetyl H acetylacetyl 8004 acetyl H acetyl acetyl H acetyl acetyl acetyl acetyl acetylH H 8005 acetyl H acetyl acetyl H acetyl acetyl acetyl acetyl acetyl Hacetyl 8006 acetyl H acetyl acetyl H acetyl acetyl acetyl acetyl acetylacetyl H 8007 acetyl H acetyl acetyl H acetyl acetyl acetyl acetylacetyl acetyl acetyl 8008 acetyl H acetyl acetyl acetyl H H H H H H H8009 acetyl H acetyl acetyl acetyl H H H H H H acetyl 8010 acetyl Hacetyl acetyl acetyl H H H H H acetyl H 8011 acetyl H acetyl acetylacetyl H H H H H acetyl acetyl 8012 acetyl H acetyl acetyl acetyl H H HH acetyl H H 8013 acetyl H acetyl acetyl acetyl H H H H acetyl H acetyl8014 acetyl H acetyl acetyl acetyl H H H H acetyl acetyl H 8015 acetyl Hacetyl acetyl acetyl H H H H acetyl acetyl acetyl 8016 acetyl H acetylacetyl acetyl H H H acetyl H H H 8017 acetyl H acetyl acetyl acetyl H HH acetyl H H acetyl 8018 acetyl H acetyl acetyl acetyl H H H acetyl Hacetyl H 8019 acetyl H acetyl acetyl acetyl H H H acetyl H acetyl acetyl8020 acetyl H acetyl acetyl acetyl H H H acetyl acetyl H H 8021 acetyl Hacetyl acetyl acetyl H H H acetyl acetyl H acetyl 8022 acetyl H acetylacetyl acetyl H H H acetyl acetyl acetyl H 8023 acetyl H acetyl acetylacetyl H H H acetyl acetyl acetyl acetyl 8024 acetyl H acetyl acetylacetyl H H acetyl H H H H 8025 acetyl H acetyl acetyl acetyl H H acetylH H H acetyl 8026 acetyl H acetyl acetyl acetyl H H acetyl H H acetyl H8027 acetyl H acetyl acetyl acetyl H H acetyl H H acetyl acetyl 8028acetyl H acetyl acetyl acetyl H H acetyl H acetyl H H 8029 acetyl Hacetyl acetyl acetyl H H acetyl H acetyl H acetyl 8030 acetyl H acetylacetyl acetyl H H acetyl H acetyl acetyl H 8031 acetyl H acetyl acetylacetyl H H acetyl H acetyl acetyl acetyl 8032 acetyl H acetyl acetylacetyl H H acetyl acetyl H H H 8033 acetyl H acetyl acetyl acetyl H Hacetyl acetyl H H acetyl 8034 acetyl H acetyl acetyl acetyl H H acetylacetyl H acetyl H 8035 acetyl H acetyl acetyl acetyl H H acetyl acetyl Hacetyl acetyl 8036 acetyl H acetyl acetyl acetyl H H acetyl acetylacetyl H H 8037 acetyl H acetyl acetyl acetyl H H acetyl acetyl acetyl Hacetyl 8038 acetyl H acetyl acetyl acetyl H H acetyl acetyl acetylacetyl H 8039 acetyl H acetyl acetyl acetyl H H acetyl acetyl acetylacetyl acetyl 8040 acetyl H acetyl acetyl acetyl H acetyl H H H H H 8041acetyl H acetyl acetyl acetyl H acetyl H H H H acetyl 8042 acetyl Hacetyl acetyl acetyl H acetyl H H H acetyl H 8043 acetyl H acetyl acetylacetyl H acetyl H H H acetyl acetyl 8044 acetyl H acetyl acetyl acetyl Hacetyl H H acetyl H H 8045 acetyl H acetyl acetyl acetyl H acetyl H Hacetyl H acetyl 8046 acetyl H acetyl acetyl acetyl H acetyl H H acetylacetyl H 8047 acetyl H acetyl acetyl acetyl H acetyl H H acetyl acetylacetyl 8048 acetyl H acetyl acetyl acetyl H acetyl H acetyl H H H 8049acetyl H acetyl acetyl acetyl H acetyl H acetyl H H acetyl 8050 acetyl Hacetyl acetyl acetyl H acetyl H acetyl H acetyl H 8051 acetyl H acetylacetyl acetyl H acetyl H acetyl H acetyl acetyl 8052 acetyl H acetylacetyl acetyl H acetyl H acetyl acetyl H H 8053 acetyl H acetyl acetylacetyl H acetyl H acetyl acetyl H acetyl 8054 acetyl H acetyl acetylacetyl H acetyl H acetyl acetyl acetyl H 8055 acetyl H acetyl acetylacetyl H acetyl H acetyl acetyl acetyl acetyl 8056 acetyl H acetylacetyl acetyl H acetyl acetyl H H H H 8057 acetyl H acetyl acetyl acetylH acetyl acetyl H H H acetyl 8058 acetyl H acetyl acetyl acetyl H acetylacetyl H H acetyl H 8059 acetyl H acetyl acetyl acetyl H acetyl acetyl HH acetyl acetyl 8060 acetyl H acetyl acetyl acetyl H acetyl acetyl Hacetyl H H 8061 acetyl H acetyl acetyl acetyl H acetyl acetyl H acetyl Hacetyl 8062 acetyl H acetyl acetyl acetyl H acetyl acetyl H acetylacetyl H 8063 acetyl H acetyl acetyl acetyl H acetyl acetyl H acetylacetyl acetyl 8064 acetyl H acetyl acetyl acetyl H acetyl acetyl acetylH H H 8065 acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl H Hacetyl 8066 acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl Hacetyl H 8067 acetyl H acetyl acetyl acetyl H acetyl acetyl acetyl Hacetyl acetyl 8068 acetyl H acetyl acetyl acetyl H acetyl acetyl acetylacetyl H H 8069 acetyl H acetyl acetyl acetyl H acetyl acetyl acetylacetyl H acetyl 8070 acetyl H acetyl acetyl acetyl H acetyl acetylacetyl acetyl acetyl H 8071 acetyl H acetyl acetyl acetyl H acetylacetyl acetyl acetyl acetyl acetyl 8072 acetyl H acetyl acetyl acetylacetyl H H H H H H 8073 acetyl H acetyl acetyl acetyl acetyl H H H H Hacetyl 8074 acetyl H acetyl acetyl acetyl acetyl H H H H acetyl H 8075acetyl H acetyl acetyl acetyl acetyl H H H H acetyl acetyl 8076 acetyl Hacetyl acetyl acetyl acetyl H H H acetyl H H 8077 acetyl H acetyl acetylacetyl acetyl H H H acetyl H acetyl 8078 acetyl H acetyl acetyl acetylacetyl H H H acetyl acetyl H 8079 acetyl H acetyl acetyl acetyl acetyl HH H acetyl acetyl acetyl 8080 acetyl H acetyl acetyl acetyl acetyl H Hacetyl H H H 8081 acetyl H acetyl acetyl acetyl acetyl H H acetyl H Hacetyl 8082 acetyl H acetyl acetyl acetyl acetyl H H acetyl H acetyl H8083 acetyl H acetyl acetyl acetyl acetyl H H acetyl H acetyl acetyl8084 acetyl H acetyl acetyl acetyl acetyl H H acetyl acetyl H H 8085acetyl H acetyl acetyl acetyl acetyl H H acetyl acetyl H acetyl 8086acetyl H acetyl acetyl acetyl acetyl H H acetyl acetyl acetyl H 8087acetyl H acetyl acetyl acetyl acetyl H H acetyl acetyl acetyl acetyl8088 acetyl H acetyl acetyl acetyl acetyl H acetyl H H H H 8089 acetyl Hacetyl acetyl acetyl acetyl H acetyl H H H acetyl 8090 acetyl H acetylacetyl acetyl acetyl H acetyl H H acetyl H 8091 acetyl H acetyl acetylacetyl acetyl H acetyl H H acetyl acetyl 8092 acetyl H acetyl acetylacetyl acetyl H acetyl H acetyl H H 8093 acetyl H acetyl acetyl acetylacetyl H acetyl H acetyl H acetyl 8094 acetyl H acetyl acetyl acetylacetyl H acetyl H acetyl acetyl H 8095 acetyl H acetyl acetyl acetylacetyl H acetyl H acetyl acetyl acetyl 8096 acetyl H acetyl acetylacetyl acetyl H acetyl acetyl H H H 8097 acetyl H acetyl acetyl acetylacetyl H acetyl acetyl H H acetyl 8098 acetyl H acetyl acetyl acetylacetyl H acetyl acetyl H acetyl H 8099 acetyl H acetyl acetyl acetylacetyl H acetyl acetyl H acetyl acetyl 8100 acetyl H acetyl acetylacetyl acetyl H acetyl acetyl acetyl H H 8101 acetyl H acetyl acetylacetyl acetyl H acetyl acetyl acetyl H acetyl 8102 acetyl H acetylacetyl acetyl acetyl H acetyl acetyl acetyl acetyl H 8103 acetyl Hacetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl 8104acetyl H acetyl acetyl acetyl acetyl acetyl H H H H H 8105 acetyl Hacetyl acetyl acetyl acetyl acetyl H H H H acetyl 8106 acetyl H acetylacetyl acetyl acetyl acetyl H H H acetyl H 8107 acetyl H acetyl acetylacetyl acetyl acetyl H H H acetyl acetyl 8108 acetyl H acetyl acetylacetyl acetyl acetyl H H acetyl H H 8109 acetyl H acetyl acetyl acetylacetyl acetyl H H acetyl H acetyl 8110 acetyl H acetyl acetyl acetylacetyl acetyl H H acetyl acetyl H 8111 acetyl H acetyl acetyl acetylacetyl acetyl H H acetyl acetyl acetyl 8112 acetyl H acetyl acetylacetyl acetyl acetyl H acetyl H H H 8113 acetyl H acetyl acetyl acetylacetyl acetyl H acetyl H H acetyl 8114 acetyl H acetyl acetyl acetylacetyl acetyl H acetyl H acetyl H 8115 acetyl H acetyl acetyl acetylacetyl acetyl H acetyl H acetyl acetyl 8116 acetyl H acetyl acetylacetyl acetyl acetyl H acetyl acetyl H H 8117 acetyl H acetyl acetylacetyl acetyl acetyl H acetyl acetyl H acetyl 8118 acetyl H acetylacetyl acetyl acetyl acetyl H acetyl acetyl acetyl H 8119 acetyl Hacetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetyl 8120acetyl H acetyl acetyl acetyl acetyl acetyl acetyl H H H H 8121 acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl 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acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl 8136 acetyl acetyl H HH H H H H H H H 8137 acetyl acetyl H H H H H H H H H acetyl 8138 acetylacetyl H H H H H H H H acetyl H 8139 acetyl acetyl H H H H H H H Hacetyl acetyl 8140 acetyl acetyl H H H H H H H acetyl H H 8141 acetylacetyl H H H H H H H acetyl H acetyl 8142 acetyl acetyl H H H H H H Hacetyl acetyl H 8143 acetyl acetyl H H H H H H H acetyl acetyl acetyl8144 acetyl acetyl H H H H H H acetyl H H H 8145 acetyl acetyl H H H H HH acetyl H H acetyl 8146 acetyl acetyl H H H H H H acetyl H acetyl H8147 acetyl acetyl H H H H H H acetyl H acetyl acetyl 8148 acetyl acetylH H H H H H acetyl acetyl H H 8149 acetyl acetyl H H H H H H acetylacetyl H acetyl 8150 acetyl acetyl H H H H H H acetyl acetyl acetyl H8151 acetyl acetyl H H H H H H acetyl acetyl acetyl acetyl 8152 acetylacetyl H H H H H acetyl H H H H 8153 acetyl acetyl H H H H H acetyl H HH acetyl 8154 acetyl acetyl H H H H H acetyl H H acetyl H 8155 acetylacetyl H H H H H acetyl H H acetyl acetyl 8156 acetyl acetyl H H H H Hacetyl H acetyl H H 8157 acetyl acetyl H H H H H acetyl H acetyl Hacetyl 8158 acetyl acetyl H H H H H acetyl H acetyl acetyl H 8159 acetylacetyl H H H H H acetyl H acetyl acetyl acetyl 8160 acetyl acetyl H H HH H acetyl acetyl H H H 8161 acetyl acetyl H H H H H acetyl acetyl H Hacetyl 8162 acetyl acetyl H H H H H acetyl acetyl H acetyl H 8163 acetylacetyl H H H H H acetyl acetyl H acetyl acetyl 8164 acetyl acetyl H H HH H acetyl acetyl acetyl H H 8165 acetyl acetyl H H H H H acetyl acetylacetyl H acetyl 8166 acetyl acetyl H H H H H acetyl acetyl acetyl acetylH 8167 acetyl acetyl H H H H H acetyl acetyl acetyl acetyl acetyl 8168acetyl acetyl H H H H acetyl H H H H H 8169 acetyl acetyl H H H H acetylH H H H acetyl 8170 acetyl acetyl H H H H acetyl H H H acetyl H 8171acetyl acetyl H H H H acetyl H H H acetyl acetyl 8172 acetyl acetyl H HH H acetyl H H acetyl H H 8173 acetyl acetyl H H H H acetyl H H acetyl Hacetyl 8174 acetyl acetyl H H H H acetyl H H acetyl acetyl H 8175 acetylacetyl H H H H acetyl H H acetyl acetyl acetyl 8176 acetyl acetyl H H HH acetyl H acetyl H H H 8177 acetyl acetyl H H H H acetyl H acetyl H Hacetyl 8178 acetyl acetyl H H H H acetyl H acetyl H acetyl H 8179 acetylacetyl H H H H acetyl H acetyl H acetyl acetyl 8180 acetyl acetyl H H HH acetyl H acetyl acetyl H H 8181 acetyl acetyl H H H H acetyl H acetylacetyl H acetyl 8182 acetyl acetyl H H H H acetyl H acetyl acetyl acetylH 8183 acetyl acetyl H H H H acetyl H acetyl acetyl acetyl acetyl 8184acetyl acetyl H H H H acetyl acetyl H H H H 8185 acetyl acetyl H H H Hacetyl acetyl H H H acetyl 8186 acetyl acetyl H H H H acetyl acetyl H Hacetyl H 8187 acetyl acetyl H H H H acetyl acetyl H H acetyl acetyl 8188acetyl acetyl H H H H acetyl acetyl H acetyl H H 8189 acetyl acetyl H HH H acetyl acetyl H acetyl H acetyl 8190 acetyl acetyl H H H H acetylacetyl H acetyl acetyl H 8191 acetyl acetyl H H H H acetyl acetyl Hacetyl acetyl acetyl 8192 acetyl acetyl H H H H acetyl acetyl acetyl H HH 8193 acetyl acetyl H H H H acetyl acetyl acetyl H H acetyl 8194 acetylacetyl H H H H acetyl acetyl acetyl H acetyl H 8195 acetyl acetyl H H HH acetyl acetyl acetyl H acetyl acetyl 8196 acetyl acetyl H H H H acetylacetyl acetyl acetyl H H 8197 acetyl acetyl H H H H acetyl acetyl acetylacetyl H acetyl 8198 acetyl acetyl H H H H acetyl acetyl acetyl acetylacetyl H 8199 acetyl acetyl H H H H acetyl acetyl acetyl acetyl acetylacetyl 8200 acetyl acetyl H H H acetyl H H H H H H 8201 acetyl acetyl HH H acetyl H H H H H acetyl 8202 acetyl acetyl H H H acetyl H H H Hacetyl H 8203 acetyl acetyl H H H acetyl H H H H acetyl acetyl 8204acetyl acetyl H H H acetyl H H H acetyl H H 8205 acetyl acetyl H H Hacetyl H H H acetyl H acetyl 8206 acetyl acetyl H H H acetyl H H Hacetyl acetyl H 8207 acetyl acetyl H H H acetyl H H H acetyl acetylacetyl 8208 acetyl acetyl H H H acetyl H H acetyl H H H 8209 acetylacetyl H H H acetyl H H acetyl H H acetyl 8210 acetyl acetyl H H Hacetyl H H acetyl H acetyl H 8211 acetyl acetyl H H H acetyl H H acetylH acetyl acetyl 8212 acetyl acetyl H H H acetyl H H acetyl acetyl H H8213 acetyl acetyl H H H acetyl H H acetyl acetyl H acetyl 8214 acetylacetyl H H H acetyl H H acetyl acetyl acetyl H 8215 acetyl acetyl H H Hacetyl H H acetyl acetyl acetyl acetyl 8216 acetyl acetyl H H H acetyl Hacetyl H H H H 8217 acetyl acetyl H H H acetyl H acetyl H H H acetyl8218 acetyl acetyl H H H acetyl H acetyl H H acetyl H 8219 acetyl acetylH H H acetyl H acetyl H H acetyl acetyl 8220 acetyl acetyl H H H acetylH acetyl H acetyl H H 8221 acetyl acetyl H H H acetyl H acetyl H acetylH acetyl 8222 acetyl acetyl H H H acetyl H acetyl H acetyl acetyl H 8223acetyl acetyl H H H acetyl H acetyl H acetyl acetyl acetyl 8224 acetylacetyl H H H acetyl H acetyl acetyl H H H 8225 acetyl acetyl H H Hacetyl H acetyl acetyl H H acetyl 8226 acetyl acetyl H H H acetyl Hacetyl acetyl H acetyl H 8227 acetyl acetyl H H H acetyl H acetyl acetylH acetyl acetyl 8228 acetyl acetyl H H H acetyl H acetyl acetyl acetyl HH 8229 acetyl acetyl H H H acetyl H acetyl acetyl acetyl H acetyl 8230acetyl acetyl H H H acetyl H acetyl acetyl acetyl acetyl H 8231 acetylacetyl H H H acetyl H acetyl acetyl acetyl acetyl acetyl 8232 acetylacetyl H H H acetyl acetyl H H H H H 8233 acetyl acetyl H H H acetylacetyl H H H H acetyl 8234 acetyl acetyl H H H acetyl acetyl H H Hacetyl H 8235 acetyl acetyl H H H acetyl acetyl H H H acetyl acetyl 8236acetyl acetyl H H H acetyl acetyl H H acetyl H H 8237 acetyl acetyl H HH acetyl acetyl H H acetyl H acetyl 8238 acetyl acetyl H H H acetylacetyl H H acetyl acetyl H 8239 acetyl acetyl H H H acetyl acetyl H Hacetyl acetyl acetyl 8240 acetyl acetyl H H H acetyl acetyl H acetyl H HH 8241 acetyl acetyl H H H acetyl acetyl H acetyl H H acetyl 8242 acetylacetyl H H H acetyl acetyl H acetyl H acetyl H 8243 acetyl acetyl H H Hacetyl acetyl H acetyl H acetyl acetyl 8244 acetyl acetyl H H H acetylacetyl H acetyl acetyl H H 8245 acetyl acetyl H H H acetyl acetyl Hacetyl acetyl H acetyl 8246 acetyl acetyl H H H acetyl acetyl H acetylacetyl acetyl H 8247 acetyl acetyl H H H acetyl acetyl H acetyl acetylacetyl acetyl 8248 acetyl acetyl H H H acetyl acetyl acetyl H H H H 8249acetyl acetyl H H H acetyl acetyl acetyl H H H acetyl 8250 acetyl acetylH H H acetyl acetyl acetyl H H acetyl H 8251 acetyl acetyl H H H acetylacetyl acetyl H H acetyl acetyl 8252 acetyl acetyl H H H acetyl acetylacetyl H acetyl H H 8253 acetyl acetyl H H H acetyl acetyl acetyl Hacetyl H acetyl 8254 acetyl acetyl H H H acetyl acetyl acetyl H acetylacetyl H 8255 acetyl acetyl H H H acetyl acetyl acetyl H acetyl acetylacetyl 8256 acetyl acetyl H H H acetyl acetyl acetyl acetyl H H H 8257acetyl acetyl H H H acetyl acetyl acetyl acetyl H H acetyl 8258 acetylacetyl H H H acetyl acetyl acetyl acetyl H acetyl H 8259 acetyl acetyl HH H acetyl acetyl acetyl acetyl H acetyl acetyl 8260 acetyl acetyl H H Hacetyl acetyl acetyl acetyl acetyl H H 8261 acetyl acetyl H H H acetylacetyl acetyl acetyl acetyl H acetyl 8262 acetyl acetyl H H H acetylacetyl acetyl acetyl acetyl acetyl H 8263 acetyl acetyl H H H acetylacetyl acetyl acetyl acetyl acetyl acetyl 8264 acetyl acetyl H H acetylH H H H H H H 8265 acetyl acetyl H H acetyl H H H H H H acetyl 8266acetyl acetyl H H acetyl H H H H H acetyl H 8267 acetyl acetyl H Hacetyl H H H H H acetyl acetyl 8268 acetyl acetyl H H acetyl H H H Hacetyl H H 8269 acetyl acetyl H H acetyl H H H H acetyl H acetyl 8270acetyl acetyl H H acetyl H H H H acetyl acetyl H 8271 acetyl acetyl H Hacetyl H H H H acetyl acetyl acetyl 8272 acetyl acetyl H H acetyl H H Hacetyl H H H 8273 acetyl acetyl H H acetyl H H H acetyl H H acetyl 8274acetyl acetyl H H acetyl H H H acetyl H acetyl H 8275 acetyl acetyl H Hacetyl H H H acetyl H acetyl acetyl 8276 acetyl acetyl H H acetyl H H Hacetyl acetyl H H 8277 acetyl acetyl H H acetyl H H H acetyl acetyl Hacetyl 8278 acetyl acetyl H H acetyl H H H acetyl acetyl acetyl H 8279acetyl acetyl H H acetyl H H H acetyl acetyl acetyl acetyl 8280 acetylacetyl H H acetyl H H acetyl H H H H 8281 acetyl acetyl H H acetyl H Hacetyl H H H acetyl 8282 acetyl acetyl H H acetyl H H acetyl H H acetylH 8283 acetyl acetyl H H acetyl H H acetyl H H acetyl acetyl 8284 acetylacetyl H H acetyl H H acetyl H acetyl H H 8285 acetyl acetyl H H acetylH H acetyl H acetyl H acetyl 8286 acetyl acetyl H H acetyl H H acetyl Hacetyl acetyl H 8287 acetyl acetyl H H acetyl H H acetyl H acetyl acetylacetyl 8288 acetyl acetyl H H acetyl H H acetyl acetyl H H H 8289 acetylacetyl H H acetyl H H acetyl acetyl H H acetyl 8290 acetyl acetyl H Hacetyl H H acetyl acetyl H acetyl H 8291 acetyl acetyl H H acetyl H Hacetyl acetyl H acetyl acetyl 8292 acetyl acetyl H H acetyl H H acetylacetyl acetyl H H 8293 acetyl acetyl H H acetyl H H acetyl acetyl acetylH acetyl 8294 acetyl acetyl H H acetyl H H acetyl acetyl acetyl acetyl H8295 acetyl acetyl H H acetyl H H acetyl acetyl acetyl acetyl acetyl8296 acetyl acetyl H H acetyl H acetyl H H H H H 8297 acetyl acetyl H Hacetyl H acetyl H H H H acetyl 8298 acetyl acetyl H H acetyl H acetyl HH H acetyl H 8299 acetyl acetyl H H acetyl H acetyl H H H acetyl acetyl8300 acetyl acetyl H H acetyl H acetyl H H acetyl H H 8301 acetyl acetylH H acetyl H acetyl H H acetyl H acetyl 8302 acetyl acetyl H H acetyl Hacetyl H H acetyl acetyl H 8303 acetyl acetyl H H acetyl H acetyl H Hacetyl acetyl acetyl 8304 acetyl acetyl H H acetyl H acetyl H acetyl H HH 8305 acetyl acetyl H H acetyl H acetyl H acetyl H H acetyl 8306 acetylacetyl H H acetyl H acetyl H acetyl H acetyl H 8307 acetyl acetyl H Hacetyl H acetyl H acetyl H acetyl acetyl 8308 acetyl acetyl H H acetyl Hacetyl H acetyl acetyl H H 8309 acetyl acetyl H H acetyl H acetyl Hacetyl acetyl H acetyl 8310 acetyl acetyl H H acetyl H acetyl H acetylacetyl acetyl H 8311 acetyl acetyl H H acetyl H acetyl H acetyl acetylacetyl acetyl 8312 acetyl acetyl H H acetyl H acetyl acetyl H H H H 8313acetyl acetyl H H acetyl H acetyl acetyl H H H acetyl 8314 acetyl acetylH H acetyl H acetyl acetyl H H acetyl H 8315 acetyl acetyl H H acetyl Hacetyl acetyl H H acetyl acetyl 8316 acetyl acetyl H H acetyl H acetylacetyl H acetyl H H 8317 acetyl acetyl H H acetyl H acetyl acetyl Hacetyl H acetyl 8318 acetyl acetyl H H acetyl H acetyl acetyl H acetylacetyl H 8319 acetyl acetyl H H acetyl H acetyl acetyl H acetyl acetylacetyl 8320 acetyl acetyl H H acetyl H acetyl acetyl acetyl H H H 8321acetyl acetyl H H acetyl H acetyl acetyl acetyl H H acetyl 8322 acetylacetyl H H acetyl H acetyl acetyl acetyl H acetyl H 8323 acetyl acetyl HH acetyl H acetyl acetyl acetyl H acetyl acetyl 8324 acetyl acetyl H Hacetyl H acetyl acetyl acetyl acetyl H H 8325 acetyl acetyl H H acetyl Hacetyl acetyl acetyl acetyl H acetyl 8326 acetyl acetyl H H acetyl Hacetyl acetyl acetyl acetyl acetyl H 8327 acetyl acetyl H H acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl 8328 acetyl acetyl H H acetylacetyl H H H H H H 8329 acetyl acetyl H H 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acetyl Hacetyl H H acetyl H 8347 acetyl acetyl H H acetyl acetyl H acetyl H Hacetyl acetyl 8348 acetyl acetyl H H acetyl acetyl H acetyl H acetyl H H8349 acetyl acetyl H H acetyl acetyl H acetyl H acetyl H acetyl 8350acetyl acetyl H H acetyl acetyl H acetyl H acetyl acetyl H 8351 acetylacetyl H H acetyl acetyl H acetyl H acetyl acetyl acetyl 8352 acetylacetyl H H acetyl acetyl H acetyl acetyl H H H 8353 acetyl acetyl H Hacetyl acetyl H acetyl acetyl H H acetyl 8354 acetyl acetyl H H acetylacetyl H acetyl acetyl H acetyl H 8355 acetyl acetyl H H acetyl acetyl Hacetyl acetyl H acetyl acetyl 8356 acetyl acetyl H H acetyl acetyl Hacetyl acetyl acetyl H H 8357 acetyl acetyl H H acetyl acetyl H acetylacetyl acetyl H acetyl 8358 acetyl acetyl H H acetyl acetyl H acetylacetyl acetyl acetyl H 8359 acetyl acetyl H H acetyl acetyl H acetylacetyl acetyl acetyl acetyl 8360 acetyl acetyl H H acetyl acetyl acetylH H H H H 8361 acetyl acetyl H H acetyl acetyl acetyl H H H H acetyl8362 acetyl acetyl H 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acetyl H acetyl Hacetyl acetyl H H acetyl acetyl H 8495 acetyl acetyl H acetyl H acetylacetyl H H acetyl acetyl acetyl 8496 acetyl acetyl H acetyl H acetylacetyl H acetyl H H H 8497 acetyl acetyl H acetyl H acetyl acetyl Hacetyl H H acetyl 8498 acetyl acetyl H acetyl H acetyl acetyl H acetyl Hacetyl H 8499 acetyl acetyl H acetyl H acetyl acetyl H acetyl H acetylacetyl 8500 acetyl acetyl H acetyl H acetyl acetyl H acetyl acetyl H H8501 acetyl acetyl H acetyl H acetyl acetyl H acetyl acetyl H acetyl8502 acetyl acetyl H acetyl H acetyl acetyl H acetyl acetyl acetyl H8503 acetyl acetyl H acetyl H acetyl acetyl H acetyl acetyl acetylacetyl 8504 acetyl acetyl H acetyl H acetyl acetyl acetyl H H H H 8505acetyl acetyl H acetyl H acetyl acetyl acetyl H H H acetyl 8506 acetylacetyl H acetyl H acetyl acetyl acetyl H H acetyl H 8507 acetyl acetyl Hacetyl H acetyl acetyl acetyl H H acetyl acetyl 8508 acetyl acetyl Hacetyl H acetyl acetyl acetyl H acetyl H H 8509 acetyl acetyl H acetyl Hacetyl acetyl acetyl H acetyl H acetyl 8510 acetyl acetyl H acetyl Hacetyl acetyl acetyl H acetyl acetyl H 8511 acetyl acetyl H acetyl Hacetyl acetyl acetyl H acetyl acetyl acetyl 8512 acetyl acetyl H acetylH acetyl acetyl acetyl acetyl H H H 8513 acetyl acetyl H acetyl H acetylacetyl acetyl acetyl H H acetyl 8514 acetyl acetyl H acetyl H acetylacetyl acetyl acetyl H acetyl H 8515 acetyl acetyl H acetyl H acetylacetyl acetyl acetyl H acetyl acetyl 8516 acetyl acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl H H 8517 acetyl acetyl H acetyl Hacetyl acetyl acetyl acetyl acetyl H acetyl 8518 acetyl acetyl H acetylH acetyl acetyl acetyl acetyl acetyl acetyl H 8519 acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetyl 8520 acetylacetyl H acetyl acetyl H H H H H H H 8521 acetyl acetyl H acetyl acetylH H H H H H acetyl 8522 acetyl acetyl H acetyl acetyl H H H H H acetyl H8523 acetyl acetyl H acetyl acetyl H H H H H acetyl acetyl 8524 acetylacetyl H acetyl acetyl H H H H acetyl H 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acetyl H acetyl H H acetyl H acetyl 8558 acetyl acetyl Hacetyl acetyl H acetyl H H acetyl acetyl H 8559 acetyl acetyl H acetylacetyl H acetyl H H acetyl acetyl acetyl 8560 acetyl acetyl H acetylacetyl H acetyl H acetyl H H H 8561 acetyl acetyl H acetyl acetyl Hacetyl H acetyl H H acetyl 8562 acetyl acetyl H acetyl acetyl H acetyl Hacetyl H acetyl H 8563 acetyl acetyl H acetyl acetyl H acetyl H acetyl Hacetyl acetyl 8564 acetyl acetyl H acetyl acetyl H acetyl H acetylacetyl H H 8565 acetyl acetyl H acetyl acetyl H acetyl H acetyl acetyl Hacetyl 8566 acetyl acetyl H acetyl acetyl H acetyl H acetyl acetylacetyl H 8567 acetyl acetyl H acetyl acetyl H acetyl H acetyl acetylacetyl acetyl 8568 acetyl acetyl H acetyl acetyl H acetyl acetyl H H H H8569 acetyl acetyl H acetyl acetyl H acetyl acetyl H H H acetyl 8570acetyl acetyl H acetyl acetyl H acetyl acetyl H H acetyl H 8571 acetylacetyl H acetyl acetyl H acetyl acetyl H H acetyl acetyl 8572 acetylacetyl H acetyl acetyl H acetyl acetyl H 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acetyl acetyl acetyl acetyl HH H H 8633 acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H H Hacetyl 8634 acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H Hacetyl H 8635 acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H Hacetyl acetyl 8636 acetyl acetyl H acetyl acetyl acetyl acetyl acetyl Hacetyl H H 8637 acetyl acetyl H acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl 8638 acetyl acetyl H acetyl acetyl acetyl acetyl acetylH acetyl acetyl H 8639 acetyl acetyl H acetyl acetyl acetyl acetylacetyl H acetyl acetyl acetyl 8640 acetyl acetyl H acetyl acetyl acetylacetyl acetyl acetyl H H H 8641 acetyl acetyl H acetyl acetyl acetylacetyl acetyl acetyl H H acetyl 8642 acetyl acetyl H acetyl acetylacetyl acetyl acetyl acetyl H acetyl H 8643 acetyl acetyl H acetylacetyl acetyl acetyl acetyl acetyl H acetyl acetyl 8644 acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl acetyl acetyl H H 8645 acetyl acetylH acetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl 8646 acetylacetyl H 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acetyl H H acetyl acetylH H H acetyl acetyl 8748 acetyl acetyl acetyl H H acetyl acetyl H Hacetyl H H 8749 acetyl acetyl acetyl H H acetyl acetyl H H acetyl Hacetyl 8750 acetyl acetyl acetyl H H acetyl acetyl H H acetyl acetyl H8751 acetyl acetyl acetyl H H acetyl acetyl H H acetyl acetyl acetyl8752 acetyl acetyl acetyl H H acetyl acetyl H acetyl H H H 8753 acetylacetyl acetyl H H acetyl acetyl H acetyl H H acetyl 8754 acetyl acetylacetyl H H acetyl acetyl H acetyl H acetyl H 8755 acetyl acetyl acetyl HH acetyl acetyl H acetyl H acetyl acetyl 8756 acetyl acetyl acetyl H Hacetyl acetyl H acetyl acetyl H H 8757 acetyl acetyl acetyl H H acetylacetyl H acetyl acetyl H acetyl 8758 acetyl acetyl acetyl H H acetylacetyl H acetyl acetyl acetyl H 8759 acetyl acetyl acetyl H H acetylacetyl H acetyl acetyl acetyl acetyl 8760 acetyl acetyl acetyl H Hacetyl acetyl acetyl H H H H 8761 acetyl acetyl acetyl H H acetyl acetylacetyl H H H acetyl 8762 acetyl acetyl acetyl H H acetyl acetyl acetyl HH 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acetyl acetyl H acetyl H acetyl acetyl HH acetyl H 8827 acetyl acetyl acetyl H acetyl H acetyl acetyl H H acetylacetyl 8828 acetyl acetyl acetyl H acetyl H acetyl acetyl H acetyl H H8829 acetyl acetyl acetyl H acetyl H acetyl acetyl H acetyl H acetyl8830 acetyl acetyl acetyl H acetyl H acetyl acetyl H acetyl acetyl H8831 acetyl acetyl acetyl H acetyl H acetyl acetyl H acetyl acetylacetyl 8832 acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl H H H8833 acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl H H acetyl8834 acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl H acetyl H8835 acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl H acetylacetyl 8836 acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl acetylH H 8837 acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl acetyl Hacetyl 8838 acetyl acetyl acetyl H acetyl H acetyl acetyl acetyl acetylacetyl H 8839 acetyl acetyl acetyl H acetyl H acetyl acetyl acetylacetyl acetyl acetyl 8840 acetyl acetyl acetyl H acetyl acetyl H H 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acetyl H acetyl H H H H 8857 acetyl acetyl acetyl H acetylacetyl H acetyl H H H acetyl 8858 acetyl acetyl acetyl H acetyl acetyl Hacetyl H H acetyl H 8859 acetyl acetyl acetyl H acetyl acetyl H acetyl HH acetyl acetyl 8860 acetyl acetyl acetyl H acetyl acetyl H acetyl Hacetyl H H 8861 acetyl acetyl acetyl H acetyl acetyl H acetyl H acetyl Hacetyl 8862 acetyl acetyl acetyl H acetyl acetyl H acetyl H acetylacetyl H 8863 acetyl acetyl acetyl H acetyl acetyl H acetyl H acetylacetyl acetyl 8864 acetyl acetyl acetyl H acetyl acetyl H acetyl acetylH H H 8865 acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl H Hacetyl 8866 acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl Hacetyl H 8867 acetyl acetyl acetyl H acetyl acetyl H acetyl acetyl Hacetyl acetyl 8868 acetyl acetyl acetyl H acetyl acetyl H acetyl acetylacetyl H H 8869 acetyl acetyl acetyl H acetyl acetyl H acetyl acetylacetyl H acetyl 8870 acetyl acetyl acetyl H acetyl acetyl H acetylacetyl acetyl acetyl H 8871 acetyl acetyl acetyl H acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl 8872 acetyl acetyl acetyl H acetylacetyl acetyl H H H H H 8873 acetyl acetyl acetyl H acetyl acetyl acetylH H H H acetyl 8874 acetyl acetyl acetyl H acetyl acetyl acetyl H H Hacetyl H 8875 acetyl acetyl acetyl H acetyl acetyl acetyl H H H acetylacetyl 8876 acetyl acetyl acetyl H acetyl acetyl acetyl H H acetyl H H8877 acetyl acetyl acetyl H acetyl acetyl acetyl H H acetyl H acetyl8878 acetyl acetyl acetyl H acetyl acetyl acetyl H H acetyl acetyl H8879 acetyl acetyl acetyl H acetyl acetyl acetyl H H acetyl acetylacetyl 8880 acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl H H H8881 acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl H H acetyl8882 acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl H acetyl H8883 acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl H acetylacetyl 8884 acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl acetylH H 8885 acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl Hacetyl 8886 acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl acetylacetyl H 8887 acetyl acetyl acetyl H acetyl acetyl acetyl H acetylacetyl acetyl acetyl 8888 acetyl acetyl acetyl H acetyl acetyl acetylacetyl H H H H 8889 acetyl acetyl acetyl H acetyl acetyl acetyl acetyl HH H acetyl 8890 acetyl acetyl acetyl H acetyl acetyl acetyl acetyl H Hacetyl H 8891 acetyl acetyl acetyl H acetyl acetyl acetyl acetyl H Hacetyl acetyl 8892 acetyl acetyl acetyl H acetyl acetyl acetyl acetyl Hacetyl H H 8893 acetyl acetyl acetyl H acetyl acetyl acetyl acetyl Hacetyl H acetyl 8894 acetyl acetyl acetyl H acetyl acetyl acetyl acetylH acetyl acetyl H 8895 acetyl acetyl acetyl H acetyl acetyl acetylacetyl H acetyl acetyl acetyl 8896 acetyl acetyl acetyl H acetyl acetylacetyl acetyl acetyl H H H 8897 acetyl acetyl acetyl H acetyl acetylacetyl acetyl acetyl H H acetyl 8898 acetyl acetyl acetyl H acetylacetyl acetyl acetyl acetyl H acetyl H 8899 acetyl acetyl acetyl Hacetyl acetyl acetyl acetyl acetyl H acetyl acetyl 8900 acetyl acetylacetyl H acetyl acetyl acetyl acetyl acetyl acetyl H H 8901 acetylacetyl acetyl H acetyl acetyl acetyl acetyl acetyl acetyl H acetyl 8902acetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl acetyl acetylH 8903 acetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl acetylacetyl acetyl 8904 acetyl acetyl acetyl acetyl H H H H H H H H 8905acetyl acetyl acetyl acetyl H H H H H H H acetyl 8906 acetyl acetylacetyl acetyl H H H H H H acetyl H 8907 acetyl acetyl acetyl acetyl H HH H H H acetyl acetyl 8908 acetyl acetyl acetyl acetyl H H H H H acetylH H 8909 acetyl acetyl acetyl acetyl H H H H H acetyl H acetyl 8910acetyl acetyl acetyl acetyl H H H H H acetyl acetyl H 8911 acetyl acetylacetyl acetyl H H H H H acetyl acetyl acetyl 8912 acetyl acetyl acetylacetyl H H H H acetyl H H H 8913 acetyl acetyl acetyl acetyl H H H Hacetyl H H acetyl 8914 acetyl acetyl acetyl acetyl H H H H acetyl Hacetyl H 8915 acetyl acetyl acetyl acetyl H H H H acetyl H acetyl acetyl8916 acetyl acetyl acetyl acetyl H H H H acetyl acetyl H H 8917 acetylacetyl acetyl acetyl H H H H acetyl acetyl H acetyl 8918 acetyl acetylacetyl acetyl H H H H acetyl acetyl acetyl H 8919 acetyl acetyl acetylacetyl H H H H acetyl acetyl acetyl acetyl 8920 acetyl acetyl acetylacetyl H H H acetyl H H H H 8921 acetyl acetyl acetyl acetyl H H Hacetyl H H H acetyl 8922 acetyl acetyl acetyl acetyl H H H acetyl H Hacetyl H 8923 acetyl acetyl acetyl acetyl H H H acetyl H H acetyl acetyl8924 acetyl acetyl acetyl acetyl H H H acetyl H acetyl H H 8925 acetylacetyl acetyl acetyl H H H acetyl H acetyl H acetyl 8926 acetyl acetylacetyl acetyl H H H acetyl H acetyl acetyl H 8927 acetyl acetyl acetylacetyl H H H acetyl H acetyl acetyl acetyl 8928 acetyl acetyl acetylacetyl H H H acetyl acetyl H H H 8929 acetyl acetyl acetyl acetyl H H Hacetyl acetyl H H acetyl 8930 acetyl acetyl acetyl acetyl H H H acetylacetyl H acetyl H 8931 acetyl acetyl acetyl acetyl H H H acetyl acetyl Hacetyl acetyl 8932 acetyl acetyl acetyl acetyl H H H acetyl acetylacetyl H H 8933 acetyl acetyl acetyl acetyl H H H acetyl acetyl acetyl Hacetyl 8934 acetyl acetyl acetyl acetyl H H H acetyl acetyl acetylacetyl H 8935 acetyl acetyl acetyl acetyl H H H acetyl acetyl acetylacetyl acetyl 8936 acetyl acetyl acetyl acetyl H H acetyl H H H H H 8937acetyl acetyl acetyl acetyl H H acetyl H H H H acetyl 8938 acetyl acetylacetyl acetyl H H acetyl H H H acetyl H 8939 acetyl acetyl acetyl acetylH H acetyl H H H acetyl acetyl 8940 acetyl acetyl acetyl acetyl H Hacetyl H H acetyl H H 8941 acetyl acetyl acetyl acetyl H H acetyl H Hacetyl H acetyl 8942 acetyl acetyl acetyl acetyl H H acetyl H H acetylacetyl H 8943 acetyl acetyl acetyl acetyl H H acetyl H H acetyl acetylacetyl 8944 acetyl acetyl acetyl acetyl H H acetyl H acetyl H H H 8945acetyl acetyl acetyl acetyl H H acetyl H acetyl H H acetyl 8946 acetylacetyl acetyl acetyl H H acetyl H acetyl H acetyl H 8947 acetyl acetylacetyl acetyl H H acetyl H acetyl H acetyl acetyl 8948 acetyl acetylacetyl acetyl H H acetyl H acetyl acetyl H H 8949 acetyl acetyl acetylacetyl H H acetyl H acetyl acetyl H acetyl 8950 acetyl acetyl acetylacetyl H H acetyl H acetyl acetyl acetyl H 8951 acetyl acetyl acetylacetyl H H acetyl H acetyl acetyl acetyl acetyl 8952 acetyl acetylacetyl acetyl H H acetyl acetyl H H H H 8953 acetyl acetyl acetyl acetylH H acetyl acetyl H H H acetyl 8954 acetyl acetyl acetyl acetyl H Hacetyl acetyl H H acetyl H 8955 acetyl acetyl acetyl acetyl H H acetylacetyl H H acetyl acetyl 8956 acetyl acetyl acetyl acetyl H H acetylacetyl H acetyl H H 8957 acetyl acetyl acetyl acetyl H H acetyl acetyl Hacetyl H acetyl 8958 acetyl acetyl acetyl acetyl H H acetyl acetyl Hacetyl acetyl H 8959 acetyl acetyl acetyl acetyl H H acetyl acetyl Hacetyl acetyl acetyl 8960 acetyl acetyl acetyl acetyl H H acetyl acetylacetyl H H H 8961 acetyl acetyl acetyl acetyl H H acetyl acetyl acetyl HH acetyl 8962 acetyl acetyl acetyl acetyl H H acetyl acetyl acetyl Hacetyl H 8963 acetyl acetyl acetyl acetyl H H acetyl acetyl acetyl Hacetyl acetyl 8964 acetyl acetyl acetyl acetyl H H acetyl acetyl acetylacetyl H H 8965 acetyl acetyl acetyl acetyl H H acetyl acetyl acetylacetyl H acetyl 8966 acetyl acetyl acetyl acetyl H H acetyl acetylacetyl acetyl acetyl H 8967 acetyl acetyl acetyl acetyl H H acetylacetyl acetyl acetyl acetyl acetyl 8968 acetyl acetyl acetyl acetyl Hacetyl H H H H H H 8969 acetyl acetyl acetyl acetyl H acetyl H H H H Hacetyl 8970 acetyl acetyl acetyl acetyl H acetyl H H H H acetyl H 8971acetyl acetyl acetyl acetyl H acetyl H H H H acetyl acetyl 8972 acetylacetyl acetyl acetyl H acetyl H H H acetyl H H 8973 acetyl acetyl acetylacetyl H acetyl H H H acetyl H acetyl 8974 acetyl acetyl acetyl acetyl Hacetyl H H H acetyl acetyl H 8975 acetyl acetyl acetyl acetyl H acetyl HH H acetyl acetyl acetyl 8976 acetyl acetyl acetyl acetyl H acetyl H Hacetyl H H H 8977 acetyl acetyl acetyl acetyl H acetyl H H acetyl H Hacetyl 8978 acetyl acetyl acetyl acetyl H acetyl H H acetyl H acetyl H8979 acetyl acetyl acetyl acetyl H acetyl H H acetyl H acetyl acetyl8980 acetyl acetyl acetyl acetyl H acetyl H H acetyl acetyl H H 8981acetyl acetyl acetyl acetyl H acetyl H H acetyl acetyl H acetyl 8982acetyl acetyl acetyl acetyl H acetyl H H acetyl acetyl acetyl H 8983acetyl acetyl acetyl acetyl H acetyl H H acetyl acetyl acetyl acetyl8984 acetyl acetyl acetyl acetyl H acetyl H acetyl H H H H 8985 acetylacetyl acetyl acetyl H acetyl H acetyl H H H acetyl 8986 acetyl acetylacetyl acetyl H acetyl H acetyl H H acetyl H 8987 acetyl acetyl acetylacetyl H acetyl H acetyl H H acetyl acetyl 8988 acetyl acetyl acetylacetyl H acetyl H acetyl H acetyl H H 8989 acetyl acetyl acetyl acetyl Hacetyl H acetyl H acetyl H acetyl 8990 acetyl acetyl acetyl acetyl Hacetyl H acetyl H acetyl acetyl H 8991 acetyl acetyl acetyl acetyl Hacetyl H acetyl H acetyl acetyl acetyl 8992 acetyl acetyl acetyl acetylH acetyl H acetyl acetyl H H H 8993 acetyl acetyl acetyl acetyl H acetylH acetyl acetyl H H acetyl 8994 acetyl acetyl acetyl acetyl H acetyl Hacetyl acetyl H acetyl H 8995 acetyl acetyl acetyl acetyl H acetyl Hacetyl acetyl H acetyl acetyl 8996 acetyl acetyl acetyl acetyl H acetylH acetyl acetyl acetyl H H 8997 acetyl acetyl acetyl acetyl H acetyl Hacetyl acetyl acetyl H acetyl 8998 acetyl acetyl acetyl acetyl H acetylH acetyl acetyl acetyl acetyl H 8999 acetyl acetyl acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl acetyl 9000 acetyl acetyl acetylacetyl H acetyl acetyl H H H H H 9001 acetyl acetyl acetyl acetyl Hacetyl acetyl H H H H acetyl 9002 acetyl acetyl acetyl acetyl H acetylacetyl H H H acetyl H 9003 acetyl acetyl acetyl acetyl H acetyl acetyl HH H acetyl acetyl 9004 acetyl acetyl acetyl acetyl H acetyl acetyl H Hacetyl H H 9005 acetyl acetyl acetyl acetyl H acetyl acetyl H H acetyl Hacetyl 9006 acetyl acetyl acetyl acetyl H acetyl acetyl H H acetylacetyl H 9007 acetyl acetyl acetyl acetyl H acetyl acetyl H H acetylacetyl acetyl 9008 acetyl acetyl acetyl acetyl H acetyl acetyl H acetylH H H 9009 acetyl acetyl acetyl acetyl H acetyl acetyl H acetyl H Hacetyl 9010 acetyl acetyl acetyl acetyl H acetyl acetyl H acetyl Hacetyl H 9011 acetyl acetyl acetyl acetyl H acetyl acetyl H acetyl Hacetyl acetyl 9012 acetyl acetyl acetyl acetyl H acetyl acetyl H acetylacetyl H H 9013 acetyl acetyl acetyl acetyl H acetyl acetyl H acetylacetyl H acetyl 9014 acetyl acetyl acetyl acetyl H acetyl acetyl Hacetyl acetyl acetyl H 9015 acetyl acetyl acetyl acetyl H acetyl acetylH acetyl acetyl acetyl acetyl 9016 acetyl acetyl acetyl acetyl H acetylacetyl acetyl H H H H 9017 acetyl acetyl acetyl acetyl H acetyl acetylacetyl H H H acetyl 9018 acetyl acetyl acetyl acetyl H acetyl acetylacetyl H H acetyl H 9019 acetyl acetyl acetyl acetyl H acetyl acetylacetyl H H acetyl acetyl 9020 acetyl acetyl acetyl acetyl H acetylacetyl acetyl H acetyl H H 9021 acetyl acetyl acetyl acetyl H acetylacetyl acetyl H acetyl H acetyl 9022 acetyl acetyl acetyl acetyl Hacetyl acetyl acetyl H acetyl acetyl H 9023 acetyl acetyl acetyl acetylH acetyl acetyl acetyl H acetyl acetyl acetyl 9024 acetyl acetyl acetylacetyl H acetyl acetyl acetyl acetyl H H H 9025 acetyl acetyl acetylacetyl H acetyl acetyl acetyl acetyl H H acetyl 9026 acetyl acetylacetyl acetyl H acetyl acetyl acetyl acetyl H acetyl H 9027 acetylacetyl acetyl acetyl H acetyl acetyl acetyl acetyl H acetyl acetyl 9028acetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl H H9029 acetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetyl acetyl Hacetyl 9030 acetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetylacetyl acetyl H 9031 acetyl acetyl acetyl acetyl H acetyl acetyl acetylacetyl acetyl acetyl acetyl 9032 acetyl acetyl acetyl acetyl acetyl H HH H H H H 9033 acetyl acetyl acetyl acetyl acetyl H H H H H H acetyl9034 acetyl acetyl acetyl acetyl acetyl H H H H H acetyl H 9035 acetylacetyl acetyl acetyl acetyl H H H H H acetyl acetyl 9036 acetyl acetylacetyl acetyl acetyl H H H H acetyl H H 9037 acetyl acetyl acetyl acetylacetyl H H H H acetyl H acetyl 9038 acetyl acetyl acetyl acetyl acetyl HH H H acetyl acetyl H 9039 acetyl acetyl acetyl acetyl acetyl H H H Hacetyl acetyl acetyl 9040 acetyl acetyl acetyl acetyl acetyl H H Hacetyl H H H 9041 acetyl acetyl acetyl acetyl acetyl H H H acetyl H Hacetyl 9042 acetyl acetyl acetyl acetyl acetyl H H H acetyl H acetyl H9043 acetyl acetyl acetyl acetyl acetyl H H H acetyl H acetyl acetyl9044 acetyl acetyl acetyl acetyl acetyl H H H acetyl acetyl H H 9045acetyl acetyl acetyl acetyl acetyl H H H acetyl acetyl H acetyl 9046acetyl acetyl acetyl acetyl acetyl H H H acetyl acetyl acetyl H 9047acetyl acetyl acetyl acetyl acetyl H H H acetyl acetyl acetyl acetyl9048 acetyl acetyl acetyl acetyl acetyl H H acetyl H H H H 9049 acetylacetyl acetyl acetyl acetyl H H acetyl H H H acetyl 9050 acetyl acetylacetyl acetyl acetyl H H acetyl H H acetyl H 9051 acetyl acetyl acetylacetyl acetyl H H acetyl H H acetyl acetyl 9052 acetyl acetyl acetylacetyl acetyl H H acetyl H acetyl H H 9053 acetyl acetyl acetyl acetylacetyl H H acetyl H acetyl H acetyl 9054 acetyl acetyl acetyl acetylacetyl H H acetyl H acetyl acetyl H 9055 acetyl acetyl acetyl acetylacetyl H H acetyl H acetyl acetyl acetyl 9056 acetyl acetyl acetylacetyl acetyl H H acetyl acetyl H H H 9057 acetyl acetyl acetyl acetylacetyl H H acetyl acetyl H H acetyl 9058 acetyl acetyl acetyl acetylacetyl H H acetyl acetyl H acetyl H 9059 acetyl acetyl acetyl acetylacetyl H H acetyl acetyl H acetyl acetyl 9060 acetyl acetyl acetylacetyl acetyl H H acetyl acetyl acetyl H H 9061 acetyl acetyl acetylacetyl acetyl H H acetyl acetyl acetyl H acetyl 9062 acetyl acetylacetyl acetyl acetyl H H acetyl acetyl acetyl acetyl H 9063 acetylacetyl acetyl acetyl acetyl H H acetyl acetyl acetyl acetyl acetyl 9064acetyl acetyl acetyl acetyl acetyl H acetyl H H H H H 9065 acetyl acetylacetyl acetyl acetyl H acetyl H H H H acetyl 9066 acetyl acetyl acetylacetyl acetyl H acetyl H H H acetyl H 9067 acetyl acetyl acetyl acetylacetyl H acetyl H H H acetyl acetyl 9068 acetyl acetyl acetyl acetylacetyl H acetyl H H acetyl H H 9069 acetyl acetyl acetyl acetyl acetyl Hacetyl H H acetyl H acetyl 9070 acetyl acetyl acetyl acetyl acetyl Hacetyl H H acetyl acetyl H 9071 acetyl acetyl acetyl acetyl acetyl Hacetyl H H acetyl acetyl acetyl 9072 acetyl acetyl acetyl acetyl acetylH acetyl H acetyl H H H 9073 acetyl acetyl acetyl acetyl acetyl H acetylH acetyl H H acetyl 9074 acetyl acetyl acetyl acetyl acetyl H acetyl Hacetyl H acetyl H 9075 acetyl acetyl acetyl acetyl acetyl H acetyl Hacetyl H acetyl acetyl 9076 acetyl acetyl acetyl acetyl acetyl H acetylH acetyl acetyl H H 9077 acetyl acetyl acetyl acetyl acetyl H acetyl Hacetyl acetyl H acetyl 9078 acetyl acetyl acetyl acetyl acetyl H acetylH acetyl acetyl acetyl H 9079 acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl acetyl acetyl acetyl 9080 acetyl acetyl acetyl acetylacetyl H acetyl acetyl H H H H 9081 acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl H H H acetyl 9082 acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl H H acetyl H 9083 acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl H H acetyl acetyl 9084 acetyl acetyl acetyl acetyl acetylH acetyl acetyl H acetyl H H 9085 acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl H acetyl H acetyl 9086 acetyl acetyl acetyl acetyl acetylH acetyl acetyl H acetyl acetyl H 9087 acetyl acetyl acetyl acetylacetyl H acetyl acetyl H acetyl acetyl acetyl 9088 acetyl acetyl acetylacetyl acetyl H acetyl acetyl acetyl H H H 9089 acetyl acetyl acetylacetyl acetyl H acetyl acetyl acetyl H H acetyl 9090 acetyl acetylacetyl acetyl acetyl H acetyl acetyl acetyl H acetyl H 9091 acetylacetyl acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl acetyl 9092acetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetyl H H9093 acetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetyl Hacetyl 9094 acetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetylacetyl acetyl H 9095 acetyl acetyl acetyl acetyl acetyl H acetyl acetylacetyl acetyl acetyl acetyl 9096 acetyl acetyl acetyl acetyl acetylacetyl H H H H H H 9097 acetyl acetyl acetyl acetyl acetyl acetyl H H HH H acetyl 9098 acetyl acetyl acetyl acetyl acetyl acetyl H H H H acetylH 9099 acetyl acetyl acetyl acetyl acetyl acetyl H H H H acetyl acetyl9100 acetyl acetyl acetyl acetyl acetyl acetyl H H H acetyl H H 9101acetyl acetyl acetyl acetyl acetyl acetyl H H H acetyl H acetyl 9102acetyl acetyl acetyl acetyl acetyl acetyl H H H acetyl acetyl H 9103acetyl acetyl acetyl acetyl acetyl acetyl H H H acetyl acetyl acetyl9104 acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl H H H 9105acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl H H acetyl 9106acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl H acetyl H 9107acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl H acetyl acetyl9108 acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl acetyl H H9109 acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl acetyl Hacetyl 9110 acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl acetylacetyl H 9111 acetyl acetyl acetyl acetyl acetyl acetyl H H acetylacetyl acetyl acetyl 9112 acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl H H H H 9113 acetyl acetyl acetyl acetyl acetyl acetyl H acetyl HH H acetyl 9114 acetyl acetyl acetyl acetyl acetyl acetyl H acetyl H Hacetyl H 9115 acetyl acetyl acetyl acetyl acetyl acetyl H acetyl H Hacetyl acetyl 9116 acetyl acetyl acetyl acetyl acetyl acetyl H acetyl Hacetyl H H 9117 acetyl acetyl acetyl acetyl acetyl acetyl H acetyl Hacetyl H acetyl 9118 acetyl acetyl acetyl acetyl acetyl acetyl H acetylH acetyl acetyl H 9119 acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl H acetyl acetyl acetyl 9120 acetyl acetyl acetyl acetyl acetylacetyl H acetyl acetyl H H H 9121 acetyl acetyl acetyl acetyl acetylacetyl H acetyl acetyl H H acetyl 9122 acetyl acetyl acetyl acetylacetyl acetyl H acetyl acetyl H acetyl H 9123 acetyl acetyl acetylacetyl acetyl acetyl H acetyl acetyl H acetyl acetyl 9124 acetyl acetylacetyl acetyl acetyl acetyl H acetyl acetyl acetyl H H 9125 acetylacetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetyl H acetyl 9126acetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetyl acetylH 9127 acetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetylacetyl acetyl 9128 acetyl acetyl acetyl acetyl acetyl acetyl acetyl H HH H H 9129 acetyl acetyl acetyl acetyl acetyl acetyl acetyl H H H Hacetyl 9130 acetyl acetyl acetyl acetyl acetyl acetyl acetyl H H Hacetyl H 9131 acetyl acetyl acetyl acetyl acetyl acetyl acetyl H H Hacetyl acetyl 9132 acetyl acetyl acetyl acetyl acetyl acetyl acetyl H Hacetyl H H 9133 acetyl acetyl acetyl acetyl acetyl acetyl acetyl H Hacetyl H acetyl 9134 acetyl acetyl acetyl acetyl acetyl acetyl acetyl HH acetyl acetyl H 9135 acetyl acetyl acetyl acetyl acetyl acetyl acetylH H acetyl acetyl acetyl 9136 acetyl acetyl acetyl acetyl acetyl acetylacetyl H acetyl H H H 9137 acetyl acetyl acetyl acetyl acetyl acetylacetyl H acetyl H H acetyl 9138 acetyl acetyl acetyl acetyl acetylacetyl acetyl H acetyl H acetyl H 9139 acetyl acetyl acetyl acetylacetyl acetyl acetyl H acetyl H acetyl acetyl 9140 acetyl acetyl acetylacetyl acetyl acetyl acetyl H acetyl acetyl H H 9141 acetyl acetylacetyl acetyl acetyl acetyl acetyl H acetyl acetyl H acetyl 9142 acetylacetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetyl H 9143acetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetyl acetyl acetylacetyl 9144 acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H HH H 9145 acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H H Hacetyl 9146 acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H Hacetyl H 9147 acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl HH acetyl acetyl 9148 acetyl acetyl acetyl acetyl acetyl acetyl acetylacetyl H acetyl H H 9149 acetyl acetyl acetyl acetyl acetyl acetylacetyl acetyl H acetyl H acetyl 9150 acetyl acetyl acetyl acetyl acetylacetyl acetyl acetyl H acetyl acetyl H 9151 acetyl acetyl acetyl acetylacetyl acetyl acetyl acetyl H acetyl acetyl acetyl 9152 acetyl acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl H H H 9153 acetylacetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H H acetyl 9154acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl H acetylH 9155 acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl acetyl Hacetyl acetyl 9156 acetyl acetyl acetyl acetyl acetyl acetyl acetylacetyl acetyl acetyl H H 9157 acetyl acetyl acetyl acetyl Acetyl acetylacetyl acetyl acetyl acetyl H acetyl 9158 acetyl acetyl acetyl acetylAcetyl acetyl acetyl acetyl acetyl acetyl acetyl H

The synthetic oligosaccharide of the present invention comprises alinker X. In one embodiment, the linker X is a bond. In anotherembodiment the linker at one end exhibits a grouping able to enter intoa covalent bonding with a reactive functional group of the carrier, e.g.an amino, thiol, or carboxyl group, and at the other end a groupinglikewise able to enter into a covalent bonding with a hydroxyl group oran amino group of an oligosaccharide according to the present invention.Between the two functional groups of the linker molecule there is abiocompatible bridging molecule of suitable length, e.g. substituted orunsubstituted heteroalkylene, arylalkylene, alkylene, alkenylene, or(oligo)alkylene glycol groups. Linkers preferably comprises ansubstituted or unsubstituted (C₁-C₁₀) alkylene group or an substitutedor unsubstituted (C₂-C₁₀) alkenylene group.

In one embodiment the linker is —(CH₂)_(p)S—, where p is an integerselected from the group consisting of 3, 4, 5, 6, 7, 8, 9, 10.

In one embodiment, the present invention provides oligosaccharides 1b or1d:

where R¹, R², n, and Y are defined as in oligosaccharide 1a; and p is aninteger from 1 to 10.

Oligosaccharides 1a and 1b/d have a definite number of monosaccharideunits. As indicated above, the number of monosaccharide units may beexpressed by n+1. In one embodiment, n may be between about 3 and 100,preferably between about 3 and 50. In other embodiments, n is betweenabout 5 and 25 units, about 6 and 30 units, about 6 and 24 units, andabout 6 and 18 units. In another embodiment n may be 3, 4, 5, 6, 7, 8,9, 10, 11, 12, 13, 14, 15, 16, or 17.

Oligosaccharides of the present invention may be further defined by thepercentage of acetylated residues to non-acetylated residues and by thepattern (e.g. spacing) of acetylated residues relative to non-acetylatedresidues. For example, in oligosaccharides 1a and 1b/d the number ofCOCH₃ groups in R¹ and R² may be defined by z, whereby and thepercentage of acetylated monosaccharide units is y, where y isz/(n+1)*100. In one embodiment, y is 90% or less, 80% or less, 70% orless, 60% or less, 50% or less, 40% or less, 30% or less, 20% or less,or 10% or less. In another embodiment, y may be 40% or less, 30% orless, 20% or less, 15% or less, 10% or less, 5% or less etc. In anotherembodiment, y may be at least 10%, at least 20%, at least 30%, at least40%, at least 50%, at least 60%, at least 70%, at least 80%, at least90%, or any combination of less than the above disclosed y values or atleast equal to any of the above described y values.

In another embodiment, the oligosaccharides of the present invention mayinclude a run of consecutive acetylated residues in one portion, asecond run of consecutive non-acetylated residues in another portion,and/or singularly placed acetylated or non-acetylated residues elsewherethroughout.

The present invention essentially allows the synthesis ofoligosaccharides having a specific, fixed acetylated pattern. Moreparticularly, they may be characterized by structures in whichindividual acetylation positions and oligosaccharide length areengineered into a fixed, predetermined pattern. As such, theoligosaccharides of the present invention are distinguished from thoseproduced by existing methods that result at best in heterogeneouspopulations of mixed sequence oligo-β-(1→6)-glucosamines in which theindividual position(s) of acetylated residues is varied from oneoligosaccharide to another, and where the number or percent ofacetylated residues in the population is an average.

The following embodiments exemplify the oligosaccharides 1a of thepresent invention:

In oligosaccharides 37, 40, and 34, X and Y are as defined foroligosaccharide 1a. In particular, 37, 40, and 34 exemplify thiololigosaccharides which may be conjugated to any carrier (Y) according tothe present invention. By way of example, 37, 40, and 34 may beconjugated to form BSA conjugates such as 41, 43, and 45, respectively,or they may be conjugated to form KLH conjugates such as 42, 44, and 46,respectively.

Exemplary bacteria known or suspected to expressoligo-β-(1→6)-glucosamine PNAG- and/or dPNAG structures include, but arenot limited to Staphylococcus species, such as S. aureus and S.epidermidis; Escherichia coli; Yersinia species (spp.), such as Y.pestis, Y. pseudotuberculosis, and Y. entercolitica; Bordetella spp.,including B. pertussis, B. bronchiseptica, and B. parapertussis;Aggregatibacter actinomycetemcomitans, Actinobacillus pleuropneumoniae;Acinetobacter spp.; Burkholderia spp.; Stenatrophomonas maltophilia,Klebsiella spp., and Shigella spp. Accordingly, specific dPNAG/PNAGoligosaccharides may be modified, depending on the specificcompositional makeup, including acetylation profiles of these antigensin their respective bacterial species.

Suitable linkers comprise at one end a grouping able to enter into acovalent bonding with a reactive functional group of the carrier, e.g.an amino, thiol, or carboxyl group, and at the other end a groupinglikewise able to enter into a covalent bonding with a hydroxyl group ofan oligosaccharide according to the present invention. Between the twofunctional groups of the linker molecule there is a biocompatiblebridging molecule of suitable length, e.g. substituted or unsubstitutedheteroalkylene, arylalkylene, alkylene, alkenylene, or (oligo)alkyleneglycol groups. Linkers preferably comprise substituted or unsubstituted(C₁-C₁₀)alkylene or (C₂-C₁₀)alkenylene groups.

If present, linkers or their respective precursors are able to reactwith thiol groups on the carrier are, for example, maleimide andcarboxyl groups; preferred groupings able to react with aldehyde orcarboxyl groups are, for example, amino or thiol groups. Preferredcovalent attachments between linkers and carriers include thioethersfrom reaction of a thiol with an α-halo carbonyl or α-halo nitrile,including reactions of thiols with maleimide; hydrazides from reactionof a hydrazide or hydrazine with an activated carbonyl group (e.g.activated NHS-ester or acid halide); triazoles from reaction of an azidewith an alkyne (e.g. via “click chemistry”); and oximes from reaction ofa hydroxylamine and an aldehyde or ketone as disclosed, for example, inLees et al., Vaccine, 24:716, 2006. Although amine-based conjugationchemistries could be used in principle for coupling linkers and/orspacers to the oligosaccharides described herein, these approaches wouldtypically sacrifice uniformity inasmuch as the oligosaccharides of thepresent invention typically contain a plurality of amines bonded tosecond carbon of the respective monosaccharide units.

Further suitable linker molecules are known to skilled workers andcommercially available or can be designed as required and depending onthe functional groups present and can be prepared by known methods.

Suitable carriers are known in the art (See e.g., Remington'sPharmaceutical Sciences (18th ed., Mack Easton, Pa. (1990)) and mayinclude, for example, proteins, peptides, lipids, polymers, dendrimers,virosomes, virus-like particles (VLPs), or combinations thereof, whichby themselves may not display particular antigenic properties, but cansupport immunogenic reaction of a host to the oligosaccharides of thepresent invention (antigens) displayed at the surface of the carrier(s).

Preferably, the carrier is a protein carrier, including but are notlimited to, bacterial toxoids, toxins, exotoxins, and nontoxicderivatives thereof, such as tetanus toxoid, tetanus toxin Fragment C,diphtheria toxoid, CRM (a nontoxic diphtheria toxin mutant) such as CRM197, cholera toxoid, Staphylococcus aureus exotoxins or toxoids,Escherichia coli heat labile enterotoxin, Pseudomonas aeruginosaexotoxin A, including recombinantly produced, genetically detoxifiedvariants thereof; bacterial outer membrane proteins, such as Neisseriameningitidis serotype B outer membrane protein complex (OMPC), outermembrane class 3 porin (rPorB) and other porins; keyhole limpethemocyanine (KLH), hepatitis B virus core protein, thyroglobulin,albumins, such as bovine serum albumin (BSA), human serum albumin (HSA),and ovalbumin; pneumococcal surface protein A (PspA), pneumococcaladhesin protein (PsaA); purified protein derivative of tuberculin (PPD);transferrin binding proteins, polyamino acids, such aspoly(lysine:glutamic acid); peptidyl agonists of TLR-5 (e.g. flagellinof motile bacteria like Listeria); and derivatives and/or combinationsof the above carriers. Preferred carriers for use in humans includetetanus toxoid, CRM 197, and OMPC.

Depending on the type of bonding between the linker and the carrier, andthe structural nature of the carrier and oligosaccharide, a carrier maydisplay on average, for example, 1 to 500, 1 to 100, 1 to 20, or 3 to 9oligosaccharide units on its surface.

Methods for attaching an oligosaccharide to a carrier, such as a carrierprotein are conventional, and a skilled practitioner can createconjugates in accordance with the present invention using conventionalmethods. Guidance is also available in various disclosures, including,for example, U.S. Pat. Nos. 4,356,170; 4,619,828; 5,153,312; 5,422,427;and 5,445,817; and in various print and online Pierce proteincross-linking guides and catalogs (Thermo Fisher, Rockford, Ill.).

In one embodiment, the carbohydrate antigens of the present inventionare conjugated to CRM 197, a commercially available protein carrier usedin a number of FDA approved vaccines. CRM-conjugates have the advantageof being easier to synthesize, purify and characterize than other FDAapproved carriers such as OMPC. Carbohydrate antigens may be conjugatedto CRM via thiol-bromoacetyl conjugation chemistry. CRM activation maybe achieved by reacting the lysine side chains with the NHS ester ofbromoacetic acid using standard conditions as previously described inU.S. Pat. Appl. Publ. 2007-0134762, the disclosures of which areincorporated by reference herein. CRM may be functionalized with 10-20bromoacetyl groups per protein (n=10-20) prior to conjugation.Conjugation may be performed at pH=9 to avoid aggregation of CRM.Careful monitoring of pH must be employed to ensure complete CRMreaction with NHS-bromoacetate while minimizing background hydrolysis ofCRM. Activated CRM may be purified by size exclusion chromatographyprior to conjugation. Antigen-CRM conjugates may be synthesized byreacting thiol-terminated carbohydrate antigens withbromoacetamide-activated CRM.

CRM conjugates may be purified via size exclusion chromatography toremove and recover any unreacted carbohydrate. MBTH (specific for GlcNAcresidues) and Bradford assays may be used to determinecarbohydrate:protein ratio and protein content, respectively, aspreviously described (Manzi et al., Curr. Prot. Mol. Biol., section17.9.1 (Suppl. 32), 1995. In preferred embodiments, a minimumcarbohydrate content of about 15% by weight for each conjugate may begenerated. Typically, a conjugate may include about 3-20 antigens perprotein carrier.

In another embodiment, oligosaccharide antigens may be conjugated to oneor more carriers suitable for development of diagnostic assays,including ELISAs and microarrays. Exemplary carriers for use in suchassays include bovine serum albumin (BSA), keyhole limpet hemocyanine(KLH), biotin, a label, a glass slide or a gold surface. By way ofexample, synthetic oligosaccharide antigens may be conjugated to BSA bya thiol-maleimide coupling procedure (FIG. 5B). Maleimide-BSA contains15-20 maleimide groups per protein (n=15-20). Accordingly,oligosaccharide antigens may be conjugated to maleimide functionalizedBSA, whereby a 20-fold molar excess of the antigen is reacted withcommercially available Imject maleimide BSA (Pierce) in maleimideconjugation buffer (Pierce). Conjugation may be performed at pH=7.2 toavoid hydrolysis of the maleimide group during conjugation.

BSA conjugates may be purified via size exclusion chromatography toremove and recover any unreacted carbohydrate. Characterization via MBTHand Bradford assays may be performed along with MALDI-MS to provideinformation on the carbohydrate content and valency of the conjugates.In preferred embodiments, conjugates will contain a minimum carbohydratecontent of about 10% by weight per BSA conjugate and >8 antigen copiesper conjugate.

Methods for Synthesizing Oligo-β-(1-6)-Glucosamine Structures

In another aspect, the invention provides a method for assembling mixedsequence oligo-β-(1→6)-glucosamine structures 1.

The synthetic oligosaccharides 3 according to the present invention canbe synthesized by selective coupling of the donor building blocks 3awith acceptor building blocks 3b.

The structure of the donor building block 3a is shown below:

wherein the each PG¹ is independently selected from the group consistingof NPhth, NHTroc, NHTFA, NHTCA, NHCbz, and N₃;.

The oxygen protecting group(s) PG_(ox) may be independently selectedfrom the group consisting of acetyl (Ac), benzoate, trifluoro benzoate,4-chlorobenzoate, benzyl, and 4-halobenzyl

The protecting group PG² is independently selected from the groupconsisting of tertbutyl dimethylsilyl (TBS), triethylsilyl (TES),tert-butyldiphenylsilyl (TBDPS), monochloracetate, trifluoroacetate,levulinoyl, 4-O-acetyl, 2,2-dimethylbutanoate, trityl, dimethoxytrityl,9-fluoreneylmethoxycarbonyl (Fmoc), allyloxycarbonyl (AllOC) andnaphthyl. Tertbutyl dimethylsilyl (TBS) and tert-butyldiphenylsilyl(TBDPS) are preferred.

The activating group L is selected from the group consisting oftrichloroacetimidate (TCl), N-phenyl-trifluoroacetimidate, thioethyl,thiophenyl, thiotolyl, thioadamantyl, thioisopropyl, dibutyl phosphate,dibenzyl phosphate, and diphenylphosphate. Trichloroacetimidate (TCl)and N-phenyl-trifluoroacetimidate are preferred.

The donor building block has a defined number of monosaccharide units m.In one embodiment, m is equal or greater than 1. In another embodiment,the number of units m is between 1 and 17. In another embodiment, thenumber of units m is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,16, or 17. In another embodiment the number of monomeric units m ispreferably 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11.

The structure of the acceptor building block 3b is shown below:

wherein in the acceptor building block 3b, each PG¹ is independentlyselected from the group consisting of NPhth, NHTroc, NHTFA, NHTCA,NHCbz, and N₃.

The oxygen protective groups PG_(ox) are independently selected from thegroup consisting of acetate, benzoate, trifluorobenzoate,4-chlorobenzoate, benzyl, or 4-halobenzyl, 9-fluoreneylmethoxycarbonyl(Fmoc), and allyloxycarbonyl (AllOC)

The protective group PG³ is selected from the group consisting of(C₂-C₁₀)alkenyl, or (C₂-C₁₀)alkynyl. —CH₂CH═CH₂, —CH₂CCH (propargyl),and —CH₂CH₂CH₂CH═CH₂ (pent-4-enyl) are preferred.

The acceptor building block has a defined number of monosaccharide unitso. In one embodiment, m is equal or greater than 1. In anotherembodiment, the number of units o is between 1 and 17. In anotherembodiment, the number of units is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 13, 14, 15, 16, or 17. In another embodiment the number of monomericunits o is preferably 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11.

In one embodiment m+o≧4.

To allow for the introduction of two different R¹ and/or R² groups foroligosaccharides of the present invention 1a, at least two different PG¹groups, namely PG^(1a) and PG^(1b), are present in the coupledoligosaccharide 3:

In case the coupled oligosaccharide 3 does not provide for the finalnumber of monosaccharide units, the coupled oligomer can be convertedinto a corresponding acceptor block by removal of the PG² group, asshown below:

The methods for removal of the protecting group PG² are know to thoseskilled in the art. For example, if PG² is TBS, the TBS may be removedby treatment with a Lewis acid such as Sc(OTf)₃, and if PG² is Fmoc, theFmoc may be removed by treatment under basic conditions such as2,6-lutidine/triethylamine.

Alternatively, the coupled product can also be converted into a newdonor building block by removal of the protecting group PG³ andintroduction of the activating group L, as shown below:

The methods for removal of the protecting group PG³ are known to thoseskilled in the art. For example, if PG³ is allyl, the allyl group may beremoved by treatment with a catalyst such as Ir[COD(PMePh₂)]PF₆,

If the final number of monosaccharide units is not yet achieved in theproduct 3, the converted oligosaccharides 4a/b can be used as donor oracceptor building blocks for a further coupling reaction to build uplarger oligosaccharides of the present invention.

The coupled oligosaccharide 3 can be further reacted to theoligosaccharide 1a by removal of the respective protecting groupsPG^(1a/b), PG², pG^(ox) and/or PG³.

The protecting group PG² can be removed by methods known in the art,such as the procedure outlined in SOP1 for the removal of the preferredprotecting group TBS.

The coupled product 3 contains at least two different protecting groupsPG¹, PG^(1a) and PG^(1b), at least one of which is selectively removedand thus allows for a selective reaction of the deprotected group(s)while the other protecting groups may still be in place. In oneembodiment, in a first step, the protecting group PG^(1a) is removed. Ina preferred embodiment, the protecting group PG^(1a) is NHTroc. In oneembodiment the second protecting group PG^(1b) remains in place when thefirst protecting group PG^(1a) is selectively removed.

In one embodiment, the deprotected N-groups are converted into aN-acetyl group. In another embodiment, the N-acetylation is performed insitu. In another embodiment, the acetylation of the deprotected N-groupsis done in a separate reaction step.

The reaction conditions used for the selective removal of the protectivegroup PG^(1a) have to be carefully chosen such that any damage of thefurther protecting groups in the oligosaccharide is avoided. Inparticular, any removal or damage of the second N-protecting groupPG^(1b) has to be avoided in order to allow for a selective introductionof a substituent at the first unprotected nitrogen such as an acetylgroup.

In a preferred embodiment PG^(1a) is NHTroc and PG^(1b) is NPhth. Theselective removal of the Troc-protecting group is achieved by a reactionin the presence of Zinc. In a preferred embodiment the Zn is activated.Activation of the Zn can be done for example by treatment with HCl.

In case, the removal of the NHTroc group is done in situ with theN-acetylation, a mixture of Ac₂O:AcOH is present. Preferably the mixtureof Ac₂O:AcOH is present in a ratio (v:v) from 10:1 to 1:10, morepreferably from 5:1 to 1:5, and most preferably from 3:1 to 1:3.Typically, the reaction is performed in an ether solvent such as Et₂O,Dioxane, or THF, and preferably THF.

In one embodiment the presence of other metals than Zn is excluded inthis reaction.

The protecting group PG^(1b) is removed by methods known to the personskilled in the art. In a preferred embodiment, the protecting groupPG^(1b) is NPhth.

The protecting group PG_(ox) is removed by methods known to the personskilled in the art. In a preferred embodiment the protecting groupsPG_(ox) are selected from the group consisting of acetate and benzoateand more preferably is acetate.

In embodiments, wherein the linker X is a bond, removal of theprotecting group PG³ is sufficient. The carrier group Y may be bond tothe oligosaccharide directly.

The protecting group PG³ may optionally be converted into a linker groupor a precursor thereof. Alternatively, after removal of the protectinggroup PG³ by methods known to the person skilled in the art, a linkergroup may be introduced.

Suitable linker groups are substituted or unsubstituted heteroalkylene,arylalkylene, alkylene, alkenylene, or (oligo)alkylene glycol groups.Linker groups preferably comprise substituted or unsubstituted (C₁-C₁₀)alkylene moieties or an substituted or unsubstituted (C₂-C₁₀) alkenylenemoieties.

In one embodiment the PG³ group is —CH₂CH═CH₂. This group may beconverted into a linker-CH₂CH₂CH₂—S— by addition of thiol acetic acidunder suitable conditions and optionally subsequent removal of theacetate group. Suitable reaction conditions are known to the personskilled in the art such as for example described in SOP6 (Example 7).

In a further embodiment the linker group is —(CH₂)_(p)S—, where p is aninteger selected from the group consisting of 3, 4, 5, 6, 7, 8, 9, 10.

In one embodiment the removal of the protecting groups PG^(1b), PG_(ox)and optionally PG³ is done in subsequent steps, In another embodiment,the removal of the protecting groups PG^(1b), PG_(o) and optionally PG³is done is performed in a single step reaction. Suitable reactionconditions for the removal of the protective groups are known to theperson skilled in the art, such as exemplified in SOP7 (Example 8).

Suitable conditions for the removal of the protective groups are knownto the person skilled in the art (see for example T. W. Greene, P. G. M.Wuts “Protective Groups in Organic Synthesis”, Wiley & Sons, 3^(rd)edition, 1999 herein incorporated by reference in its entirety). InTable 10 below, standard reaction conditions are listed, which may beapplied to remove the respective protecting groups. However, it shouldbe noted that in the present invention, the one N-protecting groupPG^(1a) is selectively removed while at least one further N-protectinggroup PG^(1b) is still present in the oligosaccharide.

TABLE 10 Protecting groups and suitable removal conditions Abbre-viation Full name Removal conditions N-protecting groups (PG¹) - stableto conditions used to remove PG² N-Phth Phthaloyl Hydrazine, ethylenediamine NH-Troc 2,2,2-trichloro- Zn, THF, H₂O ethoxycarbonyl NH-TFATrifluoroacetyl Strong base NH-TCA Trichloroacetyl NH₃, EtOH, CHCl₃;Bu₃SnH, AlBN NH-Cbz Benzyloxycarbonyl H₂, Pd on Carbon N3 Azide H₂, Pdon Carbon O-protecting groups (PG_(ox) independently) - stable toconditions used to remove PG² Ac Acetyl Hydrazine; Mild Base; AcCl, MeOHBz Benzoyl Hydrazine; Mild Base Trifluorobenzoate Hydrazine; Mild Base4-chlorobenzoate Hydrazine; Mild Base Bn Benzyl H₂, Pd on Carbon4-halobenzyl H₂, Pd on Carbon; Pd, amine, Lewis acid relay O-protectinggroups (PG²) TBS tert- Sc(OTf)₃, CH₃CN, H₂O; butyldimethylsilyl TBAF,AcOH; HF TES Triethylsilyl TBAF, AcOH; HF TBDPS tert- TBAF, AcOH; HFbutyldiphenylsilyl MCA Monochloracetate NH₃, MeOH, THF TFATrifluoroacetate NH₃, MeOH, THF Lev Levulinoyl Hydrazine ADMB 4-O-acetyl2,2- DBU, MeOH dimethylbutanoate Tr Triphenylmethyl Mild Acid DMTDimethoxytrityl Mild Acid FMOC 9-fluorenylmethyl DBU; lutidine; Et₃N,carbonate Pyridine; Mild base Alloc Allyl oxycarbonyl Rh(PPh₃)₃Cl;PdCl₂(PPh₃)₂; Pd(PPh₃)₄ Nap Napthyl DDQ; Cerium ammonium nitrateActivating group (L) TCI or Trichloroacetimidate TMSOTf, TBSOTf,BF₃—OEt₂ TCA N-phenyl- TMSOTf, TBSOTf, trifluoroacetimidate BF₃—OEt₂,TfOH SEt Thioethyl NIS, TfOH SPh Thiophenyl NIS, TfOH STol ThiotolylNIS, TfOH SAdm Thioadamantyl NIS, TfOH S(iPr) Thioisopropyl NIS, TfOHdibutyl phosphate TMSOTf, TBSOTf, BF₃—OEt₂ dibenzyl phosphate TMSOTf,TBSOTf, BF₃—OEt₂ Diphenylphosphate TMSOTf, TBSOTf, BF₃—OEt₂ ProtectingGroup PG³ Allyl —OCH₂CH═CH₂ [Ir(COD)(PMePh₂)₂]PF₆, OsO₄; PdCl₂, acetatebuffer Propargyl —OCH₂CCH Co(CO)₈, H₂O Pentenyl —OCH₂CH₂CH₂CH═CH₂ NBS,TfOH; NBS, H₂O

The deprotected oligosaccharide may be further attached to a carriergroup. Suitable carrier groups are described above.

In a further aspect the present invention is directed to a method ofselectively converting an N-Troc group in an N-Troc protected aminosugarin the presence of at least a further protecting group into an N-acetylgroup, the method comprising reacting an N-Troc protected aminosugarwith a mixture of Ac₂O and AcOH in the presence of Zn.

In one embodiment, the aminosugar is selected from the group consistingof glucosamine, galactosamine, mannosamine, and fucosamine.

In one embodiment the Zn is activated. Activation of the Zn can be donefor example by treatment with HCl.

In one embodiment the removal of the N-Troc group is done in situ withthe N-acetylation. In this case, a mixture of Ac₂O:AcOH is present.Preferably the mixture of Ac₂O:AcOH is present in a ratio (v:v) from10:1 to 1:10, more preferably from 5:1 to 1:5, and most preferably from3:1 to 1:3.

Typically, the reaction is performed in an ether solvent such as Et₂O,Dioxane, or THF, and preferably THF.

In one embodiment the reaction is performed at ambient temperatures.

Building Blocks for Synthesizing Oligo-β-(1-6) Glucosamine Structures

Preferred Building blocks for the synthesis of the oligosaccharides ofthe present invention are described below including the fourmonosaccharide building blocks 6, 8, 14, and 47. The four buildingblocks include donor building blocks 8 and 14, and acceptor buildingblocks 6 and 47 below.

Building blocks 6 and 8 further contain an —NPhth group for selectiveamine group protection of individual monosaccharide units. Buildingblocks 14 and 47 contain a protective —NHTroc group for selectiveprotection and subsequent acetylation of individual monosaccharideunits.

Acceptor building blocks 6 and 47 have a linker precursor incorporatedat the reducing end, which may be reacted with thioacetic acid anddeblocked to form a conjugation-ready thiol for conjugation to a carrieras further described above. For example, when incorporated into anoligosaccharide of the present invention, the —O—CH₂—CH═CH₂ group at thereducing end may be converted into a linker comprising the sequence,—O—(CH₂)₃—SH as further described in FIGS. 5B, 6B, and 7.

The four monosaccharide building blocks 6, 8, 14, and 47 may besynthesized from a single monosaccharide 1 as shown in FIG. 3.

In a further aspect, the invention provides mixed disaccharide buildingblocks which can be used in combination with other monosaccharide- ordisaccharide building blocks to form higher-order dPNAG/PNAG structures.In FIG. 4A, monosaccharide donor 14 is reacted with monosaccharideacceptor 6 to form a mixed disaccharide building block 15 in which thefirst monosaccharide unit is protected for selective acetylation and theamine in the second monosaccharide unit is selectively protected. InFIG. 4B, monosaccharide donor 8 is reacted with monosaccharide acceptor47 to form a mixed disaccharide building block 49 in which the amine inthe first monosaccharide unit is selectively protected and the secondmonosaccharide unit position is protected for selective acetylation.

In FIG. 4A, disaccharide building block 15 can be converted into adisaccharide donor 17 or a disaccharide acceptor 48 for furthercouplings to other acceptors or donors, respectively. Likewise, in FIG.4B, disaccharide building block 49 can be converted into a disaccharidedonor 51 or a disaccharide acceptor 52 for further couplings to otheracceptors or donors, as well. For example, disaccharide donors 17 and 51can be coupled with either of the monosaccharide acceptors 6 and 47 toform trisaccharides, or they can be coupled with disaccharide acceptors48 and 52 to form tetrasaccharides.

In another aspect, the present invention provides disaccharide blocksfor forming consecutive acetylated residues or consecutivenon-acetylated resides. In FIG. 4C, monosaccharide donor 14 is reactedwith monosaccharide acceptor 47 to form a disaccharide building block 53in which each of the two monosaccharide units is protected for selectiveacetylation. In FIG. 4D, monosaccharide donor 8 is reacted withmonosaccharide acceptor 6 to from a disaccharide building block 18 inwhich each of the 2-position amines in the two monosaccharide units isprotected.

In FIG. 4C, disaccharide building block 53 can be converted into adisaccharide donor 55 or a disaccharide acceptor 56 for furthercouplings to other acceptors or donors, respectively. Likewise, in FIG.4D, disaccharide building block 18 can be converted into a disaccharidedonor 20 or a disaccharide acceptor 57 for further couplings to otheracceptors or donors, as well. For example, disaccharide donors 20 and 55can be coupled with either of the monosaccharide acceptors 6 and 47 toform trisaccharides or they can be coupled with any of theabove-described disaccharide acceptors 48, 52, 56, or 57 to formtetrasaccharides.

Any of the above-described donors can be coupled to any complementaryacceptor according to the method of the present invention. Accordingly,by coupling the monosaccharide-, disaccharide-, or other higher orderdonor modules of higher length with complementary monosaccharide-,disaccharide-, or other higher order acceptor modules of higher length,any mixed sequence oligosaccharide of the present invention can beformed in which the individual acetylation positions and oligosaccharidelength are engineered into a given synthesis process in a pre-determinedfashion.

Exemplary donor and acceptor building blocks for the synthesis of theoligosaccharides of the present invention are shown below:

Suitable Trisaccharide donor building blocks are

Suitable tetrasaccharide donor building blocks are

Suitable trisaccharide acceptor building blocks are:

Exemplary tetramer acceptor building blocks are:

Compositions and methods for synthesizing exemplary oligosaccharides aredescribed in the Examples below.

In FIGS. 3-10, syntheses of various oligosaccharides of the presentinvention proceed by a number of standard operating procedures (SOPs).In another aspect, the present invention provides a number of SOPs (orreaction steps) for synthesizing dPNAG/PNAG oligosaccharides, includingSOP 1, removal of 1° TBS group(s); SOP 2, removal of allyl group(s); SOP3, trichloroacetimidate formation; SOP 4, glycosylation usingtrichloroacetimidate donors; SOP 5, removal of N-Troc group and in situN-acetylation; SOP 6, thiol addition to olefin; and SOP 7, removal ofO-acetate, N-phthaloyl and S-acetate groups. SOPs 1-7 are furtherdetailed in the Examples below.

In some cases, the above-described protecting groups may be substitutedwith other protecting groups customarily considered in carbohydratechemistry, including those mentioned in “Protective Groups in OrganicSynthesis”, 3.sup.rd edition, T. W. Greene and P. G. M. Wuts (Ed.), JohnWiley and Sons, New York, 1999. By way of example, O-acetate groups maybe replaced with O-benzoate groups for producing the antigens.

Compositions

In another aspect, the present invention provides compositionscontaining dPNAG/PNAG oligosaccharides 1a and a pharmaceuticallyacceptable vehicle. The compositions are preferably immunogenic andimmunoprotective.

The present invention contemplates the use of single- and multi-valentvaccines comprising any of the synthetic oligosaccharides describedherein. The identification of a single oligosaccharide antigen elicitinga protective immune response can facilitate development of asingle-antigen vaccine candidate against one or more bacterial target(s)expressing dPNAG/PNAG. Thus, in one embodiment, the compositions maycontain a single oligosaccharide 1a.

The present invention further contemplates multi-antigen vaccinecandidates and vaccines thereof. In one embodiment, the inventionprovides a composition containing two, three, four or more differentoligosaccharides 1a.

In another embodiment, the invention provides a composition containingtwo, three, four or more different oligosaccharides, including at leastone oligosaccharide 1a and at least one oligosaccharide 1c:

where R¹ is always H or always COCH₃; n is at least 3, X is a bond or alinker, and Y is H or a carrier (i.e., oligosaccharides 1c are fullyacetylated or fully non-acetylated). When two or more oligosaccharidesare used in a composition, the oligosaccharides are preferably formedseparately and combined (either prior to conjugation to the carrier orafter conjugation), so that the ratio of each can be controlled.

Suitable vehicles and their formulation, inclusive of other humanproteins, e.g., human serum albumin, are described, for example, inRemington's Pharmaceutical Sciences (18th ed., Mack Easton Pa. (1990)).Pharmaceutically acceptable vehicles may include any vehicle that doesnot itself induce the production of antibodies harmful to the individualreceiving the composition. Suitable vehicles may include large, slowlymetabolized macromolecules such as proteins, polysaccharides, polylacticacids, polyglycolic acids, polymeric amino acids, amino acid copolymers;inactive virus particles, insoluble aluminum compounds, calciumphosphate, liposomes, virosomes, ISCOMS, microparticles, emulsions, andVLPs.

The compositions of the present invention may further include one ormore adjuvants. An oligosaccharide-protein conjugate composition mayfurther include one or more immunogenic adjuvant(s). An immunogenicadjuvant is a compound that, when combined with an antigen, increasesthe immune response to the antigen as compared to the response inducedby the antigen alone so that less antigen can be used to achieve asimilar response. For example, an adjuvant may augment humoral immuneresponses, cell-mediated immune responses, or both.

Those of skill in the art will appreciate that the terms “adjuvant,” and“carrier,” can overlap to a significant extent. For example, a substancewhich acts as an “adjuvant” may also be a “carrier,” and certain othersubstances normally thought of as “carriers,” for example, may alsofunction as an “adjuvant.” Accordingly, a substance which may increasethe immunogenicity of the synthetic oligosaccharide or carrierassociated therewith is a potential adjuvant. As used herein, a carrieris generally used in the context of a more directed site-specificconjugation to an oligosaccharide of the present invention, whereby anadjuvant is generally used in a less specific or more generalizedstructural association therewith.

Exemplary adjuvants and/or adjuvant combinations may be selected fromthe group consisting of mineral salts, including aluminum salts, such asaluminum phosphate and aluminum hydroxide (alum) (e.g., Alhydrogel™,Superfos, Denmark) and calcium phosphate; RIBI, which contains threecomponents extracted from bacteria, monophosphoryl lipid A, trehalosedimycolate, and cell wall skeleton (MPL+TDM+CWS) in a 2% squalene/Tween80 emulsion, whereby any of the 3 components MPL, TDM or CWS may also beused alone or combined 2 by 2; toll-like receptor (TLR) agonists,including, for example, agonists of TLR-1 (e.g. tri-acyl lipopeptides);agonists of TLR-2 [e.g. peptidoglycan of gram-positive bacteria likestreptococci and staphylococci; lipoteichoic acid]; agonists of TLR-3(e.g. double-stranded RNA and their analogs such as poly 1:C); agonistsof TLR-4 (e.g. lipopolysaccharide (endotoxin) of gram-negative bacterialike Salmonella and E. coli); agonists of TLR-5 (e.g. flagellin ofmotile bacteria like Listeria); agonists of TLR-6 (e.g. with TLR-2peptidoglycan and certain lipids (diacyl lipopeptides)); agonists ofTLR-7 (e.g. single-stranded RNA (ssRNA) genomes of such viruses asinfluenza, measles, and mumps; and small synthetic guanosine-baseantiviral molecules like loxoribine and ssRNA and their analogs);agonists of TLR-8 (e.g. binds ssRNA); agonists of TLR-9 (e.g.unmethylated CpG of the DNA of the pathogen and their analogs; agonistsof TLR-10 (function not defined) and TLR-11- (e.g. binds proteinsexpressed by several infectious protozoans (Apicomplexa), specifictoll-like receptor agonists include monophosphoryl lipid A (MPL®), 3De-β-acylated monophosphoryl lipid A (3 D-MPL), OM-174 (E. coli lipid Aderivative); OM triacyl lipid A derivative, and other MPL®- or lipidA-based formulations and combinations thereof, including MPL®-SE, RC-529(Dynavax Technologies), AS01 (liposomes+MPL+QS21), AS02 (oil-in-waterPL+QS-21), and AS04 (Alum+MPL) (GlaxoSmith Kline, Pa.),CpG-oligodeoxynucleotides (ODNs) containing immunostimulatory CpGmotifs, double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C),and other oligonucleotides or polynucleotides optionally encapsulated inliposomes; oil-in-water emulsions, including AS03 (GlaxoSmith Kline,Pa.), MF-59 (microfluidized detergent stabilized squalene oil-in-wateremulsion; Novartis), and Montanide ISA-51 VG (stabilized water-in-oilemulsion) and Montanide ISA-720 (stabilized water/squalene; SeppicPharmaceuticals, Fairfield, N.J.); cholera toxin B subunit; saponins,such as Quil A or QS21, an HPLC purified non-toxic fraction derived fromthe bark of Quillaja Saponaria Molina (STIMULON™ (Antigenics, Inc.,Lexington, Mass.) and saponin-based adjuvants, includingimmunostimulating complexes (ISCOMs; structured complex of saponins andlipids) and other ISCOM-based adjuvants, such as ISCOMATRIX™ andAbISCO®-100 and -300 series adjuvants (Isconova AB, Uppsala, Sweden);QS21 and 3 D-MPL together with an oil in water emulsion as disclosed inU.S. Pat. Appl. No. 2006/0073171; stearyl tyrosine (ST) and amideanalogs thereof; virus-like particles (VLPs) and reconstituted influenzavirosomes (IRIVs); complete Freund's adjuvant (CFA); incomplete Freund'sadjuvant (IFA); E. coli heat-labile enterotoxin (LT); immune-adjuvants,including cytokines, such as IL-2, IL-12, GM-CSF, Flt3, accessorymolecules, such as B7.1, and mast cell (MC) activators, such as mastcell activator compound 48/80 (C48/80); water-insoluble inorganic salts;liposomes, including those made from DNPC/Chol and DC Chol; micelles;squalene; squalane; muramyl dipeptides, such asN-acetyl-muramyl-L-threonyl-D-isoglutamine (thr-MDP) as found in U.S.Pat. No. 4,606,918, N-acetyl-normuramyl-L-alanyl-D-isoglutamine(nor-MDP), andN-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(1′2′-dipalmitoyl-n-glycero-3-hydroxyphosphoryl;SAF-1 (Syntex); AS05 (GlaxoSmith Kline, Pa.); and combinations thereof.

In preferred embodiments, adjuvant potency may be enhanced by combiningmultiple adjuvants as described above, including combining variousdelivery systems with immunopotentiating substances to formmulti-component adjuvants with the potential to act synergistically toenhance antigen-specific immune responses in vivo. Exemplaryimmunopotentiating substances include the above-described adjuvants,including, for example, MPL and synthetic derivatives, MDP andderivatives, oligonucleotides (CpG etc), ds RNAs, alternativepathogen-associated molecular patterns (PAMPs) (E. coli heat labileenterotoxin; flagellin, saponins (QS-21 etc), small molecule immunepotentiators (SMIPs, e.g., resiquimod [R848]), cytokines, andchemokines.

Methods of Treating or Preventing Staphyloccus Infections

Oligosaccharide Compositions

In one embodiment, the present invention provides pharmaceuticallyacceptable immunogenic or immunoprotective oligosaccharide compositionsand their use in methods for preventing Staphylococcus infection in apatient in need thereof. In one embodiment, comprising administering aneffective amount of an oligosaccharide of the present invention. Animmunogenic or immunoprotective composition will include a “sufficientamount” or “an immunologically effective amount” of a dPNAG/PNAG-proteinconjugate according to the present invention, as well as any of theabove mentioned components, for purposes of generating an immuneresponse or providing protective immunity, as further defined herein.

Administration of the oligosaccharide- or oligosaccharide conjugatecompositions or antibodies, as described herein may be carried out byany suitable means, including by parenteral administration (e.g.,intravenously, subcutaneously, intradermally, or intramuscularly); bytopical administration, of for example, antibodies to an airway surface;by oral administration; by in ovo injection in birds, for example, andthe like. Preferably, they are administered intramuscularly.

Typically, the compositions may be prepared as injectables, either asliquid solutions or suspensions; solid forms suitable for solution in,or suspension in, liquid vehicles prior to injection. An aqueouscomposition for parenteral administration, for example, may include asolution of the immunogenic component(s) dissolved or suspended in apharmaceutically acceptable vehicle or diluent, preferably a primarilyaqueous vehicle. An aqueous composition may be formulated as a sterile,pyrogen-free buffered saline or phosphate-containing solution, which mayinclude a preservative or may be preservative free. Suitablepreservatives include benzyl alcohol, parabens, thimerosal,chlorobutanol, and benzalkonium chloride, for example. Aqueous solutionsare preferably approximately isotonic, and its tonicity may be adjustedwith agents such as sodium tartrate, sodium chloride, propylene glycol,and sodium phosphate. Additionally, auxiliary substances required toapproximate physiological conditions, including pH adjusting andbuffering agents, tonicity adjusting agents, wetting or emulsifyingagents, pH buffering substances, and the like, including sodium acetate,sodium lactate, sodium chloride, potassium chloride, calcium chloride,sorbitan monolaurate, triethanolamine oleate, etc. may be included withthe vehicles described herein.

Compositions may be formulated in a solid or liquid form for oraldelivery. For solid compositions, nontoxic and/or pharmaceuticallyacceptable solid vehicles may include, for example, pharmaceuticalgrades of mannitol, lactose, starch, magnesium stearate, sodiumsaccharin, talcum, cellulose, glucose, sucrose, magnesium carbonate, andthe like. For oral administration, a pharmaceutically acceptablenontoxic composition may be formed by incorporating any of the normallyemployed excipients, including those vehicles previously listed, and aunit dosage of an active ingredient, that is, one or more compounds ofthe invention, whether conjugated to a carrier or not. Topicalapplication of antibodies to an airway surface can be carried out byintranasal administration (e.g., by use of dropper, swab, or inhalerwhich deposits a pharmaceutical formulation intranasally). Topicalapplication of the antibodies to an airway surface can also be carriedout by inhalation administration, such as by creating respirableparticles of a pharmaceutical formulation (including both solidparticles and liquid particles) containing the antibodies as an aerosolsuspension, and then causing the subject to inhale the respirableparticles. Methods and apparatuses for administering respirableparticles of pharmaceutical formulations are well known, and anyconventional technique can be employed. Oral administration may be inthe form of an ingestible liquid or solid formulation.

The preparation of such pharmaceutical compositions is within theordinary skill in the art, and may be guided by standard reference bookssuch as Remington the Science and Practice of Pharmacy, LippincottWilliams & Wilkins; 21 ed., May 1, 2005, which is incorporated herein byreference.

The concentration of the oligosaccharides of the invention in thepharmaceutical formulations can vary widely, i.e., from less than about0.1%, usually at or at least about 0.1% to as much as 20% to 50% or moreby weight, and may be selected on the basis of fluid volumes,viscosities, stability, etc., and/or in accordance with the particularmode of administration selected. A human unit dose form of the compoundsand composition is typically included in a pharmaceutical compositionthat comprises a human unit dose of an acceptable vehicle, preferably anaqueous vehicle, and is administered in a volume of fluid that is knownby those of skill in the art to be used for administration of suchcompositions to humans, and is adjusted according to commonly understoodprinciples for a particular subject to be treated. Thus in oneembodiment, the invention provides a unit dosage of the vaccinecomponents of the invention in a suitable amount of an aqueous solution,such as 0.1-3 ml, preferably 0.2-2 mL.

The compositions of the present invention may be administered to anyanimal species at risk for developing an infection by a microbialspecies expressing a PNAG and/or PNAG antigen.

The present invention can also be used to treat or prevent otherbacteria infections where the bacterium is known or suspected to expressPNAG or dPNAG. Suitable bacteria that can be treated with the presentinvention include Staphylococcus species, such as S. aureus and S.epidermidis; Escherichia coli; Yersinia species (spp.), such as Y.pestis, Y. pseudotuberculosis, and Y. entercolitica; Bordetella spp.,including B. pertussis, B. bronchiseptica, and B. parapertussis;Aggregatibacter actinomycetemcomitans, Actinobacillus pleuropneumoniae;Acinetobacter spp.; Burkholderia spp.; Stenatrophomonas maltophilia,Klebsiella spp., and Shigella spp. Accordingly, specific dPNAG/PNAGoligosaccharides may be modified, depending on the specificcompositional makeup, including acetylation profiles of these antigensin their respective bacterial species.

The treatment may be given in a single dose schedule, or preferably amultiple dose schedule in which a primary course of treatment may bewith 1-10 separate doses, followed by other doses given at subsequenttime intervals required to maintain and or reinforce the response, forexample, at 1-4 months for a second dose, and if needed, a subsequentdose(s) after several months. Examples of suitable treatment schedulesinclude: (i) 0, 1 month and 6 months, (ii) 0, 7 days and 1 month, (iii)0 and 1 month, (iv) 0 and 6 months, or other schedules sufficient toelicit the desired responses expected to reduce disease symptoms, orreduce severity of disease.

The amounts effective for inducing an immune response or providingprotective immunity will depend on a variety of factors, including theoligosaccharide composition, conjugation to a carrier, inclusion andnature of adjuvant(s), the manner of administration, the weight andgeneral state of health of the patient, and the judgment of theprescribing physician. By way of example, the amounts may generallyrange for the initial immunization (that is for a prophylacticadministration) from about 1.0 μg to about 5,000 μg of oligosaccharidefor a 70 kg patient, (e.g., 1.0 μg, 2.0 μg, 2.5 μg, 3.0 μg, 3.5 μg, 4.0μg, 4.5 μg, 5.0 μg, 7.5 μg, 10 μg, 12.5 μg, 15 μg, 17.5 μg, 20 μg, 25μg, 30 μg, 35 μg, 40 μg, 45 μg, 50 μg, 75 μg, 100 μg, 250 μg, 500 μg,750 μg, 1,000 μg, 1,500 μg, 2,000 μg, 2,500 μg, 3,000 μg, 3,500 μg,4,000 μg, 4,500 μg or 5,000 μg). The actual dose administered to asubject is often, but not necessarily, determined according to anappropriate amount per kg of the subject's body weight. For example, aneffective amount may be about 0.1 μg to 5 μg/kg body weight.

A primary dose may optionally be followed by boosting dosages of fromabout 1.0 to about 1,000 of peptide (e.g., 1.0 μg, 2.0 μg, 2.5 μg, 3.0μg, 3.5 μg, 4.0 μg, 4.5 μg, 5.0 μg, 7.5 μg, 10 μg, 12.5 μg, 15 μg, 17.5μg, 20 μg, 25 μg, 30 μg, 35 μg, 40 μg, 45 μg, 50 μg, 75 μg, 100 μg, 250μg, 500 μg, 750 μg, 1,000 μg, 1,500 μg, 2,000 μg, 2,500 μg, 3,000 μg,3,500 μg, 4,000 μg, 4,500 μg or 5,000 μg) pursuant to a boosting regimenover weeks to months depending upon the patient's response and conditionby measuring specific T cell activity in the patient's blood.

The immunogenic compositions comprising a compound of the invention maybe suitable for use in adult humans or in children, including youngchildren or others at risk for contracting an infection caused by adPNAG/PNAG-expressing bacterial species. Optionally such a compositionmay be administered in combination with other pharmaceutically activesubstances, and frequently it will be administered in combination withother vaccines as part of a childhood vaccination program.

Antibody Compositions

In another embodiment, the invention provides an antibody preparationagainst one or more oligo-β-(1→6)-glucosamine 1a in accordance with thepresent invention. The antibody preparation may include any member fromthe group consisting of polyclonal antibody, monoclonal antibody, mousemonoclonal IgG antibody, humanized antibody, chimeric antibody, fragmentthereof, or combination thereof.

Pharmaceutical antibody compositions may be used in a method forproviding passive immunity against a bacterial target species ofinterest, including S. aureus and other dPNAG/PNAG-expressing bacteria.A pharmaceutical antibody composition may be administered to an animalsubject, preferably a human, in an amount sufficient to prevent orattenuate the severity, extent of duration of the infection by thebacterial target species of interest.

The administration of the antibody may be either prophylactic (prior toanticipated exposure to a bacterial infection) or therapeutic (after theinitiation of the infection, at or shortly after the onset of thesymptoms). The dosage of the antibodies will vary depending upon factorsas the subject's age, weight and species. In general, the dosage of theantibody may be in a range from about 1-10 mg/kg body weight. In apreferred embodiment, the antibody is a humanized antibody of the IgG orthe IgA class. The route of administration of the antibody may be oralor systemic, for example, subcutaneous, intramuscular or intravenous.

Antibodies in Diagnostic Assays

In a further aspect, the present invention provides compositions andmethods for inducing production of antibodies for diagnosing, treating,and/or preventing one or more infections caused by dPNAG/PNAG expressingbacteria.

Antisera to dPNAG/PNAG conjugates may be generated in New Zealand whiterabbits by 3-4 subcutaneous injections over 13 weeks. A pre-immune bleedmay generate about 5 mL of baseline serum from each rabbit. A primeinjection (10 μg antigen equivalent) may be administered as an emulsionin complete Freund's adjuvant (CFA). Subsequent injections (5 μg antigenequivalent) may be given at three week intervals in incomplete Freund'sadjuvant (IFA). Rabbits may be bled every two weeks commencing one weekafter the third immunization. Approximately 25-30 mL of serum per rabbitmay be generated from each bleeding event and frozen at −80° C. Serummay be analyzed by ELISA against the corresponding dPNAG/PNAG conjugateas described below. In addition, antisera from later bleeds may beaffinity purified as further described below.

The oligosaccharides and antibodies generated therefrom can be used asdiagnostic reagents for detecting dPNAG-PNAG structures or antibodiesthereagainst, which are present in biological samples. The detectionreagents may be used in a variety of immunodiagnostic techniques, knownto those of skill in the art, including ELISA- and microarray-relatedtechnologies. In addition, these reagents may be used to evaluateantibody responses, including serum antibody levels, to immunogenicoligosaccharide conjugates. The assay methodologies of the inventiontypically involve the use of labels such as fluorescent,chemiluminescent, radioactive, enzymatic labels or dye molecules, and/orsecondary immunologic reagents for direct or indirect detection of acomplex between an antigen or antibody in a biological sample and acorresponding antibody or antigen bound to a solid support.

Such assays typically involve separation of unbound antibody in a liquidphase from a solid phase support to which antibody-antigen complexes arebound. Solid supports which can be used in the practice of the inventioninclude substrates such as nitrocellulose (e.g., in membrane ormicrotiter well form); polyvinylchloride (e.g., sheets or microtiterwells); polystyrene latex (e.g., beads or microtiter plates);polyvinylidine fluoride; diazotized paper; nylon membranes; activatedbeads, magnetically responsive beads, and the like.

Typically, a solid support is first reacted with a first bindingcomponent (e.g., an anti-dPNAG-PNAG antibody or dPNAG-PNAGoligosaccharide) under suitable binding conditions such that the firstbinding component is sufficiently immobilized to the support. In somecases, mobilization to the support can be enhanced by first coupling theantibody or oligosaccharide to a protein with better binding properties,or that provides for immobilization of the antibody or antigen on thesupport without significant loss of antibody binding activity orspecificity. Suitable coupling proteins include, but are not limited to,macromolecules such as serum albumins including bovine serum albumin(BSA), keyhole limpet hemocyanin (KLH), immunoglobulin molecules,thyroglobulin, ovalbumin, and other proteins well known to those skilledin the art. Other molecules that can be used to bind antibodies thesupport include polysaccharides, polylactic acids, polyglycolic acids,polymeric amino acids, amino acid copolymers, and the like. Suchmolecules and methods of coupling these molecules are well known tothose of ordinary skill in the art and are described in, for example,U.S. Pat. No. 7,595,307, U.S. Pat. Appl. No. US 2009/0155299, thedisclosures and cited references therein of which are incorporated byreference herein.

The following examples are included for purposes of illustration and arenot intended to limit the scope of the invention.

EXAMPLES Example 1 Generation of dPNAG/PNAG Test Libraries

The above-described monosaccharide- and disaccharide building blockswere used in higher antigen assembly to initially provide a route forforming three large, defined poly-glucosamine structures. Thus, aninitial library was generated from three basic hexamer units or “analogcores” (FIG. 2B) corresponding to: (1) a fully acetylated N-acetyl PNAG(ANC-PNAG; exemplified by thiol oligosaccharide 58), (2) a partiallyacetylated (16.7%) PNAG (ANC-dPNAG exemplified by thiol oligosaccharide37) and (3) a fully non-acetylated PNAG (ANC-PNG; exemplified by thiololigosaccharide 61).

Molecules generated with the first analog core in the initial PNAGlibrary represented by 58, 59, 60 can serve as a control group and tomimic functionally the major secreted component of staphylococcalbiofilm.

The second analog core containing a partially acetylated PNAG moleculeexemplified by oligosaccharides 37, 40, 34, and conjugates thereof (seeFIG. 2B) represents one possible product of chemical or ica B-mediateddeacetylation (16.7% N-acetyl), which was shown by thesemi-synthetically prepared version to confer opsonic andimmunoprotective capability. The synthetic antigens herein arestructurally defined molecules wherein the N-acetyl groups are regularlyspaced every 6 glucosamine units. A significant portion of the multiplefree amine groups in these antigens are likely to be protonated atphysiologic pH and will have a major impact on the physical properties,such as tertiary structure and solubility.

The third analog core exemplifying a fully deacetylated PNAG molecule asrepresented by 61, 62, 63 in FIG. 2B. The third analog core presents athree-dimensional structure or tertiary structure distinguished fromnaturally derived deacetylated PNG structures and is similar tosynthetic PNAGs recently described (Gening et al., Infect. Immun.,78:764, 2010, epub Nov. 30, 2009).

Key building blocks were divided into two batches; in each case, one wasconverted into an acceptor, the other into a donor. Coupling of thedonor and acceptor units provided a key monosaccharide or disaccharideunits for use in higher antigen assembly so as to provide an efficientroute to large, defined poly-glucosamine structures. To produce themixed-N-acetyl sequences (Ag 3, 6, and 9), an N-Troc protective groupwas employed to facilitate selective replacement with an N-acetyl. Thischemistry was highly selective and produced a set of three mixedN-acetyl sequences (6, 12, and 18-mer) with one, two and three N-acetylgroups respectively. This corresponds to 16.7% incorporation ofN-acetyl, similar to the average degree of N-acetylation found in themost active naturally-derived heterogeneous materials (Maira-Litran etal., Infect. Immun., 73:6752, 2005).

Each protected antigen was reacted with thioacetic acid to install athioacetate at the reducing end as a conjugation site (See Scheme 2 ofBuskas et al., J. Org. Chem., 65:958, 2000). Removal of the protectinggroups provided two sets of compounds, the 100% poly-NH₂ sequences (by61, 62, 63) and the 16.7% N-acetyl substituted structures (thiololigosaccharides 37, 40, 34). Reaction of a portion of the 100% poly-NH₂sequences with acetic anhydride under aqueous conditions provided the100% poly-N-acetyl sequences (58, 59, 60). All synthetic antigens werepurified via size exclusion chromatography (BioGel P2 or P4) and fullycharacterized by ¹H-NMR, ¹³C-NMR and mass spectroscopy.

The PNAG-based library set contains 9 structures comprised of moleculesvarying by the 3 core unit analogs used and by 3 different moleculelengths (FIG. 2B). Complete analytical characterization (NMR, MS, HPLC,elemental analysis) demonstrated that each molecule was over 98% purecompound.

Example 2 Standard Operating Procedure (SOP) 1: Removal of 1° TBS Group

To a solution of the starting tert-butyldimethylsilyl (TBS) containingmaterial (35 mmol) in CH₃CN (500 mL) were added H₂O (50 mL) over 10minutes. Scandium trifluoromethanesulfonate trihydrate (Sc(OTf)₃, 400mg, 0.8 mmol) were added and the reaction mixture was stirred at roomtemperature for 24 hours. The reaction mixture was then diluted withEtOAc (500 mL) and washed with saturated aqueous NaHCO₃ and brine. Theorganic solution was dried over Na₂SO₄, filtered and concentrated.Purification via silica gel chromatography (EtOAc/Heptanes; 50-100%EtOAc gradient) afforded the desired deprotected product. Typicalisolated yields for the product formation varied between 60-92%.

Example 3 SOP 2: Removal of Allyl Group

A solution of 1,5-cyclooctadienebis(methyldiphenylphosphine)iridium(I)hexafluorophosphate (Ir cat.; 0.3 mmol) in THF (50 mL) was purged withhydrogen bubbling until a clear yellow solution remained (˜15 minutes).The activated Ir catalyst solution was then purged with nitrogenbubbling for 15 minutes. A solution of the allyl glycoside (10 mmol) inTHF (20 mL) was added in one portion to the Ir catalyst solution and theresulting reaction mixture was stirred for 30 minutes. The inertatmosphere was removed and a solution of N-methylmorpholine N-oxide(NMO, 50% aqueous, 20 mL) was added followed by osmium tetroxide (0.03mmol). The resulting biphasic reaction mixture was stirred in the darkfor 2 h, then quenched with 20 mL 1M aqueous Na₂S₂O₄. After vigorousstirring for 1 h, the organic phase was partitioned, diluted with EtOAc(400 mL) and washed with 1M HCl (aq.), H₂O and brine. The organics weredried over Na₂SO₄, filtered and concentrated. Purification via silicagel chromatography (EtOAc/Heptanes; 50-100% EtOAc gradient) afforded thedesired hydroxyl product. Typical isolated yields for the productformation varied between 80-95%.

Example 4 SOP 3: Tricholoracetimidate Formation

Formation with DBU.

A solution of the starting sugar (4 mmol) in CH₂Cl₂ (20 mL) was treatedwith trichloroacetonitrile (5 mL). To the reaction mixture were added1,8-diazabicyclo[5.4.0]undec-7-ene (DBU, 0.1 mL, 0.6 mmol) dropwise. Thereaction mixture was stirred at room temperature for 1 h, thenconcentrated to a viscous oil. Purification via filtration through asilica gel plug pre-treated with EtOAc containing 0.1% TEA afforded thedesired trichloroacetimidate product. Typical isolated yields for theproduct formation varied between 80-95%.

Formation with K₂CO₃.

A solution of the starting sugar (4 mmol) in CH₂Cl₂ (20 mL) was treatedwith trichloroacetonitrile (5 mL). K₂CO₃ (5 g) was added to the reactionmixture and the heterogeneous solution was stirred for 12 h. Thereaction mixture was filtered through celite, rinsed with CH₂Cl₂ andconcentrated in vacuo. Purification via filtration through a silica gelplug pre-treated with EtOAc containing 0.1% TEA afforded the desiredtrichloroacetimidate product. Typical isolated yields for the productformation varied between 80-95%.

Example 5 SOP 4: Glycoslyation Using Trichloroacetimidate Donors

Glycosyl trichloroacetimidate (12.0 mmol) and glycosyl acceptor (10.0mmol) were combined, co-evaporated with toluene (3×20 mL) and dried invacuo for 1 h. The resulting mixture was dissolved in dry CH₂Cl₂ (50 mL)under nitrogen and the reaction mixture was cooled to −20° C. A solutionof trimethylsilyl trifluoromethanesulfonate (TMSOTf, 0.10 M in CH₂Cl₂,0.12 mL, 1.2 mmol) was added dropwise over 10 minutes and the reactionstirred for an additional 30 minutes. The reaction mixture was dilutedwith CH₂Cl₂ (50 mL) and washed with saturated aqueous NaHCO₃ and brine.The organic solution was dried over Na₂SO₄, filtered and concentrated.Purification via silica gel chromatography (EtOAc/Heptanes; 50-100%EtOAc gradient) afforded the desired coupling product. Typical isolatedyields for the product formation varied between 60-97%.

Example 6 SOP 5: Removal of N-Troc Group and In Situ N-Acetylation

Starting N-Troc oligosaccharide (0.22 mmol) was dissolved inTHF:Ac₂O:AcOH (8:3:1, v:v:v; 20 mL). The reaction mixture was treatedwith activated Zn (15 mmol) and stirred at room temperature for 1 h. Thereaction mixture was diluted with EtOAc, filtered through celite andwashed with saturated aqueous NaHCO₃ and brine. Purification via silicagel chromatography (EtOAc/Heptanes; 100% EtOAc gradient) afforded thedesired N-Acetate product. Typical isolated yields for the productformation varied between 60-90%.

Zinc activation: Zinc (50 g, powdered) was washed with 200 mL each: 2MHCl (aqueous), H₂O, EtOH and THF. The solids were dried in vacuoovernight to a constant weight.

Example 7 SOP 6: Thiol Addition to Olefin

Starting allyl glycoside (0.22 mmol) was dissolved in 1,4-dioxane (5mL). The solution was degassed with nitrogen. Thiol acetic acid (2.2mmol) and 2,2′-azobis(isobutyronitrile) (0.088 mmol) were added and thereaction mixture was degassed a second time. The reaction was heated to75° C. for 3 h, then cooled to room temperature and quenched withcyclohexene (0.2 mL). After concentration, the crude reaction mixturewas purified via silica gel chromatography (EtOAc/Heptanes; 50-100%EtOAc gradient) to provide the thiolated reaction product. Typicalisolated yields for the product formation varied between 70-95%.

Example 8 SOP7: Removal of O-Acetate, N-Phthaloyl, and S-Acetate Groups

Starting protected oligosaccharide (0.06 mmol) was dissolved in MeOH (10mL). Hydrazine hydrate (1 mL) was added and the reaction mixture washeated to 65° C. for 3 h. White precipitates formed upon heating. After3 h at 65° C., H₂O (5 mL) was added and the reaction mixture was stirredat 65° C. for an additional 12 h. The reaction mixture was concentratedin vacuo and co-evaporated with H₂O (3×5 mL). Purification via sizeexclusion chromatography (Biogel P-2 Media, 1″×24″ column, gravitypressure, H₂O eluent) afforded the desired fully deprotectedoligosaccharides as a mixture of thiol-disulfide products. Typicalisolated yields for the product formation varied between 60-85%.

Example 9 Synthesis of Monosaccharide Building Blocks

FIG. 3 outlines the reaction scheme for synthesizing the monosaccharidebuilding blocks, which proceeds according to the following steps.

Synthesis of Building Blocks 6 and 8 for Selective Amine GroupProtection of Individual Monosaccharide Units

Glucosamine 1 (90 g, 0.23 mol), (prepared as described in Tetrahedron1997, 53, 12, 4159) was dissolved in pyridine (405 mL) and triethylamine(36.5 mL). The solution was stirred for 15 minutes followed by theaddition of phthalic anhydride (22 g, 0.15 mmol). The reaction mixturewas maintained at room temperature in a water bath for 30 minutes.Triethylamine (40.5 mL) and phthalic anhydride (22 g, 0.15 mmol) wereadded and stirred at room temperature for an additional 45 minutes. Thereaction mixture was heated to 90° C. and acetic anhydride (121.5 mL)was added. The reaction mixture was maintained at 90-95° C. for 10minutes followed by concentration in vacuo to a thick, yellow syrup. Thecrude product was dissolved in CH₂Cl₂ (1.0 L) and washed with H₂O (3×500mL). The organic solution was dried over Na₂SO₄, filtered andconcentrated to a syrup. The product was recovered via recrystallizationfrom ethanol (300 mL, 190 proof, 0.1% MeOH). Recovered 103 g product 2,93% yield. To a solution of 2 (103 g, 0.21 mol) in CH₂Cl₂ (700 mL) wereadded allyl alcohol (62 mL). The reaction mixture was purged with N₂ andcooled to 0° C. SnCl₄ (62 mL) was added dropwise over 1 h. The reactionmixture was kept at 0° C. for 6 h then warmed to room temperature andstirred for 48 h. The solution was poured into ice water (1 L),separated and the organics were washed with 3×500 mL H₂O, dried overNa₂SO₄, filtered and concentrated to a syrup. Recovered 3 (100 g) as ayellow oil. A solution of 3 (1.0 g, 2.1 mmol) was dissolved in MeOH (10mL) and cooled to 0° C. Acetyl chloride (0.75 mL) was added dropwiseover 5 minutes. The solution was allowed to warm to room temperatureover 2 h and stirred for an additional 48 h. The reaction mixture wasconcentrated in vacuo to afford 4 (0.7 g) as a white solid. Startingmonomer 4 (49.2 g, 0.141 mol) was dissolved in pyridine (160 mL) andcooled to 0° C. under N₂. A solution of tert-butyldimethylsilyl chloride(TBSCl, 21.3 g, 0.141 mol) in CH₂Cl₂ (70 mL) was added over 1 h and thetemperature was maintained at <1° C. The reaction mixture was stirredfor an additional 1 h at 0° C., then a second portion of TBSCl (2.0 g,0.014 mol) in CH₂Cl₂ (7 mL) was added and stirred at 0° C. for 1 h. Thereaction mixture was warmed to room temperature for 2 h and thenre-cooled to 0° C. Acetic anhydride (80 mL) was added over 1 h at 0° C.and the solution was warmed to room temperature overnight. After 12 h atrt, the reaction mixture was poured onto ice water (1 L) and stirred for1 h. The biphasic solution was extracted with EtOAc in 3 portions (1 L,then 2×250 mL). The combined organics were concentrated and the productrecrystallized from hot ethanol (300 mL) to give 5 (66 g, 86% yield) asa white solid. TBS removal was performed as described in SOP 1 using 5(32 g, 59 mmol) and Sc(OTf)₃ (400 mg, 0.8 mmol). Product 6 was formed in88% yield (22.5 g). Allyl removal was performed as described in SOP 2using Ir catalyst (1.0 g, 1.2 mmol), 5 (70 g, 127 mmol), 50% aqueous NMO(100 mL) and OsO₄ (20 mg, 0.08 mmol). Product 7 was formed in 94% yield(61 g). Glycosyl trichloroacetimidate 8 was formed as described in SOP3a using 7 (61 g, 120 mmol), trichloroacetonitrile (30 mL) and DBU (1mL). Product 8 was formed in 96% yield (75.9 g).

Synthesis of Monosaccharide Building Blocks 14 and 47 for SelectiveProtection and Subsequent Acetylation of Individual Monosaccharide Units

Starting sugar 1 (50 g, 130 mmol; see FIG. 3) was dissolved in THF (350mL). With constant stirring, a solution of NaHCO₃ (22 g in 170 mL H₂O)was added slowly over 20 minutes. The reaction mixture was stirred foran additional 20 minutes. Troc-Cl (18.5 mL, 60 mmol) was added over 10minutes followed by a second portion (18.5 mL, 60 mmol). After 1 hour,the reaction mixture was diluted with H₂O (500 mL) and EtOAc (1 L). Theorganics were partitioned and washed with 2×250 mL brine, dried overNa₂SO₄, filtered and concentrated. Product 9 was recovered inquantitative yield (69 g). To a solution of 9 (78 g, 0.15 mol) in CH₂Cl₂(350 mL) were added allyl alcohol (43 mL). The reaction mixture waspurged with N₂ and cooled to 0° C. SnCl₄ (43 mL) was added dropwise over1 h. The reaction mixture was kept at 0° C. for 6 h then warmed to roomtemperature and stirred for 24 h. The solution was poured into ice water(1 L), separated and the organics were washed with 3×500 mL H₂O, driedover Na₂SO₄, filtered and concentrated to a syrup. Recovered 10 (72 g)as a yellow oil in 92% yield. A solution of 10 (72 g, 138 mmol) wasdissolved in MeOH (300 mL) and cooled to 0° C. Acetyl chloride (30 mL)was added dropwise over 5 minutes. The solution was allowed to warm toroom temperature over 2 h and stirred for an additional 48 h. Thereaction mixture Was concentrated in vacuo to afford 11 (54 g) as ayellow syrup that was used in the next step without furtherpurification. Starting monomer 11 (54 g, 0.138 mol) was dissolved inpyridine (180 mL) and cooled to 0° C. under N₂. A solution oftert-butyldimethylsilyl chloride (TBSCl, 23.7 g, 0.157 mol) in CH₂Cl₂(75 mL) was added over 1 h and the temperature was maintained at <1° C.The reaction mixture was stirred for an additional 1 h at 0° C., then asecond portion of TBSCl (4.0 g, 0.028 mol) in CH₂Cl₂ (10 mL) was addedand stirred at 0° C. for 1 h. The reaction mixture was warmed to roomtemperature for 2 h and then re-cooled to 0° C. Acetic anhydride (80 mL)was added over 1 h at 0° C. and the solution was warmed to roomtemperature overnight. After 12 h at rt, the reaction mixture was pouredonto ice water (1 L) and stirred for 1 h. The biphasic solution wasextracted with EtOAc in 3 portions (1 L, then 2×250 mL). The combinedorganics were concentrated and the product recrystallized from hotethanol (300 mL) to give 12 (65 g, 80% yield) as a white solid. Allylremoval was performed as described in SOP 2 using Ir catalyst (0.6 g,0.7 mmol), 12 (32 g, 54 mmol), 50% aqueous NMO (50 mL) and OsO₄ (10 mg,0.04 mmol). Product 13 was formed in 70% yield (21 g, 38 mmol). Glycosyltrichloroacetimidate 14 was formed as described in SOP 3 using 13 (21 g,38 mmol), trichloroacetonitrile (30 mL) and K₂CO₃ (20 g). Product 14 wasformed in 97% yield (25.5 g).

Example 10 Synthesis of Disaccharide Building Blocks

FIG. 4A-4D outline reaction schemes for synthesizing variousdisaccharide building blocks, including those depicted in FIG. 4A whichproceeds according to the following steps. In FIG. 4A, coupling wasperformed as described in SOP 4 using trichloroacetimidate 14 (13.2 g,19.1 mmol), acceptor 6 (6.34 g, 14.7 mmol) and TMSOTf (2.94 mL, 0.5 M inCH₂Cl₂, 1.47 mmol). Product 15 was formed in 80% yield (11.04 g). Allylremoval was performed as described in SOP 2 using Ir catalyst (0.25 g,0.3 mmol), 15 (10 g, 10 mmol), 50% aqueous NMO (25 mL) and OsO₄ (5 mg,0.02 mmol). Product 16 was formed in 90% yield (9 g, 9 mmol). Glycosyltrichloroacetimidate 17 was formed as described in SOP 3 using 16 (9 g,9 mmol), trichloroacetonitrile (20 mL) and K₂CO₃ (10 g). Product 17 wasformed in quantitative yield (10 g).

The reaction schemes depicted in FIGS. 4B-4D employ monosaccharidebuilding block starting materials (as shown), but essentially the samesteps and SOPs (-1, -2, -3, and -4) as described above. For example, inFIG. 4C, coupling was performed as described in SOP 4 using:trichloroacetimidate 14 (12 g, 17.2 mmol), acceptor 47 (6.86 g, 14.3mmol) and TMSOTf (1.43 mL, 1.0 M in CH₂Cl₂, 1.43 mmol). Product 48 wasformed in 98% yield (14.2 g, 14 mmol).

Example 11 Synthesis of Mixed-N-acetyl oligo-β-(1→6)-glucosamineStructures

FIG. 5A-5B depict a reaction scheme for synthesizing a mixed-N-acetyloligo-β-(1→6)-glucosamine 6-mer (37 in FIG. 2B), which proceedsaccording to the following steps. Utilization of monosaccharide anddisaccharide building blocks described in FIGS. 3 and 4A-4D inconjunction with the indicated SOPs additionally described in Examples2-8 exemplify the methodologies and reagents for synthesizingmixed-N-acetyl oligo-β-(1→6)-glucosamine structures, includingoligosaccharides 37, 40, and 34 in FIG. 2B, the syntheses of which areoutlined in FIGS. 5A, 5B (6-mer, 37), FIGS. 6A, 6B (12-mer, 40), andFIGS. 7A, 7B (18-mer, 34) and further described below.

Synthesis of Mixed-N-acetyl oligo-β-(1→6)-glucosamine 6-mer thiol 37

Referring to FIG. 5A, coupling was performed as described in SOP 4 usingtrichloroacetimidate 8 (65 g, 101 mmol), acceptor 6 (36.3 g, 84 mmol)and TMSOTf (8.4 mL, 1.0 M in CH₂Cl₂, 8.4 mmol). Product 18 was formed in96% yield (75 g). TBS removal was performed as described in SOP 1 using18 (35 g, 38 mmol) and Sc(OTf)₃ (400 mg, 0.8 mmol). Product 21 wasformed in 84% yield (26 g, 32 mmol). Allyl removal was performed asdescribed in SOP 2 using Ir catalyst (0.50 g, 0.6 mmol), 18 (50 g, 55mmol), 50% aqueous NMO (50 mL) and OsO₄ (10 mg, 0.04 mmol). Product 19was formed in 77% yield (37.5 g, 42.5 mmol). Glycosyltrichloroacetimidate 20 was formed as described in SOP 3 using 19 (37 g,42 mmol), trichloroacetonitrile (20 mL) and DBU (0.6 mL). Product 20 wasformed in quantitative yield (44 g). Coupling was performed as describedin SOP 4 using trichloroacetimidate 20 (35 g, 34 mmol), acceptor 21 (23g, 28 mmol) and TMSOTf (2.8 mL, 1.0 M in CH₂Cl₂, 2.8 mmol). Product 22was formed in 82% yield (38 g). TBS removal was performed as describedin SOP 1 using 22 (37 g, 22 mmol) and Sc(OTf)₃ (400 mg, 0.8 mmol).Product 23 was formed in 68% yield (24 g, 15 mmol).

Referring now to FIG. 5B, coupling was performed as described in SOP 4using trichloroacetimidate 17 (9.9 g, 9.2 mmol), acceptor 23 (12 g, 7.7mmol) and TMSOTf (0.77 mL, 1.0 M in CH₂Cl₂, 0.77 mmol). Product 24 wasformed in 83% yield (15.7 g, 6.4 mmol). TBS removal was performed asdescribed in SOP 1 using 24 (4.55 g, 1.8 mmol) and Sc(OTf)₃ (60 mg, 0.12mmol). Product 27 was formed in 83% yield (3.6 g, 1.5 mmol). Exchange ofN-Troc for N-Acetate groups was performed as described in SOP 5 using 27(0.50 g, 0.23 mmol) and Zn (1 g) in THF:Ac₂O:AcOH (20 mL). Product 35was formed in 51% yield (0.25 g, 0.12 mmol). Thiol addition wasperformed as described in SOP 6 using 35 (0.20 g, 0.09 mmol), HSAc (0.5mL) and AIBN (50 mg). Product 36 was formed in 78% yield (0.16 g, 0.07mmol). Deprotection was performed as described in SOP 7 using 36 (0.15g, 0.06 mmol) and hydrazine (1 mL). Product 37 was formed in 90% yield(0.07 g, 0.054 mmol).

Synthesis of Mixed-N-acetyl oligo-β-(16)-glucosamine 12-mer thiol

As depicted in FIGS. 6A and 6B, synthesis of the mixed-N-acetyloligo-β-(1→6)-glucosamine 12-mer thiol proceeded according to thefollowing steps. With reference to FIG. 6A, allyl removal in 24 wasperformed as described in SOP 2 using Ir catalyst (0.25 g, 0.3 mmol), 24(7.5 g, 3.0 mmol), 50% aqueous NMO (25 mL) and OsO₄ (5 mg, 0.04 mmol).Product 25 was formed in 93% yield (7.0 g, 2.8 mmol). Glycosyltrichloroacetimidate 26 was formed from 25 as described in SOP 3b using25 (7.0 g, 2.8 mmol), trichloroacetonitrile (10 mL) and K₂CO₃ (7 g).Product 26 was formed in 86% yield (6.3 g, 2.4 mmol). TBS removal of wasperformed as described in SOP 1 using 24 (4.55 g, 1.8 mmol) and Sc(OTf)₃(60 mg, 0.12 mmol). Product 27 was formed in 83% yield (3.6 g, 1.5mmol). Coupling of 26 and 27 was performed as described in SOP 4 usingtrichloroacetimidate 26 (4.2 g, 1.6 mmol), acceptor 27 (3.2 g, 1.36mmol) and TMSOTf (1.36 mL, 0.1 M in CH₂Cl₂, 0.136 mmol). Product 28 wasformed in 65% yield (4.2 g, 0.88 mmol). TBS removal in 28 was performedas described in SOP 1 using 28 (4.0 g, 0.84 mmol) and Sc(OTf)₃ (60 mg,0.12 mmol). Product 29 was formed in 63% yield (2.6 g, 0.55 mmol);

Referring now to FIG. 6B, (6) exchange of N-Troc for N-Acetate groups in29 was performed as described in SOP 5 using 29 (0.47 g, 0.10 mmol) andZn (1 g) in THF:Ac₂O:AcOH (20 mL). Product 38 was formed in 90% yield(0.4 g, 0.09 mmol). Thiol addition to 38 was performed as described inSOP 6 using 38 (0.40 g, 0.09 mmol), HSAc (0.5 mL) and AIBN (50 mg).Product 39 was formed in 57% yield (0.23 g, 0.51 mmol). Deprotection of39 and formation of 40 was performed as described in SOP 7 using 39(0.22 g, 0.065 mmol) and hydrazine (3 mL). Product 40 was formed in 73%yield (0.10 g, 0.047 mmol).

Synthesis of Mixed-N-acetyl oligo-β-(1→6)-glucosamine 18-mer thiol

As depicted in FIG. 7, synthesis of the mixed-N-acetyloligo-(3-(1→6)-glucosamine 18-mer thiol proceeded according to thefollowing steps. Coupling of 26 and 29 was performed as described in SOP4 using trichloroacetimidate 26 (1.17 g, 0.455 mmol), acceptor 29 (1.41g, 0.303 mmol) and TMSOTf (0.3 mL, 0.1 M in CH₂Cl₂, 0.03 mmol). Product30 was formed in 67% yield (1.4 g, 0.20 mmol). TBS removal in 30 wasperformed as described in SOP 1 using 30 (2 g, 0.29 mmol) and Sc(OTf)₃(40 mg, 0.08 mmol). Product 31 was formed in 90% yield (0.18 g, 0.26mmol). Exchange of N-Troc for N-Acetate groups in 31 was performed asdescribed in SOP 5 using 31 (0.73 g, 0.10 mmol) and Zn (1 g) inTHF:Ac₂O:AcOH (20 mL). Product 32 was formed in 92% yield (0.6 g, 0.092mmol). Thiol addition to 32 was performed as described in SOP 6 using 32(0.6 g, 0.092 mmol), HSAc (0.₅ mL) and AIBN (50 mg). Product 33 wasformed in 83% yield (0.5 g, 0.076 mmol). Deprotection of 33 andformation of 34 was performed as described in SOP 7 using 33 (0.5 g,0.076 mmol) and hydrazine (3 mL). Product 34 was formed in 79% yield(0.19 g, 0.06 mmol).

Table 1 provides supporting characterization data for selected antigensand intermediates described in Example 11.

TABLE 1 Molecule NMR Mass Spec Series Description # ¹H ¹³C Theo. ESI(Pos. Mode) MALDI 6-mer Troc/Phth 27 ✓ 2355 2376 (M + Na⁺) NHAc/Phth 35✓ 2221 2277 (M⁺ + HOAc) NHAc/Phth/SAc 36 ✓ 2340 2353 (M⁺) NHAc/NH₂ 37 ✓✓ 1101 1101 (M⁺) 12-mer Troc/Phth 29 ✓ 4652 4674 (M + Na⁺) NHAc/Phth 38✓ 4386 4409 (M + Na⁺) NHAc/Phth/SAc 39 ✓ 4459 4482 (M + Na⁺) NHAc/NH₂ 40✓ ✓ 2109 2110 (M + H⁺) 18-mer Troc/Phth 31 ✓ 6949 6973 (M + Na⁺)NHAc/Phth 32 ✓ 6549 6572 (M + Na⁺) NHAc/Phth/SAc 33 ✓ 6622 6668 (M⁺ +HOAc) NHAc/NH₂ 34 ✓ ✓ 3117 1039 (M⁺³) 3140 (M + Na⁺)

In Table 1, protein assays were performed according to the method ofBradford, M. Anal. Biochem. 1976, 72, 248. Maldi analysis was performedusing 2,5-dihydroxybenzoid acid as a matrix. Copy numbers weredetermined by the formula: copynumber=[Maldi_((observed))−76,000_((Maldi of BSA alone))]/antigen MW.Carbohydrate content in KLH sample was extrapolated from BSA using theformula: KLH carbohydrate content=BSA carbohydrate content/2.65.

Example 12 Conjugation of Mixed-N-acetyl oligo-β-(1→6)-glucosaminethiols to BSA and KLH

Conjugation of Mixed-N-acetyl oligo-β-(1→6)-glucosamine 6-mer thiol 34to BSA and KLH

FIGS. 8A and 8B depict reaction schemes for conjugating a mixed-N-acetyloligo-β-(1→6)-glucosamine 6-mer thiol 37 to BSA and KLH as follows.First, a conjugation stock solution of hexamer thiol 37 was prepared bydissolving the hexamer thiol 37 (4.2 mg, 3.81 μmol) in water (0.300 mL).A solution of tris(2-carboxyethyl)phosphine (TCEP) in water (40 μL, 0.05M, 1.95 μmol) was added and stirred for 1 hour. Imject® ConjugationBuffer (Pierce, 300 μL) was added to provide a stock solution forconjugation to BSA (FIG. 8A) and KLH (FIG. 8B).

With reference to FIG. 8A, the conjugation stock solution of hexamerthiol 37 (500 μL, 3.0 μmol) was added to a solution ofmaleimide-activated bovine serum albumin (Imject® BSA, Pierce, Rockford,Ill.) (5 mg, —1.5 μmol maleimide) in Imject® Conjugation Buffer (Pierce,250 μL diluted with 250 μL water) and the resulting solution stirred for18 hours at room temperature. The reaction mixture was purified byde-salting on D-Salt P-6000 10 mL column (Pierce, Rockford, Ill.). Thecolumn was pre-equilibrated with 30 mL of purification buffer (Pierce,Prod. No. 77159), the crude material loaded onto the column and elutedwith purification buffer. 1-mL fractions were collected and analyzed forprotein content by absorbance at 280 nm (A₂₈₀). Fractions containingprotein were combined and lyophilized to give the desired hexamer-BSAconjugate 41.

Turning now to FIG. 8B, the conjugation stock solution of hexamer thiol37 (140 μL, 0.86 μmol) was added to a solution of maleimide-activatedkeyhole limpet hemocyanin (Imject® KLH, Pierce, Rockford, Ill.) (5 mg,˜0.43 μmol maleimide) in water (0.5 mL) was added and the resultingsolution stirred overnight at room temperature. The reaction mixture waspurified by de-salting on D-Salt P-6000 10 mL column (Pierce, Rockford,Ill.). The column was pre-equilibrated with 30 mL of purification buffer(Pierce, Prod. No. 77159), the crude material loaded onto the column andeluted with purification buffer. 1-mL fractions were collected andanalyzed for protein content by absorbance at 280 nm (A₂₈₀). Fractionscontaining protein were combined and lyophilized to give the desiredhexamer-KLH conjugate 42.

Conjugation of Mixed-N-acetyl oligo-β-(1→6)-glucosamine 12-mer thiol 40to BSA and KLH

FIGS. 9A and 9B depict reaction schemes for conjugating mixed-N-acetyloligo-β-(1→6)-glucosamine 12-mers (Ag 9 in FIG. 2B) to BSA and KLH asfollows. First, a conjugation stock solution of 12-per thiol 40 wasprepared by dissolving the 12-mer 40 (8.1 mg, 3.84 μmol) in water (300μL). A solution of tris(2-carboxyethyl)phosphine (TCEP) in water (30 μL,0.05 M, 1. 5 μmol) was added and stirred for 1 hour. Imject® ConjugationBuffer (Pierce, 300 μL) was added to provide a stock solution forconjugation to BSA (FIG. 9A) and KLH (FIG. 9B).

With reference to FIG. 9A, the conjugation stock solution of 12-merthiol 40 (500 μL, 3.0 μmol) was added to a solution ofmaleimide-activated bovine serum albumin (Imject® BSA, Pierce, Rockford,Ill.) (5 mg, ˜1.5 μmol maleimide) in Imject® Conjugation Buffer (Pierce,250 μL diluted with water, 250 μL) and the resulting solution stirredfor 18 hours at room temperature. The reaction mixture was purified byde-salting on D-Salt P-6000 10 mL column (Pierce, Rockford, Ill.). Thecolumn was pre-equilibrated with 30 mL of purification buffer (Pierce,Prod. No. 77159), the crude material loaded onto the column and elutedwith purification buffer. 1-mL fractions were collected and analyzed forprotein content by absorbance at 280 nm (A₂₈₀). Fractions containingprotein were combined and lyophilized to give the desired 12-mer-BSAconjugate 43.

Turning now to FIG. 9B, the conjugation stock solution of 12-mer thiol40 (140 μL, 0.86 μmol) was added to a solution of maleimide-activatedkeyhole limpet hemocyanin (Imject® KLH, Pierce, Rockford, Ill.) (5 mg,˜0.43 μmol maleimide) in water (0.5 mL) was added and the resultingsolution stirred overnight at room temperature. The reaction mixture waspurified by de-salting on D-Salt P-6000 10 mL column (Pierce, Rockford,Ill.). The column was pre-equilibrated with 30 mL of purification buffer(Pierce, Prod. No. 77159), the crude material loaded onto the column andeluted with purification buffer. 1-mL fractions were collected andanalyzed for protein content by absorbance at 280 nm (A₂₈₀). Fractionscontaining protein were combined and lyophilized to give the desired12-mer-KLH conjugate 44.

Conjugation of Mixed-N-acetyl oligo-β-(1→6)-glucosamine 18-mer thiol 34to BSA and KLH

FIGS. 10A and 10B depict reaction schemes for conjugating mixed-N-acetyloligo-β-(1→6)-glucosamine 18-mers (Ag 3 in FIG. 2B) to BSA and KLH asfollows. First, a conjugation stock solution of 18-mer thiol 34 wasprepared by dissolving the 18-mer 34 (12 mg, 3.8 μmol) in water (0.3mL). A suspension of tris(2-carboxyethyl)phosphine (TCEP)-bound agaroseresin in water (200 μL, ˜1 μmol) was added and stirred for 1 hour. TheTCEP-resin was filtered and to the filtrate was added Imject®Conjugation Buffer (Pierce, 300 μL) to provide a stock solution forconjugation to KLH (FIG. 10A) and BSA (FIG. 10B).

With reference to FIG. 10A, the conjugation stock solution of 18-merthiol 34 (0.5 mL, 3.0 μmol) was added to a solution ofmaleimide-activated bovine serum albumin (Imject® BSA, Pierce, Rockford,Ill.) (5 mg, ˜1.5 mol maleimide) in Imject® Conjugation Buffer (Pierce,250 μL diluted with water, 2500 μL) and the resulting solution stirredfor 18 hours at room temperature. The reaction mixture was purified byde-salting on D-Salt P-6000 10 mL column (Pierce, Rockford, Ill.). Thecolumn was pre-equilibrated with 30 mL of purification buffer (Pierce,Prod. No. 77159), the crude material loaded onto the column and elutedwith purification buffer. 1-mL fractions were collected and analyzed forprotein content by absorbance at 280 nm (A₂₈₀). Fractions containingprotein were combined and lyophilized to give the desired 18-mer-BSAconjugate 45.

Turning now to FIG. 10B, the conjugation stock solution of 18-mer thiol34 (0.14 mL, 0.86 μmol) was added to a solution of keyhole limpethemocyanin (Imject® KLH, Pierce, Rockford, Ill.) (5 mg, ˜0.43 μmolmaleimide) in water (500 μL) and the resulting solution stirred for 18hours at room temperature. The reaction mixture was purified byde-salting on D-Salt P-6000 10 mL column (Pierce, Rockford, Ill.). Thecolumn was pre-equilibrated with 30 mL of purification buffer (Pierce,Prod. No. 77159), the crude material loaded onto the column and elutedwith purification buffer. 1-mL fractions were collected and analyzed forprotein content by absorbance at 280 nm (A₂₈₀). Fractions containingprotein were combined and lyophilized to give the desired 18-mer-KLHconjugate 46.

Table 2 provides supporting characterization data for the antigenconjugates described in Example 12.

TABLE 2 Protein Assay % Carbohydrate Conjugate BSA KLH Antigen Ave Copy# Description (mg/mL) (mg/mL) MALDI MW Number MALDI Sample 41 S-6Mix-BSA1.62 100,900 1101 23 23% 42 S-6Mix-KLH 0.85 1101  9% 43 S-12Mix-BSA 0.98112,100 2109 17 30% 44 S-12Mix-KLH 1.32 2109 11% 45 S-18Mix-BSA 1.33126,251 3117 16 38% 46 S-18Mix-KLH 1.21 3117 14%

In Table 2, protein assays, Maldi analysis, copy numbers, andcarbohydrate content were determined as described above with referenceto Table 1.

Example 13 Serum Antibody Production and Purification

Antisera to antigen-KLH conjugates were raised in New Zealand whiterabbits by four subcutaneous injections of antigen-KLH conjugate over 13weeks. A pre-immune bleed generated 5 mL of baseline serum from eachrabbit. The prime injection (10 μg antigen equivalent) was given as anemulsion in complete Freund's adjuvant (CFA). Subsequent injections (5μg antigen equivalent) were given at three week intervals in incompleteFreund's adjuvant (IFA). Rabbits were bled every two weeks commencingone week after the third immunization. Approximately 25-30 mL of serumper rabbit was generated for each bleeding event, and was aliquoted into1-mL aliquots and frozen at −80° C. Serum was analyzed by ELISA againstthe corresponding antigen-BSA conjugate as described in Example 3 below.

Affinity purification of antisera was conducted with serum from thethird bleed from each rabbit. Affinity purification was carried out bycoupling of antigen-BSA conjugates to CNBr-activated Sepharose 4B.Briefly, CNBr-activated Sepharose 4B (0.8 g, 2.5 ml of final gel volume)was washed and re-swelled on a sintered glass filter with 1 mM HCl, thencoupling buffer (0.1 M NaHCO₃, 0.25M NaCl, pH 8.5). Antigen-BSAconjugate (1 mg) was dissolved in coupling buffer, mixed with the gelsuspension and incubated overnight at 40° C. Unreacted active groupswere capped with glycine buffer (0.2M, pH 8.1) and excess adsorbedconjugated was washed away with coupling buffer, then acetate buffer(0.1 M containing 0.5M NaCl, pH 4.3). The column was equilibrated withphosphate buffered saline (PBS), pH 7.7.

Antisera were affinity purified by diluting clear antiserum (5 mL) 1:1with PBS pH 7.7 and applying the diluted antisera to the affinity columnat the rate of 0.3 ml/min and absorbance of eluate was monitored at 280nm. Unbound material (flow through) was collected and analyzed by ELISAusing the general ELISA procedure. The column was washed with PBS untilA280 reached baseline. Bound antibodies were eluted with 0.2M glycine(pH 1.85) into one fraction until the A280 returned to baseline.Fractions were neutralized with 1M Tris-HCl, pH 8.5 immediately aftercollection and the OD at 280 nm was determined. ELISA analysis wasconducted using the corresponding antigen-BSA conjugate according to thegeneral ELISA protocol to confirm the recovered antibody and the removalof all the antibodies from the original serum. Antibody quantificationwas determined by A280 reading of the antibody (a small amount wasdiluted to give an OD value of about 1.0) and this value was divided bythe extinction coefficient of IgG, 1.4, to give mg/mL. The solutionswere concentrated to ˜1-2 mg/mL, dialyzed against PBS with 0.02% sodiumazide, aliquoted and frozen at −80° C.

Example 14 ELISA Plate Preparation and Use

An oligosaccharide-BSA conjugate solution was prepared by dissolving theconjugate in carbonate buffer (1.59 g Na₂CO₃, 2.93 g NaHCO₃, 0.20 gNaN₃, dissolved and diluted to 1 L in H₂O, final pH 9.5) at aconcentration of 5-10 μg/mL. COSTAR flat bottom EIA 8-well strips wereincubated with oligosaccharide-BSA conjugate solution (100 μL per well)for 24 hours in a humidity chamber to coat the well surfaces. Coatingsolution was removed, each well was rinsed twice with water, and driedon a paper towel. Blocking solution (0.1% BSA in PBS with 0.02%thimerosal, 200 μL) was added to each well and incubated for 2 hours ina humidity chamber. Blocking solution was removed; each well was rinsedwith water and dried on a paper towel.

Serum samples were prepared by 1:5 serial dilutions starting from a1:1,000 dilution of serum in 0.1% BSA in PBS with 0.02% thimerosal.Diluted serum (100 μL) was added to each well and incubated for 2 hoursat room temperature in a humidity chamber. The serum solution wasremoved, the wells were rinsed twice with water and dried on a papertowel. Goat anti-rabbit-HRP conjugate solution (100 μL/well) was addedand incubated for 2 hours at room temperature in a humidity chamber. TheHRP-conjugate solution was removed, and wells were washed three timeswith PBS/0.02% thimerosal/0.05% tween-20, twice with water, and dried ona paper towel. TMB solution (100 μL/well) was added and developed atroom temperature. The reaction was stopped by the addition of 1N HCl(100 μL/well) and the wells were read immediately at A450 (absorbance at450 nm). The titer of the test serum was designated as the dilutionwhich gave an optical density (OD₄₅₀) reading of 0.1 above background.

Example 15 Rabbit Immunogenicity and ELISA Results

Immunogenicity of Synthetic Antigen-KLH Conjugates in Rabbits (ELISA).

FIGS. 11A-11C depict IgG antibody titers as a function ofantibody-antigen complex absorption (OD₄₅₀) at 3 serum dilutions ofimmune sera obtained from 3 successive bleeds (pre-immune, ^(1st) bleed,and final bleed) in rabbits (n=2) immunized with antigen-KLH conjugatescorresponding to (A) 6-Mix-KLH 42; (B) 12-Mix-KLH 44; and (C) 18-Mix-KLH46. In each case, the antisera were incubated on ELISA plates adsorbedwith their corresponding BSA conjugate, specifically, (A) 6-Mix-BSA 41;(B) 12-Mix-BSA 43; and (C) 18-Mix-BSA 45 as described the ELISA protocolabove (Example 14).

FIGS. 11D-11F depict antigen-specific IgG antibody titers fromantigen-KLH conjugate-derived antibodies recovered at three successivestages of purification, including the pre-affinity purification fraction(3^(rd) bleed), the flow-through fraction, and the antibody-enriched(purified) fraction. Results are shown as a function of antibody-antigencomplex absorption (OD₄₅₀) at the indicated serum dilutions obtainedfrom the above-described antibody-enriched fractions generated againstantigen-KLH conjugates corresponding to (A) 6-Mix-KLH 42; (B) 12-Mix-KLH44; and (C) 18-Mix-KLH 46. In each case, the antisera were incubated onELISA plates adsorbed with their corresponding BSA conjugate,specifically, (A) 6-Mix-BSA 41; (B) 12-Mix-BSA 43; and (C) 18-Mix-BSA45.

Affinity purification of 10 mL of 3^(rd) bleed sera (in each case)yielded: 5.5 mL of a purified 6-Mix Ab solution at 2.3 mg/mL (12.7 mgpurified Ab total); 5.4 mL of a purified 12-Mix Ab solution at 5.5 mg/mL(29.7 mg purified Ab total); and 5.4 mL of purified 18-Mix Ab solutionat 1.7 mg/mL (9.2 mg purified Ab total).

Example 16 Specificity and Cross-Reactivity of Antisera to DifferentAntigens

FIGS. 12A-12G depict the results of a cross-ELISA assay examining thespecificity and cross-reactivity between fully non-acetylated (6-NH₂ 61,12-NH₂ 62, 18-NH₂ 63;); mixed (6-Mix 37, 12-Mix 40, 18-Mix 34) and fullyacetylated (6-NHAc 58, 12-NHAc 59, 18-NHAc 60;)oligo-β-(1→6)-glucosamines and antibodies derived therefrom. In FIGS.12A-12G, antisera from rabbits immunized with the indicated antigen-KLHconjugates corresponding to (left to right) 6-NH₂, 6-Mix 42, 6-NHAc,12-NH₂ 44, 12-Mix, 12-NHAc, 18-NH₂, 18-Mix 46, and 18-NHAc wereincubated in each case with an ELISA plate adsorbed with a differentantigen-BSA conjugate, specifically (A) 6-NH₂-BSA 64; (B) 6-Mix-BSA 41;(C) 6-NHAc-BSA 65; (D) 12-NH₂-BSA 66; (E) 12-Mix-BSA 43; (F)12-NHAc-BSA;. (G) 18-Mix-BSA 45. Results are shown as a function ofantibody-antigen complex absorption (OD₄₅₀) representing the averagesfrom of antisera from two rabbits in each case at the indicated serumdilutions, whereby total OD₄₅₀ is measured by subtracting away thebackground OD₄₅₀ from KLH antibodies alone. The results surprisinglyshowed that antibodies against the 12-Mix-KLH conjugate 44 antigen(16.7% acetylation) cross-reacted strongly with all of the antigensscreened, including fully non-acetylated, mixed, and fully acetylatedantigens, and typically to a greater extent than antibodies against thefully acetylated or fully aminylated oligosaccharides.

Example 17 Whole-Cell ELISA Experiment

FIGS. 13A-13D depict the results of a whole-cell ELISA assay examiningthe binding of pre-immune sera (A, C) or immune sera (B, D) generatedfrom rabbits immunized against (left to right) KLH control, fullynon-acetylated antigen (12-NH₂) 62; mixed antigen (12-Mix) 44 and fullyacetylated antigen (12-NHAc) 59 and Staphylococcus epidermidis coatedonto ELISA fixed with methanol (A, B) or formalin (C, D). Results areshown as a function of antibody-antigen complex absorption (OD₄₅₀) atthe indicated serum dilutions. The results surprisingly showed that atthe higher dilutions, antibodies against the poorly acetylated12-Mix-KLH conjugate 44 antigen (16.7% acetylation) reacted morestrongly to S. epidermidis than antibodies against the fullynon-acetylated (12-NH₂) or fully acetylated (12-NHAc) antigens eventhough the PNAG/dPNAG from natural S. epidermidis isolates are highlyacetylated.

Example 18 Opsonophaoocytic Assay

The opsonophagocytic (bacterial killing) activity of serum samples wasdetermined in an assay using S. aureus ATCC strain 25904 in the presenceof phagocytic cells and complement.

Freshly isolated human PMN's were used as the effector cells in thisassay. PMN's were isolated according to standard protocols known in theart. Briefly, approximately 60 mL of whole human blood was collectedinto 8×10-mL EDTA Vacutainer tubes. The blood from each tube was removedand carefully layered over approximately 15-mL of PMN separation mediumin each of 4×50-mL conical tubes. The mixture was centrifuged at 450×gfor 35 minutes at room temperature. The PNM layers from each tube werewithdrawn and combined in a single tube, diluted with one volume of 0.5×sterile saline and mixed gently. The suspension was centrifuged at 450×gfor 10 minutes at room temperature, and the supernatant was removed anddiscarded. The PMN pellet was resuspended in 5 mL of sterile saline andcentrifuged again at 400-450×g for 10 minutes at room temperature. ThePMN pellet was resuspended in a volume of SMEM medium to give 5×10⁷PMN's per mL (PMN's were counted using a hemocytometer using standardprotocols).

Approximately 50 ul of a stock solution of target bacteria were grown ontryptic soy agar plates with 5% sheep red blood cells (blood agarplates) and incubated overnight at 36-38° C. The bacterial lawn wastransferred to a sterile 50 ml conical containing 30 mls of tryptic soybroth with 1% (w/v) glucose. The bacteria were grown in a shaking waterbatch set for 40 strokes per minute at 36-38° C. for 2-3 hours. Thebacterial suspension was adjusted to a % T of 72-75% (1 cm light path)and 2.7-3.0 ul of this suspension was mixed with 1.4 mls of TSB for afinal concentration of approximately 5-6×10⁴ cfu/ml.

Antisera raised to the antigen-carrier conjugates or antibody controlsolutions were serially diluted and 40 ul of each dilution of eachantiserum or control antibody were added to each well of a 96-well roundbottom plate (Nunc 163320 or equivalent). Antibody dilutions were madein DMEM/F12 medium buffered with 10 mM HEPES to maintain a pH of7.2-7.6.

Forty ul of the PMN cell suspension was added to each well of the96-well assay plate followed by addition of 10 ul of complement (atdifferent dilutions) per well. The complement was derived from humanserum treated with protein A and protein L to extract inherentantibodies reactive with the target bacteria.

The OP reaction was initiated with the addition of 10 ul of thebacterial suspension to each well and the plate was incubated at 36-37°C. in a shaking incubator at ˜100 rpm for 30-40 minutes.

Following addition of the bacteria to the assay plate, the reagents weremixed by rapid pipetting up and down 20-25 times using a multichannelpipettor set at 10 ul. After mixing a sample was removed from each well,diluted 20-fold in water containing 0.1% BSA and 0.01% Tween20. Thesesamples were designated the T₀ samples and 100 ul of each T₀ sample wastransferred to a blood agar plate, allowed to dry, inverted andincubated overnight at 36-37° C.

After transfer of the T₀ samples the assay plate was incubated at 36-37°C. in an orbital shaking incubator at 250-300 rpm for an additional 90minutes. At the end of this incubation period samples were taken fromeach well, diluted and plated as described above (T₉₀ samples).

Assay controls included PMN's alone, PMN's with complement and referenceantibody. The percentage of bacterial killing was calculated using theformula:

$\frac{\left( {{{Number}\mspace{14mu} {of}\mspace{14mu} {colonies}\mspace{14mu} T_{0}} - {{Number}\mspace{14mu} {of}\mspace{14mu} {colonies}\mspace{14mu} T_{90}}} \right)}{\left( {{Number}\mspace{14mu} {of}\mspace{14mu} {Colonies}\mspace{14mu} T_{0}} \right)}*100$

The results are shown below:

TABLE C′ mediated killing of S. epidermidis (ATCC 25984)(Anti-serum @1:40) Bacterial Death (%) Pre-immune 3^(rd) bleed Positive control 0 5Carrier 50 70 Antiserum 1 (Ag8-Carrier) 30 80 Antiserum 2 (Ag9-Carrier)0 70

TABLE C′ mediated killing of S. aureus Newman (Anti-serum @ 1:100)Bacterial Death (%) Pre-immune 3^(rd) bleed Ag8 30 70 Ag9 0 50 Ag10 2060 Ag10 10 80

Example 19 In Vivo Challenge Protocol

Five week old female Crl:CD-1° Swiss outbred mice were acclimated for 7days prior to study start. Mice were randomized into study groups (n=10per group) the day before initial immunization. Test articles werereconstituted using sterile saline to the appropriate dosingconcentration (10 μg glycan equivalent of test article/1004 solution).Each dose was mixed with an equal volume (1004) of CFA or IFA to form astable emulsion. On Day 0, mice were administered a single subcutaneous(SC) treatment of the appropriate test or control article at a volume of100 μL. Prime immunizations were followed by two boost immunizations onDays 11 and 22. A separate group of untreated mice (untreated control)were not be vaccinated.

On Day 29, each mouse was challenged via intravenous tail injection (IV)route with Staphylococcus aureus Newman strain at a concentration ofapproximately 4×10⁹ CFU/mL in a dose volume of 0.2 mL. Bacteriainoculation suspensions were prepared by harvesting isolated coloniesseeding 50-mL of fresh Trypticase Soy Broth (TSB). The culture wasincubated (37° C.) with shaking for approximately 3-5 hours, washed andresuspended. The concentration in the final culture was adjusted to4.0×10⁹ CFU/mL dose using a spectrophotometer (Target OD₆₂₀=3.0). Theconcentration was verified using the dilution plate count method.

On Days −3, 10, 21 and 28 mice were bled via retro-orbital sinus(approx. 0.2 mL) into serum separator tubes for processing of sera(stored frozen at −20° C.). On Days 30, 31 and 32, mice were bled in thesub-mandibular region (approx. 0.1 mL) onto solid media for bacteremiaanalysis. All surviving animals will be euthanized via CO₂ asphyxiationon Day 36. The percentage of survival and mortality for each group wasdetermined and microbiological analyses of blood were expressed as±bacteremia.

The results are shown below:

TABLE Day 7 Survival % survival Vaccine group dPNAG1-carrier(Ag8-Carrier) 88 dPNAG2-carrier (Ag9-Carrier) 78 PNAG-carrier(Ag10-Carrier) 60 Control group Carrier alone 60 untreated 50

It is intended that the foregoing detailed description be regarded asillustrative rather than limiting, and that it be understood that it isthe following claims, including all equivalents, that are intended todefine the spirit and scope of this invention.

1. A homogenous composition consisting essentially of a syntheticoligosaccharide 1a

wherein R¹ and R² are independently selected from H or C(O)CH₃; n is aninteger of at least 3, X is a bond or a linker, and Y is H or a carrier;wherein at least one R¹ or R² in the oligosaccharide is H and at leastanother one is C(O)CH₃; wherein each occurrence of R¹ can be the same ordifferent. 2-113. (canceled)